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  1. Article ; Online: Ethnic diversity fosters the social integration of refugee students.

    Boda, Zsófia / Lorenz, Georg / Jansen, Malte / Stanat, Petra / Edele, Aileen

    Nature human behaviour

    2023  Volume 7, Issue 6, Page(s) 881–891

    Abstract: Forced migration has become a global megatrend, and many refugees are school aged. As social integration is key to their wellbeing and success, it is pivotal to determine factors that promote the social integration of refugee youth within schools. Here, ... ...

    Abstract Forced migration has become a global megatrend, and many refugees are school aged. As social integration is key to their wellbeing and success, it is pivotal to determine factors that promote the social integration of refugee youth within schools. Here, using a large, nationally representative social network dataset from Germany, we examine the relationships of refugee adolescents with their peers (304 classrooms, 6,390 adolescents and 487 refugees). We find that refugee adolescents have fewer friends and are more often rejected as desk mates than their classmates. Crucially, however, they are less rejected in more diverse classrooms. This results from two basic processes: (1) more opportunities to meet other ethnic minority peers, who are more accepting of refugees in general and (2) higher acceptance of refugee adolescents by ethnic majority peers in more diverse settings. Our results can help promote the social adjustment of young refugees in school and mitigate the negative consequences of prejudice.
    MeSH term(s) Adolescent ; Humans ; Child ; Refugees ; Ethnicity ; Minority Groups ; Students ; Social Integration
    Language English
    Publishing date 2023-04-27
    Publishing country England
    Document type Journal Article
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-023-01577-x
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  2. Article ; Online: Social comparison effects on academic self-concepts-Which peers matter most?

    Jansen, Malte / Boda, Zsófia / Lorenz, Georg

    Developmental psychology

    2022  Volume 58, Issue 8, Page(s) 1541–1556

    Abstract: Social comparisons with peers are important sources of self-development during adolescence. Many previous studies showed that students' academic self-concepts (ASC) form by contrasting one's own achievement with the average of one's class or school (the ... ...

    Abstract Social comparisons with peers are important sources of self-development during adolescence. Many previous studies showed that students' academic self-concepts (ASC) form by contrasting one's own achievement with the average of one's class or school (the Big-Fish-Little-Pond Effect [BFLPE]). Based on social comparison theory, however, we would expect some peers to be more likely social comparison targets than other peers, for example, because they are more visible or students perceive them as similar to themselves. In this study, we used sociometric data to analyze which peers play the most important role for social comparison effects on ASC. We examined how the average achievement of friends, study partners, peers perceived as popular by the student, as well as same-gender and same-ethnic peers affect the general ASC and how these effects compare to the effect of the classroom's average achievement. The study was based on a German longitudinal sample of 2,438 students (44% no recent immigrant background, 19% Turkish immigrant background, 10% Eastern European immigrant background, 27% other immigrant background) from 117 school classes that were followed from grade 9 to 10. Results from longitudinal social network analysis do not confirm substantial incremental effects of specific types of peers, while class average achievement showed a stable negative effect (confirming the BFLPE). In addition, we could provide evidence for social selection effects based on ASC. We conclude that classrooms provide a specific setting that imposes social comparisons with the "generalized peer" rather than with specific subgroups of peers. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
    MeSH term(s) Achievement ; Humans ; Peer Group ; Schools ; Self Concept ; Social Comparison
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2066223-3
    ISSN 1939-0599 ; 0012-1649
    ISSN (online) 1939-0599
    ISSN 0012-1649
    DOI 10.1037/dev0001368
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  3. Article ; Online: Evaluation of corneal biomechanical properties using the ocular response analyzer and the dynamic Scheimpflug-Analyzer Corvis ST in high pressure and normal pressure open-angle glaucoma patients.

    Ramm, Lisa / Herber, Robert / Lorenz, Georg / Jasper, Carolin S / Pillunat, Lutz E / Pillunat, Karin R

    PloS one

    2023  Volume 18, Issue 1, Page(s) e0281017

    Abstract: Purpose: To characterize differences in corneal biomechanics in high (HPG) and normal pressure (NPG) primary open-angle glaucoma, and its association to disease severity.: Methods: Corneal biomechanical properties were measured using the Ocular ... ...

    Abstract Purpose: To characterize differences in corneal biomechanics in high (HPG) and normal pressure (NPG) primary open-angle glaucoma, and its association to disease severity.
    Methods: Corneal biomechanical properties were measured using the Ocular Response Analyzer (ORA) and the dynamic Scheimpflug-Analyzer Corvis ST (CST). Disease severity was functionally assessed by automated perimetry (Humphrey field analyzer) and structurally with the Heidelberg Retina Tomograph. To avoid a possible falsification by intraocular pressure, central corneal thickness and age, which strongly influence ORA and CST measurements, group matching was performed. Linear mixed models and generalized estimating equations were used to consider inter-eye correlation.
    Results: Following group matching, 60 eyes of 38 HPG and 103 eyes of 60 NPG patients were included. ORA measurement revealed a higher CRF in HPG than in NPG (P < 0.001). Additionally, the CST parameter integrated radius (P < 0.001) was significantly different between HPG and NPG. The parameter SSI (P < 0.001) representing corneal stiffness was higher in HPG than in NPG. Furthermore, regression analysis revealed associations between biomechanical parameters and indicators of disease severity. In HPG, SSI correlated to RNFL thickness. In NPG, dependencies between biomechanical readings and rim area, MD, and PSD were shown.
    Conclusion: Significant differences in corneal biomechanical properties were detectable between HPG and NPG patients which might indicate different pathophysiological mechanisms underlying in both entities. Moreover, biomechanical parameters correlated to functional and structural indices of diseases severity. A reduced corneal deformation measured by dynamic methods was associated to advanced glaucomatous damage.
    MeSH term(s) Humans ; Glaucoma, Open-Angle ; Cornea ; Low Tension Glaucoma ; Tonometry, Ocular/methods ; Intraocular Pressure ; Biomechanical Phenomena
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0281017
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  4. Article ; Online: Impact of Janus Kinase Inhibition on the Treatment of Axial Spondyloarthropathies.

    Hammitzsch, Ariane / Lorenz, Georg / Moog, Philipp

    Frontiers in immunology

    2020  Volume 11, Page(s) 591176

    Abstract: Many immune cells and effector molecules (e.g. cytokines, Interferons, growth factors) utilize different combinations of Janus kinase (JAK) and signal transducer and activator of transcription (STAT) molecules to transduce signals from the cell surface ... ...

    Abstract Many immune cells and effector molecules (e.g. cytokines, Interferons, growth factors) utilize different combinations of Janus kinase (JAK) and signal transducer and activator of transcription (STAT) molecules to transduce signals from the cell surface to the nucleus, where they regulate transcription. This pathway is basically involved in almost all inflammatory diseases and also in the interleukin (IL)-23/IL-17 cascade, which is an essential part of the pathogenesis of spondyloarthropathies (SpA). Upon evidence from
    MeSH term(s) Animals ; Biomarkers ; Clinical Trials as Topic ; Drug Evaluation, Preclinical ; Humans ; Janus Kinase Inhibitors/pharmacology ; Janus Kinase Inhibitors/therapeutic use ; Janus Kinases/metabolism ; Molecular Targeted Therapy/methods ; STAT Transcription Factors/metabolism ; Signal Transduction/drug effects ; Spondylarthropathies/diagnosis ; Spondylarthropathies/drug therapy ; Spondylarthropathies/etiology ; Spondylarthropathies/metabolism ; Treatment Outcome
    Chemical Substances Biomarkers ; Janus Kinase Inhibitors ; STAT Transcription Factors ; Janus Kinases (EC 2.7.10.2)
    Language English
    Publishing date 2020-10-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.591176
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  5. Article ; Online: Neutrophils, Dendritic Cells, Toll-Like Receptors, and Interferon-α in Lupus Nephritis.

    Lorenz, Georg / Anders, Hans-Joachim

    Seminars in nephrology

    2015  Volume 35, Issue 5, Page(s) 410–426

    Abstract: Finding better treatments for lupus nephritis requires an understanding of the pathogenesis of the causative systemic disease, how this leads to kidney disease, and how lupus nephritis progresses to end-stage kidney disease. Here, we provide a brief ... ...

    Abstract Finding better treatments for lupus nephritis requires an understanding of the pathogenesis of the causative systemic disease, how this leads to kidney disease, and how lupus nephritis progresses to end-stage kidney disease. Here, we provide a brief conceptual overview on the related pathomechanisms. As a main focus we discuss in detail the roles of neutrophils, dendritic cells, Toll-like receptors, and interferon-α in the pathogenesis of lupus nephritis by separately reviewing their roles in extrarenal systemic autoimmunity and in intrarenal inflammation and immunopathology.
    MeSH term(s) Adaptive Immunity/immunology ; Antigen-Antibody Complex/immunology ; Autoantibodies/immunology ; Autoantigens/immunology ; Dendritic Cells/immunology ; Extracellular Traps/immunology ; Humans ; Immunity, Innate/immunology ; Interferon-alpha/immunology ; Lupus Erythematosus, Systemic/immunology ; Lupus Nephritis/immunology ; Neutrophils/immunology ; Toll-Like Receptors/immunology
    Chemical Substances Antigen-Antibody Complex ; Autoantibodies ; Autoantigens ; Interferon-alpha ; Toll-Like Receptors
    Language English
    Publishing date 2015-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2015.08.003
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    In stock of ZB MED Cologne/Königswinter

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  6. Article: A case of pulmonary embolism caused by compression of the vena cava by intra-abdominal masses in autosomal polycystic kidney disease.

    Holzmann-Littig, Christopher / Lorenz, Georg / Wen, Ming / Heemann, Uwe / Renders, Lutz

    Clinical case reports

    2020  Volume 8, Issue 7, Page(s) 1149–1152

    Abstract: Dyspnea can have among other reasons pulmonological and cardiological causes. In cases with intra-abdominal masses such as in severe autosomal dominant polycystic kidney disease, mechanical occlusion of the vena cava may result in pulmonary embolism. ...

    Abstract Dyspnea can have among other reasons pulmonological and cardiological causes. In cases with intra-abdominal masses such as in severe autosomal dominant polycystic kidney disease, mechanical occlusion of the vena cava may result in pulmonary embolism.
    Language English
    Publishing date 2020-04-13
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2852
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  7. Article ; Online: Automatic ECG-based detection of left ventricular hypertrophy and its predictive value in haemodialysis patients.

    Letz, Theresa / Hörandtner, Carina / Braunisch, Matthias C / Gundel, Peter / Matschkal, Julia / Bachler, Martin / Lorenz, Georg / Körner, Andreas / Schaller, Carolin / Lattermann, Moritz / Holzinger, Andreas / Heemann, Uwe / Wassertheurer, Siegfried / Schmaderer, Christoph / Mayer, Christopher C

    Physiological measurement

    2023  Volume 44, Issue 7

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Humans ; Hypertrophy, Left Ventricular/complications ; Hypertrophy, Left Ventricular/diagnosis ; Electrocardiography/methods ; Risk Factors ; Renal Dialysis ; Hypertension
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1149545-5
    ISSN 1361-6579 ; 0967-3334
    ISSN (online) 1361-6579
    ISSN 0967-3334
    DOI 10.1088/1361-6579/acdfb3
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  8. Article: Immunophenotypic Characterization of Citrate-Containing A Concentrates in Maintenance Hemodialysis: A Pre-Post Study.

    Shen, Yuli / Schmaderer, Christoph / Ossadnik, Andreas / Hammitzsch, Arianne / Carbajo-Lozoya, Javier / Bachmann, Quirin / Bonell, Vera / Braunisch, Matthias Christoph / Heemann, Uwe / Pham, Dang / Kemmner, Stephan / Lorenz, Georg

    International journal of nephrology

    2023  Volume 2023, Page(s) 7772677

    Abstract: Introduction: Due to chronic inflammation, maintenance hemodialysis (MHD) patients continue to show excess mortality. Acetate-free citrate-buffered A concentrates could be a way to improve the biocompatibility of the procedure, reduce chronic ... ...

    Abstract Introduction: Due to chronic inflammation, maintenance hemodialysis (MHD) patients continue to show excess mortality. Acetate-free citrate-buffered A concentrates could be a way to improve the biocompatibility of the procedure, reduce chronic inflammation, and thus in the long term improve the prognosis of patients.
    Methods: Using a pre-post design (3 months of acetate followed by 3 months of citrate-acidified A concentrates in standard bicarbonate-based dialysate hemodialysis, CiaHD) and linear mixed model analysis in 61 stable HD patients, we assessed the impact of CiaHD on counts and phenotypes of peripheral T cells and monocytes by flow cytometry.
    Results: Switching to CiaHD left C-reactive protein (CRP) levels and leucocyte counts unaffected. However, CiaHD increased lymphocyte counts ex vivo. Furthermore, we found a decrease in total CD3+CD4+CD69+ ((10
    Conclusion: Compared with acetate, CiaHD has a minor impact on lymphocyte counts and CD4+T-cell activation, which was independent of systemic CRP and ionized magnesium, calcium levels, and other dialysis prescription modalities.
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573904-9
    ISSN 2090-2158 ; 2090-214X
    ISSN (online) 2090-2158
    ISSN 2090-214X
    DOI 10.1155/2023/7772677
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  9. Article ; Online: Toll-like receptor activation in the pathogenesis of lupus nephritis.

    Lorenz, Georg / Lech, Maciej / Anders, Hans-Joachim

    Clinical immunology (Orlando, Fla.)

    2017  Volume 185, Page(s) 86–94

    Abstract: The pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis is complex but no longer enigmatic. Much progress has been made to on the polygenetic origin of lupus in identifying gene variants that permit the loss of tolerance against ... ...

    Abstract The pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis is complex but no longer enigmatic. Much progress has been made to on the polygenetic origin of lupus in identifying gene variants that permit the loss of tolerance against nuclear autoantigens. Along the same line in about 50% of lupus patients additional genetic weaknesses promote immune complex glomerulonephritis and filtration barrier dysfunction. Here we briefly summarize the pathogenesis of SLE with a focus on loss of tolerance and the role of toll-like receptors in the "pseudo"-antiviral immunity concept of systemic lupus. In addition, we discuss the local role of Toll-like receptors in intrarenal inflammation and kidney remodeling.
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2016.07.015
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  10. Conference proceedings: Zusammenhang zwischen kornealen dynamischen Deformationsparametern und Strukturparametern des Sehnervenkopfes bei primär chronischem Offenwinkelglaukom

    Lorenz, Georg / Herber, R. / Pillunat, L.E. / Pillunat, K.R.

    2020  , Page(s) 19sag18

    Event/congress Jahrestagung 2019 der Sächsischen Augenärztlichen Gesellschaft; Leipzig; Sächsische Augenärztliche Gesellschaft; 2019
    Keywords Medizin, Gesundheit
    Publishing date 2020-02-27
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/19sag18
    Database German Medical Science

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