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  1. Book ; Thesis: Entwicklung nicht-invasiver, topographisch hochauflösender MEG-, EEG-Messverfahren im thalamokortikalen somatosensiblen System des Menschen

    Losch, Florian

    2001  

    Author's details vorgelegt von: Florian Losch
    Language German
    Size VI, 74 Bl., Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 2001
    HBZ-ID HT013547531
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 D 211 order for loan Magazin

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  2. Article ; Online: Evaluation of floral volatile patterns in the genus Narcissus using gas chromatography–coupled ion mobility spectrometry

    Losch, Florian / Liedtke, Sascha / Vautz, Wolfgang / Weigend, Maximilian

    Applications in Plant Sciences. 2023 Jan., v. 11, no. 1 p.e11506-

    2023  

    Abstract: PREMISE: Daffodils (Narcissus, Amaryllidaceae) are iconic ornamentals with a complex floral biology and many fragrant species; however, little is known about floral plant volatile organic compounds (pVOCs) across the genus and additional sampling is ... ...

    Abstract PREMISE: Daffodils (Narcissus, Amaryllidaceae) are iconic ornamentals with a complex floral biology and many fragrant species; however, little is known about floral plant volatile organic compounds (pVOCs) across the genus and additional sampling is desirable. The present study investigates whether the floral scent of 20 species of Narcissus can be characterized using gas chromatography–coupled ion mobility spectrometry (GC–IMS), with the aim of building a comparative pVOC data set for ecological and evolutionary studies. METHODS: We used a commercial GC–IMS equipped with an integrated in‐line enrichment system for a fast, sensitive, and automated pVOC analysis. This facilitates qualitative and (semi)‐quantitative measurements without sample preparation. RESULTS: The GC–IMS provided detailed data on floral pVOCs in Narcissus with very short sampling times and without floral enclosure. A wide range of compounds was recorded and partially identified. The retrieved pVOC patterns showed a good agreement with published data, and five “chemotypes” were characterized as characteristic combinations of floral volatiles. DISCUSSION: The GC–IMS setup can be applied to rapidly generate large amounts of pVOC data with high sensitivity and selectivity. The preliminary data on Narcissus obtained here indicate both considerable pVOC variability and a good correspondence of the pVOC patterns with infrageneric classification, supporting the hypothesis that floral scent could represent a considerable phylogenetic signal.
    Keywords Narcissus ; data collection ; odors ; ornamental plants ; phylogeny ; spectroscopy ; volatile organic compounds
    Language English
    Dates of publication 2023-01
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 2699923-7
    ISSN 2168-0450
    ISSN 2168-0450
    DOI 10.1002/aps3.11506
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Evaluation of floral volatile patterns in the genus

    Losch, Florian / Liedtke, Sascha / Vautz, Wolfgang / Weigend, Maximilian

    Applications in plant sciences

    2023  Volume 11, Issue 1, Page(s) e11506

    Abstract: Premise: Daffodils (: Methods: We used a commercial GC-IMS equipped with an integrated in-line enrichment system for a fast, sensitive, and automated pVOC analysis. This facilitates qualitative and (semi)-quantitative measurements without sample ... ...

    Abstract Premise: Daffodils (
    Methods: We used a commercial GC-IMS equipped with an integrated in-line enrichment system for a fast, sensitive, and automated pVOC analysis. This facilitates qualitative and (semi)-quantitative measurements without sample preparation.
    Results: The GC-IMS provided detailed data on floral pVOCs in
    Discussion: The GC-IMS setup can be applied to rapidly generate large amounts of pVOC data with high sensitivity and selectivity. The preliminary data on
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2699923-7
    ISSN 2168-0450
    ISSN 2168-0450
    DOI 10.1002/aps3.11506
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  4. Article: Reversing the Inflammatory Process-25 Years of Tumor Necrosis Factor-α Inhibitors.

    Muth, Katharina N / Rech, Juergen / Losch, Florian O / Hoerning, André

    Journal of clinical medicine

    2023  Volume 12, Issue 15

    Abstract: Immune-mediated inflammatory diseases, such as rheumatoid arthritis, psoriatic arthritis, peripheral and/or axial spondyloarthritis, Crohn's disease, and ulcerative colitis, are characterized by molecular and cellular changes in the immune system. Due to ...

    Abstract Immune-mediated inflammatory diseases, such as rheumatoid arthritis, psoriatic arthritis, peripheral and/or axial spondyloarthritis, Crohn's disease, and ulcerative colitis, are characterized by molecular and cellular changes in the immune system. Due to the systemic nature of these diseases, organs such as the liver or cardiovascular system are often affected by the inflammatory process. Tumor necrosis factor-α inhibitor therapy reduces the activation of pro-inflammatory signaling cascades, mitigates the chronic inflammatory process by restoring cellular balance, and alleviates clinical consequences, such as pain and tissue damage.
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12155039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reagent-Based Scaffold Diversity for DNA-Encoded Library Design: Solid Phase Synthesis of DNA-Tagged sp

    Škopić, Mateja Klika / Losch, Florian / McMillan, Angus E / Willeke, Niklas / Malenica, Mateo / Bering, Luis / Bode, Jeffrey / Brunschweiger, Andreas

    Organic letters

    2022  Volume 24, Issue 6, Page(s) 1383–1387

    Abstract: Reactions that require strictly dry conditions are challenging to translate to a DNA-encoded library format. Controlled pore glass solid support-connected DNA oligonucleotide-aldehyde conjugates could be condensed with SnAP reagents and cyclized to ... ...

    Abstract Reactions that require strictly dry conditions are challenging to translate to a DNA-encoded library format. Controlled pore glass solid support-connected DNA oligonucleotide-aldehyde conjugates could be condensed with SnAP reagents and cyclized to various sp
    MeSH term(s) DNA/chemical synthesis ; DNA/chemistry ; Gene Library ; Heterocyclic Compounds/chemistry ; Molecular Structure ; Solid-Phase Synthesis Techniques
    Chemical Substances Heterocyclic Compounds ; DNA (9007-49-2)
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c00228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Successful treatment of adult Dravet syndrome patients with cenobamate.

    Makridis, Konstantin L / Friedo, Anna-Lena / Kellinghaus, Christoph / Losch, Florian-Phillip / Schmitz, Bettina / Boßelmann, Christian / Kaindl, Angela M

    Epilepsia

    2022  Volume 63, Issue 12, Page(s) e164–e171

    Abstract: Dravet syndrome (DS) is a rare, drug-resistant, severe developmental and epileptic encephalopathy caused by pathogenic variants in the α subunit of the voltage-gated sodium channel gene SCN1A. Hyperexcitability in DS results from loss of function in ... ...

    Abstract Dravet syndrome (DS) is a rare, drug-resistant, severe developmental and epileptic encephalopathy caused by pathogenic variants in the α subunit of the voltage-gated sodium channel gene SCN1A. Hyperexcitability in DS results from loss of function in inhibitory interneurons. Thus sodium channel blockers are usually contraindicated in patients with DS as they may lead to disease aggravation. Cenobamate (CNB) is a novel antiseizure medication (ASM) with promising rates of seizure freedom in patients with focal-onset, drug-resistant epilepsy. CNB blocks persistent sodium currents by promoting the inactive states of sodium channels. In a multi-center study, we analyzed retrospectively the effect of an add-on therapy of CNB in adult patients with DS. We report four adult patients with DS in whom the use of CNB resulted in a significant seizure reduction of more than 80%, with a follow-up of up to 542 days. CNB was the first drug in these patients that resulted in a long-lasting and significant seizure reduction. No severe adverse events occurred. We highlight CNB as an ASM that may lead to a clinically meaningful reduction of seizure frequency in adult patients with DS. It is unclear, however, if all patients with DS benefit, requiring further investigation and functional experiments.
    MeSH term(s) Humans ; Adult ; Retrospective Studies ; Epilepsies, Myoclonic/drug therapy ; Epilepsies, Myoclonic/genetics
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 475: Show issues

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  7. Article: Reagent-Based Scaffold Diversity for DNA-Encoded Library Design: Solid Phase Synthesis of DNA-Tagged sp³-Rich Heterocycles by SnAP Chemistry

    Škopić, Mateja Klika / Losch, Florian / McMillan, Angus E. / Willeke, Niklas / Malenica, Mateo / Bering, Luis / Bode, Jeffrey / Brunschweiger, Andreas

    Organic letters. 2022 Feb. 03, v. 24, no. 6

    2022  

    Abstract: Reactions that require strictly dry conditions are challenging to translate to a DNA-encoded library format. Controlled pore glass solid support-connected DNA oligonucleotide–aldehyde conjugates could be condensed with SnAP reagents and cyclized to ... ...

    Abstract Reactions that require strictly dry conditions are challenging to translate to a DNA-encoded library format. Controlled pore glass solid support-connected DNA oligonucleotide–aldehyde conjugates could be condensed with SnAP reagents and cyclized to various sp³-rich heterocycles. The Boc-group of products provided a handle for product purification, and its facile removal under acidic conditions was tolerated by a chemically stabilized barcode. The reaction provides reagent-based scaffold diversity with functionalities for further library synthesis.
    Keywords DNA ; glass ; heterocyclic compounds
    Language English
    Dates of publication 2022-0203
    Size p. 1383-1387.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.2c00228
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Synthesis of DNA-coupled isoquinolones and pyrrolidines by solid phase ytterbium- and silver-mediated imine chemistry.

    Potowski, Marco / Kunig, Verena B K / Losch, Florian / Brunschweiger, Andreas

    MedChemComm

    2019  Volume 10, Issue 7, Page(s) 1082–1093

    Abstract: DNA-encoded libraries of chemically synthesized compounds are an important small molecule screening technology. The synthesis of encoded compounds in solution is currently restricted to a few DNA-compatible and water-tolerant reactions. Encoded compound ... ...

    Abstract DNA-encoded libraries of chemically synthesized compounds are an important small molecule screening technology. The synthesis of encoded compounds in solution is currently restricted to a few DNA-compatible and water-tolerant reactions. Encoded compound synthesis of short DNA-barcodes covalently connected to solid supports benefits from a broad range of choices of organic solvents. Here, we show that this encoded chemistry approach allows for the synthesis of DNA-coupled isoquinolones by an Yb(iii)-mediated Castagnoli-Cushman reaction under anhydrous reaction conditions and for the synthesis of highly substituted pyrrolidines by Ag(i)-mediated 1,3-dipolar azomethine ylide cycloaddition. An encoding scheme for these DNA-barcoded compounds based on a DNA hairpin is demonstrated.
    Language English
    Publishing date 2019-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2545949-1
    ISSN 2040-2511 ; 2040-2503
    ISSN (online) 2040-2511
    ISSN 2040-2503
    DOI 10.1039/c9md00042a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Real-world use and acceptance of rituximab biosimilars in non-Hodgkin lymphoma in an oncologist network in Germany.

    Otremba, Burkhard / Borchardt, Jens / Kuske, Andra / Hollnagel-Schmitz, Maike / Losch, Florian O

    Future oncology (London, England)

    2020  Volume 16, Issue 15, Page(s) 1001–1012

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents, Immunological/administration & dosage ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/therapeutic use ; Biosimilar Pharmaceuticals/administration & dosage ; Biosimilar Pharmaceuticals/adverse effects ; Biosimilar Pharmaceuticals/therapeutic use ; Child ; Female ; Germany/epidemiology ; Humans ; Lymphoma, Non-Hodgkin/diagnosis ; Lymphoma, Non-Hodgkin/drug therapy ; Lymphoma, Non-Hodgkin/epidemiology ; Male ; Middle Aged ; Oncologists ; Practice Patterns, Physicians' ; Rituximab/administration & dosage ; Rituximab/adverse effects ; Rituximab/therapeutic use ; Young Adult
    Chemical Substances Antineoplastic Agents, Immunological ; Biosimilar Pharmaceuticals ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2020-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2020-0180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6478: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Article: Screening of metal ions and organocatalysts on solid support-coupled DNA oligonucleotides guides design of DNA-encoded reactions.

    Potowski, Marco / Losch, Florian / Wünnemann, Elena / Dahmen, Janina K / Chines, Silvia / Brunschweiger, Andreas

    Chemical science

    2019  Volume 10, Issue 45, Page(s) 10481–10492

    Abstract: DNA-encoded compound libraries are a widely used technology for target-based small molecule screening. Generally, these libraries are synthesized by solution phase combinatorial chemistry requiring aqueous solvent mixtures and reactions that are ... ...

    Abstract DNA-encoded compound libraries are a widely used technology for target-based small molecule screening. Generally, these libraries are synthesized by solution phase combinatorial chemistry requiring aqueous solvent mixtures and reactions that are orthogonal to DNA reactivity. Initiating library synthesis with readily available controlled pore glass-coupled DNA barcodes benefits from enhanced DNA stability due to nucleobase protection and choice of dry organic solvents for encoded compound synthesis. We screened the compatibility of solid-phase coupled DNA sequences with 53 metal salts and organic reagents. This screening experiment suggests design of encoded library synthesis. Here, we show the reaction optimization and scope of three sp
    Language English
    Publishing date 2019-11-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/c9sc04708e
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