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  1. Article ; Online: Biofilm Inhibition of Inula viscosa (L.) Aiton and Globularia alypum L. Extracts Against Candida Infectious Pathogens and In Vivo Action on Galleria mellonella Model.

    Asraoui, Fadoua / El Mansouri, Fouad / Cacciola, Francesco / Brigui, Jamal / Louajri, Adnane / Simonetti, Giovanna

    Advanced biology

    2023  Volume 7, Issue 12, Page(s) e2300081

    Abstract: The increasing importance of fungal infections has fueled the search for new beneficial alternatives substance from plant extracts. The current study investigates the antifungal and antibiofilm activity of Inula viscosa (L.) Aiton and Globularia alypum ( ... ...

    Abstract The increasing importance of fungal infections has fueled the search for new beneficial alternatives substance from plant extracts. The current study investigates the antifungal and antibiofilm activity of Inula viscosa (L.) Aiton and Globularia alypum (L.) leaves extracts against Candida both in vitro and in vivo. The inhibition of planktonic and sessile Candida albicans and Candida glabrata growth using both leaf extracts are evaluated. Moreover; an in vivo infection model using Galleria mellonella larvae; infected and treated with the extracts are performed. All extracts show fungicidal activity; with a minimum fungicidal concentration (MFC) ranging from 128 to 512 µg mL
    MeSH term(s) Animals ; Inula ; Candidiasis/drug therapy ; Candida albicans ; Candida ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Moths/microbiology ; Larva ; Biofilms
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-08-23
    Publishing country Germany
    Document type Journal Article
    ISSN 2701-0198
    ISSN (online) 2701-0198
    DOI 10.1002/adbi.202300081
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  2. Article: Development of a new HPLC method for rapid histamine quantification in fish and fishery products without sample clean-up

    Kounnoun, Ayoub / Louajri, Adnane / Cacciola, Francesco / Baaboua, Aicha El / Mondello, Luigi / Bougtaib, Hajar / Alahlah, Naoual / Stitou, Meriem / Maadoudi, Mohamed El

    European food research & technology. 2022 June, v. 248, no. 6

    2022  

    Abstract: HPLC methods are among the most studied and validated techniques for the quantification of histamine in fish and fishery products; nonetheless, most of these methods require laborious sample extraction and purification. For this purpose, in the present ... ...

    Abstract HPLC methods are among the most studied and validated techniques for the quantification of histamine in fish and fishery products; nonetheless, most of these methods require laborious sample extraction and purification. For this purpose, in the present study, an HPLC-FLD method without any sample clean-up procedure was developed, validated and applied for histamine quantification in various fish samples. Histamine was extracted from fish and fishery products samples with perchloric acid; then a simple precolumn derivatization with o-phthalaldehyde was performed in the presence of the reducing agent 2-mercaptoethanol. Once the derivatization was carried out, the separation was performed with a reverse phase HPLC system. In terms of validation, good linearity and specificity over a concentration range from 12.5 to 200 mg/kg were achieved. Also, convenable precision with relative standard deviations smaller than 5.92%, accuracy ranged from 0.40 to 1.84%, and satisfactory recoveries ranged from 100.44 to 101.84%, were obtained. The detection and the quantification limits were calculated at 2.8 and 4.3 mg/kg, respectively. In addition, the effectiveness of the method was evaluated by the analysis of reference materials, proficiency tests and various type of samples. Moreover, the developed method was found to be simple, rapid, and reliable.
    Keywords beta-mercaptoethanol ; derivatization ; fish ; fisheries ; food research ; histamine ; perchloric acid ; reversed-phase high performance liquid chromatography ; technology
    Language English
    Dates of publication 2022-06
    Size p. 1679-1689.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 1359456-4
    ISSN 1431-4630 ; 1438-2377
    ISSN 1431-4630 ; 1438-2377
    DOI 10.1007/s00217-022-03995-z
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  3. Article ; Online: Risk factors and early renal effects of environmental exposure to the trace elements in Moroccan adolescents.

    Laamech, Jawhar / El Hangouche, Abdelkader J / Amekran, Youssra / Najdi, Adil / Ben Driss, Abdenbi / Ben Driss, El K / Louajri, Adnane / Lyoussi, Badiaa

    Minerva pediatrics

    2021  

    Abstract: Background: In Morocco, the use of leaded-gasoline is still common even after its ban in 2011, and other sources of contamination by traces elements are not regulated. We aimed to assess blood and urinary cadmium, blood lead, and total blood mercury ... ...

    Abstract Background: In Morocco, the use of leaded-gasoline is still common even after its ban in 2011, and other sources of contamination by traces elements are not regulated. We aimed to assess blood and urinary cadmium, blood lead, and total blood mercury levels in Moroccan adolescents and to identify determinants and early renal effects of exposure.
    Methods: The study included 149 school adolescents (12 to 18 years), from urban, industrial, and rural areas in Fez city (north of Morocco). Risk factors were investigated by interviews and questionnaires. Internal doses and early renal effects were evaluated by analyzing blood and urinary samples.
    Results: The mean of blood lead levels (BLLs) in all adolescents was 47.81μg/l with no difference between boys and girls. Adolescents from the urban area had the highest BLLs mean. The means of blood cadmium levels (BCLs) and urinary cadmium levels (UCLs) were 0.29μg/l and 0.45μg/l respectively, with no differences between living areas or according to sex. The total blood mercury levels (BMLs) mean was 0.52 μg/l. BMLs mean was higher in the industrial area and among boys. This can be associated to the frequency of fish intake, the use of dental amalgams fillings, and the consumption of chewing gum. Rates of early renal effects markers were low, not correlated to the metals, and may indicate that renal effects of this environmental exposure could be limited.
    Conclusions: There is an urgent need for the limitation of trace elements' sources, particularly the strict application of the laws concerning leaded-petrol prohibition.
    Language English
    Publishing date 2021-05-31
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062664-X
    ISSN 2724-5780
    ISSN (online) 2724-5780
    DOI 10.23736/S2724-5276.21.06211-X
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  4. Article ; Online: Development and Validation of a TLC-Densitometry Method for Histamine Monitoring in Fish and Fishery Products.

    Kounnoun, Ayoub / Louajri, Adnane / Cacciola, Francesco / El Cadi, Hafssa / Bougtaib, Hajar / Alahlah, Naoual / El Baaboua, Aicha / El Maadoudi, Mohamed

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 16

    Abstract: Histamine poisoning is a significant public health problem. Therefore, the monitoring of histamine content in fish and fishery products is considered to be a crucial measure in the seafood industry. In the present study, a simple and rapid densitometric ... ...

    Abstract Histamine poisoning is a significant public health problem. Therefore, the monitoring of histamine content in fish and fishery products is considered to be a crucial measure in the seafood industry. In the present study, a simple and rapid densitometric thin-layer chromatographic (TLC) method for histamine determination in fish samples was developed and validated. The samples were homogenized with 10% trichloroacetic acid and histamine was efficiently extracted. Then, an appropriate derivatization procedure was adopted with dansyl chloride. Once the derivatization was carried out, the samples were applied to silica gel TLC plates and developed by ascending chromatography with chloroform-triethylamine (6:4,
    MeSH term(s) Animals ; Chromatography, Thin Layer ; Densitometry/methods ; Fisheries ; Fishes ; Food Analysis/methods ; Food Contamination/analysis ; Histamine/analysis ; Limit of Detection ; Time Factors
    Chemical Substances Histamine (820484N8I3)
    Language English
    Publishing date 2020-08-08
    Publishing country Switzerland
    Document type Journal Article ; Validation Study
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25163611
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  5. Article: Development and Validation of a High-Performance Liquid Chromatography Method for the Determination of Histamine in Fish Samples Using Fluorescence Detection with Pre-column Derivatization

    Kounnoun, Ayoub / EL Maadoudi, Mohamed / Cacciola, Francesco / Mondello, Luigi / Bougtaib, Hajar / Alahlah, Naoual / Amajoud, Nadia / EL Baaboua, Aicha / Louajri, Adnane

    Chromatographia. 2020 July, v. 83, no. 7

    2020  

    Abstract: Histamine level determination in fish and fish products is important for human safety, fish quality and food industry. For this reason, a rapid, robust, and precise method is needed. To achieve this objective, an HPLC method with fluorescence detection ... ...

    Abstract Histamine level determination in fish and fish products is important for human safety, fish quality and food industry. For this reason, a rapid, robust, and precise method is needed. To achieve this objective, an HPLC method with fluorescence detection was developed and validated. Histamine in fish samples was efficiently extracted with perchloric acid, and purified with ion-exchange solid-phase extraction cartridge. A pre-column derivatization was adopted with ortho-phthalaldehyde (OPA) in the presence of the reducing agent 2-mercaptoethanol, and the stability of the histamine-OPA derivatives was achieved with the acidification of the reaction medium. In terms of validation, besides the excellent linear correlations, satisfactory recoveries at all spiking levels ranging between 0 and 200 mg kg⁻¹ were attained, with limit of detection calculated at 1.8 mg kg⁻¹, whereas limit of quantification determined at 5 mg kg⁻¹. The proposed method was successfully used in the analysis of reference materials and proficiency tests, and was found to be suitable, accurate, and rapid for detection and quantification of histamine in various fish samples.
    Keywords acidification ; beta-mercaptoethanol ; derivatization ; detection limit ; fish ; fluorescence ; food industry ; high performance liquid chromatography ; histamine ; humans ; ion exchange ; perchloric acid ; solid phase extraction
    Language English
    Dates of publication 2020-07
    Size p. 893-901.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 80097-1
    ISSN 0009-5893
    ISSN 0009-5893
    DOI 10.1007/s10337-020-03909-9
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  6. Article ; Online: Phytochemical Profile, Antioxidant Capacity, α-Amylase and α-Glucosidase Inhibitory Potential of Wild Moroccan

    Asraoui, Fadoua / Kounnoun, Ayoub / Cacciola, Francesco / El Mansouri, Fouad / Kabach, Imad / Oulad El Majdoub, Yassine / Alibrando, Filippo / Arena, Katia / Trovato, Emanuela / Mondello, Luigi / Louajri, Adnane

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 11

    Abstract: Medicinal plants offer imperative sources of innovative chemical substances with important potential therapeutic effects. Among them, the members of the ... ...

    Abstract Medicinal plants offer imperative sources of innovative chemical substances with important potential therapeutic effects. Among them, the members of the genus
    MeSH term(s) Antioxidants/chemistry ; Inula/chemistry ; Phytochemicals/chemistry ; Plant Leaves/chemistry ; alpha-Amylases/antagonists & inhibitors ; alpha-Glucosidases/drug effects
    Chemical Substances Antioxidants ; Phytochemicals ; alpha-Amylases (EC 3.2.1.1) ; alpha-Glucosidases (EC 3.2.1.20)
    Language English
    Publishing date 2021-05-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26113134
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  7. Article ; Online: Phytochemical Investigation and Antioxidant Activity of

    Asraoui, Fadoua / Kounnoun, Ayoub / Cadi, Hafssa El / Cacciola, Francesco / Majdoub, Yassine Oulad El / Alibrando, Filippo / Mandolfino, Filippo / Dugo, Paola / Mondello, Luigi / Louajri, Adnane

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 3

    Abstract: The Moroccan flora is rich in medicinal plants that are commonly used in folk medicine for the treatment of various diseases. The present study was designed to investigate the total phenolic and flavonoid contents, as well as the antioxidant properties ... ...

    Abstract The Moroccan flora is rich in medicinal plants that are commonly used in folk medicine for the treatment of various diseases. The present study was designed to investigate the total phenolic and flavonoid contents, as well as the antioxidant properties of leaves extracts from
    MeSH term(s) Antioxidants/chemistry ; Antioxidants/pharmacology ; Flavonoids/analysis ; Phenols/analysis ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Plantaginaceae/chemistry ; Solvents/chemistry
    Chemical Substances Antioxidants ; Flavonoids ; Phenols ; Phytochemicals ; Solvents
    Language English
    Publishing date 2021-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26030759
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