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  1. Article ; Online: Optical phased array neural probes for beam-steering in brain tissue.

    Sacher, Wesley D / Chen, Fu-Der / Moradi-Chameh, Homeira / Liu, Xinyu / Felts Almog, Ilan / Lordello, Thomas / Chang, Michael / Naderian, Azadeh / Fowler, Trevor M / Segev, Eran / Xue, Tianyuan / Mahallati, Sara / Valiante, Taufik A / Moreaux, Laurent C / Poon, Joyce K S / Roukes, Michael L

    Optics letters

    2022  Volume 47, Issue 5, Page(s) 1073–1076

    Abstract: Implantable silicon neural probes with integrated nanophotonic waveguides can deliver patterned dynamic illumination into brain tissue at depth. Here, we introduce neural probes with integrated optical phased arrays and demonstrate optical beam steering ... ...

    Abstract Implantable silicon neural probes with integrated nanophotonic waveguides can deliver patterned dynamic illumination into brain tissue at depth. Here, we introduce neural probes with integrated optical phased arrays and demonstrate optical beam steering in vitro. Beam formation in brain tissue is simulated and characterized. The probes are used for optogenetic stimulation and calcium imaging.
    MeSH term(s) Brain/diagnostic imaging ; Optogenetics ; Silicon
    Chemical Substances Silicon (Z4152N8IUI)
    Language English
    Publishing date 2022-02-18
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.441609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Visible-light silicon nitride waveguide devices and implantable neurophotonic probes on thinned 200 mm silicon wafers.

    Sacher, Wesley D / Luo, Xianshu / Yang, Yisu / Chen, Fu-Der / Lordello, Thomas / Mak, Jason C C / Liu, Xinyu / Hu, Ting / Xue, Tianyuan / Guo-Qiang Lo, Patrick / Roukes, Michael L / Poon, Joyce K S

    Optics express

    2019  Volume 27, Issue 26, Page(s) 37400–37418

    Abstract: We present passive, visible light silicon nitride waveguides fabricated on ≈ 100 µm thick 200 mm silicon wafers using deep ultraviolet lithography. The best-case propagation losses of single-mode waveguides were ≤ 2.8 dB/cm and ≤ 1.9 dB/cm over ... ...

    Abstract We present passive, visible light silicon nitride waveguides fabricated on ≈ 100 µm thick 200 mm silicon wafers using deep ultraviolet lithography. The best-case propagation losses of single-mode waveguides were ≤ 2.8 dB/cm and ≤ 1.9 dB/cm over continuous wavelength ranges of 466-550 nm and 552-648 nm, respectively. In-plane waveguide crossings and multimode interference power splitters are also demonstrated. Using this platform, we realize a proof-of-concept implantable neurophotonic probe for optogenetic stimulation of rodent brains. The probe has grating coupler emitters defined on a 4 mm long, 92 µm thick shank and operates over a wide wavelength range of 430-645 nm covering the excitation spectra of multiple opsins and fluorophores used for brain stimulation and imaging.
    Language English
    Publishing date 2019-12-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.27.037400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Implantable photonic neural probes for light-sheet fluorescence brain imaging.

    Sacher, Wesley D / Chen, Fu-Der / Moradi-Chameh, Homeira / Luo, Xianshu / Fomenko, Anton / Shah, Prajay T / Lordello, Thomas / Liu, Xinyu / Almog, Ilan Felts / Straguzzi, John N / Fowler, Trevor M / Jung, Youngho / Hu, Ting / Jeong, Junho / Lozano, Andres M / Lo, Patrick Guo-Qiang / Valiante, Taufik A / Moreaux, Laurent C / Poon, Joyce K S /
    Roukes, Michael L

    Neurophotonics

    2021  Volume 8, Issue 2, Page(s) 25003

    Abstract: Significance: ...

    Abstract Significance:
    Language English
    Publishing date 2021-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2781943-7
    ISSN 2329-4248 ; 2329-423X
    ISSN (online) 2329-4248
    ISSN 2329-423X
    DOI 10.1117/1.NPh.8.2.025003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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