Article ; Online: How microcompetition with latent viruses can cause α synuclein aggregation, mitochondrial dysfunction, and eventually Parkinson's disease.
2021 Volume 27, Issue 1, Page(s) 52–57
Abstract: The cause of most Parkinson's disease cases is unknown. However, it is well documented that mitochondrial dysfunction and misfolded α synuclein aggregation are important cellular abnormalities associated with the disease. In this paper, we use the ... ...
Abstract | The cause of most Parkinson's disease cases is unknown. However, it is well documented that mitochondrial dysfunction and misfolded α synuclein aggregation are important cellular abnormalities associated with the disease. In this paper, we use the microcompetition model to show how latent viruses, which infect the central and peripheral nervous systems, can cause the observed mitochondrial dysfunction and excess α synuclein aggregation, and eventually, Parkinson's disease. |
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MeSH term(s) | Animals ; Humans ; Latent Infection/metabolism ; Mitochondria/pathology ; Parkinson Disease/pathology ; Protein Aggregation, Pathological/metabolism ; Protein Aggregation, Pathological/pathology ; Virus Latency/physiology ; Viruses/metabolism ; alpha-Synuclein/metabolism |
Chemical Substances | alpha-Synuclein |
Language | English |
Publishing date | 2021-01-06 |
Publishing country | United States |
Document type | Journal Article ; Review |
ZDB-ID | 1283265-0 |
ISSN | 1538-2443 ; 1355-0284 |
ISSN (online) | 1538-2443 |
ISSN | 1355-0284 |
DOI | 10.1007/s13365-020-00929-x |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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