LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Lou, Shuyi"
  2. AU="Figueiredo, Rodrigo S"
  3. AU=Fleet James C
  4. AU="Brohawn, David G"
  5. AU="Cho, Chun-Chieh"
  6. AU="van Raalte, Daniël H"
  7. AU="Zargarian, Loussiné"
  8. AU=Hascalovici Jacob
  9. AU="Spagnolo, Jennifer B"
  10. AU="Anderloni, Giulia"
  11. AU="Ahmad, Shoaib"
  12. AU="Du, Roujia"
  13. AU="Colmenero-Repiso, Ana"
  14. AU="Alvarez-Carbonell, David"
  15. AU="Phelippeau, Michael"
  16. AU="Lunghi, Laura"
  17. AU=Giersiepen Klaus
  18. AU="Drobyshev, Sergey"
  19. AU="Timme, Kathleen H"
  20. AU=Sfriso Paolo
  21. AU="Kim, John S"
  22. AU=Farkash Evan A AU=Farkash Evan A
  23. AU="Xia, Xueqian"

Suchergebnis

Treffer 1 - 2 von insgesamt 2

Suchoptionen

  1. Artikel ; Online: Dihydromyricetin reverses capecitabine-induced peripheral myelin dysfunction through modulation of oxidative stress.

    Fang, Jie / Lou, Shuyi / Zhou, Xinyi / Lou, Dayong / Zhou, Liqin / Bian, Rong

    Clinical and experimental pharmacology & physiology

    2024  Band 51, Heft 3, Seite(n) e13833

    Abstract: Previous clinical reports have shown that capecitabine, an oral prodrug of 5-fluorouracil (5-Fu), can induce peripheral neuropathy, resulting in numbness, paresthesia and hypoesthesia. However, the mechanism through which capecitabine causes peripheral ... ...

    Abstract Previous clinical reports have shown that capecitabine, an oral prodrug of 5-fluorouracil (5-Fu), can induce peripheral neuropathy, resulting in numbness, paresthesia and hypoesthesia. However, the mechanism through which capecitabine causes peripheral nerve injury remains unclear. Here, we demonstrate that systemic administration of capecitabine leads to myelin abnormalities in the peripheral nerves of mice, which are possibly attributed to the death of Schwann cells, the myelinating cells in the peripheral nervous system. Furthermore, our results show that 5-Fu induces significant oxidative stress in Schwann cells by inhibiting the expression of the anti-oxidative protein DJ-1, leading to a decrease in Schwann cell markers. We found that the anti-oxidant dihydromyricetin (DMY) reverses 5-Fu-induced Schwann cell death and oxidative stress and alleviates capecitabine-induced myelin abnormalities. Taken together, our data indicate that capecitabine induces peripheral myelin dysfunction by regulating DJ-1-mediated oxidative stress in Schwann cells and reveal DMY as a potential therapeutic strategy for capecitabine-induced peripheral neuropathy.
    Mesh-Begriff(e) Mice ; Animals ; Myelin Sheath/metabolism ; Capecitabine/metabolism ; Oxidative Stress ; Peripheral Nervous System Diseases/metabolism ; Fluorouracil/toxicity ; Flavonols
    Chemische Substanzen Capecitabine (6804DJ8Z9U) ; dihydromyricetin (KD8QND6427) ; Fluorouracil (U3P01618RT) ; Flavonols
    Sprache Englisch
    Erscheinungsdatum 2024-01-30
    Erscheinungsland Australia
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 189277-0
    ISSN 1440-1681 ; 0305-1870 ; 0143-9294
    ISSN (online) 1440-1681
    ISSN 0305-1870 ; 0143-9294
    DOI 10.1111/1440-1681.13833
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 990: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Schisandrin B attenuates lipopolysaccharide-induced activation of hepatic stellate cells through Nrf-2-activating anti-oxidative activity.

    Yao, Zhongcai / Han, Jibo / Lou, Shuyi / Jiang, Liqin / Xu, Jianjiang / Zhou, Yaxi / Fang, Weiqin / Li, Xiaolin / Zhou, Liqin / Qian, Yuanyuan / Lou, Dayong

    International journal of clinical and experimental pathology

    2018  Band 11, Heft 10, Seite(n) 4917–4925

    Abstract: Activated hepatic stellate cells (HSCs) are known to have a potential role in increasing the deposition of ECM and elevating proliferation in liver fibrosis, which can be driven by lipopolysaccharide (LPS). Schisandrin B (SB) is a dibenzocyclooctadiene ... ...

    Abstract Activated hepatic stellate cells (HSCs) are known to have a potential role in increasing the deposition of ECM and elevating proliferation in liver fibrosis, which can be driven by lipopolysaccharide (LPS). Schisandrin B (SB) is a dibenzocyclooctadiene derivative of Schisandra chinensis with anti-oxidative stress activity, but its effective target is unknown. Here, we have evaluated whether SB is protective against the LPS-induced activation of HSCs and have explored the underlying anti-oxidative stress mechanisms of SB. HSCs were treated with SB 1 h prior to LPS, and then incubated for indicated time. Nrf-2 in HSCs was inhibited genetically. The simultaneous effects on Nrf-2 activity, oxidative stress, cell proliferation, and ECM deposition were examined. SB decreased LPS-induced cell proliferation, fibrosis, and oxidative stress in HSCs. We further demonstrated that the protective effects of SB in LPS-induced HSCs activation involve the modulation of Nrf-2. SB, specifically targeting Nrf-2, attenuates the oxidative stress in HSCs. SB also reduces LPS-induced fibrosis and cell viability in HSCs. In addition, Nrf-2 may serve as a therapeutic target for infections or periods of chronic oxidative stress and may help with future drug discovery.
    Sprache Englisch
    Erscheinungsdatum 2018-10-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2418306-4
    ISSN 1936-2625 ; 1936-2625
    ISSN (online) 1936-2625
    ISSN 1936-2625
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang