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  1. Book ; Thesis: Effects of hypoxia and activated B cells on multipotent mesenchymal stromal cells

    Scarpone, Roberta / Lorenz, Hanns-Martin

    2021  

    Institution Universität Heidelberg
    Author's details vorgelegt von Roberta Scarpone ; Doktorvater: Herrn Prof. Dr. med. Hanns-Martin Lorenz
    Language English
    Size 69 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
    Note Text Englisch, Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT020994176
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2021 E 823 order for loan Magazin

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  2. Article ; Online: Arzneitherapie der rheumatoiden Arthritis – wo stehen Biologika und neue synthetische Basistherapeutika heute?

    Kaudewitz, Dorothee / Lorenz, Hanns-Martin

    Innere Medizin (Heidelberg, Germany)

    2023  Volume 64, Issue 10, Page(s) 1005–1012

    Abstract: Biologics and Janus kinase (JAK) inhibitors play an important role in the treatment of rheumatoid arthritis. As new therapeutic developments have emerged in recent decades, the morbidity and mortality of rheumatoid arthritis have been significantly ... ...

    Title translation Drug therapy of rheumatoid arthritis: where do biologics and novel synthetic disease-modifying antirheumatic drugs stand today?
    Abstract Biologics and Janus kinase (JAK) inhibitors play an important role in the treatment of rheumatoid arthritis. As new therapeutic developments have emerged in recent decades, the morbidity and mortality of rheumatoid arthritis have been significantly reduced. The characterization of the structure and function of immune cell receptors has led to the development of biologics that specifically inhibit cytokines and immune cell receptors. An important therapeutic addition was the approval of JAK inhibitors, which act directly on intracellular signaling by tyrosine kinases. This article provides an overview of the current therapeutic options for rheumatoid arthritis with a special focus on indication, mechanism of action and the place in the treatment algorithm of biologics and JAK inhibitors.
    MeSH term(s) Humans ; Antirheumatic Agents/therapeutic use ; Biological Products/therapeutic use ; Janus Kinase Inhibitors/therapeutic use ; Arthritis, Rheumatoid/drug therapy
    Chemical Substances Antirheumatic Agents ; Biological Products ; Janus Kinase Inhibitors
    Language German
    Publishing date 2023-07-26
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7099
    ISSN (online) 2731-7099
    DOI 10.1007/s00108-023-01554-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CAR T-Cell Therapy in Autoimmune Disease.

    Merkt, Wolfgang / Lorenz, Hanns-Martin / Schmitt, Michael

    The New England journal of medicine

    2024  Volume 390, Issue 17, Page(s) 1628–1629

    MeSH term(s) Humans ; Autoimmune Diseases/therapy ; Autoimmune Diseases/immunology ; Immunotherapy, Adoptive ; Receptors, Chimeric Antigen/immunology ; T-Lymphocytes/immunology ; Receptors, Antigen, T-Cell/therapeutic use ; Animals
    Chemical Substances Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Journal Article ; Review ; Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2403705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  4. Book ; Thesis: Modifying immunometabolism of CD8+ T cells in rheumatoid arthritis and its influence on synovial fibroblasts

    Meyer, André Philipp / Lorenz, Hanns-Martin

    2020  

    Institution Universität Heidelberg
    Author's details vorgelegt von André Philipp Meyer ; Doktorvater: Herr Prof. Dr. med. Hanns-Martin Lorenz
    Language English
    Size VIII, 151 Seiten, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2020
    Note Text Englisch, Zusammenfassung in deutscher und englischer Sprache ; Im Titel ist "+" hochgestellt
    HBZ-ID HT021134794
    Database Catalogue ZB MED Medicine, Health

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  5. Book ; Online ; Thesis: Bidirectional Interaction of Differently Activated and Polarized Monocytes/Macrophages and Stromal Cells in Context of Tissue Remodeling in Chronic Inflammatory Disease

    Li, Jia [Verfasser] / Lorenz, Hanns-Martin [Akademischer Betreuer]

    2024  

    Author's details Jia Li ; Betreuer: Hanns-Martin Lorenz
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek Heidelberg
    Publishing place Heidelberg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article ; Online: Sex-specific differences in ICOS

    Wu, Lisa / Kälble, Florian / Lorenz, Hanns-Martin / Zeier, Martin / Schaier, Matthias / Steinborn, Andrea

    Clinical and experimental medicine

    2024  Volume 24, Issue 1, Page(s) 47

    Abstract: Systemic lupus erythematosus (SLE) is a sex biased chronic autoimmune disease affecting predominantly females during reproductive ages. Changes in the ratio of inducible costimulatory molecule (ICOS) ...

    Abstract Systemic lupus erythematosus (SLE) is a sex biased chronic autoimmune disease affecting predominantly females during reproductive ages. Changes in the ratio of inducible costimulatory molecule (ICOS)
    MeSH term(s) Male ; Humans ; Female ; T-Lymphocyte Subsets ; T-Lymphocytes, Regulatory ; Lupus Erythematosus, Systemic ; Cell Differentiation ; Inducible T-Cell Co-Stimulator Protein/metabolism
    Chemical Substances ICOS protein, human ; Inducible T-Cell Co-Stimulator Protein
    Language English
    Publishing date 2024-03-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2053018-3
    ISSN 1591-9528 ; 1591-8890
    ISSN (online) 1591-9528
    ISSN 1591-8890
    DOI 10.1007/s10238-024-01307-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5481: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: bDMARD can prevent the progression of AA amyloidosis to end-stage renal disease.

    Kvacskay, Peter / Hegenbart, Ute / Lorenz, Hanns-Martin / Schönland, Stefan O / Blank, Norbert

    Annals of the rheumatic diseases

    2024  

    Abstract: Introduction: AA amyloidosis (AA) can be the consequence of any chronic inflammatory disease. AA is associated with chronic inflammatory diseases (cid+AA), autoinflammatory syndromes (auto+AA) or AA of unknown origin or idiopathic AA (idio+AA). The ... ...

    Abstract Introduction: AA amyloidosis (AA) can be the consequence of any chronic inflammatory disease. AA is associated with chronic inflammatory diseases (cid+AA), autoinflammatory syndromes (auto+AA) or AA of unknown origin or idiopathic AA (idio+AA). The major organ manifestation is renal AA that can progress to end-stage renal disease (ESRD) and multiple organ failure.
    Materials and methods: This study is a monocentric retrospective analysis of the renal outcome and survival of patients with cid+AA (n=34), auto+AA (n=24) and idio+AA (n=25) who were treated with cytokine-inhibiting biological disease-modifying antirheumatic drugs (bDMARDs).
    Results: 83 patients with renal AA were identified and followed for a mean observational period of 4.82 years. C reactive protein (CRP), serum amyloid alpha and proteinuria were significantly reduced with bDMARD therapy. Progression to ESRD was prevented in 60% (cid+AA), 88% (auto+AA) and 81% (idio+AA) of patients. Tocilizumab was given to 34 patients with cid+AA and idio+AA and was more effective in reducing CRP and progression to ESRD and death compared with other bDMARDs.
    Conclusions: bDMARDs reduce systemic inflammation in various diseases, leading to a reduction of proteinuria and prevention of ESRD. Importantly, tocilizumab was more effective than other bDMARDs in controlling systemic inflammation in patients with chronic inflammatory diseases and idiopathic AA, leading to better renal and overall survival.
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2023-225114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.114: Show issues Location:
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    Zs.MO 167: Show issues

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  8. Article ; Online: Rheumaerkrankungen im Kindes- und Erwachsenenalter – ganz ähnlich und ganz unterschiedlich.

    Huppertz, Hans-Iko / Hospach, Toni / Lorenz, Hanns-Martin

    Zeitschrift fur Rheumatologie

    2022  Volume 81, Issue 1, Page(s) 1–3

    Title translation Rheumatic diseases in childhood and adulthood-Very similar and very different.
    MeSH term(s) Adult ; Humans ; Rheumatic Diseases/diagnosis ; Rheumatic Diseases/epidemiology
    Language German
    Publishing date 2022-02-04
    Publishing country Germany
    Document type Editorial
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-021-01148-3
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    Uh III Zs.128: Show issues Location:
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  9. Book ; Thesis: Untersuchungen über physiologische immuninhibierende Mechanismen am Beispiel der Signaltransduktion durch CD45 und der Regulation des programmierten Zelltodes

    Lorenz, Hanns-Martin

    1998  

    Author's details vorgelegt von Hanns-Martin Lorenz
    Language German
    Size Getr. Zählung : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen-Nürnberg, Univ., Habil.-Schr., 1998
    HBZ-ID HT010838668
    Database Catalogue ZB MED Medicine, Health

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  10. Article ; Online: Respiratory involvement in connective tissue diseases.

    Xanthouli, Panagiota / Echampati, Ishan / Lorenz, Hanns-Martin / Heussel, Claus Peter / Benjamin, Nicola

    European journal of internal medicine

    2023  Volume 120, Page(s) 11–16

    Abstract: Pulmonary involvement is doubtless one the most fatal organ manifestations of the autoimmune rheumatic diseases (ARD) and involves the parenchyma, the vessels, the respiratory system itself, but also the muscles and the pleura. Close and regular ... ...

    Abstract Pulmonary involvement is doubtless one the most fatal organ manifestations of the autoimmune rheumatic diseases (ARD) and involves the parenchyma, the vessels, the respiratory system itself, but also the muscles and the pleura. Close and regular screening assessments, identification of risk factors, clinical signs associated with the existence of lung disease should alarm the involved physicians treating these patients. The accurate classification is essential, as different treatment options are nowadays available. Pulmonary manifestations of ARD will be analyzed in this review article with special emphasis on interstitial lung disease and pulmonary hypertension.
    MeSH term(s) Humans ; Connective Tissue Diseases/complications ; Lung Diseases, Interstitial/etiology ; Hypertension, Pulmonary/complications ; Lung ; Autoimmune Diseases/complications ; Rheumatic Diseases/complications
    Language English
    Publishing date 2023-10-14
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.09.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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