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Article ; Online: Anisocoria and optic neuritis associated with Mycoplasma pneumoniae infection.

Gayoso-Cantero, Diego / Sarró-Fuentes, Claudia / Barón-Rubio, Manuel / Losa-García, Juan Emilio

Enfermedades infecciosas y microbiologia clinica (English ed.)

2023 Volume 41, Issue 5, Page(s) 312–314

MeSH term(s)	Humans ; Pneumonia, Mycoplasma/complications ; Anisocoria/complications ; Optic Neuritis/etiology ; Optic Neuritis/complications
Language	English
Publishing date	2023-01-14
Publishing country	Spain
Document type	Case Reports ; Journal Article
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2023.01.001
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Article ; Online: Intestinal spirochetosis in a Spanish hospital.

Chichón Sánchez, Marta / López Brasal, Laura / Losa García, Juan Emilio

Medicina clinica

2020 Volume 156, Issue 10, Page(s) 521–522

Title translation	Espiroquetosis intestinal en un hospital terciario de Madrid.
MeSH term(s)	Colon ; Hospitals ; Humans ; Intestinal Mucosa ; Spirochaetales Infections/diagnosis ; Spirochaetales Infections/epidemiology
Language	Spanish
Publishing date	2020-07-02
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2020.04.047
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Article ; Online: Integration of beta-lactam allergy evaluation in a Spanish antibiotic stewardship programme.

Moreno-Nuñez, Leonor / Rosado-Ingelmo, Ana / González-Moreno, Ana / Martín-Segarra, Oriol / Hervás-Gómez, Rafael / Sanz-Márquez, Sira / Pérez-Fernández, Elia / Losa-García, Juan-Emilio / Tejedor-Alonso, Miguel-Angel

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

2023 Volume 53, Issue 12, Page(s) 1314–1317

MeSH term(s)	Humans ; beta-Lactams/adverse effects ; Antimicrobial Stewardship ; Hypersensitivity ; Anti-Bacterial Agents/adverse effects ; Drug Hypersensitivity/diagnosis ; Penicillins
Chemical Substances	beta-Lactams ; Anti-Bacterial Agents ; Penicillins
Language	English
Publishing date	2023-09-05
Publishing country	England
Document type	Journal Article
ZDB-ID	645204-8
ISSN	1365-2222 ; 0954-7894 ; 0960-2178
ISSN (online)	1365-2222
ISSN	0954-7894 ; 0960-2178
DOI	10.1111/cea.14388
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Article ; Online: Impact of Penicillin Allergy Label on Length of Stay and Mortality in Hospitalized Patients through a Clinical Administrative National Dataset.

Pérez-Encinas, Montserrat / Lorenzo-Martínez, Susana / Losa-García, Juan Emilio / Walter, Stefan / Tejedor-Alonso, Miguel Angel

International archives of allergy and immunology

2021 Volume 183, Issue 5, Page(s) 498–506

Abstract: Background: Penicillin allergy is a common problem in the management of infectious diseases. The aim of this study was to determine the impact of penicillin allergy on length of hospital stay (LOHS) among hospitalized adult patients and on in-hospital ... ...

Abstract	Background: Penicillin allergy is a common problem in the management of infectious diseases. The aim of this study was to determine the impact of penicillin allergy on length of hospital stay (LOHS) among hospitalized adult patients and on in-hospital mortality at a national level. Methods: A retrospective cohort study of adult patients discharged from the Spanish Hospital System between 2006 and 2015 was conducted using the Minimum Basic Data Set (MBDS). We compared LOHS and in-hospital mortality of adult patients whose records contained penicillin allergy code V14.0 (International Classification of Diseases, Ninth Revision, Clinical Modification) as a secondary diagnosis, with a random sample without such a code. Results: We identified 981,291 admissions with code V14.0, which corresponded to 2.63% of all hospitalizations. Adults patients with a penicillin allergy label were significantly older than patients without such a label, with a median of 70 years (interquartile range [IQR]: 51-80) versus 63 years (IQR: 40-77). The proportion of women and the prevalence of infectious diseases were higher in the group with a penicillin allergy label (61.40% vs. 53.84%; 34.04% vs. 30.01%; respectively). We found a higher median Elixhauser-Van Walraven score in hospitalized patients with an allergy label. The median LOHS for hospitalizations with a penicillin allergy label (5 [IQR: 2-9]) was significantly longer than that in those without such a label (4 [IQR: 2-9]). Multivariate analysis showed an increase in LOHS due to the penicillin allergy label (odds ratio [OR] [95% confidence interval [CI]: 1.061 [1.057-1.065]) and a decrease in mortality in penicillin allergy records (OR [95% CI]: 0.834 [0.825-0.844]). Conclusion: In our study, the prevalence of a penicillin allergy label in hospitalized patients, using the MBDS, is low. Hospitalizations with an allergy label was associated with a longer LOHS. However, penicillin-allergic patients did not show higher mortality rates. Inaccurate reporting of penicillin allergies may have an impact on healthcare resources.
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Delivery of Health Care ; Drug Hypersensitivity/drug therapy ; Female ; Humans ; Length of Stay ; Penicillins/adverse effects ; Retrospective Studies
Chemical Substances	Anti-Bacterial Agents ; Penicillins
Language	English
Publishing date	2021-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1108932-5
ISSN	1423-0097 ; 1018-2438
ISSN (online)	1423-0097
ISSN	1018-2438
DOI	10.1159/000520644
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Article ; Online: Asymptomatic portal vein thrombosis associated to acute cytomegalovirus infection in an immunocompetent patient.

Mendoza Lizardo, Sandra Scarleth / Losa García, Juan Emilio / Moreno Nuñez, Leonor

Medicina clinica

2017 Volume 150, Issue 2, Page(s) 82–83

Title translation	Trombosis portal asintomática asociada a infección aguda por citomegalovirus en paciente inmunocompetente.
MeSH term(s)	Acute Disease ; Adult ; Asymptomatic Diseases ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/immunology ; Female ; Humans ; Immunocompetence ; Portal Vein ; Venous Thrombosis/diagnosis ; Venous Thrombosis/immunology ; Venous Thrombosis/virology
Language	Spanish
Publishing date	2017-09-14
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2017.07.013
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Article ; Online: Antibiotic discontinuation through an antibiotic treatment optimization program in emergency department patients with low suspicion of infection.

Martínez-de la Cruz, Paula / Moreno-Núñez, Leonor / Álvarez-Atienza, Sara / Sanz-Márquez, Sira / Valverde-Canovas, José Francisco / Losa-García, Juan Emilio

Enfermedades infecciosas y microbiologia clinica (English ed.)

2022 Volume 41, Issue 7, Page(s) 423–425

Abstract: Introduction: One of the most important strategies of PROA in the Emergency Department (ED) is the accurate diagnosis of infection to avoid inappropriate prescription. Our objective is to evaluate patients who receive antibiotics despite not having ... ...

Abstract	Introduction: One of the most important strategies of PROA in the Emergency Department (ED) is the accurate diagnosis of infection to avoid inappropriate prescription. Our objective is to evaluate patients who receive antibiotics despite not having objective data of infection. Methods: We carried out a cross-sectional study of patients admitted to the ED of the Hospital Universitario Fundación Alcorcón in which it was recommended to suspend the antibiotic through the PROA. Clinical and epidemiological characteristics and 30-day follow-up were analyzed to assess readmissions and mortality. Results: 145 patients were analyzed. It was recommended to suspend the antibiotic in 25. 44% of them had a diagnosis of urinary infection. The suspension recommendation was accepted by 88%. No patient died and one was readmitted. Conclusions: An important percentage of patients are prescribed antibiotics despite not having infection criteria, the clinical evolution after suspension of antibiotics was favorable.
Language	English
Publishing date	2022-11-06
Publishing country	Spain
Document type	Journal Article
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2022.10.004
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Article ; Online: Sexually transmitted infections in a cohort of HIV-positive patients.

Nuno-Gonzalez, Almudena / López Estebaranz, José Luis / Losa Garcia, Juan Emilio

Medicina clinica

2016 Volume 148, Issue 7, Page(s) 329–330

Title translation	Infecciones de transmisión sexual en una cohorte de pacientes VIH positivos.
MeSH term(s)	Female ; HIV Infections/complications ; HIV Infections/epidemiology ; HIV Infections/transmission ; Humans ; Male ; Retrospective Studies ; Spain/epidemiology
Language	Spanish
Publishing date	2016-12-28
Publishing country	Spain
Document type	Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2016.11.014
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Article ; Online: Experience in the use of dalbavancin in diabetic foot infection.

Navarro-Jiménez, Gema / Fuentes-Santos, Cristina / Moreno-Núñez, Leonor / Alfayate-García, Jesús / Campelo-Gutierrez, Carolina / Sanz-Márquez, Sira / Pérez-Fernández, Elia / Velasco-Arribas, María / Hervás-Gómez, Rafael / Martín-Segarra, Oriol / Losa-García, Juan Emilio

Enfermedades infecciosas y microbiologia clinica (English ed.)

2022 Volume 40, Issue 6, Page(s) 296–301

Abstract: Objective: To describe the clinical experience with dalbavancin in the treatment of diabetic foot infection in a multidisciplinary unit of a second level hospital.: Methods: A retrospective, descriptive study was made with all patients with diabetic ... ...

Abstract	Objective: To describe the clinical experience with dalbavancin in the treatment of diabetic foot infection in a multidisciplinary unit of a second level hospital. Methods: A retrospective, descriptive study was made with all patients with diabetic foot infection treated with dalbavancin in the Diabetic Foot Unit of Hospital Universitario Fundación Alcorcón, covering the period from September 2016 to December 2019. Demographic parameters and comorbidities, characteristics of the infection and treatment with dalbavancin were recorded. The cure rate is estimated at 90 days after finishing the treatment. Results: A total of 23 patients with diabetic foot infection (osteomyelitis) started treatment with dalbavancin, 19 were men and the mean age was 65 years. The microorganisms most frequently isolated for the indication of treatment with dalbavancin were Staphylococcus aureus (11) and Corynebacterium striatum (7). Dalbavancin was used as a second choice therapy in 22 cases, in 11 due to toxicity from other antibiotics. The median duration of treatment was 5 (4-7) weeks; the most frequent dose of dalbavancin (8 patients) was 1000 mg followed by 500 mg weekly for 5 weeks. 3 patients presented mild side effects (nausea and gastrointestinal discomfort). At 90 days after completion of dalbavancin therapy, 87% (20) of the patients were cured (95% CI: 65.2%-94.52%). Conclusion: Patients with osteomyelitis due to gram-positive microorganisms who received as part of the multidisciplinary antibiotic treatment with dalbavancin, had a high rate of cure with adequate tolerance and few side effects. Dalbavancin offers a safe alternative in treating deep diabetic foot infection.
MeSH term(s)	Aged ; Anti-Bacterial Agents ; Communicable Diseases ; Diabetes Mellitus/chemically induced ; Diabetes Mellitus/drug therapy ; Diabetic Foot/chemically induced ; Diabetic Foot/complications ; Diabetic Foot/drug therapy ; Female ; Humans ; Male ; Osteomyelitis/drug therapy ; Osteomyelitis/microbiology ; Retrospective Studies ; Teicoplanin/analogs & derivatives
Chemical Substances	Anti-Bacterial Agents ; Teicoplanin (61036-62-2) ; dalbavancin (808UI9MS5K)
Language	English
Publishing date	2022-04-27
Publishing country	Spain
Document type	Journal Article
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2022.03.001
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Article ; Online: Human papilloma virus dermatosis in human immunodeficiency virus-positive patients: A 14-year retrospective study in 965 patients.

Nuno-Gonzalez, Almudena / Losa Garcia, Juan Emilio / López Estebaranz, José Luis / Martin-Rios, María Dolores

Medicina clinica

2017 Volume 148, Issue 9, Page(s) 401–404

Abstract: Introduction: The incidence of the human papilloma virus (HPV) has not dropped in HIV-positive patients despite the discovery of antiretroviral therapy (ART). Our goal is to assess the prevalence of HPV in HIV patients and its relationship with the ... ...

Title translation	Dermatosis por virus de papiloma humano (VPH) en pacientes infectados por el virus de la inmunodeficiencia humana (VIH): estudio retrospectivo de 965 pacientes durante 14 años.
Abstract	Introduction: The incidence of the human papilloma virus (HPV) has not dropped in HIV-positive patients despite the discovery of antiretroviral therapy (ART). Our goal is to assess the prevalence of HPV in HIV patients and its relationship with the epidemiological and virological characteristics of HIV patients. Patients and methods: Retrospective cohort of 965 patients diagnosed with HIV from 1998 to 2012. We analyzed patients' demographic factors and factors related to the HPV. Results: Of the 965 patients examined, 333 consulted a dermatologist. Of these, 52 patients had genital warts (15.6%), 43 had common warts (12.9%) and 8% had both conditions. In total, 28.5% of patients had a skin lesion caused by HPV. Discussion and conclusion: This is the first longitudinal observational study carried out on HIV-positive patients in the era of ART in which HPV infection is the most common skin pathology. We observed a similar trend in countries with access to ART. This study spreads awareness on the importance of preventing HPV and the difficulty of treating it in HIV-positive patients.
Language	Spanish
Publishing date	2017-05-10
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2016.12.034
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Article ; Online: Experience in the use of dalbavancin in diabetic foot infection.

Enfermedades infecciosas y microbiologia clinica (English ed.)

2021

Title translation	Experiencia con el uso de dalbavancina en la infección profunda de pie diabético.
Abstract	Objective: To describe the clinical experience with dalbavancin in the treatment of diabetic foot infection in a multidisciplinary unit of a second level hospital. Methods: A retrospective, descriptive study was made with all patients with diabetic foot infection treated with dalbavancin in the Diabetic Foot Unit of Hospital Universitario Fundación Alcorcón, covering the period from September 2016 to December 2019. Demographic parameters and comorbidities, characteristics of the infection and treatment with dalbavancin were recorded. The cure rate was estimated at 90 days after finishing the treatment. Results: A total of 23 patients with diabetic foot infection (osteomyelitis) started treatment with dalbavancin, 19 were men and the mean age was 65 years. The microorganisms most frequently isolated for the indication of treatment with dalbavancin were Staphylococcus aureus (11) and Corynebacterium striatum (7). Dalbavancin was used as a second choice therapy in 22 cases, in 11 due to toxicity from other antibiotics. The median duration of treatment was 5 (4-7) weeks; the most frequent dose of dalbavancin (8 patients) was 1000mg followed by 500mg weekly for 5 weeks. 3 patients presented mild side effects (nausea and gastrointestinal discomfort). At 90 days after completion of dalbavancin therapy, 87% (20) of the patients were cured (95% CI: 65.2%-94.52%). Conclusion: Patients with osteomyelitis due to gram-positive microorganisms who received as part of the multidisciplinary antibiotic treatment with dalbavancin, had a high rate of cure with adequate tolerance and few side effects. Dalbavancin offers a safe alternative in treating deep diabetic foot infection.
Language	Spanish
Publishing date	2021-01-12
Publishing country	Spain
Document type	Journal Article
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimc.2020.11.013
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