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  1. Article ; Online: Use of transcriptomics for diagnosis of infections and sepsis in children: A narrative review.

    Casini, Francesca / Valentino, Maria Sole / Lorenzo, Marc Garcia / Caiazzo, Roberta / Coppola, Crescenzo / David, Daniela / Di Tonno, Raffaella / Giacomet, Vania

    Acta paediatrica (Oslo, Norway : 1992)

    2024  Volume 113, Issue 4, Page(s) 670–676

    Abstract: Aim: The aim of this review was to summarise the most recent evidence about the use of omics-based techniques as an instrument for a more rapid and accurate characterisation of respiratory tract infections, neurological infections and sepsis in ... ...

    Abstract Aim: The aim of this review was to summarise the most recent evidence about the use of omics-based techniques as an instrument for a more rapid and accurate characterisation of respiratory tract infections, neurological infections and sepsis in paediatrics.
    Methods: We performed a narrative review using PubMed and a set of inclusion criteria: English language articles, clinical trials, meta-analysis and reviews including only paediatric population inherited to this topic in the last 15 years.
    Results: The examined studies suggest that host gene expression signatures are an effective method to characterise the different types of infections, to distinguish infection from colonisation and, in some cases, to assess the severity of the disease in children.
    Conclusions: 'Omics-based techniques' may help to define the aetiology of infections in paediatrics, representing a useful tool to choose the most appropriate therapies and limit antibiotic resistance.
    MeSH term(s) Child ; Humans ; Anti-Bacterial Agents/therapeutic use ; Sepsis/diagnosis ; Sepsis/genetics ; Sepsis/drug therapy ; Respiratory Tract Infections ; Gene Expression Profiling ; Language
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-19
    Publishing country Norway
    Document type Meta-Analysis ; Journal Article ; Review
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.17119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characterization of severe asthma in the pediatric population.

    Perez, Amalui Vasquez / Pol, Anna Bobé / Hernandez, Elizabeth Rua / Lorenzo, Marc García / Serra, Alba Gomez / Bosque-García, Montserrat

    Allergologia et immunopathologia

    2021  Volume 49, Issue 2, Page(s) 60–65

    Abstract: Introduction and objectives: Relationship between the causal mechanisms of pediatric severe asthma and severity of symptoms would be helpful for developing personalized strategies for treatment and prevention.: Materials and methods: For this study, ... ...

    Abstract Introduction and objectives: Relationship between the causal mechanisms of pediatric severe asthma and severity of symptoms would be helpful for developing personalized strategies for treatment and prevention.
    Materials and methods: For this study, 698 medical histories of asthmatics between 6 and 18 years of age were reviewed in a period of 2 years. Variables analyzed were: age, sex, ethnicity, perinatological history, allergy history, asthma predictive index (API), exposure to tobacco, heavy traffic or epithelium, lung function, age of onset of symptoms, hospitalization admissions/PICU, systemic corticosteroids, daily symptoms control, device prescribe for daily control, and adherence.
    Results: A total of 86 children with severe asthma were included (12.3%). Mean age 13.3 +/- 1.86 years, sex ratio1:1, mean age of symptom onset 2.765 +/- 3.06 years, mean IgE 1076.18KU / L +/- 1136, mean eosinophils 604c / mcl +/- 511.9, mean of FEV1 93.15% +/- 16.3. Evidently, 70 children (81.4%) had positive API, 68 (79.1%) rhinitis, 34 (39.5%) atopic dermatitis. 73 (83.9%) sensitized to inhalants and 56 (65.1%) to dermatophagoides, 39 (45.3%) passive smokers, 19 (22.1%) exposure to heavy traffic; 55 (64%) showed symptoms with exercise, 35 (40.7%) had audible wheezing. The mean systemic corticosteroid cycles/year was 3.63 +/- 3.23, mean PICU admissions 0.36 +/- 0.83, mean hospital admissions 4.31 +/- 5.3, average emergency room visits/year 19.44 +/- 16.28. 38 (56.7%) had good adherence, 44 (51%) used an MDI device and 39 (45.3%) used dry powder.
    Conclusions: Children with severe asthma meet the following criteria: premature, positive API, rhinitis, atopic dermatitis, high IgE, eosinophilia, passive smokers, exposure to heavy traffic, decreased lung function, and low adherence to controller medication.
    MeSH term(s) Adolescent ; Anti-Asthmatic Agents/therapeutic use ; Asthma/blood ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/immunology ; Child ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/immunology ; Eosinophils/immunology ; Female ; Humans ; Leukocyte Count ; Male ; Medication Adherence/statistics & numerical data ; Rhinitis, Allergic, Perennial/epidemiology ; Rhinitis, Allergic, Perennial/immunology ; Risk Factors ; Severity of Illness Index ; Tobacco Smoke Pollution/adverse effects ; Tobacco Smoke Pollution/statistics & numerical data
    Chemical Substances Anti-Asthmatic Agents ; Tobacco Smoke Pollution
    Language English
    Publishing date 2021-03-01
    Publishing country Singapore
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 193144-1
    ISSN 1578-1267 ; 0301-0546
    ISSN (online) 1578-1267
    ISSN 0301-0546
    DOI 10.15586/aei.v49i2.65
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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