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Article ; Online: Circulating estrogens and estrogens within the breast among postmenopausal BRCA1/2 mutation carriers.

Loud, Jennifer T

2014 Volume 148, Issue 3, Page(s) 691–692

MeSH term(s)	BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Breast Neoplasms/blood ; Estradiol/blood ; Estrone/blood ; Female ; Humans
Chemical Substances	BRCA1 Protein ; BRCA2 Protein ; Estrone (2DI9HA706A) ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2014-12
Publishing country	Netherlands
Document type	Comment ; Letter
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-014-3186-1
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Article ; Online: Cancer Screening and Early Detection in the 21

Loud, Jennifer T / Murphy, Jeanne

Seminars in oncology nursing

2017 Volume 33, Issue 2, Page(s) 121–128

Abstract: Objective: To review the trends in and principles of cancer screening and early detection.: Data sources: Journal articles, United States Preventive Services Task Force (USPSTF) publications, professional organization position statements, and ... ...

Abstract	Objective: To review the trends in and principles of cancer screening and early detection. Data sources: Journal articles, United States Preventive Services Task Force (USPSTF) publications, professional organization position statements, and evidence-based summaries. Conclusion: Cancer screening has contributed to decreasing the morbidity and mortality of cancer. Efforts to improve the selection of candidates for cancer screening, to understand the biological basis of carcinogenesis, and the development of new technologies for cancer screening will allow for improvements in cancer screening over time. Implications for nursing practice: Nurses are well-positioned to lead the implementation of cancer screening recommendations in the 21
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Early Detection of Cancer/nursing ; Early Detection of Cancer/trends ; Evidence-Based Nursing/trends ; Female ; Forecasting ; Humans ; Male ; Mass Screening/nursing ; Mass Screening/trends ; Middle Aged ; Neoplasms/diagnosis ; Neoplasms/nursing ; Nurse's Role ; United States
Language	English
Publishing date	2017-03-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632682-1
ISSN	1878-3449 ; 0749-2081
ISSN (online)	1878-3449
ISSN	0749-2081
DOI	10.1016/j.soncn.2017.02.002
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Article ; Online: Introduction.

Eggert, Julia A / Loud, Jennifer T

Seminars in oncology nursing

2017 Volume 33, Issue 2, Page(s) 119–120

MeSH term(s)	Early Detection of Cancer/trends ; Forecasting ; Humans ; Mass Screening/trends ; Neoplasms/diagnosis ; Neoplasms/prevention & control ; Primary Prevention/trends ; Risk Factors
Language	English
Publishing date	2017-03-23
Publishing country	United States
Document type	Editorial
ZDB-ID	632682-1
ISSN	1878-3449 ; 0749-2081
ISSN (online)	1878-3449
ISSN	0749-2081
DOI	10.1016/j.soncn.2017.02.001
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Article: Direct-to-Consumer Genetic and Genomic Testing: Preparing Nurse Practitioners for Genomic Healthcare.

Loud, Jennifer T

The journal for nurse practitioners : JNP

2010 Volume 6, Issue 8, Page(s) 585–594

Abstract: Rapidly emerging technologies make it possible for consumers to acquire information that is intended to explain their inherited susceptibility to disease and facilitate tailored healthcare services through direct-to-consumer (DTC) marketing of personal ... ...

Abstract	Rapidly emerging technologies make it possible for consumers to acquire information that is intended to explain their inherited susceptibility to disease and facilitate tailored healthcare services through direct-to-consumer (DTC) marketing of personal genetic (PG) and personal genomic (PGM) testing. However, the health benefits and risks associated with these technologies are largely unknown. Consumers will turn to their healthcare providers, including nurse practitioners, to interpret test results and seek guidance on how to use these test results for medical decision-making. Nurse practitioners will need to constantly update their practice skills in response to advances in genomic technology that create new expectations among patients and lead to substantial changes in healthcare delivery.
Language	English
Publishing date	2010-10-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2202063-9
ISSN	1878-058X ; 1555-4155
ISSN (online)	1878-058X
ISSN	1555-4155
DOI	10.1016/j.nurpra.2010.06.007
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Article ; Online: Uptake and timing of bilateral and contralateral risk-reducing mastectomy in women with Li-Fraumeni syndrome.

Siegel, Atara / Bremer, Renee C / Klein, William M P / Savage, Sharon A / Loud, Jennifer T / Khincha, Payal P

Breast cancer research and treatment

2021 Volume 191, Issue 1, Page(s) 159–167

Abstract: Purpose: Women with Li-Fraumeni Syndrome (LFS) often consider risk-reducing mastectomy (RRM) due to extremely high risk of breast cancer at early ages. Data on uptake of RRM in LFS are scarce, and are inferred from experience in women with pathogenic ... ...

Abstract	Purpose: Women with Li-Fraumeni Syndrome (LFS) often consider risk-reducing mastectomy (RRM) due to extremely high risk of breast cancer at early ages. Data on uptake of RRM in LFS are scarce, and are inferred from experience in women with pathogenic variants (PVs) in BRCA1/2, despite differences in cancer risks. This study evaluated RRM uptake in a cohort of women with LFS. Methods: Women (n = 205) with LFS enrolled in NCI's LFS study reported lifetime cancer diagnoses and mastectomies and completed questionnaires regarding reproductive history, cancer worry and risk perceptions. A subset of women participating in an annual cancer screening study received counseling regarding RRM. Results: 65% (n = 71) of women diagnosed with presumed unilateral breast cancer (n = 109) underwent contralateral RRM over their lifetime. Nearly half (49%, n = 25) of the women who did not complete contralateral RRM within one year of their breast cancer diagnosis (n = 51) developed contralateral breast cancer (median interval = 6 years). Only 18.5% (n = 15) of women without breast cancer history (n = 81) underwent bilateral RRM. Median age at bilateral RRM of 39 years was sub-optimal for breast cancer risk reduction. Contralateral RRM was associated with early genetic diagnosis, participation in the screening study, and fewer prior cancers. Bilateral RRM uptake was associated with having had children, having breastfed, and high cancer worry. Conclusion: Uptake of contralateral RRM is high in women with LFS. The frequency of contralateral breast cancer necessitates active discussion of benefits of contralateral RRM and counseling regarding bilateral RRM should be tailored to the early age at risk of breast cancer onset in LFS. There is a need for research into the survival and long-term benefits of RRM in LFS.
MeSH term(s)	Breast Neoplasms/epidemiology ; Breast Neoplasms/genetics ; Breast Neoplasms/surgery ; Child ; Early Detection of Cancer ; Female ; Germ-Line Mutation ; Humans ; Li-Fraumeni Syndrome/epidemiology ; Li-Fraumeni Syndrome/genetics ; Mastectomy ; Unilateral Breast Neoplasms
Language	English
Publishing date	2021-10-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-021-06410-5
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Article ; Online: A major step forward for BRCA1/2-related cancer risk management.

Mai, Phuong L / Loud, Jennifer T / Greene, Mark H

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2014 Volume 32, Issue 15, Page(s) 1531–1533

MeSH term(s)	BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Fallopian Tube Neoplasms ; Female ; Humans ; Incidence ; Mutation ; Ovarian Neoplasms ; Ovariectomy/mortality
Chemical Substances	BRCA1 Protein ; BRCA1 protein, human ; BRCA2 Protein ; BRCA2 protein, human
Language	English
Publishing date	2014-05-20
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2013.54.8925
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article ; Online: Family Identity and Roles in the Context of Li-Fraumeni Syndrome: "No One's Like Us Mutants".

Wilsnack, Catherine / Young, Jennifer L / Merrill, Shana L / Groner, Victoria / Loud, Jennifer T / Bremer, Renee C / Greene, Mark H / Khincha, Payal P / Werner-Lin, Allison

Health & social work

2021 Volume 46, Issue 4, Page(s) 299–307

Abstract: Li-Fraumeni syndrome (LFS) is a rare hereditary cancer syndrome in which individuals have a significantly increased risk of developing multiple cancers throughout the life span. An LFS diagnosis may shift the individual's sense of self and tolerance of ... ...

Abstract	Li-Fraumeni syndrome (LFS) is a rare hereditary cancer syndrome in which individuals have a significantly increased risk of developing multiple cancers throughout the life span. An LFS diagnosis may shift the individual's sense of self and tolerance of cancer risk as they engage in cancer screening and cancer prevention activities. This study examined the impact of family identity on health decision making, communication, and role function. Forty-five families completed one or more interviews during an annual, protocol-specific cancer screening study. An interdisciplinary team analyzed 66 interviews using interpretive description and modified grounding theory. Thematically, identity emerged as an evolving construct regarding self and/or family, embedded in historical and ongoing experiences with LFS. Notions of individual and shared family identities guided decision making related to healthcare and influenced interpersonal communication and role function between supportive networks and families. Alignment between individual, family, and generational identities may shape engagement in genetic testing, risk management, and family life. Medical teams that are unequipped to address the psychosocial challenges that LFS populations face may include mental health professionals on interprofessional care teams to navigate risk management and consequential familial conflict.
MeSH term(s)	Early Detection of Cancer ; Health Personnel ; Humans ; Li-Fraumeni Syndrome/genetics ; Mass Screening
Language	English
Publishing date	2021-10-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	448861-1
ISSN	1545-6854 ; 0360-7283
ISSN (online)	1545-6854
ISSN	0360-7283
DOI	10.1093/hsw/hlab032
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Zs.A 1407: Show issues

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Article ; Online: Reproductive factors associated with breast cancer risk in Li-Fraumeni syndrome.

Khincha, Payal P / Best, Ana F / Fraumeni, Joseph F / Loud, Jennifer T / Savage, Sharon A / Achatz, Maria Isabel

European journal of cancer (Oxford, England : 1990)

2019 Volume 116, Page(s) 199–206

Abstract: Li-Fraumeni syndrome (LFS) is a rare autosomal dominant cancer predisposition syndrome with exceptionally high lifetime cancer risks, caused primarily by germline TP53 variants. Early-onset breast cancer is the most common cancer in women with LFS. ... ...

Abstract	Li-Fraumeni syndrome (LFS) is a rare autosomal dominant cancer predisposition syndrome with exceptionally high lifetime cancer risks, caused primarily by germline TP53 variants. Early-onset breast cancer is the most common cancer in women with LFS. Associations between female reproductive factors and breast cancer risk have been widely studied in the general population and BRCA1/2 mutation carriers but not in LFS. We evaluated whether reproductive factors are associated with breast cancer in LFS. Questionnaire data were collected for 152 women with confirmed germline TP53 variants enrolled in the National Cancer Institute's LFS study (NCT01443468); of which, 85 had breast cancer, confirmed by pathology/medical reports. Fisher's exact test and Cox proportional hazards were used to calculate the effect of reproductive factors on breast cancer risk. Lifetime breastfeeding for at least 7 months was associated with lower breast cancer risk (hazard ratio [HR] 0.57, p = 0.05). Parity did not independently change breast cancer risk (HR 1.08, p = 0.8) but suggested an increased risk with older age at first live birth (HR 2.14, p = 0.05). Age at menarche (HR 1.09, p = 0.24) and use of oral contraceptives (HR 0.88; p = 0.7) did not significantly affect breast cancer risk. In this first study of reproductive factors and breast cancer in women with LFS, breastfeeding was observed to be protective against breast cancer risk, especially with at least 7 months of lifetime breastfeeding. Older age at first live birth was suggested to slightly increase breast cancer risk. Larger prospective studies of reproductive factors are warranted in women with LFS before making definitive clinical recommendations.
MeSH term(s)	Adult ; Breast Feeding ; Breast Neoplasms/etiology ; Contraceptives, Oral, Hormonal/therapeutic use ; Female ; Humans ; Li-Fraumeni Syndrome/complications ; Menarche/physiology ; Middle Aged ; Parity/physiology ; Retrospective Studies ; Risk Factors ; Young Adult
Chemical Substances	Contraceptives, Oral, Hormonal
Language	English
Publishing date	2019-06-15
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Intramural
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2019.05.005
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Legacies and Relationships: Diverse Social Networks and BRCA1/2 Risk Management Decisions and Actions.

Ersig, Anne L / Werner-Lin, Allison / Hoskins, Lindsey / Young, Jennifer / Loud, Jennifer T / Peters, June / Greene, Mark H

Journal of family nursing

2018 Volume 25, Issue 1, Page(s) 28–53

Abstract: In families with hereditary breast/ovarian cancer, complex disease histories challenge established patterns of family communication and influence decision-making for clinical surveillance, genetic testing, and risk management. An interdisciplinary team ... ...

Abstract	In families with hereditary breast/ovarian cancer, complex disease histories challenge established patterns of family communication and influence decision-making for clinical surveillance, genetic testing, and risk management. An interdisciplinary team examined longitudinal interview data from women with identified BRCA1/2 mutations to assess interactions within family and social networks about risk information communication and management. We used interpretive description to identify motivation, content, and derived benefit of these interactions. Participants discussed risk information and management strategies with biological and nonbiological network members for multiple purposes: discharging responsibility for risk information dissemination, protecting important relationships, and navigating decision trajectories. Evolving interactions with loved ones balanced long-standing family communication patterns with differing personal preferences for privacy or open sharing, whereas interactions with nonbiological network members expanded participants' range of choices for sources of risk management information. Ongoing assessment of social networks may help support engagement with risk management by aligning with patient social needs.
MeSH term(s)	Adult ; BRCA1 Protein ; BRCA2 Protein/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/psychology ; Decision Making ; Family/psychology ; Female ; Genetic Predisposition to Disease ; Genetic Testing ; Humans ; Interviews as Topic ; Middle Aged ; Mutation ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/psychology ; Pedigree ; Risk Management ; Social Networking
Chemical Substances	BRCA1 Protein ; BRCA1 protein, human ; BRCA2 Protein ; BRCA2 protein, human
Language	English
Publishing date	2018-12-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2070209-7
ISSN	1552-549X ; 1074-8407
ISSN (online)	1552-549X
ISSN	1074-8407
DOI	10.1177/1074840718815844
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Article ; Online: Prospectively Identified Incident Testicular Cancer Risk in a Familial Testicular Cancer Cohort.

Pathak, Anand / Adams, Charleen D / Loud, Jennifer T / Nichols, Kathryn / Stewart, Douglas R / Greene, Mark H

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2015 Volume 24, Issue 10, Page(s) 1614–1621

Abstract: Background: Human testicular germ cell tumors (TGCT) have a strong genetic component and a high familial relative risk. However, linkage analyses have not identified a rare, highly penetrant familial TGCT (FTGCT) susceptibility locus. Currently, ... ...

Abstract	Background: Human testicular germ cell tumors (TGCT) have a strong genetic component and a high familial relative risk. However, linkage analyses have not identified a rare, highly penetrant familial TGCT (FTGCT) susceptibility locus. Currently, multiple low-penetrance genes are hypothesized to underlie the familial multiple-case phenotype. The observation that two is the most common number of affected individuals per family presents an impediment to FTGCT gene discovery. Clinically, the prospective TGCT risk in the multiple-case family context is unknown. Methods: We performed a prospective analysis of TGCT incidence in a cohort of multiple-affected-person families and sporadic-bilateral-case families; 1,260 men from 140 families (10,207 person-years of follow-up) met our inclusion criteria. Age-, gender-, and calendar time-specific standardized incidence ratios (SIR) for TGCT relative to the general population were calculated using SEERStat. Results:* Eight incident TGCTs occurred during prospective FTGCT cohort follow-up (versus 0.67 expected; SIR = 11.9; 95% CI, 5.1-23.4; excess absolute risk = 7.2/10,000). We demonstrate that the incidence rate of TGCT is greater among bloodline male relatives from multiple-case testicular cancer families than that expected in the general population, a pattern characteristic of adult-onset Mendelian cancer susceptibility disorders. Two of these incident TGCTs occurred in relatives of sporadic-bilateral cases (0.15 expected; SIR = 13.4; 95% CI, 1.6-48.6). Conclusions: Our data are the first to indicate that despite relatively low numbers of affected individuals per family, members of both multiple-affected-person FTGCT families and sporadic-bilateral TGCT families comprise high-risk groups for incident testicular cancer. Impact: Men at high TGCT risk might benefit from tailored risk stratification and surveillance strategies.
MeSH term(s)	Adult ; Family ; Follow-Up Studies ; Genetic Predisposition to Disease ; Humans ; Incidence ; Male ; Maryland/epidemiology ; Neoplasms, Germ Cell and Embryonal/epidemiology ; Neoplasms, Germ Cell and Embryonal/genetics ; Phenotype ; Prospective Studies ; Risk Assessment/methods ; Risk Factors ; SEER Program ; Testicular Neoplasms/epidemiology ; Testicular Neoplasms/genetics
Language	English
Publishing date	2015-08-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-14-1240
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