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Article ; Online: Efficacy of Tildrakizumab for the Treatment of Difficult-to-Treat Areas

Marco Galluzzo / Marina Talamonti / Arnaldo Cioni / Virginia Maffei / Ruslana Gaeta Shumak / Lorenzo Tofani / Luca Bianchi / Elena Campione

Journal of Clinical Medicine, Vol 11, Iss 2631, p

Scalp, Nail, Palmoplantar and Genital Psoriasis

2022 Volume 2631

Abstract: Tildrakizumab, an IL-23 inhibitor, is effective and safe for the improvement of moderate-to-severe chronic plaque psoriasis. However, little evidence is available on the use of this biologic in psoriasis in difficult-to-treat locations. In this ... ...

Abstract	Tildrakizumab, an IL-23 inhibitor, is effective and safe for the improvement of moderate-to-severe chronic plaque psoriasis. However, little evidence is available on the use of this biologic in psoriasis in difficult-to-treat locations. In this retrospective analysis, we treated patients with 100 mg tildrakizumab at Day 0, after 4 weeks and every 12 weeks thereafter. Disease severity and treatment response was assessed by the Psoriasis Area and Severity Index (PASI), the static Physician’s Global Assessment of Genitalia (sPGA-G), the Psoriasis Scalp Severity Index (PSSI), Nail Psoriasis Severity Index (NAPSI) and the Palmoplantar Psoriasis Area and Severity Index (ppPASI) at baseline and after 4, 12 and 28 weeks. We followed 18 patients (mean age 49.1 ± 12.7 years, 61.1% male) with psoriasis localized to the genital region (N = 7), scalp (N = 6), nails (N = 5) and palmar/plantar areas (N = 7). PASI score decreased from 11.5 at baseline to 3.1 and 2.4 at 12 and 28 weeks. Tildrakizumab treatment decreased sPGA-G (3.3 to 0.2), PSSI (36.2 to 2.7), NAPSI (48.4 to 15.7) and ppPASI (5.3 to 0) from baseline to 28 weeks, respectively. Data from this real-life retrospective analysis shows that tildrakizumab is an effective option for the management of psoriasis in difficult-to-treat areas.
Keywords	psoriasis ; tildrakizumab ; PASI ; NAPSI ; PSSI ; sPGA-G ; Medicine ; R
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Magnetic nanoantioxidants with improved radical-trapping stoichiometry as stabilizers for inhibition of peroxide formation in ethereal solvents

Caterina Viglianisi / Alessia Scarlini / Lorenzo Tofani / Stefano Menichetti / Andrea Baschieri / Riccardo Amorati

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 7

Abstract: Abstract Graphite-coated magnetic cobalt nanoparticles (CoNPs) decorated with hindered phenolic antioxidant analogues of 2,6-di-tert-butyl-4-methylphenol (BHT, E321) provided easily removable nanoantioxidants capable of preventing the autoxidation of ... ...

Abstract	Abstract Graphite-coated magnetic cobalt nanoparticles (CoNPs) decorated with hindered phenolic antioxidant analogues of 2,6-di-tert-butyl-4-methylphenol (BHT, E321) provided easily removable nanoantioxidants capable of preventing the autoxidation of organic solvents as tetrahydrofuran (THF).
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Regional Citrate Anticoagulation and Systemic Anticoagulation during Pediatric Continuous Renal Replacement Therapy

Emanuele Buccione / Stefano Bambi / Laura Rasero / Lorenzo Tofani / Tessa Piazzini / Carlo Della Pelle / Khadija El Aoufy / Zaccaria Ricci / Stefano Romagnoli / Gianluca Villa

Journal of Clinical Medicine, Vol 11, Iss 3121, p

A Systematic Literature Review

2022 Volume 3121

Abstract: Background: Clotting is a major drawback of continuous renal replacement therapy (CRRT) performed on critically ill pediatric patients. Although anticoagulation is recommended to prevent clotting, limited results are available on the effect of each ... ...

Abstract	Background: Clotting is a major drawback of continuous renal replacement therapy (CRRT) performed on critically ill pediatric patients. Although anticoagulation is recommended to prevent clotting, limited results are available on the effect of each pharmacological strategy in reducing filter clotting in pediatric CRRT. This study defines which anticoagulation strategy, between regional citrate anticoagulation (RCA) and systemic anticoagulation with heparin, is safer and more efficient in reducing clotting, patient mortality, and treatment complications during pediatric CRRT. Methods: A systematic literature review was run considering papers published in English until December 2021 and describing patients’ and treatments’ complications in CRRT performed with heparin and RCA on patients aged less than 18 years. Results: Eleven studies were considered, cumulatively comprising 1.706 CRRT sessions (62% with systemic anticoagulation and 38% with RCA). Studies have consistently identified RCA’s superiority over systemic anticoagulation with heparin in prolonging circuit life. The pooled estimate (95% CI) of filter clotting risk showed that RCA is a protective factor for clotting risk (RR = 0.204). Conclusions: RCA has a potential role in prolonging circuit life and seems superior to systemic anticoagulation with heparin in decreasing the risk of circuit clotting during CRRT performed in critically ill pediatric patients.
Keywords	continuous renal replacement therapy ; pediatric intensive care unit ; anticoagulation methods ; systemic anticoagulation ; regional anticoagulation ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lung Ultrasound B-Lines in the Evaluation of the Extent of Interstitial Lung Disease in Systemic Sclerosis

Cosimo Bruni / Lavinia Mattolini / Lorenzo Tofani / Luna Gargani / Nicholas Landini / Nicola Roma / Gemma Lepri / Martina Orlandi / Serena Guiducci / Silvia Bellando-Randone / Chiara Romei / Yukai Wang / Marco Matucci-Cerinic

Diagnostics, Vol 12, Iss 7, p

2022 Volume 1696

Abstract: Background: Chest computed tomography (CT) is the gold standard for the evaluation of systemic sclerosis-related interstitial lung disease (SSc-ILD). Lung ultrasound (LUS) is a radiation-free tool that identifies the B-lines as a main feature of ILD. We ... ...

Abstract	Background: Chest computed tomography (CT) is the gold standard for the evaluation of systemic sclerosis-related interstitial lung disease (SSc-ILD). Lung ultrasound (LUS) is a radiation-free tool that identifies the B-lines as a main feature of ILD. We aimed to investigate the role of LUS in the evaluation of the extent of SSc-ILD. Methods: Adult SSc patients underwent pulmonary function tests (PFTs), LUS and CT. The CT images were qualitatively, semi-quantitatively (the Wells score on five levels and the categorical Goh et al. staging) and quantitatively (histogram-based densitometry) analysed for ILD. LUS quantified B-lines in 21 intercostal spaces on both the anterior and posterior chest wall. Results: Out of the 77 SSc patients eligible for the study, 35 presented with ILD on CT (21 limited, 14 extensive). Total B-lines significantly differentiated ILD vs. no ILD (median 24 vs. 8, p < 0.001). Posterior and total B-lines significantly differentiated limited from absent ILD, while anterior B-lines distinguished extensive from limited ILD. Total B-lines correlated with the Wells score (r = 0.446, p < 0.001) and MLA (r = −0.571, p < 0.001); similar results were confirmed when anterior and posterior B-lines were analysed separately. Conclusions: LUS is a useful tool to identify SSc-ILD and to correlate with different evaluations of ILD extent and severity.
Keywords	systemic sclerosis ; interstitial lung disease ; computed tomography ; ultrasound ; radiomics ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Use of Guselkumab for the Treatment of Moderate-to-Severe Plaque Psoriasis

Marco Galluzzo / Lorenzo Tofani / Paolo Lombardo / Alessandra Petruzzellis / Dionisio Silvaggio / Colin Gerard Egan / Luca Bianchi / Marina Talamonti

Journal of Clinical Medicine, Vol 9, Iss 2170, p

A 1 Year Real-Life Study

2020 Volume 2170

Abstract: Little information is available from real-life studies evaluating the efficacy of guselkumab in moderate-to-severe psoriasis. In this real-life study, we retrospectively examined a database of 52 patients with moderate-to-severe psoriasis treated with ... ...

Abstract	Little information is available from real-life studies evaluating the efficacy of guselkumab in moderate-to-severe psoriasis. In this real-life study, we retrospectively examined a database of 52 patients with moderate-to-severe psoriasis treated with guselkumab (100 mg, s.c.) and followed for 1 year. Disease severity and treatment response was assessed by the Psoriasis Area and Severity Index (PASI) at baseline and after 4, 12, 20, 28, 36, 44, and 52 weeks. Predictors of a PASI response were evaluated by univariate and multivariate regression. After 12 months, 84.2% of patients (mean age 51.3 ± 14.1 years) treated with guselkumab achieved a PASI score of <3. Furthermore, PASI score decreased from 20 ± 13.3 at baseline to 4.4 ± 4.7 and 2.7 ± 3.9 at 12 and 20 weeks, and PASI 75, 90, and 100 response was achieved in 84.2%, 78.9%, and 63.2% of patients respectively at 12 months. Stepwise multivariate regression analysis revealed that previous biological treatment and the presence of comorbidities were associated with poorer response between 28–44 weeks, however the presence of obesity per se was not associated with poorer response. Difficult-to-treat areas were also improved as early as 12 weeks following guselkumab. Guselkumab was observed to be effective and safe in patients with moderate-severe chronic psoriasis in a real world-setting.
Keywords	Psoriasis ; biological drugs ; guselkumab ; Psoriasis Area and Severity Index (PASI) ; real-life ; Medicine ; R
Subject code	616
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Cross-Sectional Study on 3-(2-Deoxy-β-D-Erythro-Pentafuranosyl)Pyrimido[1,2-α]Purin-10(3H)-One Deoxyguanosine Adducts among Woodworkers in Tuscany, Italy

Filippo Cellai / Fabio Capacci / Carla Sgarrella / Carla Poli / Luciano Arena / Lorenzo Tofani / Roger W. Giese / Marco Peluso

International Journal of Molecular Sciences, Vol 20, Iss 11, p

2019 Volume 2763

Abstract: Occupational exposure to wood dust has been estimated to affect 3.6 million workers within the European Union (EU). The most serious health effect caused by wood dust is the nasal and sinonasal cancer (SNC), which has been observed predominantly among ... ...

Abstract	Occupational exposure to wood dust has been estimated to affect 3.6 million workers within the European Union (EU). The most serious health effect caused by wood dust is the nasal and sinonasal cancer (SNC), which has been observed predominantly among woodworkers. Free radicals produced by inflammatory reactions as a consequence of wood dust could play a major role in SNC development. Therefore, we investigated the association between wood dust and oxidative DNA damage in the cells of nasal epithelia, the target site of SNC. We have analyzed oxidative DNA damage by determining the levels of 3-(2-deoxy-β-D-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M 1 dG), a major-peroxidation-derived DNA adduct and a biomarker of cancer risk in 136 woodworkers compared to 87 controls in Tuscany, Italy. We then examined the association of M 1 dG with co-exposure to volatile organic compounds (VOCs), exposure length, and urinary 15-F 2t isoprostane (15-F 2t -IsoP), a biomarker of oxidant status. Wood dust at the workplace was estimated by the Information System for Recording Occupational Exposures to Carcinogens. M 1 dG was measured using 32 P-postlabeling and mass spectrometry. 15-F 2t -IsoP was analyzed using ELISA. Results show a significant excess of M 1 dG in the woodworkers exposed to average levels of 1.48 mg/m 3 relative to the controls. The overall mean ratio (MR) between the woodworkers and the controls was 1.28 (95% C.I. 1.03−1.58). After stratification for smoking habits and occupational status (exposure to wood dust alone and co-exposure to VOCs), the association of M 1 dG with wood dust (alone) was even greater in non-smokers workers, MR of 1.43 (95% C.I. 1.09−1.87). Conversely, not consistent results were found in ex-smokers and current smokers. M 1 dG was significantly associated with co-exposure to VOCs, MR of 1.95 (95% C.I. 1.46−2.61), and occupational history, MR of 2.47 (95% C.I. 1.67−3.62). Next, the frequency of M 1 dG was significantly correlated to the urinary excretion of 15-F 2t -IsoP, regression coefficient (β) = 0.442 ± 0.172 (SE). Consistent with the hypothesis of a genotoxic mechanism, we observed an enhanced frequency of M 1 dG adducts in woodworkers, even at the external levels below the regulatory limit. Our data implement the understanding of SNC and could be useful for the management of the adverse effects caused by this carcinogen.
Keywords	wood dust ; nasal epithelia ; VOCs ; M 1 dG ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	333
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Dysmetabolisms and Comorbidities on the Efficacy and Safety of Biological Therapy in Chronic Inflammatory Joint Diseases

Laura Cometi / Cosimo Bruni / Nicolò Chiti / Lorenzo Tofani / Francesca Nacci / Francesca Bartoli / Silvia Bellando-Randone / Daniela Melchiorre / Ginevra Fiori / Serena Guiducci / Marco Matucci-Cerinic

Journal of Clinical Medicine, Vol 9, Iss 1310, p

2020 Volume 1310

Abstract: In the present study we evaluated how systemic arterial hypertension (SAH), dyslipidemia and diabetes mellitus influence the efficacy, safety and retention rate of biological disease-modifying anti-rheumatic drug (bDMARD) treatment in rheumatic ... ...

Abstract	In the present study we evaluated how systemic arterial hypertension (SAH), dyslipidemia and diabetes mellitus influence the efficacy, safety and retention rate of biological disease-modifying anti-rheumatic drug (bDMARD) treatment in rheumatic musculoskeletal disorders (RMDs). The charts of RMD patients treated with the first-line bDMARD were reviewed, collecting data on safety, efficacy and comorbidities at prescription (baseline, BL), after 6 months (6M) and at last observation on bDMARD (last observation time, LoT). In 383 RMD patients, a higher rate of adverse events at 6M ( p = 0.0402) and at LoT ( p = 0.0462) was present in dyslipidemic patients. Patients who developed dyslipidemia or SAH during bDMARD treatment had similar results (dyslipidemia p = 0.0007; SAH p = 0.0319) with a longer bDMARD retention as well (dyslipidemia p < 0.0001; SAH p < 0.0001). SAH patients on angiotensin converting enzyme inhibitors (ACEis) or angiotensin-II receptor blockers (ARBs) continued bDMARDs for longer than non-exposed patients ( p = 0.001), with higher frequency of drug interruption for long-standing remission rather than inefficacy or adverse reactions ( p = 0.0258). Similarly, dyslipidemic patients on statins had a better bDMARD retention than not-exposed patients ( p = 0.0420). In conclusion, SAH and dyslipidemia may be associated with higher frequency of adverse events but a better drug retention of first-line bDMARD in RMDs, suggesting an additional effect of ACEis/ARBs or statins on the inflammatory process and supporting their use in RMD bDMARD patients with SAH/dyslipidemia.
Keywords	arterial hypertension ; dyslipidemia ; bDMARDs ; rheumatoid arthritis ; psoriatic arthritis ; ankylosing spondylitis ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Oral Lactobacillus Species in Systemic Sclerosis

Daniela Melchiorre / Maria Teresa Ceccherini / Eloisa Romano / Laura Cometi / Khadija El-Aoufy / Silvia Bellando-Randone / Angela Roccotelli / Cosimo Bruni / Alberto Moggi-Pignone / Davide Carboni / Serena Guiducci / Gemma Lepri / Lorenzo Tofani / Giacomo Pietramellara / Marco Matucci-Cerinic

Microorganisms, Vol 9, Iss 1298, p

2021 Volume 1298

Abstract: In systemic sclerosis (SSc), the gastrointestinal tract (GIT) plays a central role in the patient’s quality of life. The microbiome populates the GIT, where a relationship between the Lactobacillus and gastrointestinal motility has been suggested. In ... ...

Abstract	In systemic sclerosis (SSc), the gastrointestinal tract (GIT) plays a central role in the patient’s quality of life. The microbiome populates the GIT, where a relationship between the Lactobacillus and gastrointestinal motility has been suggested. In this study, the analysis of oral Lactobacillus species in SSc patients and healthy subjects using culture-independent molecular techniques, together with a review of the literature on microbiota and lactobacilli in SSc, has been carried out. Twenty-nine SSc female patients (mean age 62) and twenty-three female healthy subjects (HS, mean age 57.6) were enrolled and underwent tongue and gum swab sampling. Quantitative PCR was conducted in triplicate using Lactobacillus specific primers rpoB 1, rpoB 1o and rpoB 2 for the RNA-polymerase β subunit gene. Our data show significantly ( p = 0.0211) lower Lactobacillus spp rpoB sequences on the tongue of patients with SSc compared to HS. The mean value of the amount of Lactobacillus ssprpoB gene on the gumsofSSc patients was minor compared to HS. A significant difference between tongue and gums ( p = 0.0421) was found in HS but not in SSc patients. In conclusion, our results show a lower presence of Lactobacillus in the oral cavity of SSc patients. This strengthens the hypothesis that Lactobacillus may have both a protective and therapeutic role in SSc patients.
Keywords	oral microbiome ; Lactobacillus spprpoB gene ; SSc ; qPCR ; quality of life ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
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Article ; Online: Structure and conformational dynamics of an aromatic sulfonamide

Stefano Menichetti / Chiara Biagioli / Caterina Viglianisi / Lorenzo Tofani / Lodovico Lunazzi / Michele Mancinelli / Andrea Mazzanti

ARKIVOC, Vol 2015, Iss 4, Pp 66-

NMR, X-Ray and computational studies

2015 Volume 79

Keywords	Organic chemistry ; QD241-441
Language	English
Publishing date	2015-02-01T00:00:00Z
Publisher	Arkat USA, Inc.
Document type	Article ; Online
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Article ; Online: Serum Organ-Specific Anti-Heart and Anti-Intercalated Disk Autoantibodies as New Autoimmune Markers of Cardiac Involvement in Systemic Sclerosis

Diagnostics, Vol 11, Iss 2165, p

Frequency, Clinical and Prognostic Correlates

2021 Volume 2165

Abstract: Background: Heart involvement (HInv) in systemic sclerosis (SSc) may relate to myocarditis and is associated with poor prognosis. Serum anti-heart (AHA) and anti-intercalated disk autoantibodies (AIDA) are organ and disease-specific markers of isolated ... ...

Abstract	Background: Heart involvement (HInv) in systemic sclerosis (SSc) may relate to myocarditis and is associated with poor prognosis. Serum anti-heart (AHA) and anti-intercalated disk autoantibodies (AIDA) are organ and disease-specific markers of isolated autoimmune myocarditis. We assessed frequencies, clinical correlates, and prognostic impacts of AHA and AIDA in SSc. Methods: The study included consecutive SSc patients ( n = 116, aged 53 ± 13 years, 83.6% females, median disease duration 7 years) with clinically suspected heart involvement (symptoms, abnormal ECG, abnormal troponin I or natriuretic peptides, and abnormal echocardiography). All SSc patients underwent CMR. Serum AHA and AIDA were measured by indirect immunofluorescence in SSc and in control groups of non-inflammatory cardiac disease (NICD) ( n = 160), ischemic heart failure (IHF) ( n = 141), and normal blood donors (NBD) ( n = 270). AHA and AIDA status in SSc was correlated with baseline clinical, diagnostic features, and outcome. Results: The frequency of AHA was higher in SSc (57/116, 49%, p < 0.00001) than in NICD (2/160, 1%), IHF (2/141, 1%), or NBD (7/270, 2.5%). The frequency of AIDA was higher (65/116, 56%, p < 0.00001) in SSc than in NICD (6/160, 3.75%), IHF (3/141, 2%), or NBD (1/270, 0.37%). AHAs were associated with interstitial lung disease ( p = 0.04), history of chest pain ( p = 0.026), abnormal troponin ( p = 0.006), AIDA ( p = 0.000), and current immunosuppression ( p = 0.01). AHAs were associated with death ( p = 0.02) and overall cardiac events during follow-up ( p = 0.017). Conclusions: The high frequencies of AHA and AIDA suggest a high burden of underdiagnosed autoimmune HInv in SSc. In keeping with the negative prognostic impact of HInv in SSc, AHAs were associated with dismal prognosis.
Keywords	myocarditis ; autoimmunity ; autoantibodies ; systemic sclerosis ; prognosis ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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