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  1. Article ; Online: Editorial: A multidisciplinary approach to treatment of severe chronic airway disease (CAD): focus on biomarkers.

    López-Rodríguez, Raquel / Bobolea, Irina / Melero, Carlos / Rial, Manuel J

    Frontiers in allergy

    2024  Volume 5, Page(s) 1357886

    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Editorial
    ISSN 2673-6101
    ISSN (online) 2673-6101
    DOI 10.3389/falgy.2024.1357886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Silver: An underdiagnosed allergen?

    Lopez Rodriguez, Raquel / Goday Bujan, Jaime

    Contact dermatitis

    2021  Volume 84, Issue 6, Page(s) 464–466

    MeSH term(s) Aged, 80 and over ; Dermatitis, Allergic Contact/etiology ; Humans ; Leg ; Male ; Ointments ; Patch Tests ; Silver/adverse effects ; Varicose Ulcer/drug therapy
    Chemical Substances Ointments ; Silver (3M4G523W1G)
    Language English
    Publishing date 2021-01-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 193121-0
    ISSN 1600-0536 ; 0105-1873
    ISSN (online) 1600-0536
    ISSN 0105-1873
    DOI 10.1111/cod.13765
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    Zs.A 1116: Show issues Location:
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  3. Article ; Online: Sputum cytokines associated with raised FeNO after anti-IL5 biologic therapy in severe asthma.

    Hekking, Pieter-Paul / Zhang, Kayla / Garrido, Carmen Paz Venegas / Lopez-Rodriguez, Raquel / Kjarsgaard, Melanie / Mukherjee, Manali / Nair, Parameswaran

    Allergy

    2024  

    Language English
    Publishing date 2024-01-10
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.16011
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  4. Article: Autoinflammatory gene mutations associated with eosinophilia and asthma.

    Alotaibi, Bashayr M / Lopez Rodriguez, Raquel / Garrido, Carmen Venegas / Gonzalez Bravo, Lucia / Khalidi, Nader / Nair, Parameswaran

    Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

    2023  Volume 19, Issue 1, Page(s) 76

    Abstract: Background: Respiratory conditions, such as asthma, are infrequently associated with auto-inflammatory diseases. We describe five patients with uncontrolled respiratory symptoms that were seen at St. Joesph's Healthcare in Hamilton for severe asthma ... ...

    Abstract Background: Respiratory conditions, such as asthma, are infrequently associated with auto-inflammatory diseases. We describe five patients with uncontrolled respiratory symptoms that were seen at St. Joesph's Healthcare in Hamilton for severe asthma management diagnosed with rare autoinflammatory conditions using genetic molecular analysis.
    Case presentation: Five patients are included in this case series. Gene mutations associated with familial Mediterranean fever, Yao syndrome, Cryopyrin-associated periodic syndrome, and Majeed syndrome were considered to explain partly the patient's clinical manifestation after comprehensive clinical, biochemical, hematological investigations ruled out other disorders such as parasitosis, Allergic Bronchopulmonary Fungosis, Eosinophilic Granulomatosis with Poly Angitis, IgG4 disease, and Hypereosinophilia syndrome.
    Conclusions: Complex patients initially presenting with respiratory conditions in addition to unexplained autoinflammatory conditions are a diagnostic challenge. Genetic molecular testing provides healthcare practitioners with useful information that may diagnose underlying auto-inflammatory diseases in undifferentiated patients. Role of inflammasome-activation in asthma and eosinophilia needs further investigation.
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2434973-2
    ISSN 1710-1492 ; 1710-1484
    ISSN (online) 1710-1492
    ISSN 1710-1484
    DOI 10.1186/s13223-023-00837-9
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  5. Article ; Online: Clinical and diagnostic features of 33 patients with aquagenic urticaria.

    López-Rodríguez, Raquel / Castelo Galvan, Helena / Perez-Quintero, Olinda / Rial Prado, Manuel Jorge / Gomez-Fariñas, Carolina / Parra Arrondo, Antonio / Hernandez, Jorge Suanzes / Veleiro Pérez, Beatriz

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 10, Page(s) 3272–3274

    Language English
    Publishing date 2023-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.06.029
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    Zs.A 7086: Show issues Location:
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  6. Article ; Online: Serodominance Profile in a Dust Mite Complex Region.

    López-Rodríguez, Raquel / Rial, Manuel Jorge / Esteban-Gorgojo, Ignacio / Veleiro Pérez, Beatriz / López-Araújo, Gustavo Adolfo / Pérez-Quintero, Olinda / Carballas, Clara / Parra, Antonio / Pineda, Fernando

    International archives of allergy and immunology

    2022  Volume 183, Issue 8, Page(s) 843–851

    Abstract: Background/objective: The objective of this study was to describe the molecular sensitization profile of mite allergy in an area with a high environmental exposure of house dust mites (HDM) and storage mites.: Methods: Skin prick tests were performed ...

    Abstract Background/objective: The objective of this study was to describe the molecular sensitization profile of mite allergy in an area with a high environmental exposure of house dust mites (HDM) and storage mites.
    Methods: Skin prick tests were performed with standardized extracts (DIATER, Madrid, Spain). A specific commercial molecular panel (MADx) for Dermatophagoides pteronyssinus (Dpt), Dermatophagoides farinae (Dfar), Lepidoglyphus destructor (Ldt), Tyrophagus putrescentiae (Tput), and Blomia tropicalis (Blot) was correlated with clinical parameters in Galician (northwestern of Spain) HDM allergic patients.
    Results: Fifty patients (60% female) met the inclusion and exclusion criteria. All of the patient's present rhinitis (50), 28% (14) rhinitis and asthma, and 18% (9) atopic dermatitis (AD). Hundred patients had a positive prick test for Dpt, followed by Dfar (92%), Ldt and Tput (74%), and Blot (68%). More than 50% recognized specific IgE for Der p 1, Der p 2, reaching 86% in the case of Der p 23. No statistically significant differences in IgE levels were found between patients with/without asthma and those with mild or moderate-severe rhinitis. Der p 7 was higher among rhinitis patients (p value 0.05). AD relative risk (RR) was increased in patients sensitized to Der f 2, Der p 2, and Der p 23. Der p 10 decreases the risk to have AD (RR 0.80).
    Conclusion: The evaluation of IgE results in a comprehensive panel of allergens allows differentiation of serological reactivity profiles with their clinical expression, to perform an optimal management. Improvements in component resolved diagnosis and more research on the clinical relevance of mite allergens are needed to achieve a genuine diagnosis leading to specific immunotherapy.
    MeSH term(s) Allergens ; Animals ; Antigens, Dermatophagoides ; Asthma ; Dermatitis, Atopic/chemically induced ; Female ; Humans ; Immunoglobulin E ; Male ; Molecular Diagnostic Techniques ; Pyridinolcarbamate ; Pyroglyphidae ; Rhinitis/diagnosis ; Skin Tests
    Chemical Substances Allergens ; Antigens, Dermatophagoides ; Immunoglobulin E (37341-29-0) ; Pyridinolcarbamate (81R511UV73)
    Language English
    Publishing date 2022-04-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000523869
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    Uh III Zs.155: Show issues Location:
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  7. Article ; Online: Quality of life against seasonal vs perennial allergens: ESPRINT-15 modified in the pediatric population.

    López-Rodríguez, Raquel / Sanz, Juan Hidalgo / Rial, Manuel Jorge / Pérez, Beatriz Veleiro / Hernández, Jorge Suanzes / López-Silvarrey, Angel / Alonso, Margarita Vila / Vera, César García / Guerrero, María Teresa Cenarro / Velillas, Juan José Lasarte / Hernández, María Isabel Moneo / Malo, María José Sánchez / Lombardía, Carmen Rodríguez

    Allergologia et immunopathologia

    2022  Volume 50, Issue 5, Page(s) 16–22

    Abstract: Introduction: Allergic rhinitis (AR) is a clinical syndrome characterized by IgE-mediated inflammation of the nasal mucosa. The present study investigates the quality of life (QoL) with AR among adults, using widely validated questionnaires, unlike in ... ...

    Abstract Introduction: Allergic rhinitis (AR) is a clinical syndrome characterized by IgE-mediated inflammation of the nasal mucosa. The present study investigates the quality of life (QoL) with AR among adults, using widely validated questionnaires, unlike in pediatric patients.
    Materials and methods: A cross-sectional descriptive observational study was conducted, analyzing the QoL of 102 children with AR aged between 10-15 years, belonging to two health centers (HC) in Zaragoza and two HC in Coruña. The comparison of means between the two groups is carried out using the Student's test or the Mann-Whitney test, considering a value of p˂0.05 to be significant.
    Results: Around 102 children were studied, with a majority (59.8%) being male and a mean age of 12 years. Around 76.5% have a family history of atopy. It was found that AR is more prevalent in Zaragoza (p ˂0.005), and asthmais highly prevalent in Coruña (p ˂0.001). The most important sensitizations are pollen in Zaragoza (p ˂0.05) and dust mites in A Coruña (p ˂0.001). More treatment needs and associated comorbidities (p˂0.05) were observed in A Coruña. The results of the ESPRINT-15 show that 63% of the patients have a good QoL, 27% fair, and 8.8%, poor. Those sensitized to mites have a worse score (p = 0.02). It was found that 52% of children experienced improvement during home confinement, with no notable differences between the two populations. The use of the mask favored QoL in patients from Zaragoza (p ˂0.001).
    Conclusion: It was concluded that AR influences the QoL in pediatric patients. Greater QoL involvement, need for treatment, and comorbidities are observed in patients sensitized to dust mites compared to those sensitized to pollens. It was also observed that masks improved the symptoms, stopping patients being sensitized to pollens.
    MeSH term(s) Adolescent ; Adult ; Allergens ; Animals ; Child ; Cross-Sectional Studies ; Dust ; Female ; Humans ; Male ; Pyroglyphidae ; Quality of Life ; Rhinitis, Allergic/epidemiology ; Seasons
    Chemical Substances Allergens ; Dust
    Language English
    Publishing date 2022-09-01
    Publishing country Singapore
    Document type Journal Article ; Observational Study
    ZDB-ID 193144-1
    ISSN 1578-1267 ; 0301-0546
    ISSN (online) 1578-1267
    ISSN 0301-0546
    DOI 10.15586/aei.v50i5.624
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