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  1. Article ; Online: Biomarkers in kidney transplantation: Where do we stand?

    López-Abad, A / Piana, A / Prudhomme, T / Bañuelos Marco, B / Dönmez, M I / Pecoraro, A / Boissier, R / Campi, R / Breda, A / Territo, A

    Actas urologicas espanolas

    2024  

    Language Spanish
    Publishing date 2024-01-06
    Publishing country Spain
    Document type Editorial
    ISSN 2173-5786
    ISSN (online) 2173-5786
    DOI 10.1016/j.acuroe.2024.01.003
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  2. Article ; Online: New frontiers in kidney transplantation: Towards the extended reality.

    Piana, A / Pecoraro, A / Dönmez, M I / Prudhomme, T / Bañuelos Marco, B / López Abad, A / Campi, R / Boissier, R / Checcucci, E / Amparore, D / Porpiglia, F / Breda, A / Territo, A

    Actas urologicas espanolas

    2023  

    Language Spanish
    Publishing date 2023-11-18
    Publishing country Spain
    Document type Editorial
    ISSN 2173-5786
    ISSN (online) 2173-5786
    DOI 10.1016/j.acuroe.2023.11.005
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  3. Article ; Online: Increase of acute-phase reactants after kidney transplantation of non-infectious cause.

    López-Abad, Alicia / Llorente Viñas, Santiago / López Cubillana, Pedro / Llorente Esteban, Santiago / Aznar Martínez, Laura / Vidal Crespo, Natalia / Gómez Gómez, Guillermo Antonio / Cabezuelo Romero, Juan Bernardo

    Nefrologia

    2024  Volume 44, Issue 1, Page(s) 103–105

    MeSH term(s) Acute-Phase Proteins ; Kidney Transplantation ; C-Reactive Protein
    Chemical Substances Acute-Phase Proteins ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2024-02-17
    Publishing country Spain
    Document type Letter
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2024.02.008
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  4. Article: Robot-Assisted Radical Prostatectomy in Renal Transplant Recipients: A Systematic Review.

    Piana, Alberto / Pecoraro, Alessio / Sidoti, Flavio / Checcucci, Enrico / Dönmez, Muhammet İrfan / Prudhomme, Thomas / Bañuelos Marco, Beatriz / López Abad, Alicia / Campi, Riccardo / Boissier, Romain / Di Dio, Michele / Porpiglia, Francesco / Breda, Alberto / Territo, Angelo

    Journal of clinical medicine

    2023  Volume 12, Issue 21

    Abstract: Robot-assisted radical prostatectomy (RARP) has been shown to achieve excellent oncological outcomes with a low rate of complications in patients with prostate cancer. However, data on RARP in renal transplant recipients (RT) are dispersed. A literature ... ...

    Abstract Robot-assisted radical prostatectomy (RARP) has been shown to achieve excellent oncological outcomes with a low rate of complications in patients with prostate cancer. However, data on RARP in renal transplant recipients (RT) are dispersed. A literature search was conducted through April 2023 using PubMed/Medline, Embase and Web of Science databases. The primary aim was to evaluate the safety, oncologic and clinical outcomes of RARP in RT recipients. The secondary aim was to identify surgical technique modifications required to avoid iatrogenic damage to the transplanted kidney. A total of 18 studies comprising 186 patients met the inclusion criteria. Age at the time of treatment ranged 43-79 years. Biopsy results showed a high prevalence of low- and intermediate-risk disease. Operative time ranged between 108.3 and 400 mins, while estimated blood loss ranged from 30 to 630 mL. Length of hospital stay ranged from 3 to 6 days whereas duration of catheterization was between 5 and 18 days. Perioperative complication rate was 17.1%. Overall positive surgical margin rate was 24.19%, while biochemical recurrence was observed in 10.21% (19/186 patients). Modifications to the standard surgical technique were described in 13/18 studies. Modifications in port placement were described in 7/13 studies and performed in 19/88 (21.6%) patients. Surgical technique for the development of the Retzius space was reported in 13/18 studies. Data on lymphadenectomy were reported in 15/18 studies. Bilateral lymphadenectomy was described in 3/18 studies and performed in 4/89 (4.5%) patients; contralateral lymphadenectomy was reported in 7/18 studies and performed in 41/125 (32.8%) patients. RARP in RTRs can be considered relatively safe and feasible. Oncological results yielded significantly worse outcomes in terms of PSM and BCR rate compared to the data available in the published studies, with an overall complication rate highly variable among the studies included. On the other hand, low graft damage during the procedure was observed. Main criticisms came from different tumor screening protocols and scarce information about lymphadenectomy techniques and outcomes among the included studies.
    Language English
    Publishing date 2023-10-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12216754
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  5. Article ; Online: Management of de-novo graft masses in kidney transplantation recipients: focusing on available data and unmet clinical needs.

    López-Abad, Alicia / Pecoraro, Alessio / Prudhomme, Thomas / Piana, Alberto / Amparore, Daniele / Bertolo, Riccardo / Marchioni, Michele / Muselaers, Stijn / Wu, Zhenjie / Territo, Angelo / Campi, Riccardo

    Minerva urology and nephrology

    2023  Volume 75, Issue 2, Page(s) 242–245

    MeSH term(s) Kidney Transplantation/adverse effects ; Immunosuppressive Agents ; Graft Rejection
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2023-03-27
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062840-4
    ISSN 2724-6442
    ISSN (online) 2724-6442
    DOI 10.23736/S2724-6051.23.05311-9
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Graft survival and postoperative complications following orthotopic renal transplantation.

    Territo, Angelo / Selvi, İsmail / Malçok, Aydan / Boissier, Romain / Campi, Riccardo / Prudhomme, Thomas / Pecoraro, Alessio / Piana, Alberto / Lopez-Abad, Alicia / Bañuelos Marco, Beatriz / Breda, Alberto / Dönmez, M İrfan

    Clinical transplantation

    2023  Volume 38, Issue 1, Page(s) e15220

    Abstract: The iliac fossa is the most commonly used site to place the graft in renal transplantation in adults. However, iliac fossa may not be used in various conditions. Thus, orthotopic renal transplantation becomes a viable alternative for these selected ... ...

    Abstract The iliac fossa is the most commonly used site to place the graft in renal transplantation in adults. However, iliac fossa may not be used in various conditions. Thus, orthotopic renal transplantation becomes a viable alternative for these selected patients. Given the technically challenging surgery and limited number of patients, data on the long-term outcomes on this regard are scarce. This narrative review serves as an update on the clinical outcomes after orthotopic renal transplantation, focusing on overall recipient survival and renal graft survival, as well as postoperative complications. We found that studies to date showed a comparable survival rate in both recipients and renal grafts in the postoperative follow-up period after orthotopic renal transplantation with a lower complication rate compared to the published data on heterotopic renal transplantation. The results of our review may encourage transplant centers to reevaluate their policies to consider orthotopic renal transplantation as an alternative technique in cases where heterotopic kidney transplantation is not possible.
    MeSH term(s) Adult ; Humans ; Kidney Transplantation ; Graft Survival ; Kidney ; Transplants ; Postoperative Complications/etiology
    Language English
    Publishing date 2023-12-11
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.15220
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    Zs.A 2204: Show issues Location:
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  7. Article: Manual Therapy Intervention in Men With Chronic Pelvic Pain Syndrome or Chronic Prostatitis: An Exploratory Prospective Case-Series.

    Rabal Conesa, Carlos / Cao Avellaneda, Enrique / López Cubillana, Pedro / Prieto Merino, David / Khalus Plish, Alexander / Martínez Franco, Antonio / López Abad, Alicia

    Cureus

    2022  Volume 14, Issue 4, Page(s) e24481

    Abstract: Purpose Chronic pelvic pain syndrome (CPPS) is permanent pelvic pain of unknown etiology. Current theories suggest a multifactorial origin for CPPS, including urinary pathologies, psychosocial factors, prostate inflammation, infection, central ... ...

    Abstract Purpose Chronic pelvic pain syndrome (CPPS) is permanent pelvic pain of unknown etiology. Current theories suggest a multifactorial origin for CPPS, including urinary pathologies, psychosocial factors, prostate inflammation, infection, central sensitization of the nervous system, and muscular contractures or fibrosis. As there are no defined treatment protocols for CPPS, a multimodal approach is recommended. The objective of this study was to evaluate the impact of a manual therapy treatment protocol on pain, urinary symptoms, and overall quality of life. Materials and Methods Twenty-three men aged 47.36 ± 10.11 years were recruited consecutively by urologists practicing at two hospitals. All men presented prostatic tenderness with no other positive clinical history, urine cultures, or echography studies. Patients underwent six manual therapy sessions (three during the first week and three every two weeks after that) performed by a single osteopath or physiotherapist. The intervention protocol addressed the treatment of muscle structures, fascial mechanics, vascularization, innervation, emotional factors, and the need for information. The questionnaires used to evaluate outcomes included the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), the International Prostate Symptoms Score (IPSS), and a Visual Analog Scale (VAS) for pain, and the Hospital Anxiety and Depression Scale (HADS). Data were evaluated using Chi-squared or paired difference tests by an external researcher. Results The mean NIH-CPSI scores recorded for our study cohort decreased by 7.69 points (30.92%;
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.24481
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  8. Article ; Online: Bacillus Calmette-Guérin in Immunosuppressed Patient with High-Grade Nonmuscle Invasive Bladder Carcinoma.

    Aznar Martínez, Laura / López Cubillana, Pedro / López Abad, Alicia / Vidal Crespo, Natalia / Gómez Gómez, Guillermo Antonio

    Urologia internationalis

    2019  Volume 103, Issue 2, Page(s) 242–244

    Abstract: Due to their immunosuppressed status, solid organ transplant recipients are a special group of patients with an incidence of bladder cancer greater than the rest of the population, especially in the first 6 years after transplantation. Also, treatment ... ...

    Abstract Due to their immunosuppressed status, solid organ transplant recipients are a special group of patients with an incidence of bladder cancer greater than the rest of the population, especially in the first 6 years after transplantation. Also, treatment with Bacillus Calmette-Guérin, a reference therapy in nonmuscle invasive high-risk bladder cancer, may be less effective in this group of patients and could cause more adverse effects. However, the data published so far and the experience initiated in the Virgen de la Arrixaca Clinical University Hospital do not support these hypotheses.
    MeSH term(s) Adjuvants, Immunologic/therapeutic use ; Aged ; BCG Vaccine/therapeutic use ; Humans ; Immunosuppression ; Male ; Neoplasm Grading ; Neoplasm Invasiveness ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology
    Chemical Substances Adjuvants, Immunologic ; BCG Vaccine
    Language English
    Publishing date 2019-07-03
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 204045-1
    ISSN 1423-0399 ; 0042-1138
    ISSN (online) 1423-0399
    ISSN 0042-1138
    DOI 10.1159/000501108
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    Ui VI Zs.180: Show issues Location:
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  9. Article: Real-world prostate-specific antigen reduction and survival outcomes of metastatic hormone-sensitive prostate cancer patients treated with apalutamide: An observational, retrospective, and multicentre study.

    López-Abad, Alicia / Ramírez Backhaus, Miguel / Server Gómez, Gerardo / Cao Avellaneda, Enrique / Moreno Alarcón, Cristóbal / López Cubillana, Pedro / Yago Giménez, Pablo / de Pablos Rodríguez, Pedro / Juan Fita, María J / Climent Durán, Miguel Á / Guardiola Ruiz, Iris / Vidal Crespo, Natalia / Artés Artés, Miriam / Montoya Chinchilla, Raúl / Moreno Avilés, Juan / Guzmán Martínez-Valls, Pablo L / López González, Pedro Á

    Prostate international

    2023  Volume 12, Issue 1, Page(s) 20–26

    Abstract: Background: Metastatic hormone-sensitive prostate cancer (mHSPC) treatment has changed drastically during the last years with the emergence of androgen receptor-targeted agents (ARTAs). ARTA combined with androgen deprivation therapy has demonstrated ... ...

    Abstract Background: Metastatic hormone-sensitive prostate cancer (mHSPC) treatment has changed drastically during the last years with the emergence of androgen receptor-targeted agents (ARTAs). ARTA combined with androgen deprivation therapy has demonstrated better oncological and survival outcomes in these patients. However, the optimal choice among different ARTAs remains uncertain due to their analogous efficacy.
    Objectives: The objective of this study was to describe prostate-specific antigen (PSA) response and oncological outcomes of patients with mHSPC treated with apalutamide.
    Material and methods: Medical records from three different hospitals in Spain were used to conduct this study. Patients diagnosed with mHSPC and under apalutamide treatment were included between March 2021 and January 2023. Data regarding PSA response, overall survival (OS), and radiographic progression-free survival (rPFS) were collected and stratified by metastasis volume, timing, and stating.
    Results: 193 patients were included; 34.2% of patients were
    Conclusion: This real-world study on patients with mHSPC treated with apalutamide plus androgen deprivation therapy revealed robust oncological outcomes, aligning with the emerging evidence. The study's hallmark finding highlights the significance of rapid and deep PSA response as a predictor of improved oncological and survival outcomes.
    Language English
    Publishing date 2023-11-02
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2711928-2
    ISSN 2287-903X ; 2287-8882
    ISSN (online) 2287-903X
    ISSN 2287-8882
    DOI 10.1016/j.prnil.2023.10.003
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  10. Article ; Online: CD8+ T lymphocytes are sensitive to NKG2A/HLA-E licensing interaction: role in the survival of cancer patients.

    Gimeno, Lourdes / González-Lozano, Isabel / Soto-Ramírez, María F / Martínez-Sánchez, María V / López-Cubillana, Pedro / Fuster, José L / Martínez-García, Jerónimo / Martínez-Escribano, Jorge / Campillo, José A / Pons-Fuster, Eduardo / Ferri, Belén / López-Abad, Alicia / Muro, Manuel / Minguela, Alfredo

    Oncoimmunology

    2021  Volume 10, Issue 1, Page(s) 1986943

    Abstract: ... NK and ... ...

    Abstract NK and CD8
    MeSH term(s) CD8-Positive T-Lymphocytes ; Histocompatibility Antigens Class I ; Humans ; Neoplasms/genetics ; Retrospective Studies ; HLA-E Antigens
    Chemical Substances Histocompatibility Antigens Class I
    Language English
    Publishing date 2021-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-402X
    ISSN (online) 2162-402X
    ISSN 2162-402X
    DOI 10.1080/2162402X.2021.1986943
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