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  1. AU="Lotan, Dor"
  2. AU="Mattingly, M C K" AU="Mattingly, M C K"
  3. AU="Rastogi Ajay"
  4. AU="Deniz Kantar"
  5. AU="Stucky, Cheryl L"
  6. AU="Higashino, Kosaku"
  7. AU="Johnston, Sara C"
  8. AU=Fisayo Temitope
  9. AU="Buret, Laetitia"
  10. AU=Guirao Antonio
  11. AU="Tang, Anthony"
  12. AU="Garnelo, Luiza"
  13. AU=Sakanari J A AU=Sakanari J A
  14. AU="Ni, Fuchuan"
  15. AU="Anithachristy S Arumanayagam"
  16. AU="Melman, Dick"

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  1. Artikel ; Online: Pericarditis recurrence is associated with milder electrocardiographic, echocardiographic, and laboratory findings.

    Weiss, Tal / Itelman, Edward / Lotan, Dor / Segev, Amitai / Freimark, Dov / Arad, Michael / Wasserstrum, Yishay

    Internal and emergency medicine

    2024  

    Abstract: Recurrent pericarditis (RP) complicates approximately 30% of acute pericarditis (AP) cases. We sought to compare the prevalence and severity of objective findings seen in patients with RP. A retrospective single-center study during 2010-2019, including ... ...

    Abstract Recurrent pericarditis (RP) complicates approximately 30% of acute pericarditis (AP) cases. We sought to compare the prevalence and severity of objective findings seen in patients with RP. A retrospective single-center study during 2010-2019, including 765 patients diagnosed with AP. Clinical, electrocardiographic, echocardiographic, and laboratory findings were extracted from the local electronic health records. Recurrence during follow-up was documented in 134 patients (17.5%), with a median time to recurrence of 101 (± 59-251) days. The median age was 60 years (IQR 45-72), 68% were male. Most patients were defined as having idiopathic\viral pericarditis (64%). The clinical manifestation during the recurrent event of pericarditis was less prominent or attenuated when compared to the initial event-ECG signs (ST elevation 12% vs. 26%; p = 0.006, Knuckle sign 13% vs. 33%; p < 0.001, ST larger in lead L2 than L3 4% vs. 19%; p < 0.001), pericardial effusion moderate and above (11% vs. 30%; p = 0.02), and inflammatory markers (mean peak CRP levels 66 mg/l vs. 97 mg/l; p < 0.001). Similar results were seen in the subgroup of patients defined as having idiopathic\viral pericarditis. Up to 20% of patients who did not have ECG signs or a significant pericardial effusion in their 1st event demonstrated these findings during the recurrence, though still to a lesser extent compared with those who had these signs in their 1st event. The objective findings of AP are less pronounced during recurrent events. Future studies should focus on the role of advanced biomarkers and imaging in defining true RP events.
    Sprache Englisch
    Erscheinungsdatum 2024-03-29
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-024-03579-7
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  2. Artikel: The clinical course of patients with previous acute and recurrent pericarditis receiving the BNT162b2 vaccine.

    Wasserstrum, Yishay / Nadav, Sofia / Segev, Amitai / Lotan, Dor / Freimark, Dov / Arad, Michael

    International journal of cardiology. Heart & vasculature

    2022  Band 42, Seite(n) 101084

    Abstract: Background: Vaccines against SARS-COV2 have been crucial in efforts against COVID19, yet there have been reports of pericarditis following vaccination with mRNA-based vaccines.: Methods: We questioned consecutive patients with a history of acute ... ...

    Abstract Background: Vaccines against SARS-COV2 have been crucial in efforts against COVID19, yet there have been reports of pericarditis following vaccination with mRNA-based vaccines.
    Methods: We questioned consecutive patients with a history of acute pericarditis (AP) evaluated in the pericardial disease clinic during 3-11/2020 in a single tertiary center. Patients with significant myocardial involvement or pericarditis secondary to another systemic disease were excluded.
    Results: We included 64 patients in the final analysis. Mean age was 53.1 (±18), and 26 (41%) were female. At least 1 recurrence of AP was documented in 47 (73%) cases, 32 (50%) had ≥ 3 recurrences prior to vaccination. AP was considered to be idiopathic\viral in 45 (70%) cases, 20 (31%) cases were post-injury. All patients received at least 2 doses of the vaccine, and 48 patients (75%) received a 3rd dose. Two cases of breakthrough COVID19 infections were documented. Overall, 12 patients (19%) reported any adverse events. Of which, 2 had recurrent pericarditis. There was a trend for a younger age in those patients who had adverse events (median age 45 [IQR 36-61] vs. 60 [38-71], p = 0.08). no other significant difference was seen.
    Conclusion: In patients with a history of acute\recurrent pericarditis, the use of BNT162b2 was mostly uneventful, but some mild disease recurrences did occur.
    Sprache Englisch
    Erscheinungsdatum 2022-07-18
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 2818464-6
    ISSN 2352-9067
    ISSN 2352-9067
    DOI 10.1016/j.ijcha.2022.101084
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  3. Artikel ; Online: The role of temporary mechanical circulatory support as a bridge to advanced heart failure therapies or recovery.

    Oren, Daniel / Zilinyi, Robert / Lotan, Dor / Uriel, Matan / Uriel, Nir / Sayer, Gabriel

    Current opinion in cardiology

    2022  Band 37, Heft 5, Seite(n) 394–402

    Abstract: Purpose of review: Temporary mechanical circulatory support (tMCS) has become central in the treatment of refractory cardiogenic shock and can be used to bridge patients to durable MCS, heart transplant or recovery. This review will discuss contemporary ...

    Abstract Purpose of review: Temporary mechanical circulatory support (tMCS) has become central in the treatment of refractory cardiogenic shock and can be used to bridge patients to durable MCS, heart transplant or recovery. This review will discuss contemporary data regarding bridging strategies utilizing tMCS.
    Recent findings: There has been significant growth in tMCS use recently, driven by increased familiarity with tMCS devices, and increased experience with both implantation and management. Identifying goals of therapy at the time of therapy initiation can facilitate better outcomes. The three primary goals are bridge to recovery, bridge to heart transplantation or bridge to durable left ventricular assist device. Bridging to recovery requires adequate treatment of underlying conditions and optimization of haemodynamics. Bridging to heart transplantation has become more frequent following changes to the heart allocation policy. Despite early concerns, patients bridge with tMCS, including ventricular-arterial extracorporeal membrane oxygenation, do not appear to have worse posttransplant outcomes. When bridging to durable mechanical circulatory support, tMCS can be used to enhance end-organ dysfunction and improve perioperative outcomes. In situations in which none of these goals are attainable, palliative care plays a critical role to identify patient wishes and assist with withdrawal of care when necessary.
    Summary: The use of tMCS, as a bridge to recovery or heart replacement therapy in patients with refractory cardiogenic shock has grown significantly over the past decade. Multiple device choices are available and must be chosen appropriately to address the specific situation and the goals of therapy.
    Mesh-Begriff(e) Cardiotonic Agents ; Heart Failure/surgery ; Heart Transplantation ; Heart-Assist Devices ; Humans ; Shock, Cardiogenic/therapy ; Treatment Outcome
    Chemische Substanzen Cardiotonic Agents
    Sprache Englisch
    Erscheinungsdatum 2022-06-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 645186-x
    ISSN 1531-7080 ; 0268-4705
    ISSN (online) 1531-7080
    ISSN 0268-4705
    DOI 10.1097/HCO.0000000000000976
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  4. Artikel ; Online: Artificial Intelligence Assessment of Biological Age from Transthoracic Echocardiography: Discrepancies to Chronologic Age Predict Significant Excess Mortality.

    Faierstein, Kobi / Fiman, Michael / Loutati, Ranel / Rubin, Noa / Manor, Uri / Am-Shalom, Adiel / Cohen-Shelly, Michal / Blank, Nimrod / Lotan, Dor / Zhao, Qiong / Schwammenthal, Ehud / Klempfner, Robert / Zimlichman, Eyal / Raanani, Ehud / Maor, Elad

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2024  

    Abstract: Background: Age and sex can be estimated by artificial intelligence based on various sources.: Objectives: We aimed to test whether convolutional neural networks could be trained to estimate the age and predict the sex using standard transthoracic ... ...

    Abstract Background: Age and sex can be estimated by artificial intelligence based on various sources.
    Objectives: We aimed to test whether convolutional neural networks could be trained to estimate the age and predict the sex using standard transthoracic echocardiography (TTE), and to evaluate its prognostic implications.
    Methods: The algorithm was trained on 76,342 patients, validated in 22,825 patients, and tested in 20,960 patients. It was then externally validated using data from a different hospital (N=556). Finally, a prospective cohort of handheld point-of-care ultrasound (POCUS) devices (N=319; ClinicalTrials.Gov NCT05455541) was used to confirm the findings. Multivariate Cox regression model was used to investigate the association between age-estimation and chronological age with overall survival.
    Results: The mean average error in age estimation was 4.9 years, with a Pearson correlation coefficient of 0.922. The probabilistic value of sex had an overall accuracy of 96.1% and an area under the curve (AUC) of 0.993. External validation and prospective study cohorts yielded consistent results. Finally, survival analysis demonstrated that age prediction ≥ 5 years of chronological age was associated with an independent 34% increased risk of death during follow-up (p<0.001).
    Conclusions: Applying artificial intelligence to the standard TTE allows prediction of sex and estimation of age. Machine-based estimation is an independent predictor of overall survival and, with further evaluation, can be used for risk stratification and estimation of biological age.
    Sprache Englisch
    Erscheinungsdatum 2024-05-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2024.04.017
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  5. Artikel ; Online: Effect of levosimendan infusion prior to left ventricular assist device implantation on right ventricular failure.

    Segev, Amitai / Lavee, Jacob / Kassif, Yigal / Shemesh, Yedida / Kogan, Alexander / Freimark, Dov / Morgan, Avi / Lotan, Dor / Itelman, Edward / Grupper, Avishay

    Journal of cardiothoracic surgery

    2022  Band 17, Heft 1, Seite(n) 158

    Abstract: Objective: Investigate the safety and efficacy of preoperative levosimendan in patients undergoing left ventricular assist device (LVAD) implantation.: Methods: Consecutive patients who received LVADs (HeartMate-2, 3, HVAD) in a single tertiary ... ...

    Abstract Objective: Investigate the safety and efficacy of preoperative levosimendan in patients undergoing left ventricular assist device (LVAD) implantation.
    Methods: Consecutive patients who received LVADs (HeartMate-2, 3, HVAD) in a single tertiary medical center (2012-2018). INTERMACS profile 1 patients were excluded. The primary outcome was post-LVAD right ventricular failure (RVF) and inhospital mortality rates. The secondary outcomes included other clinical, echocardiographic and hemodynamic parameters at follow-up.
    Results: Final cohort consisted of 62 patients (40[65%] in the levosimendan group and 22[35%] in the no-levosimendan group). Post-operative RVF rate and inotrope or ventilation support time were similar in the levosimendan and no-levosimendan groups (7.5% vs. 13.6%; P = 0.43, median of 51 vs. 72 h; P = 0.41 and 24 vs. 27 h; P = 0.19, respectively). Length of hospitalization, both total and in the intensive care unit, was not statistically significant (median days of 13 vs. 16; P = 0.34, and 3 vs. 4; P = 0.44, respectively). Post-operative laboratory and echocardiographic parameters and in-hospital complication rate did not differ between the groups, despite worse baseline clinical parameters in the Levosimendan group. There was no significant difference in the in-hospital and long term mortality rate (2.5% vs. 4.5%; P > 0.999 and 10% vs. 27.3% respectively; P = 0.64).
    Conclusions: Levosimendan infusion prior to LVAD implantation was safe and associated with comparable results without significant improved post-operative outcomes, including RVF.
    Mesh-Begriff(e) Heart Failure/surgery ; Heart-Assist Devices/adverse effects ; Humans ; Retrospective Studies ; Simendan ; Ventricular Dysfunction, Right/etiology
    Chemische Substanzen Simendan (349552KRHK)
    Sprache Englisch
    Erscheinungsdatum 2022-06-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2227224-0
    ISSN 1749-8090 ; 1749-8090
    ISSN (online) 1749-8090
    ISSN 1749-8090
    DOI 10.1186/s13019-022-01915-6
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  6. Artikel ; Online: Recurrent outflow graft compression of HeartMate3: When the left ventricular assist device sticks to the rib.

    Lotan, Dor / Goldstein, Jonathan / Oren, Daniel / Oh, David / Uriel, Nir / Naka, Yoshifumi / Colombo, Paolo C / Takeda, Koji / Yuzefpolskaya, Melana

    JTCVS techniques

    2022  Band 17, Seite(n) 104–107

    Sprache Englisch
    Erscheinungsdatum 2022-11-04
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2022.10.017
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  7. Artikel ; Online: Sex differences in patients undergoing heart transplantation and LVAD therapy.

    Rubinstein, Gal / Lotan, Dor / Moeller, Cathrine M / DeFilippis, Ersilia M / Slomovich, Sharon / Oren, Daniel / Yuzefpolskaya, Melana / Sayer, Gabriel / Uriel, Nir

    Expert review of cardiovascular therapy

    2022  Band 20, Heft 11, Seite(n) 881–894

    Abstract: Introduction: Left ventricular assist device (LVAD) and heart transplantation (HT) are the two life-sustaining therapies that have revolutionized the management of end-stage heart failure (HF). Yet, significant sex differences exist with respect to ... ...

    Abstract Introduction: Left ventricular assist device (LVAD) and heart transplantation (HT) are the two life-sustaining therapies that have revolutionized the management of end-stage heart failure (HF). Yet, significant sex differences exist with respect to their use and effects.
    Areas covered: This review summarizes sex differences in the utilization, outcomes, and complications of LVAD and HT. Particular emphasis is placed on leading clinical trials in the field, historical and recent large registries-based analyses, as well as contemporary technological and policy changes affecting these differences.
    Expert opinion: Women with advanced HF remain under-treated with guideline-directed medical therapy and are less likely to be referred for consideration for LVAD and HT. This remains true despite newer LVAD technology and the new heart transplant allocation system. Community outreach, education, as well as increased representation of women in clinical research may reduce inequities.
    Sprache Englisch
    Erscheinungsdatum 2022-11-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1080/14779072.2022.2149493
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  8. Artikel ; Online: Combined heart and liver transplantation in a patient supported by left ventricular assist device (LVAD) with propionic acidemia.

    Lotan, Dor / DeFilippis, Ersilia M / Oren, Daniel / Vinogradsky, Alice / Rubinstein, Gal / Mathur, Abhishek / Takeda, Koji / Hua, May / Gaglio, Paul J / Szabolcs, Matthias J / Sayer, Gabriel / Uriel, Nir / Iglesias, Alejandro Daniel / Latif, Farhana

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2023  Band 33, Heft 3, Seite(n) 667–670

    Abstract: Propionic acidemia (PA) is a rare inherited metabolic disease due to inborn errors of metabolism. PA results in the accumulation of abnormal organic acid metabolites in multiple systems, mainly the central nervous system and the heart. Cardiac ... ...

    Abstract Propionic acidemia (PA) is a rare inherited metabolic disease due to inborn errors of metabolism. PA results in the accumulation of abnormal organic acid metabolites in multiple systems, mainly the central nervous system and the heart. Cardiac complications include dilated cardiomyopathy (DCM) and carry a 40-50% increased mortality risk. Liver transplantation (LT) is required in PA patients when medical treatment fails and may prevent or slow down the cardiomyopathy progression. However, severe heart disease may be a serious contraindication to LT. We present a complicated case of a PA patient, supported with a Left Ventricular Assist Device, who underwent a heart and Liver transplant. PA patients are at increased risk for metabolic acidosis during surgery, with increased anion gap and hyperammonemia. A strict multi-disciplinary approach is needed to prevent and treat metabolic decompensation. The patient had a successful heart and liver transplant after a strict treatment protocol in the pre, intra, and post-operative periods. His case highlights the complexity of PA patients and the increased risk for metabolic decompensation during surgery and provides an insight into how to manage such complicated patients.
    Mesh-Begriff(e) Humans ; Cardiomyopathies/etiology ; Cardiomyopathies/surgery ; Heart-Assist Devices ; Liver Transplantation/adverse effects ; Propionic Acidemia/complications ; Propionic Acidemia/diagnosis ; Propionic Acidemia/therapy ; Treatment Outcome ; Male
    Sprache Englisch
    Erscheinungsdatum 2023-01-03
    Erscheinungsland Netherlands
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2022.12.022
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  9. Artikel: Global, Regional, and National Burden of Myocarditis and Cardiomyopathy, 1990-2017.

    Dai, Haijiang / Lotan, Dor / Much, Arsalan Abu / Younis, Arwa / Lu, Yao / Bragazzi, Nicola Luigi / Wu, Jianhong

    Frontiers in cardiovascular medicine

    2021  Band 8, Seite(n) 610989

    Abstract: Objective: ...

    Abstract Objective:
    Sprache Englisch
    Erscheinungsdatum 2021-02-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.610989
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  10. Artikel ; Online: Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017.

    Bragazzi, Nicola Luigi / Zhong, Wen / Shu, Jingxian / Abu Much, Arsalan / Lotan, Dor / Grupper, Avishay / Younis, Arwa / Dai, Haijiang

    European journal of preventive cardiology

    2021  Band 28, Heft 15, Seite(n) 1682–1690

    Abstract: Aims: To provide the first systematic analysis of the burden and underlying causes of heart failure (HF) in 195 countries and territories from 1990 to 2017.: Methods and results: We collected detailed information on prevalence, years lived with ... ...

    Abstract Aims: To provide the first systematic analysis of the burden and underlying causes of heart failure (HF) in 195 countries and territories from 1990 to 2017.
    Methods and results: We collected detailed information on prevalence, years lived with disability (YLDs), and underlying causes of HF from the Global Burden of Disease study 2017. Numbers and age-standardized rates of HF prevalence and YLDs were compared by age, sex, socio-demographic index (SDI), and location. The proportions of HF age-standardized prevalence rates due to 23 underlying causes were also presented. Globally, the age-standardized prevalence and YLD rates of HF in 2017 were 831.0 and 128.2 per 100 000 people, a decrease of -7.2% and -0.9% from 1990, respectively. Nevertheless, the absolute numbers of HF prevalent cases and YLDs have increased by 91.9% and 106.0% from 1990, respectively. There is significant geographic and socio-demographic variation in the levels and trends of HF burden from 1990 to 2017. Among all causes of HF, ischaemic heart disease accounted for the highest proportion (26.5%) of age-standardized prevalence rate of HF in 2017, followed by hypertensive heart disease (26.2%), chronic obstructive pulmonary disease (23.4%).
    Conclusion: HF remains a serious public health problem worldwide, with increasing age-standardized prevalence and YLD rates in countries with relatively low SDI. More geo-specific strategies aimed at preventing underlying causes and improving medical care for HF are warranted to reduce the future burden of this condition.
    Mesh-Begriff(e) Global Burden of Disease ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Humans ; Prevalence ; Quality-Adjusted Life Years ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2021-02-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwaa147
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