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Article ; Online: The Long Term Residual Effects of COVID-Associated Coagulopathy

Marco Ranucci / Ekaterina Baryshnikova / Martina Anguissola / Sara Pugliese / Mara Falco / Lorenzo Menicanti

International Journal of Molecular Sciences, Vol 24, Iss 5514, p

2023 Volume 5514

Abstract: During the acute phase of COVID-19, many patients experience a complex coagulopathy characterized by a procoagulant pattern. The present study investigates the persistence of hemostatic changes in post-COVID patients at a long-term follow up, and the ... ...

Abstract	During the acute phase of COVID-19, many patients experience a complex coagulopathy characterized by a procoagulant pattern. The present study investigates the persistence of hemostatic changes in post-COVID patients at a long-term follow up, and the link with the persistence of physical and neuropsychological symptoms. We completed a prospective cohort study on 102 post-COVID patients. Standard coagulation and viscoelastic tests were performed, along with an assessment of persistent symptoms and recording of acute phase details. A procoagulant state was adjudicated in the presence of fibrinogen > 400 mg/dL, or D-dimer > 500 ng/mL, or platelet count > 450,000 cells/µL, or a maxim clot lysis at viscoelastic test < 2%. A procoagulant state was identified in 75% of the patients at 3 months follow up, 50% at 6 months, and 30% at 12–18 months. Factors associated with the persistence of a procoagulant state were age, severity of the acute phase, and persistence of symptoms. Patients with major physical symptoms carry a procoagulant state relative risk of 2.8 (95% confidence interval 1.17–6.7, p = 0.019). The association between persistent symptoms and a procoagulant state raises the hypothesis that an ongoing process of thrombi formation and/or persistent microthrombosis may be responsible for the main physical symptoms in long-COVID patients.
Keywords	COVID-19 ; post-acute COVID-19 syndrome ; coagulopathy ; fibrinolysis ; thrombosis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	150
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Surgical Ventricular Restoration for Ischemic Heart Failure

Serenella Castelvecchio / Valentina Milani / Federico Ambrogi / Marianna Volpe / Lucia Ramputi / Giovanni Soletti / Lorenzo Menicanti

Journal of Personalized Medicine, Vol 12, Iss 4, p

A Glance at a Real-World Population

2022 Volume 567

Abstract: Surgical ventricular restoration (SVR) has repeatedly been suggested as a viable therapeutic strategy for ischemic heart failure (HF) patients, although the survival benefit is still debated. We investigated a real-world population treated with SVR in a ... ...

Abstract	Surgical ventricular restoration (SVR) has repeatedly been suggested as a viable therapeutic strategy for ischemic heart failure (HF) patients, although the survival benefit is still debated. We investigated a real-world population treated with SVR in a single center with high case volumes. From July 2001 to June 2017, 648 patients (111 females) underwent SVR; coronary surgery was performed in 582 patients. Data were analyzed by dividing the population into two groups: Group I (371 patients operated between July 2001 and December 2007) and Group II (277 patients operated between January 2008 and June 2017). At baseline, Group I patients were more symptomatic for angina (47.4% versus 19.4%, p < 0.0001) and less symptomatic for HF (NYHA class III/IV, 46.3% versus 57%, p = 0.0071). The end-diastolic volume (106 mL/m 2 versus 118.3 mL/m 2 , p < 0.0001) and the end-systolic volume (70.5 mL/m 2 versus 81.5 mL/m 2 , p < 0.0001) were lower in Group I. The presence of 3-vessel coronary artery disease (CAD) was higher in Group I (73.3% versus 59.2%, p < 0.0001). Thirty-day mortality (6.64%) was similar in the two groups ( p = 0.4475). The Kaplan–Meier estimate for all-cause mortality for the entire population was 13% at 2 years, 19.2% at 4 years and 36.6% at 8 years, and the probability was not different between groups (Log-rank = 0.11). In a real-world ischemic HF population, SVR may be carried out with favorable results; in patients with worse LV remodeling and less extensive CAD, SVR showed a trend toward a better outcome.
Keywords	ischemic heart failure ; left ventricular remodeling ; surgical treatment ; Medicine ; R
Subject code	333
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The unusual journey of a retained epicardial pacing wire

Francesca Giacomazzi / Lorenzo Menicanti / Massimo Lombardi / Roberto Tramarin

Italian Journal of Medicine, Vol 11, Iss 4, Pp 396-

2017 Volume 398

Abstract: The placement of temporary epicardial pacing wires (EPWs) at the completion of cardiac surgery is a routine procedure in most centers. Complications related to their insertion, removal and retention are infrequent, yet potentially severe, including ... ...

Abstract	The placement of temporary epicardial pacing wires (EPWs) at the completion of cardiac surgery is a routine procedure in most centers. Complications related to their insertion, removal and retention are infrequent, yet potentially severe, including hemorrhage, tamponade, infection and death. Here, we describe an unusual case of retained temporary EPWs migration.
Keywords	Temporary epicardial pacing wire migration ; epicardial pacing wire complication ; Medicine ; R
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: When Outcomes Diverge

Marco Ranucci / Gianfranco Parati / Umberto Di Dedda / Maurizio Bussotti / Eustachio Agricola / Lorenzo Menicanti / Sara Bombace / Fabiana De Martino / Stefano Giovinazzo / Antonella Zambon / Roberto Menè / Maria Teresa La Rovere

Journal of Clinical Medicine, Vol 11, Iss 14, p

Age and Cardiovascular Risk as Determinants of Mortality and ICU Admission in COVID-19

2022 Volume 4099

Abstract: Background: Hospital mortality and admission to the Intensive Care Unit (ICU) are markers of disease severity in COVID-19 patients. Cardiovascular co-morbidities are one of the main determinants of negative outcomes. In this study we investigated the ... ...

Abstract	Background: Hospital mortality and admission to the Intensive Care Unit (ICU) are markers of disease severity in COVID-19 patients. Cardiovascular co-morbidities are one of the main determinants of negative outcomes. In this study we investigated the impact of cardiovascular co-morbidities on mortality and admission to the ICU in first-wave COVID-19 patients. Methods: A multicenter, retrospective, cohort study. A total of 1077 patients were analyzed for mortality and ICU admission. Cardiovascular risk factors were explored as determinants of the outcomes after correction for other confounders. Results: In the multivariable model, after correction for age, only a history of heart failure remained independently associated ( p = 0.0013) with mortality (hazard ratio 2.22, 95% confidence interval 1.37 to 3.62). Age showed a mortality risk increase of 8% per year (hazard ratio 1.08, 95% confidence interval 1.05 to 1.10, p = 0.001). The transition from ward to the ICU had, as a single determinant, the age, but in a reversed fashion (hazard ratio 0.96, 95% confidence interval 0.94 to 0.98, p = 0.0002). Conclusions: Once adjusted for the main determinant of mortality (age) heart failure only remained independently associated with mortality. Admission to the ICU was less likely for elderly patients. This may reflect the catastrophic impact of the first wave of COVID-19 pandemic in terms of ICU bed availability in Lombardy, leading to a selection process for ICU admission.
Keywords	COVID-19 ; heart failure ; cardiovascular risk factors ; Medicine ; R
Subject code	310
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: BNT162b2 Booster Dose Elicits a Robust Antibody Response in Subjects with Abdominal Obesity and Previous SARS-CoV-2 Infection

Vaccines, Vol 11, Iss 12, p

2023 Volume 1796

Abstract: Little is known about the long-term durability of the induced immune response in subjects with obesity, particularly in those with an abdominal distribution of adipose tissue. We evaluated SARS-CoV-2-specific antibody responses after BNT162b2 vaccine ... ...

Abstract	Little is known about the long-term durability of the induced immune response in subjects with obesity, particularly in those with an abdominal distribution of adipose tissue. We evaluated SARS-CoV-2-specific antibody responses after BNT162b2 vaccine booster dose, comparing individuals with and without abdominal obesity (AO), discerning between individuals previously infected or not. IgG-TrimericS were measured in 511 subjects at baseline, on the 21st day after vaccine dose 1, and at 1, 3, 6, and 9 months from dose 2, and at 1 and 3 months following the booster dose. To detect SARS-CoV-2 infection, nucleocapsid antibodies were measured at baseline and at the end of the study. Multivariable linear regression evaluated the three-month difference in the absolute variation in IgG-TrimericS levels from booster dose, showing AO and SARS-CoV-2 infection status interactions ( p = 0.016). Regardless of possible confounding factors and IgG-TrimericS levels at the booster dose, AO is associated with a higher absolute change in IgG-TrimericS in prior infected individuals ( p = 0.0125). In the same regression model, no interaction is highlighted using BMI ( p = 0.418). The robust response in the development of antibodies after booster dose, observed in people with AO and previous infection, may support the recommendations to administer a booster dose in this population group.
Keywords	abdominal obesity ; obesity ; BMI ; BNT162b2 mRNA vaccine ; antibody response ; IgG-TrimericS ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cirugía de restauración ventricular para revertir el remodelado del ventrículo izquierdo

Serenella Castelvecchio / Lorenzo Menicanti / Marisa Di Donato

Cirugía Cardiovascular, Vol 18, Iss 3, Pp 163-

2011 Volume 173

Abstract: La insuficiencia cardíaca (IC) es uno de los problemas de salud de mayor importancia en el mundo occidental en cuanto a número creciente de pacientes afectados, tasa de hospitalización y costes. A pesar de la optimización en el tratamiento médico, la ... ...

Abstract	La insuficiencia cardíaca (IC) es uno de los problemas de salud de mayor importancia en el mundo occidental en cuanto a número creciente de pacientes afectados, tasa de hospitalización y costes. A pesar de la optimización en el tratamiento médico, la mortalidad permanece elevada. El incremento del volumen ventricular tras un infarto de miocardio (IM) forma parte del proceso de remodelado. la cirugía de restauración ventricular (SVR) se introdujo como una opción terapéutica con el objetivo de reducir los volúmenes ventriculares y restaurar la geometría. Hasta ahora, se ha demostrado que la SVR mejora la función cardíaca, el estadio clínico y la supervivencia en pacientes con miocardiopatía dilatada isquémica e IC. la técnica, desde su descripción inicial, se ha refinado en los últimos 10 años en un esfuerzo para estandarizar el procedimiento y optimizar los resultados. En esta revisión se discuten las razones de revertir quirúrgicamente el remodelado de ventrículo izquierdo (VI) , la técnica, el impacto de la SVR en la función cardíaca y la supervivencia, y una información actualizada sobre los ensayos clínicos actuales y las nuevas guías clínicas.
Keywords	Infarto de miocardio ; Remodelado ventricular izquierdo ; Cirugía de restauración ventricular ; Función sistólica ; Función diastólica ; Medicine ; R ; Surgery ; RD1-811
Language	Spanish
Publishing date	2011-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors.

Marco Ranucci / Tommaso Aloisio / Umberto Di Dedda / Lorenzo Menicanti / Carlo de Vincentiis / Ekaterina Baryshnikova / Surgical and Clinical Outcome REsearch (SCORE) group

PLoS ONE, Vol 14, Iss 11, p e

2019 Volume 0225771

Abstract: BACKGROUND:Gender influences platelet biology. Women have a larger platelet count, but gender-based differences in platelet function remain debated. We performed a study addressing gender-based differences in platelet function using point-of-care ... ...

Abstract	BACKGROUND:Gender influences platelet biology. Women have a larger platelet count, but gender-based differences in platelet function remain debated. We performed a study addressing gender-based differences in platelet function using point-of-care platelet function tests (PFT). METHODS:The patient population consisted of 760 cardiac surgery patients where preoperative PFT (multiple-electrode aggregometry [MEA]) were available. Platelet count and function at the ADPtest and TRAPtest were compared in the overall population and separately in patients with or without residual effects of P2Y12 inhibitors. RESULTS:Women had a significantly (P = 0.001) higher platelet count but a non-significantly higher platelet reactivity to ADP. In clopidogrel-treated patients, the platelets ADP reactivity was significantly (P = 0.031) higher in women, and platelet count was the main determinant of platelet hyper-reactivity. Within patients under full clopidogrel effects, women with a platelet count ≥ 200,000 cells/μL had a significantly (P = 0.023) higher rate of high-on-treatment platelet reactivity (HTPR, 45.5%) with respect to males with a platelet count < 200,000 cells/μL (11.9%), with a relative risk of 6.2 (95% confidence interval 1.4-29). CONCLUSIONS:Our findings confirm that women have a larger platelet count than men, and that this is associated to a trend towards a higher platelet reactivity. HTPR is largely represented in women with a high platelet count. This generates the hypothesis that women requiring P2Y12 inhibitors could potentially benefit from larger doses of drug or should be treated with anti-platelet agents with a low rate of HTPR.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correlational study on altered epicardial adipose tissue as a stratification risk factor for valve disease progression through IL-13 signaling.

Vianello, Elena / Marrocco-Trischitta Massimiliano, Maria / Dozio, Elena / Bandera, Francesco / Tacchini, Lorenza / Canciani, Elena / Dellavia, Claudia / Schmitz, Gerd / Lorenzo, Menicanti / Corsi Romanelli Massimiliano, Marco

Journal of molecular and cellular cardiology

2019 Volume 132, Page(s) 210–218

Abstract: Aims: Genetic and environmental factors all interact in the risk of progression of valvular dysfunctions. Previous studies reported a relation between valve diseases and epicardial adipose tissue (EAT) thickness. The aim of this study was to verify the ... ...

Abstract	Aims: Genetic and environmental factors all interact in the risk of progression of valvular dysfunctions. Previous studies reported a relation between valve diseases and epicardial adipose tissue (EAT) thickness. The aim of this study was to verify the possible relationship between the molecular pattern of EAT related to IL-13 fibrogenic cytokine expression and valve dysfunction. Methods and results: A valvular heart disease (VHD) population was stratified according to their median EAT thickness (7 mm). The molecular expression of IL-13 in EAT is directly related to the molecular expression of genes associated with extracellular matrix (ECM) turnover, macrophage infiltration and promotion of the formation of ectopic calcific nodules involved in aorta coarctation and calcification. Conclusion: IL-13 gene expression in altered EAT is directly related to the expression of genes involved in ECM turnover and the formation of ectopic calcific nodules, suggesting measurements of EAT as a stratification risk factor for valve instability in the VHD patients.
MeSH term(s)	Adipose Tissue/pathology ; Aged ; Calcinosis/metabolism ; Calcinosis/pathology ; Disease Progression ; Epicardial Mapping ; Female ; Heart Valve Diseases/etiology ; Heart Valve Diseases/metabolism ; Heart Valve Diseases/pathology ; Humans ; Interleukin-13/genetics ; Interleukin-13/metabolism ; Male ; Middle Aged ; Pericardium/pathology ; Risk Factors ; Signal Transduction
Chemical Substances	Interleukin-13
Language	English
Publishing date	2019-05-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80157-4
ISSN	1095-8584 ; 0022-2828
ISSN (online)	1095-8584
ISSN	0022-2828
DOI	10.1016/j.yjmcc.2019.05.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cirugía de restauración ventricular después del estudio STICH

Jesús Herreros / Jorge C. Trainini / Lorenzo Menicanti / Noedir Stolf / Javier Cabo / Enio Buffolo

Cirugía Cardiovascular, Vol 17, Iss 1, Pp 25-

2010 Volume 35

Abstract: La insuficiencia cardíaca es uno de los problemas de salud pública de mayor envergadura. Los cambios de la geometría ventricular, con su repercusión en el pronóstico y el número limitado de donantes, ha generado un interés creciente para la aplicación de ...

Abstract	La insuficiencia cardíaca es uno de los problemas de salud pública de mayor envergadura. Los cambios de la geometría ventricular, con su repercusión en el pronóstico y el número limitado de donantes, ha generado un interés creciente para la aplicación de cirugía de restauración ventricular (SVR). Las técnicas quirúrgicas son revisadas, su correlación con los fundamentos anatomicofisiopatológicos de la insuficiencia cardíaca y sus resultados son analizados. Los estudios clínicos de SVR aportan evidencia científica para mantener y potenciar su aplicación, a pesar de los resultados de la hipótesis 2 del estudio STICH (Surgical Treatment for Ischemic Heart Failure). Presentamos un proyecto cuyo desarrollo hemos iniciado y que integra el Registro Latinoamericano de Cirugía de Restauración Ventricular (SVRIR) y los estudios de mecánica computacional. Sus objetivos son realizar aportaciones al conocimiento de la fisiopatología de la insuficiencia cardíaca, correlacionar las técnicas quirúrgicas con los fundamentos anatómicos y fisiopatológicos de la insuficiencia cardíaca, precisar los beneficios de la SVR y diseñar técnicas específicas para cada paciente.
Keywords	Insuficiencia cardíaca ; Remodelado ; Restauración ventricular ; Cardiomiopatía isquémica ; Enfermedad de Chagas ; Computacional ; Medicine ; R ; Surgery ; RD1-811
Language	Spanish
Publishing date	2010-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Interleukin-15 and soluble interleukin-15 receptor α in coronary artery disease patients

Elena Dozio / Alexis Elias Malavazos / Elena Vianello / Silvia Briganti / Giada Dogliotti / Francesco Bandera / Francesca Giacomazzi / Serenella Castelvecchio / Lorenzo Menicanti / Alexander Sigrüener / Gerd Schmitz / Massimiliano Marco Corsi Romanelli

PLoS ONE, Vol 9, Iss 3, p e

association with epicardial fat and indices of adipose tissue distribution.

2014 Volume 90960

Abstract: Interleukin-15 (IL-15) is a pro-inflammatory cytokine which signals via a specific alpha receptor subunit (IL-15Rα). Increased IL-15 level has been observed in cardiovascular patients and IL-15 immunoreactivity has been detected at vulnerable ... ...

Abstract	Interleukin-15 (IL-15) is a pro-inflammatory cytokine which signals via a specific alpha receptor subunit (IL-15Rα). Increased IL-15 level has been observed in cardiovascular patients and IL-15 immunoreactivity has been detected at vulnerable atherosclerotic plaques. Due to the association between adipose tissue distribution, inflammation and coronary artery disease (CAD), we quantified IL-15 and IL-15Rα in CAD patients with different adiposity and adipose tissue distribution and we evaluated whether epicardial adipose tissue (EAT), a visceral fat depot surrounding and infiltrating myocardium, may be a source of both molecules. IL-15 and IL-15Rα proteins were quantified by enzyme-linked immunosorbent assays. Gene expression of IL-15 and IL-15Rα in EAT depots was evaluated by one colour microarray platform. EAT thickness was measured by echocardiography. Plasmatic IL-15 and IL-15Rα levels were higher in CAD than non-CAD patients. After classification according to adipose tissue distribution, IL-15 was higher in CAD patients with increased abdominal adiposity. Increased level of IL-15Rα was observed both in CAD and non-CAD patients with increased abdominal fat. EAT was a source of IL-15 and IL-15Rα and their expression was higher in CAD patients with increased EAT thickness. In conclusion, our data suggest that circulating levels of IL-15 and IL-15Rα seem to reflect visceral distribution of adipose tissue and that EAT may be a potential source of both IL-15 and IL-15Rα. Future studies on the relationship between IL-15, visceral fat and characteristics of atherosclerotic plaques could help to better understand the complex biology of this cytokine.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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