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Article ; Online: Advances and Highlights of miRNAs in Asthma: Biomarkers for Diagnosis and Treatment.

Gil-Martínez, Marta / Lorente-Sorolla, Clara / Naharro, Sara / Rodrigo-Muñoz, José M / Del Pozo, Victoria

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: Asthma is a heterogeneous inflammatory disease of the airways that causes breathing difficulties, episodes of cough and wheezing, and in more severe cases can greatly diminish quality of life. Epigenetic regulation, including post-transcriptional ... ...

Abstract	Asthma is a heterogeneous inflammatory disease of the airways that causes breathing difficulties, episodes of cough and wheezing, and in more severe cases can greatly diminish quality of life. Epigenetic regulation, including post-transcriptional mediation of microRNAs (miRNAs), is one of the mechanisms behind the development of the range of asthma phenotypes and endotypes. As in every other immune-mediated disease, miRNAs regulate the behavior of cells that shape the airway structure as well as those in charge of the defense mechanisms in the bronchi and lungs, controlling cell survival, growth, proliferation, and the ability of cells to synthesize and secrete chemokines and immune mediators. More importantly, miRNAs are molecules with chemical and biological properties that make them appropriate biomarkers for disease, enabling stratification of patients for optimal drug selection and thereby simplifying clinical management and reducing both the economic burden and need for critical care associated with the disease. In this review, we summarize the roles of miRNAs in asthma and describe how they regulate the mechanisms of the disease. We further describe the current state of miRNAs as biomarkers for asthma phenotyping, endotyping, and treatment selection.
MeSH term(s)	Humans ; MicroRNAs/genetics ; Epigenesis, Genetic ; Quality of Life ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/genetics ; Biomarkers
Chemical Substances	MicroRNAs ; Biomarkers
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021628
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Obese Asthma Phenotype Is Associated with hsa-miR-26a-1-3p and hsa-miR-376a-3p Modulating the IGF Axis.

Gil-Martínez, Marta / Lorente-Sorolla, Clara / Rodrigo-Muñoz, José M / Naharro, Sara / García-de Castro, Zahara / Sastre, Joaquín / Valverde-Monge, Marcela / Quirce, Santiago / Caballero, María L / Olaguibel, José M / Del Pozo, Victoria

International journal of molecular sciences

2023 Volume 24, Issue 14

Abstract: Clarifying inflammatory processes and categorising asthma into phenotypes and endotypes improves asthma management. Obesity worsens severe asthma and reduces quality of life, although its specific molecular impact remains unclear. We previously ... ...

Abstract	Clarifying inflammatory processes and categorising asthma into phenotypes and endotypes improves asthma management. Obesity worsens severe asthma and reduces quality of life, although its specific molecular impact remains unclear. We previously demonstrated that hsa-miR-26a-1-3p and hsa-miR-376a-3p, biomarkers related to an inflammatory profile, discriminate eosinophilic from non-eosinophilic asthmatics. We aimed to study hsa-miR-26a-1-3p, hsa-miR-376a-3p, and their target genes in asthmatic subjects with or without obesity to find biomarkers and comprehend obese asthma mechanisms. Lung tissue samples were obtained from asthmatic patients (n = 16) and healthy subjects (n = 20). We measured miRNA expression using RT-qPCR and protein levels (IGF axis) by ELISA in confirmation samples from eosinophilic (n = 38) and non-eosinophilic (n = 39) obese (n = 26) and non-obese (n = 51) asthma patients. Asthmatic lungs showed higher hsa-miR-26a-1-3p and hsa-miR-376a-3p expression than healthy lungs. A study of seven genes regulated by these miRNAs revealed differential expression of
MeSH term(s)	Humans ; Asthma/complications ; Asthma/genetics ; Biomarkers ; Insulin-Like Growth Factor Binding Protein 3/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Obesity/complications ; Obesity/genetics ; Phenotype ; Quality of Life
Chemical Substances	Biomarkers ; Insulin-Like Growth Factor Binding Protein 3 ; MicroRNAs ; MIRN376A1 microRNA, human
Language	English
Publishing date	2023-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241411620
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Article ; Online: Moderate-High Blood Eosinophilia Is Associated with Increased Hospitalization and Other Asthma Comorbidities.

Naharro-González, Sara / Lorente-Sorolla, Clara / Rodrigo-Muñoz, José Manuel / Valverde-Monge, Marcela / Pinillos-Robles, Erwin Javier / Betancor, Diana / Fernández-Nieto, Mar / Sánchez-Mellado, Diana / Gil-Martínez, Marta / Santillán-Coello, Jessica Mireya / Villacampa-Aubá, José Miguel / Mahillo-Fernandez, Ignacio / Herrero-González, Antonio / Perez-González, Alejandro / Rodríguez-Nieto, María Jesús / Del Pozo, Victoria

Biomolecules

2024 Volume 14, Issue 1

Abstract: 1) Background: Eosinophilia has traditionally been linked to eosinophilic asthma, for which it is the gold-standard prognostic biomarker. However, the association between eosinophilia and the presence of other diseases and comorbidities is yet unclear. ( ...

Abstract	(1) Background: Eosinophilia has traditionally been linked to eosinophilic asthma, for which it is the gold-standard prognostic biomarker. However, the association between eosinophilia and the presence of other diseases and comorbidities is yet unclear. (2) Methods: For this retrospective study, we reviewed the electronic medical records of 49,909 subjects with blood eosinophilia to gather data on the presence of asthma, COPD, sleep apnea, tuberculosis, dyslipidemia, hypertension, and other cardiovascular diseases and severe CRSwNP among these subjects. Demographic features including age, sex, and smoking habits were collected, as well as the number of hospitalizations and emergency department visits. T-tests, ANOVA, Fisher test, and logistic regression models were used. (3) Results: For all age groups studied, eosinophilia was significantly more prevalent among asthmatic subjects than nonasthmatics, especially in patients also presenting CRSwNP, hypertension, and dyslipidemia. The likelihood of developing asthma, COPD, and CRSwNP, and hospitalization, was increased when BEC was above 600 eosinophils/μL. The association between asthma, CRSwNP, and BEC was corroborated by multiple logistic regressions models. (4) Conclusions: We demonstrated the association of having over 600 blood eosinophils/μL with a higher number of hospitalizations and comorbidities (CRSwNP and COPD), which proves that BEC is a highly useful parameter to consider in subjects who present blood eosinophilia.
MeSH term(s)	Humans ; Animals ; Retrospective Studies ; Asthma/complications ; Asthma/epidemiology ; Hypertension ; Hospitalization ; Mustelidae ; Pulmonary Eosinophilia ; Dyslipidemias/epidemiology ; Pulmonary Disease, Chronic Obstructive/epidemiology
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Review ; Journal Article
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom14010126
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Article ; Online: miR-144-3p Is a Biomarker Related to Severe Corticosteroid-Dependent Asthma.

Rodrigo-Muñoz, José M / Gil-Martínez, Marta / Lorente-Sorolla, Clara / García-Latorre, Raquel / Valverde-Monge, Marcela / Quirce, Santiago / Sastre, Joaquín / Del Pozo, Victoria

Frontiers in immunology

2022 Volume 13, Page(s) 858722

Abstract: MicroRNAs are non-coding molecules that act both as regulators of the epigenetic landscape and as biomarkers for diseases, including asthma. In the era of personalized medicine, there is a need for novel disease-associated biomarkers that can help in ... ...

Abstract	MicroRNAs are non-coding molecules that act both as regulators of the epigenetic landscape and as biomarkers for diseases, including asthma. In the era of personalized medicine, there is a need for novel disease-associated biomarkers that can help in classifying diseases into phenotypes for treatment selection. Currently, severe eosinophilic asthma is one of the most widely studied phenotypes in clinical practice, as many patients require higher and higher doses of corticosteroids, which in some cases fail to achieve the desired outcome. Such patients may only benefit from alternative drugs such as biologics, for which novel biomarkers are necessary. The objective of the study was to study the expression of miR-144-3p in order to discover its possible use as a diagnostic biomarker for severe asthma. For this purpose, miR-144-3p was evaluated in airway biopsies and serum from asthmatics and healthy individuals. mRNA was studied in asthmatic biopsies and smooth muscle cells transfected with miR-144-3p mimic. An
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/genetics ; Biomarkers ; Eosinophilia ; Humans ; MicroRNAs/metabolism
Chemical Substances	Adrenal Cortex Hormones ; Biomarkers ; MIRN144 microRNA, human ; MicroRNAs
Language	English
Publishing date	2022-04-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.858722
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Article ; Online: Reduced miR-146a-5p Is a Biomarker of Infant Respiratory Diseases Contributing to Immune Dysregulation in Small Airway Epithelial Cells.

Rodrigo-Muñoz, José M / Gil-Martínez, Marta / Lorente-Sorolla, Clara / Sastre, Beatriz / García-García, María Luz / Calvo, Cristina / Casas, Inmaculada / Del Pozo, Victoria

Cells

2022 Volume 11, Issue 17

Abstract: Respiratory diseases such as bronchiolitis, and those with wheezing episodes, are highly important during infancy due to their potential chronicity. Immune response dysregulation is critical in perpetuating lung damage. Epigenetic modifications including ...

Abstract	Respiratory diseases such as bronchiolitis, and those with wheezing episodes, are highly important during infancy due to their potential chronicity. Immune response dysregulation is critical in perpetuating lung damage. Epigenetic modifications including microRNA (miRNA) post-transcriptional regulation are among the factors involved in alleviating inflammation. We evaluated the expression of miR-146a-5p, a previously described negative regulator of immunity, in infants with respiratory diseases, in order to study epigenetic regulation of the immune response. Nasopharyngeal aspirate (NPA) was obtained from infants with bronchiolitis (ongoing and post-disease) or with wheezing episodes in addition to healthy controls. Virus presence was determined by nested PCR, while miRNA and gene expression were studied in cells from NPAs using qPCR. Healthy small airway epithelial cells (SAECs) were used as an in vitro model. We observe a reduction in miR-146a-5p expression in infants with either of the two diseases compared to controls, suggesting the potential of this miRNA as a disease biomarker. Post-bronchiolitis, miR-146a-5p expression increases, though without reaching levels of healthy controls. MiR-146a-5p expression correlates inversely with the immune-related gene
MeSH term(s)	Biomarkers/metabolism ; Bronchiolitis/diagnosis ; Bronchiolitis/metabolism ; Cyclooxygenase 2 ; Epigenesis, Genetic ; Epithelial Cells/immunology ; Epithelial Cells/metabolism ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/metabolism ; Respiratory Sounds
Chemical Substances	Biomarkers ; MIRN146 microRNA, human ; MicroRNAs ; Cyclooxygenase 2 (EC 1.14.99.1) ; PTGS2 protein, human (EC 1.14.99.1)
Language	English
Publishing date	2022-09-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11172746
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Article ; Online: Filaggrin and cytokines in respiratory samples of preterm infants at risk for respiratory viral infection.

Rodrigo-Muñoz, José M / Sastre, Beatriz / Sánchez-García, Laura / García-García, María Luz / Gonzalez-Carrasco, Ersilia / Fabra, Celia / Gil-Martínez, Marta / Lorente-Sorolla, Clara / García-Latorre, Raquel / Alcolea, Sonia / Casas, Inmaculada / Calvo, Cristina / Del Pozo, Victoria

Scientific reports

2022 Volume 12, Issue 1, Page(s) 21278

Abstract: Respiratory viral infections (RVIs) are frequent in preterm infants possibly inducing long-term impact on respiratory morbidity. Immune response and respiratory barriers are key defense elements against viral insults in premature infants admitted to ... ...

Abstract	Respiratory viral infections (RVIs) are frequent in preterm infants possibly inducing long-term impact on respiratory morbidity. Immune response and respiratory barriers are key defense elements against viral insults in premature infants admitted to Neonatal Intensive Care Units (NICUs). Our main goals were to describe the local immune response in respiratory secretions of preterm infants with RVIs during NICU admission and to evaluate the expression and synthesis of lung barrier regulators, both in respiratory samples and in vitro models. Samples from preterm infants that went on to develop RVIs had lower filaggrin gene and protein levels at a cellular level were compared to never-infected neonates (controls). Filaggrin, MIP-1α/CCL3 and MCP-1 levels were higher in pre-infection supernatants compared to controls. Filaggrin, HIF-1α, VEGF, RANTES/CCL5, IL-17A, IL-1β, MIP-1α and MIP-1β/CCL5 levels were higher during and after infection. ROC curve and logistic regression analysis shows that these molecules could be used as infection risk biomarkers. Small airway epithelial cells stimulated by poly:IC presented reduced filaggrin gene expression and increased levels in supernatant. We conclude that filaggrin gene and protein dysregulation is a risk factor of RVI in newborns admitted at the NICU.
MeSH term(s)	Infant, Newborn ; Humans ; Cytokines ; Infant, Premature ; Chemokine CCL3 ; Virus Diseases
Chemical Substances	Cytokines ; Chemokine CCL3
Language	English
Publishing date	2022-12-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-25897-6
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Article ; Online: JAK2-STAT Epigenetically Regulates Tolerized Genes in Monocytes in the First Encounter With Gram-Negative Bacterial Endotoxins in Sepsis.

Morante-Palacios, Octavio / Lorente-Sorolla, Clara / Ciudad, Laura / Calafell-Segura, Josep / Garcia-Gomez, Antonio / Català-Moll, Francesc / Ruiz-Sanmartín, Adolfo / Martínez-Gallo, Mónica / Ferrer, Ricard / Ruiz-Rodriguez, Juan Carlos / Álvarez-Errico, Damiana / Ballestar, Esteban

Frontiers in immunology

2021 Volume 12, Page(s) 734652

Abstract: Microbial challenges, such as widespread bacterial infection in sepsis, induce endotoxin tolerance, a state of hyporesponsiveness to subsequent infections. The participation of DNA methylation in this process is poorly known. In this study, we perform ... ...

Abstract	Microbial challenges, such as widespread bacterial infection in sepsis, induce endotoxin tolerance, a state of hyporesponsiveness to subsequent infections. The participation of DNA methylation in this process is poorly known. In this study, we perform integrated analysis of DNA methylation and transcriptional changes following
MeSH term(s)	Case-Control Studies ; DNA Methylation/genetics ; DNA Methylation/immunology ; Endotoxin Tolerance/drug effects ; Endotoxin Tolerance/genetics ; Endotoxin Tolerance/immunology ; Endotoxins/toxicity ; Epigenesis, Genetic ; Female ; Gram-Negative Bacteria/immunology ; Gram-Negative Bacterial Infections/genetics ; Gram-Negative Bacterial Infections/immunology ; Gram-Negative Bacterial Infections/microbiology ; Humans ; In Vitro Techniques ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase 2/genetics ; Janus Kinase 2/immunology ; Lipopolysaccharides/toxicity ; Male ; Monocytes/drug effects ; Monocytes/immunology ; Monocytes/microbiology ; STAT Transcription Factors/genetics ; STAT Transcription Factors/immunology ; Sepsis/genetics ; Sepsis/immunology ; Sepsis/microbiology ; Signal Transduction/genetics ; Signal Transduction/immunology ; Toll-Like Receptor 2/immunology ; Toll-Like Receptor 4/immunology
Chemical Substances	Endotoxins ; Lipopolysaccharides ; STAT Transcription Factors ; TLR2 protein, human ; TLR4 protein, human ; Toll-Like Receptor 2 ; Toll-Like Receptor 4 ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
Language	English
Publishing date	2021-11-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.734652
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Article ; Online: Analysis of Differentially Expressed MicroRNAs in Serum and Lung Tissues from Individuals with Severe Asthma Treated with Oral Glucocorticoids.

Gil-Martínez, Marta / Lorente-Sorolla, Clara / Rodrigo-Muñoz, José M / Lendínez, Miguel Ángel / Núñez-Moreno, Gonzalo / de la Fuente, Lorena / Mínguez, Pablo / Mahíllo-Fernández, Ignacio / Sastre, Joaquín / Valverde-Monge, Marcela / Quirce, Santiago / Caballero, María L / González-Barcala, Francisco J / Arismendi, Ebymar / Bobolea, Irina / Valero, Antonio / Muñoz, Xavier / Cruz, María Jesús / Martínez-Rivera, Carlos /

Plaza, Vicente / Olaguibel, José M / Del Pozo, Victoria

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: Nowadays, microRNAs (miRNAs) are increasingly used as biomarkers due to their potential contribution to the diagnosis and targeted treatment of a range of diseases. The aim of the study was to analyze the miRNA expression profiles in serum and lung ... ...

Abstract	Nowadays, microRNAs (miRNAs) are increasingly used as biomarkers due to their potential contribution to the diagnosis and targeted treatment of a range of diseases. The aim of the study was to analyze the miRNA expression profiles in serum and lung tissue from patients with severe asthma treated with oral corticosteroids (OCS) and those without OCS treatment. For this purpose, serum and lung tissue miRNAs of OCS and non-OCS asthmatic individuals were evaluated by miRNAs-Seq, and subsequently miRNA validation was performed using RT-qPCR. Additionally, pathway enrichment analysis of deregulated miRNAs was conducted. We observed altered expression by the next-generation sequencing (NGS) of 11 miRNAs in serum, of which five (hsa-miR-148b-3p, hsa-miR-221-5p, hsa-miR-618, hsa-miR-941, and hsa-miR-769-5p) were validated by RT-qPCR, and three miRNAs in lung tissue (hsa-miR-144-3p, hsa-miR-144-5p, and hsa-miR-451a). The best multivariate logistic regression model to differentiate individuals with severe asthma, treated and untreated with OCS, was to combine the serum miRNAs hsa-miR-221-5p and hsa-miR-769-5p. Expression of hsa-miR-148b-3p and hsa-miR-221-5p correlated with FEV
MeSH term(s)	Humans ; Glucocorticoids/therapeutic use ; MicroRNAs/metabolism ; Lung/metabolism ; Biomarkers ; Asthma/drug therapy ; Asthma/genetics
Chemical Substances	Glucocorticoids ; MicroRNAs ; Biomarkers
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021611
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Article ; Online: Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis.

Lorente-Sorolla, Clara / Garcia-Gomez, Antonio / Català-Moll, Francesc / Toledano, Víctor / Ciudad, Laura / Avendaño-Ortiz, José / Maroun-Eid, Charbel / Martín-Quirós, Alejandro / Martínez-Gallo, Mónica / Ruiz-Sanmartín, Adolfo / Del Campo, Álvaro García / Ferrer-Roca, Ricard / Ruiz-Rodriguez, Juan Carlos / Álvarez-Errico, Damiana / López-Collazo, Eduardo / Ballestar, Esteban

Genome medicine

2019 Volume 11, Issue 1, Page(s) 66

Abstract: Background: Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic immune response to infection, associates with reduced responsiveness to subsequent infections. How such tolerance is acquired is not well understood but is known ... ...

Abstract	Background: Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic immune response to infection, associates with reduced responsiveness to subsequent infections. How such tolerance is acquired is not well understood but is known to involve epigenetic and transcriptional dysregulation. Methods: Bead arrays were used to compare global DNA methylation changes in patients with sepsis, non-infectious systemic inflammatory response syndrome, and healthy controls. Bioinformatic analyses were performed to dissect functional reprogramming and signaling pathways related to the acquisition of these specific DNA methylation alterations. Finally, in vitro experiments using human monocytes were performed to test the induction of similar DNA methylation reprogramming. Results: Here, we focused on DNA methylation changes associated with sepsis, given their potential role in stabilizing altered phenotypes. Tolerized monocytes from patients with sepsis display changes in their DNA methylomes with respect to those from healthy controls, affecting critical monocyte-related genes. DNA methylation profiles correlate with IL-10 and IL-6 levels, significantly increased in monocytes in sepsis, as well as with the Sequential Organ Failure Assessment score; the observed changes associate with TFs and pathways downstream to toll-like receptors and inflammatory cytokines. In fact, in vitro stimulation of toll-like receptors in monocytes results in similar gains and losses of methylation together with the acquisition of tolerance. Conclusion: We have identified a DNA methylation signature associated with sepsis that is downstream to the response of monocytes to inflammatory signals associated with the acquisition of a tolerized phenotype and organic dysfunction.
MeSH term(s)	Aged ; Case-Control Studies ; Cytokines/genetics ; DNA/analysis ; DNA/genetics ; DNA Methylation ; Female ; Humans ; Inflammation/complications ; Inflammation/genetics ; Inflammation Mediators/metabolism ; Male ; Middle Aged ; Monocytes/immunology ; Monocytes/metabolism ; Monocytes/pathology ; Multiple Organ Failure/complications ; Multiple Organ Failure/genetics ; Phenotype ; Sepsis/diagnosis ; Sepsis/etiology ; Sepsis/metabolism ; Signal Transduction
Chemical Substances	Cytokines ; Inflammation Mediators ; DNA (9007-49-2)
Language	English
Publishing date	2019-10-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2484394-5
ISSN	1756-994X ; 1756-994X
ISSN (online)	1756-994X
ISSN	1756-994X
DOI	10.1186/s13073-019-0674-2
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Article ; Online: Advances and Highlights of miRNAs in Asthma: Biomarkers for Diagnosis and Treatment.

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Article ; Online: Obese Asthma Phenotype Is Associated with hsa-miR-26a-1-3p and hsa-miR-376a-3p Modulating the IGF Axis.

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Article ; Online: Moderate-High Blood Eosinophilia Is Associated with Increased Hospitalization and Other Asthma Comorbidities.

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Article ; Online: miR-144-3p Is a Biomarker Related to Severe Corticosteroid-Dependent Asthma.

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Article ; Online: Reduced miR-146a-5p Is a Biomarker of Infant Respiratory Diseases Contributing to Immune Dysregulation in Small Airway Epithelial Cells.

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Article ; Online: Filaggrin and cytokines in respiratory samples of preterm infants at risk for respiratory viral infection.

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Article ; Online: JAK2-STAT Epigenetically Regulates Tolerized Genes in Monocytes in the First Encounter With Gram-Negative Bacterial Endotoxins in Sepsis.

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Article ; Online: Analysis of Differentially Expressed MicroRNAs in Serum and Lung Tissues from Individuals with Severe Asthma Treated with Oral Glucocorticoids.

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Article ; Online: Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis.

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