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  1. AU="Lou, L X"
  2. AU="Yadollah Haji-Heydari"
  3. AU="Placidi, A"
  4. AU="Olivé, Claudia"
  5. AU="Türk, Y"
  6. AU="Brosnan, Hannah"
  7. AU="Hardy, Rowan S"
  8. AU="Demirci, Yılmaz Mehmet"
  9. AU="Dlugosz, Andrzej A"

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  1. Artikel: [Surgical timing for childhood blepharoptosis].

    Ye, J / Lou, L X

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2023  Band 59, Heft 7, Seite(n) 514–517

    Abstract: Blepharoptosis in children is one of the common pediatric eye diseases. It is not only a matter of aesthetics, but also affects visual and psychological development. How to choose the right time to operate has been controversial in clinical practice. ... ...

    Abstract Blepharoptosis in children is one of the common pediatric eye diseases. It is not only a matter of aesthetics, but also affects visual and psychological development. How to choose the right time to operate has been controversial in clinical practice. Based on the domestic and foreign research progress and clinical experience, we propose that factors, such as the etiology of blepharoptosis, visual and psychological development characteristics of children, developmental characteristics of eyelid-related muscles, and types of blepharoptosis, should be considered for selection of the timing of surgery in a personalized and standardized manner, so as to provide reference and guidance for the clinical diagnosis and treatment of blepharoptosis in children.
    Mesh-Begriff(e) Child ; Humans ; Blepharoptosis/surgery ; Oculomotor Muscles/surgery ; Retrospective Studies ; Treatment Outcome
    Sprache Chinesisch
    Erscheinungsdatum 2023-07-05
    Erscheinungsland China
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.cn112142-20230317-00104
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: [Arthroscopic-assisted fracture reduction combined with robot-navigated nail placement to treat talar neck fractures].

    Xu, M L / Shi, R J / Chen, G L / Lou, L X / Li, C H

    Zhonghua yi xue za zhi

    2022  Band 102, Heft 19, Seite(n) 1472–1475

    Abstract: This study aims to explore the clinical efficacy of arthroscopic-assisted reduction combined with robot-navigated nail placement in the treatment of talar neck fractures. The clinical data of 13 patients with talar neck fracture in Xuzhou Benevolent ... ...

    Abstract This study aims to explore the clinical efficacy of arthroscopic-assisted reduction combined with robot-navigated nail placement in the treatment of talar neck fractures. The clinical data of 13 patients with talar neck fracture in Xuzhou Benevolent Hospital from January 2018 to January 2021 were analyzed in the retrospective study. Among them, there were 9 males and 4 females, aged (36±12) years; there were 8 cases suffered on the right and 5 cases on the left. All patients were reset under arthroscopy and cannulated screws were placed in combination with three-dimensional navigation and positioning of orthopedic robot. The wounds and complications were observed in the postoperative follow-up. The activities of bilateral ankle dorsiflexion and plantar flexion were measured in the last follow-up. The visual analogue scale score (VAS) of pain in the affected feet before operation were compared with that at the last follow-up. The ankle and hind foot work energy scale of American Foot and Ankle Association (AOFAS) was used to assess the ankle function. The results showed that the wounds of 13 patients healed in one stage. The operation time was (95±45) min and the blood lose was (45±10) ml. All the patients were followed-up for (15.0±3.5) months. Two cases developed subtalar arthritis without talus necrosis and fracture nonunion. At the last follow-up, there was no significant difference in the dorsal extension and plantar flexion of the ankle between the affected side and the healthy side (25.8°±1.9° vs 26.2°±2.3°, 44.2°±2.7° vs 44.7°±2.8°, both
    Mesh-Begriff(e) Ankle Fractures/surgery ; Female ; Fracture Fixation, Internal ; Humans ; Male ; Pain ; Retrospective Studies ; Robotics ; Talus/surgery ; Treatment Outcome
    Sprache Chinesisch
    Erscheinungsdatum 2022-05-22
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 132513-9
    ISSN 0376-2491
    ISSN 0376-2491
    DOI 10.3760/cma.j.cn112137-20211227-02899
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: CircRNA_103801 accelerates proliferation of osteosarcoma cells by sponging miR-338-3p and regulating HIF-1/Rap1/PI3K-Akt pathway.

    Li, Z Q / Wang, Z / Zhang, Y / Lu, C / Ding, Q L / Ren, R / Cheng, B B / Lou, L X

    Journal of biological regulators and homeostatic agents

    2021  Band 35, Heft 3, Seite(n) 1021–1028

    Abstract: This study aimed to investigate the roles of hsa_circRNA_103801 in the progression of osteosarcoma (OS) cells. Quantitative reverse transcription-polymerase chain reaction (RT-qPCR) was used to detect the expression level of circRNA_103801 in OS cells. ... ...

    Abstract This study aimed to investigate the roles of hsa_circRNA_103801 in the progression of osteosarcoma (OS) cells. Quantitative reverse transcription-polymerase chain reaction (RT-qPCR) was used to detect the expression level of circRNA_103801 in OS cells. Cell count kit-8 and Transwell migration and invasion assays were employed to detect the proliferation, migration, and invasion abilities of OS cells. The effects of circRNA_103801 on the apoptosis of OS cells were identified by flow cytometry. The binding relationship between circRNA_103801 and miR-338-3p was verified by bioinformatics analysis. MiR-338-3p level in OS cell lines was detected by RT-qPCR. Additionally, Western blotting was utilized to detect the expression levels of HIF-1, Rap1, PI3K, and Akt in OS cells. The results showed that the expression level of circRNA_103801 was significantly up-regulated in OS patients' tissues. Inhibiting the expression level of circRNA_103801 could attenuate the proliferation, migration, and invasion abilities of OS cells. In addition, the down-regulated expression level of circRNA_103801 could induce cell apoptosis. The results of the luciferase reporter assay suggested that circRNA_103801 could be combined with miR-338-3p, and the RT-qPCR revealed that the miR-338-3p level in OS cells after knockdown of circRNA_103801 was elevated compared with the control group. The results of Western blotting suggested that the expression levels of HIF-1, Rap1, PI3K, and Akt were elevated in OS cells. In conclusion, the circRNA_103801-miR-3388-3p-HIF-1/Rap1/PI3K-Akt pathway could be a therapeutic target of OS.
    Mesh-Begriff(e) Bone Neoplasms/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Humans ; MicroRNAs/genetics ; Osteosarcoma/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Circular ; Shelterin Complex ; Telomere-Binding Proteins ; Up-Regulation
    Chemische Substanzen MIRN338 microRNA, human ; MicroRNAs ; RNA, Circular ; Shelterin Complex ; TERF2IP protein, human ; Telomere-Binding Proteins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2021-06-22
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 639196-5
    ISSN 1724-6083 ; 0393-974X
    ISSN (online) 1724-6083
    ISSN 0393-974X
    DOI 10.23812/20-725-A
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Anti-inflammatory effects of hinokitiol on human corneal epithelial cells: an in vitro study.

    Ye, J / Xu, Y-F / Lou, L-X / Jin, K / Miao, Q / Ye, X / Xi, Y

    Eye (London, England)

    2015  Band 29, Heft 7, Seite(n) 964–971

    Abstract: Purpose: This study assessed the anti-inflammatory effect and mechanism of action of hinokitiol in human corneal epithelial (HCE) cells.: Methods: HCE cells were incubated with different concentrations of hinokitiol or dimethylsulfoxide (DMSO), which ...

    Abstract Purpose: This study assessed the anti-inflammatory effect and mechanism of action of hinokitiol in human corneal epithelial (HCE) cells.
    Methods: HCE cells were incubated with different concentrations of hinokitiol or dimethylsulfoxide (DMSO), which served as a vehicle control. Cell viability was evaluated using Cell Counting Kit-8 (CCK-8) assay. After polyriboinosinic:polyribocytidylic acid (poly(I:C)) stimulus, cells with or without hinokitiol were evaluated for the mRNA and protein levels of interleukin-8 (IL-8), interleukin-6 (IL-6), and interleukin-1β (IL-1β) using real-time PCR analysis and an enzyme-linked immunosorbent assay (ELISA), respectively. Nuclear and cytoplasmic levels of nuclear factor kappa B (NF-κB) p65 protein and an inhibitor of NF-κB α (IκBα) were evaluated using western blotting.
    Results: There were no significant differences among the treatment concentrations of hinokitiol compared with cells incubated in medium only. Incubating with 100 μM hinokitiol significantly decreased the mRNA levels of IL-8 to 58.77±10.41% (P<0.01), IL-6 to 64.64±12.71% (P<0.01), and IL-1β to 54.19±8.10% (P<0.01) compared with cells stimulated with poly(I:C) alone. The protein levels of IL-8, IL-6, and IL-1β had similar trend. Further analysis revealed that hinokitiol maintained the levels of IκBα and significantly reduced NF-κB p65 subunit translocation to the nucleus which significantly inhibiting the activation of the NF-κB signal pathway.
    Conclusion: Hinokitiol showed a significant protective effect against ocular surface inflammation through inhibiting the NF-κB pathway, which may indicate the possibility to relieve the ocular surface inflammation of dry eye syndrome (DES).
    Mesh-Begriff(e) Anti-Infective Agents/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Blotting, Western ; Cell Line ; Cell Survival ; Dimethyl Sulfoxide/pharmacology ; Enzyme-Linked Immunosorbent Assay ; Epithelium, Corneal/drug effects ; Epithelium, Corneal/metabolism ; Epithelium, Corneal/pathology ; Gene Expression Profiling ; Humans ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Interleukin-8/genetics ; Interleukin-8/metabolism ; Monoterpenes/pharmacology ; NF-kappa B/antagonists & inhibitors ; Poly I-C/pharmacology ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Tropolone/analogs & derivatives ; Tropolone/pharmacology
    Chemische Substanzen Anti-Infective Agents ; Anti-Inflammatory Agents, Non-Steroidal ; CXCL8 protein, human ; IL6 protein, human ; Interleukin-1beta ; Interleukin-6 ; Interleukin-8 ; Monoterpenes ; NF-kappa B ; RNA, Messenger ; Tropolone (7L6DL16P1T) ; Poly I-C (O84C90HH2L) ; beta-thujaplicin (U5335D6EBI) ; Dimethyl Sulfoxide (YOW8V9698H)
    Sprache Englisch
    Erscheinungsdatum 2015-05-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/eye.2015.62
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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