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  1. Article ; Online: Potential effects of nutrition-based weight loss therapies in reversing obesity-related breast cancer epigenetic marks.

    Lorenzo, Paula M / Crujeiras, Ana B

    Food & function

    2021  Volume 12, Issue 4, Page(s) 1402–1414

    Abstract: Obesity is a modifiable risk factor of breast cancer and epigenetic marks were proposed as a relevant mechanistic link. These mechanisms can be remodelled by modifying lifestyle factors and this fact could be useful in the treatment of obesity-related ... ...

    Abstract Obesity is a modifiable risk factor of breast cancer and epigenetic marks were proposed as a relevant mechanistic link. These mechanisms can be remodelled by modifying lifestyle factors and this fact could be useful in the treatment of obesity-related breast cancer. This review aimed to reveal the current evidence on the effects of differences in body composition and lifestyle factors on the risk, treatment, and survival of breast cancer with a focus on the effects of weight loss therapies based on different nutrients, bioactive compounds, and Mediterranean and ketogenic diets to counteract obesity-related breast cancer epigenetic marks. This review was framed on the most relevant and recently published articles and abstracts selected in PubMed using key words related to epigenetics, lifestyle, dietary habits, nutrients, bioactive compounds, ketone bodies, and weight loss treatments in obesity and breast cancer. Several studies have demonstrated that lifestyle interventions, including dietary modifications towards a healthy diet pattern, are effective therapies to prevent the onset of breast cancer and to improve the survival after treatment. These therapies reduce the main factors associated with obesity that are links between adiposity and cancer, including oxidative stress, inflammation and epigenetic mechanisms. However, although sufficient evidence exists regarding the effects of nutrients, dietary patterns, and weight loss therapies to prevent breast cancer or to improve survival, the effects of these strategies on the oncological treatment response were less studied. This review summarises the current scientific evidence regarding these nutritional strategies as adjuvant therapies in the management of obesity-related breast cancer by remodelling epigenetic marks related to carcinogenesis.
    MeSH term(s) Body Composition ; Breast Neoplasms/etiology ; Breast Neoplasms/genetics ; Breast Neoplasms/therapy ; Diet, Healthy ; Epigenesis, Genetic/genetics ; Female ; Genetic Markers ; Humans ; Life Style ; Nutrition Therapy ; Obesity/complications ; Prognosis ; Risk Factors ; Weight Loss
    Chemical Substances Genetic Markers
    Language English
    Publishing date 2021-01-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d0fo01984d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Food components affecting the epigenome: “Ergogenetic” aids for performance

    Izquierdo, Andrea G / Portela, Manuel / Lorenzo, Paula M / Mallo, Federico / Crujeiras, Ana B

    PharmaNutrition. 2020 Dec., v. 14

    2020  

    Abstract: The interest in epigenetics has grown exponentially in recent years and this is because epigenetic marks are present in most life processes. It is known that the epigenome is determined by different environmental factors such as diet or exercise. For ... ...

    Abstract The interest in epigenetics has grown exponentially in recent years and this is because epigenetic marks are present in most life processes. It is known that the epigenome is determined by different environmental factors such as diet or exercise. For athletes, improving performance during physical activity or reducing recovery times after training are key priorities that are currently focusing on research in the world of sports. Nutritional strategies are important tools for this purpose, since more and more dietary supplements are used as ergogenic potentials. Therefore and given that nutrition modulates gene expression through epigenetic modifications, recent studies have aimed to elucidate possible epigenetic mechanisms responsible for the link between dietary supplements for athletes and improving performance during exercise. Thus, in this review we cite the latest most relevant studies carried out to date in relation to epigenetic marks associated with sports supplementation and performance.
    Keywords epigenetics ; epigenome ; exercise ; gene expression
    Language English
    Dates of publication 2020-12
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ISSN 2213-4344
    DOI 10.1016/j.phanu.2020.100231
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  3. Article: Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies

    Rodriguez-Carnero, Gemma / Lorenzo, Paula M. / Canton-Blanco, Ana / Mendizabal, Leire / Arregi, Maddi / Zulueta, Mirella / Simon, Laureano / Macia-Cortiñas, Manuel / Casanueva, Felipe F. / Crujeiras, Ana B.

    Nutrients. 2022 June 29, v. 14, no. 13

    2022  

    Abstract: Polymorphisms of genes involved in the metabolism and transport of folate and cobalamin could play relevant roles in pregnancy outcomes. This study assessed the prevalence of genetic polymorphisms of folate and cobalamin metabolism-related genes such as ... ...

    Abstract Polymorphisms of genes involved in the metabolism and transport of folate and cobalamin could play relevant roles in pregnancy outcomes. This study assessed the prevalence of genetic polymorphisms of folate and cobalamin metabolism-related genes such as MTHFR, MTR, CUBN, and SLC19A1 in pregnant women of a homogeneous Spanish population according to conception, pregnancy, delivery, and newborns complications. This study was conducted on 149 nulliparous women with singleton pregnancies. Sociodemographic and obstetrics variables were recorded, and all patients were genotyped in the MTHFR, MTR, CUBN, and SLC10A1 polymorphisms. The distribution of genotypes detected in this cohort was similar to the population distribution reported in Europe, highlighting that more than 50% of women were carriers of risk alleles of the studied genes. In women with the MTHFR risk allele, there was a statistically significant higher frequency of assisted fertilisation and a higher frequency of preeclampsia and preterm birth. Moreover, CUBN (rs1801222) polymorphism carriers showed a statistically significantly lower frequency of complications during delivery. In conclusion, the prevalence of genetic variants related to folic acid and vitamin B12 metabolic genes in pregnant women is related to mother and neonatal outcomes. Knowing the prevalence of these polymorphisms may lead to a personalised prescription of vitamin intake.
    Keywords alleles ; conception ; folic acid ; genotyping ; metabolism ; nutrient intake ; population distribution ; pre-eclampsia ; premature birth ; risk ; vitamin B12 ; vitamin supplements ; Europe
    Language English
    Dates of publication 2022-0629
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14132702
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Immunomodulatory effect of a very-low-calorie ketogenic diet compared with bariatric surgery and a low-calorie diet in patients with excessive body weight

    Lorenzo, Paula M. / Sajoux, Ignacio / Izquierdo, Andrea G. / Gomez-Arbelaez, Diego / Zulet, M Angeles / Abete, Itziar / Castro, Ana I. / Baltar, Javier / Portillo, María P. / Tinahones, Francisco J. / Martinez, J Alfredo / Casanueva, Felipe F. / Crujeiras, Ana B.

    Clinical nutrition. 2022 May 10,

    2022  

    Abstract: Inflammation and oxidative stress are the most probable mechanistic link between obesity and its co-diseases with cancer among them. The aim of this study was to evaluate whether the nutritional ketosis and weight loss induced by a very-low-calorie ... ...

    Abstract Inflammation and oxidative stress are the most probable mechanistic link between obesity and its co-diseases with cancer among them. The aim of this study was to evaluate whether the nutritional ketosis and weight loss induced by a very-low-calorie ketogenic diet (VLCKD) modulates the inflammatory and oxidative stress profile, compared with a standard, balanced hypocaloric diet (LCD) or bariatric surgery (BS) in patients with obesity. The study was performed in 79 patients with overweight or obesity and 32 normal-weight volunteers as the control group. Patients with obesity underwent a weight reduction therapy based on VLCKD, LCD or BS. The quantification of the circulating levels of a multiplexing test of cytokines and carcinogenesis/aging biomarkers, as well as of lipid peroxides and total antioxidant power, was carried out. First, we observed that pro-inflammatory cytokines increase, while anti-inflammatory cytokines decrease under excessive body weight. Relevantly, when patients underwent weight loss strategies, it was shown that energy-restricted and surgical strategies of weight loss induced changes in circulating cytokine and lipid peroxides. This effect was more notable in patients following the VLCKD than the LCD or BS and it was observed mainly in the ketosis phase of the intervention. Particularly, IL-11, IL-12, IL-2, INF-γ, INF-β, Pentraxin-3 or MMP1 changed after VLCKD. Whereas, APRIL, TWEAK, osteocalcin and IL-28A increased after BS. As far as we know, this is the first study that evaluate the time-course of cytokines and oxidative stress markers after a VLCKD as compared with a standard LCD and BS. The observed results support the immunomodulatory effect of nutritional ketosis induced by a VLCKD synergistically with weight loss as a strategy to improve innate-immunity and to prevent infections and carcinogenesis in patients with obesity.
    Keywords antioxidant activity ; bariatric surgery ; biomarkers ; carcinogenesis ; clinical nutrition ; immunomodulators ; inflammation ; innate immunity ; interleukin-11 ; interleukin-12 ; interleukin-2 ; ketogenic diet ; ketosis ; low calorie diet ; obesity ; osteocalcin ; oxidative stress ; weight loss
    Language English
    Dates of publication 2022-0510
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2022.05.007
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1774: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies.

    Rodriguez-Carnero, Gemma / Lorenzo, Paula M / Canton-Blanco, Ana / Mendizabal, Leire / Arregi, Maddi / Zulueta, Mirella / Simon, Laureano / Macia-Cortiñas, Manuel / Casanueva, Felipe F / Crujeiras, Ana B

    Nutrients

    2022  Volume 14, Issue 13

    Abstract: Polymorphisms of genes involved in the metabolism and transport of folate and cobalamin could play relevant roles in pregnancy outcomes. This study assessed the prevalence of genetic polymorphisms of folate and cobalamin metabolism-related genes such as ... ...

    Abstract Polymorphisms of genes involved in the metabolism and transport of folate and cobalamin could play relevant roles in pregnancy outcomes. This study assessed the prevalence of genetic polymorphisms of folate and cobalamin metabolism-related genes such as MTHFR, MTR, CUBN, and SLC19A1 in pregnant women of a homogeneous Spanish population according to conception, pregnancy, delivery, and newborns complications. This study was conducted on 149 nulliparous women with singleton pregnancies. Sociodemographic and obstetrics variables were recorded, and all patients were genotyped in the MTHFR, MTR, CUBN, and SLC10A1 polymorphisms. The distribution of genotypes detected in this cohort was similar to the population distribution reported in Europe, highlighting that more than 50% of women were carriers of risk alleles of the studied genes. In women with the MTHFR risk allele, there was a statistically significant higher frequency of assisted fertilisation and a higher frequency of preeclampsia and preterm birth. Moreover, CUBN (rs1801222) polymorphism carriers showed a statistically significantly lower frequency of complications during delivery. In conclusion, the prevalence of genetic variants related to folic acid and vitamin B12 metabolic genes in pregnant women is related to mother and neonatal outcomes. Knowing the prevalence of these polymorphisms may lead to a personalised prescription of vitamin intake.
    MeSH term(s) Dietary Supplements ; Female ; Folic Acid ; Genotype ; Humans ; Infant, Newborn ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Pregnancy ; Pregnant Women ; Premature Birth ; Vitamin B 12 ; Vitamins
    Chemical Substances Vitamins ; Folic Acid (935E97BOY8) ; Methylenetetrahydrofolate Reductase (NADPH2) (EC 1.5.1.20) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2022-06-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14132702
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  6. Article ; Online: Epigenetic Effects of Healthy Foods and Lifestyle Habits from the Southern European Atlantic Diet Pattern: A Narrative Review.

    Lorenzo, Paula M / Izquierdo, Andrea G / Rodriguez-Carnero, Gemma / Fernández-Pombo, Antía / Iglesias, Alba / Carreira, Marcos C / Tejera, Cristina / Bellido, Diego / Martinez-Olmos, Miguel A / Leis, Rosaura / Casanueva, Felipe F / Crujeiras, Ana B

    Advances in nutrition (Bethesda, Md.)

    2022  Volume 13, Issue 5, Page(s) 1725–1747

    Abstract: Recent scientific evidence has shown the importance of diet and lifestyle habits for the proper functioning of the human body. A balanced and healthy diet, physical activity, and psychological well-being have a direct beneficial effect on health and can ... ...

    Abstract Recent scientific evidence has shown the importance of diet and lifestyle habits for the proper functioning of the human body. A balanced and healthy diet, physical activity, and psychological well-being have a direct beneficial effect on health and can have a crucial role in the development and prognosis of certain diseases. The Southern European Atlantic diet, also named the Atlantic diet, is a unique dietary pattern that occurs in regions that present higher life expectancy, suggesting that this specific dietary pattern is associated with positive health effects. In fact, it is enriched with nutrients of high biological value, which, together with its cooking methods, physical activity promotion, reduction in carbon footprint, and promoting of family meals, promote these positive effects on health. The latest scientific advances in the field of nutri-epigenetics have revealed that epigenetic markers associated with food or nutrients and environmental factors modulate gene expression and, therefore, are involved with both health and disease. Thus, in this review, we evaluated the main aspects that define the Southern European Atlantic diet and the potential epigenetic changes associated with them based on recent studies regarding the main components of these dietary patterns. In conclusion, based on the information existing in the literature, we postulate that the Southern European Atlantic diet could promote healthy aging by means of epigenetic mechanisms. This review highlights the necessity of performing longitudinal studies to demonstrate this proposal.
    MeSH term(s) Diet ; Diet, Healthy ; Epigenesis, Genetic ; Habits ; Humans ; Life Style
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2583634-1
    ISSN 2156-5376 ; 2156-5376
    ISSN (online) 2156-5376
    ISSN 2156-5376
    DOI 10.1093/advances/nmac038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Immunomodulatory effect of a very-low-calorie ketogenic diet compared with bariatric surgery and a low-calorie diet in patients with excessive body weight.

    Lorenzo, Paula M / Sajoux, Ignacio / Izquierdo, Andrea G / Gomez-Arbelaez, Diego / Zulet, M Angeles / Abete, Itziar / Castro, Ana I / Baltar, Javier / Portillo, María P / Tinahones, Francisco J / Martinez, J Alfredo / Casanueva, Felipe F / Crujeiras, Ana B

    Clinical nutrition (Edinburgh, Scotland)

    2022  Volume 41, Issue 7, Page(s) 1566–1577

    Abstract: Background & aim: Inflammation and oxidative stress are the most probable mechanistic link between obesity and its co-diseases with cancer among them. The aim of this study was to evaluate whether the nutritional ketosis and weight loss induced by a ... ...

    Abstract Background & aim: Inflammation and oxidative stress are the most probable mechanistic link between obesity and its co-diseases with cancer among them. The aim of this study was to evaluate whether the nutritional ketosis and weight loss induced by a very-low-calorie ketogenic diet (VLCKD) modulates the inflammatory and oxidative stress profile, compared with a standard, balanced hypocaloric diet (LCD) or bariatric surgery (BS) in patients with obesity.
    Methods: The study was performed in 79 patients with overweight or obesity and 32 normal-weight volunteers as the control group. Patients with obesity underwent a weight reduction therapy based on VLCKD, LCD or BS. The quantification of the circulating levels of a multiplexing test of cytokines and carcinogenesis/aging biomarkers, as well as of lipid peroxides and total antioxidant power, was carried out.
    Results: First, we observed that pro-inflammatory cytokines increase, while anti-inflammatory cytokines decrease under excessive body weight. Relevantly, when patients underwent weight loss strategies, it was shown that energy-restricted and surgical strategies of weight loss induced changes in circulating cytokine and lipid peroxides. This effect was more notable in patients following the VLCKD than the LCD or BS and it was observed mainly in the ketosis phase of the intervention. Particularly, IL-11, IL-12, IL-2, INF-γ, INF-β, Pentraxin-3 or MMP1 changed after VLCKD. Whereas, APRIL, TWEAK, osteocalcin and IL-28A increased after BS.
    Conclusion: As far as we know, this is the first study that evaluate the time-course of cytokines and oxidative stress markers after a VLCKD as compared with a standard LCD and BS. The observed results support the immunomodulatory effect of nutritional ketosis induced by a VLCKD synergistically with weight loss as a strategy to improve innate-immunity and to prevent infections and carcinogenesis in patients with obesity.
    MeSH term(s) Bariatric Surgery ; Biomarkers ; Caloric Restriction ; Carcinogenesis ; Cytokines ; Diet, Ketogenic/adverse effects ; Diet, Reducing ; Humans ; Ketosis ; Lipid Peroxides ; Obesity/surgery ; Weight Gain ; Weight Loss
    Chemical Substances Biomarkers ; Cytokines ; Lipid Peroxides
    Language English
    Publishing date 2022-05-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2022.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1774: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: ZNF577

    Lorenzo, Paula M / Izquierdo, Andrea G / Diaz-Lagares, Angel / Carreira, Marcos C / Macias-Gonzalez, Manuel / Sandoval, Juan / Cueva, Juan / Lopez-Lopez, Rafael / Casanueva, Felipe F / Crujeiras, Ana B

    Frontiers in endocrinology

    2020  Volume 11, Page(s) 245

    Abstract: The methylation levels ... ...

    Abstract The methylation levels of
    MeSH term(s) Adiposity/genetics ; Adult ; Biomarkers, Tumor/genetics ; Body Mass Index ; Breast Neoplasms/epidemiology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; CpG Islands ; DNA Methylation ; DNA-Binding Proteins/genetics ; Diet, Mediterranean ; Epigenomics ; Female ; Follow-Up Studies ; Humans ; Leukocytes/metabolism ; Leukocytes/pathology ; Menopause/genetics ; Middle Aged ; Obesity/genetics ; Prognosis ; Promoter Regions, Genetic ; Spain/epidemiology ; Transcription Factors/genetics
    Chemical Substances Biomarkers, Tumor ; DNA-Binding Proteins ; Transcription Factors ; zinc finger protein 577, human
    Language English
    Publishing date 2020-04-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2020.00245
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  9. Article ; Online: Downregulated Adipose Tissue Expression of Browning Genes With Increased Environmental Temperatures.

    Oliveras-Cañellas, Núria / Moreno-Navarrete, José María / Lorenzo, Paula M / Garrido-Sánchez, Lourdes / Becerril, Sara / Rangel, Oriol / Latorre, Jèssica / de la Calle Vargas, Elena / Pardo, Maria / Valentí, Victor / Romero-Cabrera, Juan L / Oliva-Olivera, Wilfredo / Silva, Camilo / Diéguez, Carlos / Villarroya, Francesc / López, Miguel / Crujeiras, Ana B / Seoane, Luisa-Maria / López-Miranda, José /
    Frühbeck, Gema / Tinahones, Francisco José / Fernández-Real, José-Manuel

    The Journal of clinical endocrinology and metabolism

    2023  Volume 109, Issue 1, Page(s) e145–e154

    Abstract: Context: Climate change and global warming have been hypothesized to influence the increased prevalence of obesity worldwide. However, the evidence is scarce.: Objective: We aimed to investigate how outside temperature might affect adipose tissue ... ...

    Abstract Context: Climate change and global warming have been hypothesized to influence the increased prevalence of obesity worldwide. However, the evidence is scarce.
    Objective: We aimed to investigate how outside temperature might affect adipose tissue physiology and metabolic traits.
    Methods: The expression of genes involved in thermogenesis/browning and adipogenesis were evaluated (through quantitative polymerase chain reaction) in the subcutaneous adipose tissue (SAT) from 1083 individuals recruited in 5 different regions of Spain (3 in the North and 2 in the South). Plasma biochemical variables and adiponectin (enzyme-linked immunosorbent assay) were collected through standardized protocols. Mean environmental outdoor temperatures were obtained from the National Agency of Meteorology. Univariate, multivariate, and artificial intelligence analyses (Boruta algorithm) were performed.
    Results: The SAT expression of genes associated with browning (UCP1, PRDM16, and CIDEA) and ADIPOQ were significantly and negatively associated with minimum, average, and maximum temperatures. The latter temperatures were also negatively associated with the expression of genes involved in adipogenesis (FASN, SLC2A4, and PLIN1). Decreased SAT expression of UCP1 and ADIPOQ messenger RNA and circulating adiponectin were observed with increasing temperatures in all individuals as a whole and within participants with obesity in univariate, multivariate, and artificial intelligence analyses. The differences remained statistically significant in individuals without type 2 diabetes and in samples collected during winter.
    Conclusion: Decreased adipose tissue expression of genes involved in browning and adiponectin with increased environmental temperatures were observed. Given the North-South gradient of obesity prevalence in these same regions, the present observations could have implications for the relationship of the obesity pandemic with global warming.
    MeSH term(s) Humans ; Temperature ; Adiponectin/metabolism ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/complications ; Artificial Intelligence ; Adipose Tissue/metabolism ; Obesity/epidemiology ; Obesity/genetics ; Obesity/complications ; Adipose Tissue, White/metabolism ; Adipose Tissue, Brown/metabolism ; Thermogenesis/genetics
    Chemical Substances Adiponectin
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
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  10. Article: Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity

    Sajoux, Ignacio / Lorenzo, Paula M / Gomez-Arbelaez, Diego / Zulet, M. Angeles / Abete, Itziar / Castro, Ana I / Baltar, Javier / Portillo, María P / Tinahones, Francisco J / Martinez, J. Alfredo / Crujeiras, Ana B / Casanueva, Felipe F

    Nutrients. 2019 Oct. 04, v. 11, no. 10

    2019  

    Abstract: The preservation of muscle mass and muscle function after weight loss therapy is currently a considerable challenge in the fight against obesity. Muscle mass secretes proteins called myokines that have relevant functions in the regulation of metabolism ... ...

    Abstract The preservation of muscle mass and muscle function after weight loss therapy is currently a considerable challenge in the fight against obesity. Muscle mass secretes proteins called myokines that have relevant functions in the regulation of metabolism and health. This study was aimed to evaluate whether a very low-calorie ketogenic (VLCK) diet may modulate myokine levels, in addition to changes in body composition, compared to a standard, balanced low-calorie (LC) diet or bariatric surgery in patients with obesity. Body composition, ketosis, insulin sensitivity and myokines were evaluated in 79 patients with overweight/obesity after a therapy to lose weight with a VLCK diet, a LC diet or bariatric surgery. The follow-up was 6 months. The weight loss therapies induced changes in myokine levels in association with changes in body composition and biochemical parameters. The effects on circulating myokine levels compared to those at baseline were stronger after the VLCK diet than LC diet or bariatric surgery. Differences reached statistical significance for IL-8, MMP2 and irisin. In conclusion, nutritional interventions or bariatric surgery to lose weight induces changes in circulating myokine levels, being this effect potentially most notable after following a VLCK diet.
    Keywords bariatric surgery ; body composition ; insulin resistance ; interleukin-8 ; ketogenic diet ; ketosis ; low calorie diet ; metabolism ; muscle tissues ; muscles ; nutritional intervention ; obesity ; patients ; proteins ; weight control programs ; weight loss
    Language English
    Dates of publication 2019-1004
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11102368
    Database NAL-Catalogue (AGRICOLA)

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