LIVIVO - Search results -

Search results

Result 1 - 10 of total 41

Search options

Article: Intra-articular delivery of full-length antibodies through the use of an in situ forming depot

Fayd'herbe De Maudave, Alexis / Leconet, Wilhem / Toupet, Karine / Constantinides, Michael / Bossis, Guillaume / de Toledo, Marion / Vialaret, Jérôme / Hirtz, Christophe / Lopez-Noriega, Adolfo / Jorgensen, Christian / Noël, Daniele / Louis-Plence, Pascale / Grizot, Sylvestre / Villalba, Martin

Journal of controlled release. 2022 Jan., v. 341

2022

Abstract: Monoclonal antibodies (mAbs) are large size molecules that have demonstrated high therapeutic potential for the treatment of cancer or autoimmune diseases. Despite some excellent results, their intravenous administration results in high plasma ... ...

Abstract	Monoclonal antibodies (mAbs) are large size molecules that have demonstrated high therapeutic potential for the treatment of cancer or autoimmune diseases. Despite some excellent results, their intravenous administration results in high plasma concentration. This triggers off-target effects and sometimes poor targeted tissue distribution. To circumvent this issue, we investigated a local controlled-delivery approach using an in situ forming depot technology. Two clinically relevant mAbs, rituximab (RTX) and daratumumab (DARA), were formulated using an injectable technology based on biodegradable PEG-PLA copolymers. The stability and controlled release features of the formulations were investigated. HPLC and mass spectrometry revealed the preservation of the protein structure. In vitro binding of formulated antibodies to their target antigens and to their cellular FcγRIIIa natural killer cell receptor was fully maintained. Furthermore, encapsulated RTX was as efficient as classical intravenous RTX treatment to inhibit the in vivo tumor growth of malignant human B cells in immunodeficient NSG mice. Finally, the intra-articular administration of the formulated mAbs yielded a sustained local release associated with a lower plasma concentration compared to the intra-articular delivery of non-encapsulated mAbs. Our results demonstrate that the utilization of this polymeric technology is a reliable alternative for the local delivery of fully functional clinically relevant mAbs.
Keywords	biodegradability ; composite polymers ; humans ; intravenous injection ; mass spectrometry ; natural killer cells ; neoplasms ; protein structure ; tissue distribution
Language	English
Dates of publication	2022-01
Size	p. 578-590.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2021.12.010
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2055: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Arthritis sensory and motor scale: predicting functional deficits from the clinical score in collagen-induced arthritis.

Mausset-Bonnefont, Anne-Laure / Cren, Maïlys / Vicente, Rita / Quentin, Julie / Jorgensen, Christian / Apparailly, Florence / Louis-Plence, Pascale

Arthritis research & therapy

2019 Volume 21, Issue 1, Page(s) 264

Abstract: Background: In the collagen-induced arthritis (CIA) mouse model, inflammation readouts are usually quantified using operator-dependent clinical scoring systems, and no systematic relationship with functional deficits has been detected. In this study, we ...

Abstract	Background: In the collagen-induced arthritis (CIA) mouse model, inflammation readouts are usually quantified using operator-dependent clinical scoring systems, and no systematic relationship with functional deficits has been detected. In this study, we extensively quantified sensory and motor deficits in CIA mice during natural disease progression and therapeutic treatment. Then, we used these data to build a scale to predict functional deficits on the basis of the classical clinical score. Methods: Using the CIA mouse model, we longitudinally screened multiple approaches to assess locomotion (open field test, Catwalk™), sensitivity (Von Frey, Hargreaves, static weight-bearing tests), and inflammation (skin temperature), and identified the most accurate tests to correlate sensory and motor deficits with disease severity, measured by clinical score. We then used these tests to characterize functional deficits in control (naïve and mice injected with complete Freund's adjuvant) and CIA mice, either untreated or treated with methotrexate to prevent functional deficits. By mathematical approaches, we finally investigated the relationship between functional deficits and clinical score. Results: We found that the functional disability scores obtained with the open field, Catwalk™, Hargreaves, and skin temperature tests significantly correlated with the clinical score in CIA mice, either untreated or treated with methotrexate. Mathematical correlation showed that motor deficits, robustly characterized by two different tests, were twice more responsive than thermal sensitivity deficits. Conclusion: We propose the arthritis sensory and motor (ArthriSM) scale as a new theranostic tool to predict motor and sensory deficit based on the clinical score, in the experimental mouse model of CIA. This ArthriSM scale may facilitate the transfer of knowledge between preclinical and clinical studies.
MeSH term(s)	Animals ; Antirheumatic Agents/pharmacology ; Arthritis, Experimental/complications ; Arthritis, Rheumatoid/complications ; Inflammation/etiology ; Locomotion/physiology ; Male ; Methotrexate/pharmacology ; Mice ; Pain/etiology ; Skin Temperature
Chemical Substances	Antirheumatic Agents ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2019-12-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-019-2047-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5490: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cellular senescence impact on immune cell fate and function.

Vicente, Rita / Mausset-Bonnefont, Anne-Laure / Jorgensen, Christian / Louis-Plence, Pascale / Brondello, Jean-Marc

Aging cell

2016 Volume 15, Issue 3, Page(s) 400–406

Abstract: Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and specialized cells from various tissues of all ages, in vitro and in vivo. Here, we review recent findings on the role of cellular senescence in immune cell fate ...

Abstract	Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and specialized cells from various tissues of all ages, in vitro and in vivo. Here, we review recent findings on the role of cellular senescence in immune cell fate decisions in macrophage polarization, natural killer cell phenotype, and following T-lymphocyte activation. We also introduce the involvement of the onset of cellular senescence in some immune responses including T-helper lymphocyte-dependent tissue homeostatic functions and T-regulatory cell-dependent suppressive mechanisms. Altogether, these data propose that cellular senescence plays a wide-reaching role as a homeostatic orchestrator.
MeSH term(s)	Cell Lineage ; Cellular Senescence ; Homeostasis/immunology ; Humans ; Immunity ; Lymphocytes/cytology
Language	English
Publishing date	2016-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2113083-8
ISSN	1474-9726 ; 1474-9718
ISSN (online)	1474-9726
ISSN	1474-9718
DOI	10.1111/acel.12455
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.A 6581: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Differential Accumulation and Activation of Monocyte and Dendritic Cell Subsets in Inflamed Synovial Fluid Discriminates Between Juvenile Idiopathic Arthritis and Septic Arthritis.

Cren, Maïlys / Nziza, Nadège / Carbasse, Aurélia / Mahe, Perrine / Dufourcq-Lopez, Emilie / Delpont, Marion / Chevassus, Hugues / Khalil, Mirna / Mura, Thibault / Duroux-Richard, Isabelle / Apparailly, Florence / Jeziorski, Eric / Louis-Plence, Pascale

Frontiers in immunology

2020 Volume 11, Page(s) 1716

Abstract: Despite their distinct etiology, several lines of evidence suggest that innate immunity plays a pivotal role in both juvenile idiopathic arthritis (JIA) and septic arthritis (SA) pathophysiology. Indeed, monocytes and dendritic cells (DC) are involved in ...

Abstract	Despite their distinct etiology, several lines of evidence suggest that innate immunity plays a pivotal role in both juvenile idiopathic arthritis (JIA) and septic arthritis (SA) pathophysiology. Indeed, monocytes and dendritic cells (DC) are involved in the first line of defense against pathogens and play a critical role in initiating and orchestrating the immune response. The aim of this study was to compare the number and phenotype of monocytes and DCs in peripheral blood (PB) and synovial fluid (SF) from patients with JIA and SA to identify specific cell subsets and activation markers associated with pathophysiological mechanisms and that could be used as biomarkers to discriminate both diseases. The proportion of intermediate and non-classical monocytes in the SF and PB, respectively, were significantly higher in JIA than in SA patients. In contrast the proportion of classical monocytes and their absolute numbers were higher in the SF from SA compared with JIA patients. Higher expression of CD64 on non-classical monocyte was observed in PB from SA compared with JIA patients. In SF, higher expression of CD64 on classical and intermediate monocyte as well as higher CD163 expression on intermediate monocytes was observed in SA compared with JIA patients. Moreover, whereas the number of conventional (cDC), plasmacytoid (pDC) and inflammatory (infDC) DCs was comparable between groups in PB, the number of CD141
MeSH term(s)	Adolescent ; Arthritis, Infectious/immunology ; Arthritis, Juvenile/immunology ; Biomarkers/analysis ; Child ; Child, Preschool ; Dendritic Cells/immunology ; Female ; Humans ; Immunophenotyping ; Infant ; Male ; Monocytes/immunology ; Synovial Fluid/immunology
Chemical Substances	Biomarkers
Language	English
Publishing date	2020-07-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.01716
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Intra-articular delivery of full-length antibodies through the use of an in situ forming depot.

Journal of controlled release : official journal of the Controlled Release Society

2021 Volume 341, Page(s) 578–590

Abstract	Monoclonal antibodies (mAbs) are large size molecules that have demonstrated high therapeutic potential for the treatment of cancer or autoimmune diseases. Despite some excellent results, their intravenous administration results in high plasma concentration. This triggers off-target effects and sometimes poor targeted tissue distribution. To circumvent this issue, we investigated a local controlled-delivery approach using an in situ forming depot technology. Two clinically relevant mAbs, rituximab (RTX) and daratumumab (DARA), were formulated using an injectable technology based on biodegradable PEG-PLA copolymers. The stability and controlled release features of the formulations were investigated. HPLC and mass spectrometry revealed the preservation of the protein structure. In vitro binding of formulated antibodies to their target antigens and to their cellular FcγRIIIa natural killer cell receptor was fully maintained. Furthermore, encapsulated RTX was as efficient as classical intravenous RTX treatment to inhibit the in vivo tumor growth of malignant human B cells in immunodeficient NSG mice. Finally, the intra-articular administration of the formulated mAbs yielded a sustained local release associated with a lower plasma concentration compared to the intra-articular delivery of non-encapsulated mAbs. Our results demonstrate that the utilization of this polymeric technology is a reliable alternative for the local delivery of fully functional clinically relevant mAbs.
MeSH term(s)	Animals ; Delayed-Action Preparations/chemistry ; Mice ; Polymers/chemistry
Chemical Substances	Delayed-Action Preparations ; Polymers
Language	English
Publishing date	2021-12-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2021.12.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2055: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Nonclassical CD4+CD49b+ Regulatory T Cells as a Better Alternative to Conventional CD4+CD25+ T Cells To Dampen Arthritis Severity.

Vicente, Rita / Quentin, Julie / Mausset-Bonnefont, Anne-Laure / Chuchana, Paul / Martire, Delphine / Cren, Maïlys / Jorgensen, Christian / Louis-Plence, Pascale

Journal of immunology (Baltimore, Md. : 1950)

2016 Volume 196, Issue 1, Page(s) 298–309

Abstract: Promising immunotherapeutic strategies are emerging to restore tolerance in autoimmune diseases by triggering an increase in the number and/or the function of endogenous regulatory T (Treg) cells, which actively control pathological immune responses. ... ...

Abstract	Promising immunotherapeutic strategies are emerging to restore tolerance in autoimmune diseases by triggering an increase in the number and/or the function of endogenous regulatory T (Treg) cells, which actively control pathological immune responses. Evidence suggests a remarkable heterogeneity in peripheral Treg cells that warrants their better characterization in terms of phenotype and suppressive function, to determine which subset may be optimally suitable for a given clinical situation. We found that repetitive injections of immature dendritic cells expanded Foxp3-negative CD49b(+) Treg cells that displayed an effector memory phenotype. These expanded Treg cells were isolated ex vivo for transcriptome analysis and found to contain multiple transcripts of the canonical Treg signature shared mainly by CD25(+) but also by other subphenotypes. We characterized the CD49b(+) Treg cell phenotype, underscoring its similarities with the CD25(+) Treg cell phenotype and highlighting some differential expression patterns for several markers, including lymphocyte activation gene 3, KLRG1, CD103, ICOS, CTLA-4, and granzyme B. Comparison of the CD25(+) and CD49b(+) Treg cells' suppressive mechanisms, in vitro and in vivo, revealed the latter's potent suppressive activity, which was partly dependent on IL-10 secretion. Altogether, our results strongly suggest that expression of several canonical Treg cell markers and suppressive function could be Foxp3 independent, and underscore the therapeutic potential of IL-10-secreting CD49b(+) Treg cells in arthritis.
MeSH term(s)	Adoptive Transfer ; Animals ; Antigens, CD/metabolism ; Arthritis/immunology ; Arthritis/therapy ; CD4 Antigens/metabolism ; CTLA-4 Antigen/metabolism ; Dendritic Cells/immunology ; Dendritic Cells/transplantation ; Gene Expression Profiling ; Granzymes/metabolism ; Immunologic Memory/immunology ; Immunotherapy/methods ; Inducible T-Cell Co-Stimulator Protein/metabolism ; Integrin alpha Chains/metabolism ; Integrin alpha2/metabolism ; Interleukin-10/secretion ; Interleukin-2 Receptor alpha Subunit/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Mice, Knockout ; Receptors, Immunologic/metabolism ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/transplantation
Chemical Substances	Antigens, CD ; CD223 antigen ; CD4 Antigens ; CTLA-4 Antigen ; IL10 protein, mouse ; Icos protein, mouse ; Inducible T-Cell Co-Stimulator Protein ; Integrin alpha Chains ; Integrin alpha2 ; Interleukin-2 Receptor alpha Subunit ; Klrg1 protein, mouse ; Receptors, Immunologic ; alpha E integrins ; Interleukin-10 (130068-27-8) ; Granzymes (EC 3.4.21.-)
Language	English
Publishing date	2016-01-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1501069
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Injection of Adipose-Derived Stromal Cells in the Knee of Patients with Severe Osteoarthritis has a Systemic Effect and Promotes an Anti-Inflammatory Phenotype of Circulating Immune Cells.

Pers, Yves-Marie / Quentin, Julie / Feirreira, Rosanna / Espinoza, Francisco / Abdellaoui, Naoill / Erkilic, Nejla / Cren, Maïlys / Dufourcq-Lopez, Emilie / Pullig, Oliver / Nöth, Ulrich / Jorgensen, Christian / Louis-Plence, Pascale

Theranostics

2018 Volume 8, Issue 20, Page(s) 5519–5528

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Adipose Tissue/cytology ; Flow Cytometry ; Humans ; Knee Joint/cytology ; Knee Joint/immunology ; Mesenchymal Stem Cells/cytology ; Osteoarthritis, Knee/immunology ; Osteoarthritis, Knee/therapy ; Prospective Studies ; Stromal Cells/cytology
Language	English
Publishing date	2018-11-05
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.27674
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Systemic LPS Translocation Activates Cross-Presenting Dendritic Cells but Is Dispensable for the Breakdown of CD8+ T Cell Peripheral Tolerance in Irradiated Mice.

Espinosa-Carrasco, Gabriel / Villard, Marine / Le Saout, Cecile / Louis-Plence, Pascale / Vicente, Rita / Hernandez, Javier

PloS one

2015 Volume 10, Issue 6, Page(s) e0130041

Abstract: Lymphodepletion is currently used to enhance the efficacy of cytotoxic T lymphocyte adoptive transfer immunotherapy against cancer. This beneficial effect of conditioning regimens is due, at least in part, to promoting the breakdown of peripheral CD8+ T ... ...

Abstract	Lymphodepletion is currently used to enhance the efficacy of cytotoxic T lymphocyte adoptive transfer immunotherapy against cancer. This beneficial effect of conditioning regimens is due, at least in part, to promoting the breakdown of peripheral CD8+ T cell tolerance. Lymphodepletion by total body irradiation induces systemic translocation of commensal bacteria LPS from the gastrointestinal tract. Since LPS is a potent activator of the innate immune system, including antigen presenting dendritic cells, we hypothesized that LPS translocation could be required for the breakdown of peripheral tolerance observed in irradiated mice. To address this issue, we have treated irradiated mice with antibiotics in order to prevent LPS translocation and utilized them in T cell adoptive transfer experiments. Surprisingly, we found that despite of completely blocking LPS translocation into the bloodstream, antibiotic treatment did not prevent the breakdown of peripheral tolerance. Although irradiation induced the activation of cross-presenting CD8+ dendritic cells in the lymphoid tissue, LPS could not solely account for this effect. Activation of dendritic cells by mechanisms other than LPS translocation is sufficient to promote the differentiation of potentially autoreactive CD8+ T cells into effectors in irradiated mice. Our data indicate that LPS translocation is dispensable for the breakdown of CD8+ T cell tolerance in irradiated mice.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cross-Priming ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Flow Cytometry ; Immune Tolerance/drug effects ; Immune Tolerance/immunology ; Lipopolysaccharides/pharmacology ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Peripheral Tolerance/immunology ; T-Lymphocytes, Cytotoxic/drug effects ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism
Chemical Substances	Anti-Bacterial Agents ; Lipopolysaccharides
Language	English
Publishing date	2015-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0130041
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Polyoxidonium

Alexia, Catherine / Cren, Mailys / Louis-Plence, Pascale / Vo, Dang-Nghiem / El Ahmadi, Yasamine / Dufourcq-Lopez, Emilie / Lu, Zhao-Yang / Hernandez, Javier / Shamilov, Farkhad / Chernysheva, Olga / Vasilieva, M / Vorotnikov, I / Vishnevskay, Yana / Tupitsyn, Nikolay / Rossi, Jean-François / Villalba, Martin

Frontiers in immunology

2019 Volume 10, Page(s) 2693

Abstract: Immunotherapy, which is seen as a major tool for cancer treatment, requires, in some cases, the presence of several agents to maximize its effects. Adjuvants can enhance the effect of other agents. However, despite their long-time use, only a few ... ...

Abstract	Immunotherapy, which is seen as a major tool for cancer treatment, requires, in some cases, the presence of several agents to maximize its effects. Adjuvants can enhance the effect of other agents. However, despite their long-time use, only a few adjuvants are licensed today, and their use in cancer treatment is rare. Azoximer bromide, marketed under the trade name Polyoxidonium® (PO), is a copolymer of N-oxidized 1,4-ethylenepiperazine and (N-carboxyethyl)-1,4-ethylene piperazinium bromide. It has been described as an immune adjuvant and immunomodulator that is clinically used with excellent tolerance. PO is used in the treatment and prophylaxis of diseases connected with damage to the immune system, and there is interest in testing it in antitumor therapy. We show here that PO treatment for 1 week induced positive pathological changes in 6 out of 20 patients with breast cancer, including complete response in a triple-negative patient. This correlated with an increased tumor CD4
MeSH term(s)	Adenocarcinoma/drug therapy ; Adenocarcinoma/immunology ; Adjuvants, Immunologic/therapeutic use ; Adult ; Aged ; Breast Neoplasms/drug therapy ; Breast Neoplasms/immunology ; Cell Differentiation/drug effects ; Cell Differentiation/immunology ; Chemotherapy, Adjuvant/methods ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Female ; Humans ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Lymphocyte Activation/drug effects ; Lymphocyte Activation/immunology ; Lymphocytes, Tumor-Infiltrating/drug effects ; Lymphocytes, Tumor-Infiltrating/immunology ; Middle Aged ; Neoadjuvant Therapy/methods ; Piperazines/therapeutic use ; Polymers/therapeutic use ; T-Lymphocytes, Cytotoxic/drug effects ; T-Lymphocytes, Cytotoxic/immunology
Chemical Substances	Adjuvants, Immunologic ; Piperazines ; Polymers ; Polyoxidonium
Language	English
Publishing date	2019-11-28
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.02693
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Inducible Treg cell populations as cell based-therapy for rheumatoid arthritis

Martire Delphine / Quentin Julie / Mausset-Bonnefont Anne-Laure / Asnagli Hélène / Belmonte Nathalie / Foussat Arnaud / Jorgensen Christian / Louis-Plence Pascale

Journal of Translational Medicine, Vol 10, Iss Suppl 3, p P

2012 Volume 55

Keywords	Medicine ; R
Language	English
Publishing date	2012-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED