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Article: Lack of association of MRI determined subclinical cardiovascular disease with dizziness and vertigo in a cross-sectional population-based study

Lorbeer, Roberto / Rathmann, Wolfgang

PLOS ONE, 12(9):e0184858

2017

Abstract: OBJECTIVE: We investigated the association between subclinical cardiovascular diseases assessed by MRI examination and symptoms of dizziness and vertigo in participants of a population-based sample. METHODS: Data from 400 participants (169 women) aged ... ...

Institution	Deutsches Diabetes-Zentrum
Abstract	OBJECTIVE: We investigated the association between subclinical cardiovascular diseases assessed by MRI examination and symptoms of dizziness and vertigo in participants of a population-based sample. METHODS: Data from 400 participants (169 women) aged from 39 to 73 of a cross-sectional MRI sub-study of the “Kooperative Gesundheitsforschung in der Region Augsburg” (KORA) FF4 study from the south of Germany was used. MRI determined subclinical cardiovascular diseases include left and right ventricular structure and function as well as the presence of carotid plaque and carotid wall thickness. Cerebrum diseases include white matter lesions (WML) and cerebral microbleeds (CMB). The main outcomes of dizziness and vertigo were assessed by standardized interview. Logistic regression models were applied and adjusted odds ratios (OR) with 95% confidence intervals (CI) were provided. RESULTS: Lifetime and 12-month prevalence of dizziness and vertigo were 30% (95%CI 26% to 35%) and 21% (95%CI 17% to 26%) respectively in this sample. On multivariable analysis, cardiac and carotid measurements were not associated with dizziness and vertigo excluding orthostatic vertigo (20%, 95CI 16% to 24%). Only in male participants, there was a significant association between WML and the presence of dizziness and vertigo (OR = 2.95, 95%CI 1.08 to 8.07). There was no significant association of CMB with dizziness and vertigo. However, CMB and WML were tending to associate with a higher risk of dizziness and vertigo in the whole sample (CMB: OR = 1.48, 95%CI 0.70; 3.15; WML: OR = 1.71, 95%CI 0.80 to 3.67;), in persons with prediabetes and diabetes (WML: OR = 2.71, 95%CI 0.89 to 8.23) and in men with normal glucose metabolism (CMB: OR = 2.60, 95%CI 0.56 to 12.0; WML: OR = 3.08, 95%CI 0.58 to 16.5). CONCLUSIONS: In this sample of participants without manifest cardiovascular diseases, subclinical left and right ventricular function and carotid structure were consistently not associated with dizziness and vertigo. Subclinical cerebrum measurements, however, tend to increase the risk for dizziness and vertigo, especially in men and in persons with prediabetes or diabetes.
Keywords	Cardiovascular diseases ; Carotid arteries ; Central nervous system ; Glucose metabolism ; Diabetes mellitus ; Magnetic resonance imaging ; Stroke ; Vertigo
Language	English
Document type	Article
Database	Repository for Life Sciences

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Book ; Online ; Thesis: Magnetic resonance imaging measures of vascular structure and adipose tissue: relations to cardiovascular risk factors in the general population

Lorbeer, Roberto [Verfasser]

2022

Author's details	Roberto Lorbeer
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	English
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Age- and Sex-Specific Reference Values for Renal Volume and Association with Risk Factors for Chronic Kidney Disease in a General Population-An MRI-Based Study.

Dabers, Thomas / Sass, Peter / Fechner, Fritz / Weyer, Julian / Völzke, Henry / Mahnken, Andreas Horst / Lorbeer, Roberto / Mensel, Birger / Stracke, Sylvia

Journal of clinical medicine

2024 Volume 13, Issue 3

Abstract: Background: Renal volume (RV) is associated with renal function and with a variety of cardiovascular risk factors (CVRFs). We analysed RV using magnetic resonance imaging (MRI) in a large population-based study (Study of Health in Pomerania; SHIP-TREND) ...

Abstract	Background: Renal volume (RV) is associated with renal function and with a variety of cardiovascular risk factors (CVRFs). We analysed RV using magnetic resonance imaging (MRI) in a large population-based study (Study of Health in Pomerania; SHIP-TREND) to find sex- and age-specific reference values for RV and to test the influence of several markers on RV. The main objective is to describe reference values for RV in people from the general population without kidney disease. Methods: 1815 participants without kidney disease (930 women) aged 21-81 years were included in our study. Right and left RV with and without body surface area (BSA) indexation were compared among three age groups (22-39 years, 40-59 years, 60-81 years) by median and interquartile range and tested separately in women and men. Results: The estimated glomerular filtration rate (eGFR), serum uric acid, and right and left RV were higher in men compared to women (all Conclusion: Reference values for RV are different for age groups and sex. For any given age, female kidneys are smaller than male kidneys. RV associates positively with eGFR, but for any chosen eGFR, renal volume in females is lower compared to males. RV decreases with age, but in men showed a U-shaped correlation. This may reflect hyperfiltration and glomerular hypertrophy associated with the presence of CVRF in middle-aged males.
Language	English
Publishing date	2024-01-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13030769
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Article: Association between Large Arteries Diameter and Heart Function in Subjects Free of Cardiovascular Diseases.

von Krüchten, Ricarda / Lorbeer, Roberto / Peters, Annette / Bamberg, Fabian / Schlett, Christopher L / Mujaj, Blerim

Journal of personalized medicine

2022 Volume 12, Issue 6

Abstract: To investigate the association between Aorta (Ao), pulmonary artery (PA) diameters and the PA/Ao ratio with right (RV) and left ventricle (LV) volumetric properties in subjects free of cardiovascular diseases. In the KORA-MRI study, 339 subjects (mean ... ...

Abstract	To investigate the association between Aorta (Ao), pulmonary artery (PA) diameters and the PA/Ao ratio with right (RV) and left ventricle (LV) volumetric properties in subjects free of cardiovascular diseases. In the KORA-MRI study, 339 subjects (mean age 56.3 ± 9.1 years; 43.7% female) underwent whole-body 3T-MRI. Ao and PA were measured on DIXON sequences. Cvi42 quantified cardiac functional parameters from a SSFP sequence. The relationship between ascending (AAo), and descending aorta (DAo), as well as PA diameters, and RV and LV function were assessed using linear regression models adjusted for age, sex, and cardiovascular risk factors. AAo and DAo diameter were associated with LV end-diastolic volume (β = 4.52,
Language	English
Publishing date	2022-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12060889
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Article: Native myocardial T1 mapping: influence of spatial resolution on quantitative results and reproducibility.

Dalmer, Antonia / Meinel, Felix G / Böttcher, Benjamin / Manzke, Mathias / Lorbeer, Roberto / Weber, Marc-André / Baeßler, Bettina / Klemenz, Ann-Christin

Quantitative imaging in medicine and surgery

2023 Volume 14, Issue 1, Page(s) 20–30

Abstract: Background: Myocardial mapping techniques can be used to quantitatively assess alterations in myocardial tissue properties. This study aims to evaluate the influence of spatial resolution on quantitative results and reproducibility of native myocardial ... ...

Abstract	Background: Myocardial mapping techniques can be used to quantitatively assess alterations in myocardial tissue properties. This study aims to evaluate the influence of spatial resolution on quantitative results and reproducibility of native myocardial T1 mapping in cardiac magnetic resonance imaging (MRI). Methods: In this cross-sectional study with prospective data collection between October 2019 and February 2020, 50 healthy adults underwent two identical cardiac MRI examinations in the radiology department on the same day. T1 mapping was performed using a MOLLI 5(3)3 sequence with higher (1.4 mm × 1.4 mm) and lower (1.9 mm × 1.9 mm) in-plane spatial resolution. Global quantitative results of T1 mapping were compared between high-resolution and low-resolution acquisitions using paired Results: There was no significant difference between global quantitative results acquired with high Conclusions: Based on our data, we recommend a spatial resolution on the order of 1.9 mm × 1.9 mm for native myocardial T1 mapping using a MOLLI 5(3)3 sequence at 1.5 T particularly in individuals with higher heart rates and women.
Language	English
Publishing date	2023-11-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-23-943
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Article ; Online: Utility of clinical and MR imaging parameters for prediction and monitoring of response to capecitabine and temozolomide (CAPTEM) therapy in patients with liver metastases of neuroendocrine tumors.

Ingenerf, Maria / Auernhammer, Christoph / Lorbeer, Roberto / Winkelmann, Michael / Mansournia, Shiwa / Mansour, Nabeel / Hesse, Nina / Heinrich, Kathrin / Ricke, Jens / Berger, Frank / Schmid-Tannwald, Christine

Radiology and oncology

2024

Abstract: Background: This study explores the predictive and monitoring capabilities of clinical and multiparametric MR parameters in assessing capecitabine and temozolomide (CAPTEM) therapy response in patients with neuroendocrine tumors (NET).: Patients and ... ...

Abstract	Background: This study explores the predictive and monitoring capabilities of clinical and multiparametric MR parameters in assessing capecitabine and temozolomide (CAPTEM) therapy response in patients with neuroendocrine tumors (NET). Patients and methods: This retrospective study (n = 44) assessed CAPTEM therapy response in neuroendocrine liver metastases (NELM) patients. Among 33 monitored patients, as a subgroup of the overall study cohort, pretherapeutic and follow-up MRI data (size, apparent diffusion coefficient [ADC] values, and signal intensities), along with clinical parameters (chromogranin A [CgA] and Ki-67%), were analyzed. Progression-free survival (PFS) served as the reference. Responders were defined as those with PFS ≥ 6 months. Results: Most patients were male (75%) and had G2 tumors (76%) with a pancreatic origin (84%). Median PFS was 5.7 months; Overall Survival (OS) was 25 months. Non-responders (NR) had higher Ki-67 in primary tumors (16.5 Conclusions: Survival analysis emphasizes the need for adapted response criteria, involving combined evaluation of CgA, ADC values, and tumor size for monitoring CAPTEM response in hepatic metastasized NETs.
Language	English
Publishing date	2024-04-14
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1128829-2
ISSN	1581-3207 ; 0485-893X ; 1318-2099
ISSN (online)	1581-3207
ISSN	0485-893X ; 1318-2099
DOI	10.2478/raon-2024-0024
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Article ; Online: Whole-Body MRI-Derived Adipose Tissue Characterization and Relationship to Pulmonary Function Impairment.

Krüchten, Ricarda von / Rospleszcz, Susanne / Lorbeer, Roberto / Hasic, Dunja / Peters, Annette / Bamberg, Fabian / Schulz, Holger / Karrasch, Stefan / Schlett, Christopher L

Tomography (Ann Arbor, Mich.)

2022 Volume 8, Issue 2, Page(s) 560–569

Abstract: Background: Specification of adipose tissues by whole-body magnetic resonance imaging (MRI) was performed and related to pulmonary function parameters in a population-based cohort. Methods: 203 study participants underwent whole-body MRI and pulmonary ... ...

Abstract	Background: Specification of adipose tissues by whole-body magnetic resonance imaging (MRI) was performed and related to pulmonary function parameters in a population-based cohort. Methods: 203 study participants underwent whole-body MRI and pulmonary function tests as part of the KORA (Cooperative Health Research in the Augsburg Region) MRI study. Both visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were derived from the T1-Dixon sequence, and hepatic adipose tissue from the proton density fat fraction (PDFFhepatic). Associations between adipose tissue parameters and spirometric indices such as forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and Tiffeneau-index (FEV1/FVC) were examined using multivariate linear regression analysis excluding cofounding effects of other clinical parameters. Results: VAT (β = −0.13, p = 0.03) and SAT (β = −0.26, p < 0.001), but not PDFFhepatic were inversely associated with FEV1, while VAT (β = −0.27, p < 0.001), SAT (β = −0.41, p < 0.001), and PDFFhepatic (β = −0.17, p = 0.002) were inversely associated with FVC. PDFFhepatic was directly associated with the Tiffeneau index (β = 2.46, p < 0.001). Conclusions: In the adjusted linear regression model, VAT was inversely associated with all measured spirometric parameters, while PDFFhepatic revealed the strongest association with the Tiffeneau index. Non-invasive adipose tissue quantification measurements might serve as novel biomarkers for respiratory impairment.
MeSH term(s)	Adipose Tissue/diagnostic imaging ; Humans ; Intra-Abdominal Fat/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Subcutaneous Fat ; Whole Body Imaging
Language	English
Publishing date	2022-02-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-139X
ISSN (online)	2379-139X
DOI	10.3390/tomography8020046
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Article ; Online: Adipose tissue is associated with kidney function parameters.

Mueller-Peltzer, Katharina / von Krüchten, Ricarda / Lorbeer, Roberto / Rospleszcz, Susanne / Schulz, Holger / Peters, Annette / Bamberg, Fabian / Schlett, Christopher L / Mujaj, Blerim

Scientific reports

2023 Volume 13, Issue 1, Page(s) 9151

Abstract: Obesity is characterized by the accumulation of adipose tissue in different body compartments. Whether adipose tissue directly affects kidney function is still unknown. We aimed to investigate the role of the adipose tissue and circulating creatinine, ... ...

Abstract	Obesity is characterized by the accumulation of adipose tissue in different body compartments. Whether adipose tissue directly affects kidney function is still unknown. We aimed to investigate the role of the adipose tissue and circulating creatinine, cystatin C and kidney function in subjects free of cardio-renal diseases. In the KORA-MRI population-based study, 377 subjects (mean age 56.2 ± 9.2 years; 41.6% female) underwent whole-body 3T-MRI examination. Adipose tissue defined as visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were quantified from T1-DIXON sequence using a semi-automatic algorithm. Serum creatinine and cystatin C were measured using standard laboratory and estimated glomerular filtration rate (e-GFR) was performed based on creatinine (e-GFR
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Male ; Creatinine ; Cystatin C ; Risk Factors ; Glomerular Filtration Rate ; Obesity ; Subcutaneous Fat/diagnostic imaging ; Kidney/diagnostic imaging
Chemical Substances	Creatinine (AYI8EX34EU) ; Cystatin C
Language	English
Publishing date	2023-06-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-36390-z
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Book ; Online ; Thesis: Endocrine-metabolic markers and subclinical cardiovascular disorders

Lorbeer, Roberto [Verfasser]

2012

Author's details	Roberto Lorbeer
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	English
Publisher	Universitätsbibliothek Greifswald
Publishing place	Greifswald
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Global and Regional Test-Retest Reproducibility of Native T1 and T2 Mapping in Cardiac Magnetic Resonance Imaging.

Böttcher, Benjamin / Lorbeer, Roberto / Stöcklein, Sophia / Beller, Ebba / Lang, Cajetan I / Weber, Marc-André / Meinel, Felix G

Journal of magnetic resonance imaging : JMRI

2021 Volume 54, Issue 6, Page(s) 1763–1772

Abstract: Background: Mapping of T1 and T2 relaxation times in cardiac MRI is an invaluable tool for the diagnosis and risk stratification of a wide spectrum of cardiac diseases.: Purpose: To investigate the global and regional reproducibility of native T1 and ...

Abstract	Background: Mapping of T1 and T2 relaxation times in cardiac MRI is an invaluable tool for the diagnosis and risk stratification of a wide spectrum of cardiac diseases. Purpose: To investigate the global and regional reproducibility of native T1 and T2 mapping and to analyze the influence of demographic factors, physiological parameters, slice position, and myocardial regions on reproducibility. Study type: Prospective single-center cohort-study. Population: Fifty healthy volunteers (29 female, 21 male) with a mean age of 39.4 ± 13.7 years. Field strength/sequence: Each volunteer was investigated twice at 1.5 T using a modified look-locker inversion-recovery (MOLLI) sequence (T1 mapping) and a T2-prepared steady-state free precession (SSFP) sequence (T2 mapping). Assessment: Global T1 and T2 values were quantified for the entire left ventricle in three short-axis slices. Regional T1 and T2 values were measured for each myocardial segment and for myocardial segments grouped by slice position and anatomical region. Statistical tests: Test-retest reproducibility was assessed using intraclass correlation coefficient (ICC) and Bland-Altman statistics. A P value < 0.05 was considered statistically significant. Results: Reproducibility was good for global T1 values (ICC 0.88) and excellent for global T2 values (ICC 0.91). Reproducibility of T1 values was excellent (ICC 0.91) for midventricular slice and good for apical (ICC 0.86) and basal slice (ICC 0.81). Reproducibility of T1 mapping values was highest in the septum (ICC 0.90) compared to the anterior (0.81), lateral (0.86), and inferior (0.86) wall. For T2 mapping, reproducibility was good for all slice positions (ICC 0.86 for midventricular, 0.83 for basal, and 0.80 for apical slice). Reproducibility of T2 mapping was significantly lower for the inferior wall (ICC 0.58) than for septum (0.89), anterior (0.85), and lateral (0.87) wall. Data conclusion: Native T1 and T2 mapping has good to excellent reproducibility with significant regional differences. Evidence level: 2 TECHNICAL EFFICACY: Stage 2.
MeSH term(s)	Adult ; Female ; Heart/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Myocardium ; Predictive Value of Tests ; Prospective Studies ; Reproducibility of Results
Language	English
Publishing date	2021-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.27755
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