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Article ; Online: Microwave ablation of a solitary colorectal liver metastasis complicated by stomach perforation and gastrocutaneous fistula - a case report.

Symeonidis, S / Giankoulof, C / Christidis, P / Anestiadou, E / Loutzidou, L / Bitsianis, S / Ioannidis, O / Tsalis, K / Angelopoulos, S / Petsatodis, E

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti

2022 Volume 35, Issue 4, Page(s) 323–327

Abstract: Background: Organ perforation secondary to thermal ablation is a rare but severe complication that can occur in certain patients, in whom tissue dissection and preservation cannot be adequately achieved.: Case description: A 69-year-old man presented ...

Title translation	Mikrovlnná ablace solitární jaterní metastázy kolorektálního karcinomu komplikované perforací žaludku a gastrokutánní píštělí - kazuistika.
Abstract	Background: Organ perforation secondary to thermal ablation is a rare but severe complication that can occur in certain patients, in whom tissue dissection and preservation cannot be adequately achieved. Case description: A 69-year-old man presented with a gastrocutaneous fistula 20 days after a microwave ablation of liver metastases from colorectal cancer. Besides skin rash, local tenderness, and gastric content discharge from a wound where the probe had been placed, no other signs or symptoms were present. The patient was treated surgically, and a wedge-shaped gastric resection was performed. His postoperative course was uneventful. After 8 months, the patient underwent the same procedure for local progression of the same lesion, using a pulsed MW antenna and a dedicated hydrodissection needle, without complications. Conclusions: A gastrocutaneous fistula is a rare complication of microwave ablation. However, adequate hydrodissection can minimize the risk for the development of these complications. Proper treatment of these complications does not preclude repeated usage of microwave ablation in the future.
MeSH term(s)	Aged ; Colorectal Neoplasms/complications ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Gastric Fistula/etiology ; Gastric Fistula/surgery ; Humans ; Liver Neoplasms/therapy ; Male ; Microwaves/adverse effects ; Stomach/pathology ; Treatment Outcome
Language	English
Publishing date	2022-06-23
Publishing country	Czech Republic
Document type	Case Reports ; Journal Article
ZDB-ID	1217739-8
ISSN	1802-5307 ; 0862-495X
ISSN (online)	1802-5307
ISSN	0862-495X
DOI	10.48095/ccko2022323
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Article: Amyand's Hernia as a Random Finding in Acute Abdominal Pain and the Role of Thorough Investigation: a Case Report.

Tsalis, Konstantinos / Symeonidis, Savvas / Anestiadou, Elissavet / Bitsianis, Stefanos / Christidis, Panagiotis / Loutzidou, Lydia / Ouzounidis, Nikolaos / Kotidis, Efstathios / Gemousakakis, Georgios / Angelopoulos, Stamatios

Maedica

2022 Volume 17, Issue 3, Page(s) 720–725

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2022-12-20
Publishing country	Romania
Document type	Editorial
ZDB-ID	2399972-X
ISSN	2069-6116 ; 1841-9038
ISSN (online)	2069-6116
ISSN	1841-9038
DOI	10.26574/maedica.2022.17.3.720
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Article: Abdominal Wall Defect Reconstruction with Use of Biological Mesh and Negative Pressure Wound Therapy: a Case Report.

Symeonidis, Savvas / Anestiadou, Elissavet / Bitsianis, Stefanos / Gemousakakis, Georgios / Ntampakis, Georgios / Loutzidou, Lydia / Ouzounidis, Nikolaos / Kotidis, Efstathios / Mantzoros, Ioannis / Angelopoulos, Stamatios

Maedica

2022 Volume 17, Issue 2, Page(s) 518–523

Abstract: Objectives: ...

Abstract	Objectives:
Language	English
Publishing date	2022-07-11
Publishing country	Romania
Document type	Editorial
ZDB-ID	2399972-X
ISSN	2069-6116 ; 1841-9038
ISSN (online)	2069-6116
ISSN	1841-9038
DOI	10.26574/maedica.2022.17.2.518
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Article ; Online: A rare case of gastroesophageal adenocarcinoma in a 24-year-old male with achalasia complicated by postoperative aortoesophageal fistula due to stent placement and early local recurrence.

Ioannidis, O / Malliora, A / Mantzoros, I / Loutzidou, L / Pramateftakis, M G / Kotidis, E / Ouzounidis, N / Foutsitzis, V / Angelopoulos, S / Tsalis, K

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti

2021 Volume 34, Issue 4, Page(s) 309–312

Abstract: Background: Esophageal cancer is the 8th most common and 6th most deadly malignancy worldwide. It is an aggressive type of cancer with poor prognosis, despite advances in therapeutic methods including those in thoracoabdominal surgery, chemotherapy and ... ...

Title translation	Vzácný případ gastroezofageálního karcinomu v 24letého muže s achalázií komplikovanou pooperpační aortoezofageální píštělí v důsledku zavedení stentu a časné lokální rekurence.
Abstract	Background: Esophageal cancer is the 8th most common and 6th most deadly malignancy worldwide. It is an aggressive type of cancer with poor prognosis, despite advances in therapeutic methods including those in thoracoabdominal surgery, chemotherapy and radiotherapy. It rarely manifests in young patients, but occurs frequently in older people. It has been related with achalasia regarding mainly the squamous cell carcinoma rather than the adenocarcinoma. Infiltrating esophageal tumors and radiotherapy can lead to the development of aortoesophageal fistula, a pathological communication between the aorta and the esophagus. Case: We present the case of a 24-year-old male patient with a known history of achalasia for almost 15 years with a history of heavy smoking and drinking that presented with advanced lower esophageal adenocarcinoma. The patient was submitted, as per to his will, directly to Ivor Lewis esophagogastrectomy. One month later, dysphagia was manifested due to stenosis of the anastomosis, without any signs of local recurrence, and an esophageal metallic stent was placed. In the 3rd postoperative month, upper gastrointestinal bleeding presented due to an aortoesophageal fistula, caused by anastomotic dehiscence due to local recurrence and pressure from the stent, which was treated surgically. The patient, refusing chemotherapy at all stages, developed peritoneal carcinomatosis and died 6 months after surgery. Conclusion: Esophageal cancer is an aggressive type of cancer with a poor prognosis that is typically dia-gnosed in advanced stages. Despite the development of new therapeutic approaches, the high recurrence rate and the poor prognosis remain.
MeSH term(s)	Adenocarcinoma/etiology ; Adenocarcinoma/surgery ; Anastomosis, Surgical/adverse effects ; Esophageal Achalasia/etiology ; Esophageal Fistula/etiology ; Esophageal Neoplasms/etiology ; Esophageal Neoplasms/surgery ; Esophagectomy/adverse effects ; Esophagectomy/methods ; Gastrointestinal Hemorrhage/etiology ; Humans ; Male ; Stents/adverse effects ; Young Adult
Language	English
Publishing date	2021-10-14
Publishing country	Czech Republic
Document type	Case Reports ; Journal Article
ZDB-ID	1217739-8
ISSN	1802-5307 ; 0862-495X
ISSN (online)	1802-5307
ISSN	0862-495X
DOI	10.48095/ccko2021309
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Article ; Online: Two case reports of mesenteric and retroperitoneal actinomycosis and a narrative review of the relevant literature.

Ioannidis, Orestis / Symeonidis, Savvas / Ouzounidis, Nikolaos / Foutsitzis, Vasilis / Anestiadou, Elissavet / Christidis, Panagiotis / Loutzidou, Lydia / Fesatidou, Vasiliki / Kerasidou, Ourania / Tsalis, Konstantinos / Aggelopoulos, Stamatios

Medicine and pharmacy reports

2023 Volume 96, Issue 4, Page(s) 441–446

Abstract: Introduction: Actinomycosis is an uncommon subacute or chronic suppurative bacterial granulomatous infectious disease with clinical heterogeneity. The majority of actinomycosis cases were of extra-abdominal origin, with oro-cervico-facial cases ... ...

Abstract	Introduction: Actinomycosis is an uncommon subacute or chronic suppurative bacterial granulomatous infectious disease with clinical heterogeneity. The majority of actinomycosis cases were of extra-abdominal origin, with oro-cervico-facial cases representing 55%, abdominopelvic representing 20%, and thoracic representing 15% of total reports. Currently, abdominal actinomycosis incidence is approximately 1 case per 119,000 people, being found three times more frequently among males. We report two rare clinical presentations of abdominal actinomycosis affecting the mesentery and the retroperitoneum, respectively. Case report 1: A 58-year-old Caucasian male presented to our clinic with abdominal pain in the right upper quadrant. Pre-operative evaluation, although inconclusive, showed a mesocolic mass infiltrating the right and transverse colon. The patient underwent exploratory laparotomy. After partial resection of the mass, the histopathology report demonstrated mesenteric actinomycosis. Case report 2: A 40-year-old Caucasian male presented to our clinic complaining about a mucopurulent material from an orifice at the right inguinal region. After appropriate work-up, a large abdominopelvic, stellate mass (75 x 22.8 mm) in the retroperitoneum was revealed. Surgery along with the appropriate antibiotics was used to treat the patient. Conclusion: Preoperative suspicion and diagnosis of actinomycosis are very challenging, with a high rate of misdiagnosis often resulting in delayed treatment. Our case reports highlight that abdominal actinomycosis should always be part of differential diagnosis, especially when there is involvement of multiple organs. The gold standard treatment of actinomycosis is surgical excision with prolonged antibiotic treatment.
Language	English
Publishing date	2023-10-26
Publishing country	Romania
Document type	Case Reports
ZDB-ID	2974425-8
ISSN	2668-0572 ; 2602-0807
ISSN (online)	2668-0572
ISSN	2602-0807
DOI	10.15386/mpr-2073
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Article ; Online: Giant Adrenocortical Carcinoma: A Case Report and Review of the Relevant Literature.

Mantzoros, Ioannis / Bitsianis, Stefanos / Loutzidou, Lydia / Ntampakis, Georgios / Chatzakis, Christos / Christidis, Panagiotis / Gkiouliava, Anna / Koraki, Eleni / Aggelopoulos, Stamatios

The American journal of case reports

2021 Volume 22, Page(s) e928875

Abstract: BACKGROUND Adrenocortical carcinomas are rare and aggressive tumors often diagnosed as incidentalomas. The malignancy can present with abnormal hormone secretion or the tumor may be non-functioning and present as a palpable mass causing discomfort. Here, ...

Abstract	BACKGROUND Adrenocortical carcinomas are rare and aggressive tumors often diagnosed as incidentalomas. The malignancy can present with abnormal hormone secretion or the tumor may be non-functioning and present as a palpable mass causing discomfort. Here, we present a case of an adrenal cortical carcinoma originally identified as an incidentaloma. CASE REPORT A 63-year-old woman presented with abdominal pain and discomfort. A large abdominal mass, occupying the left upper and lower quadrant, was palpated. Imaging revealed a mass occupying the left abdomen between the stomach and the spleen, applying pressure on the pylorus, duodenum, splenic vessels, and pancreas. The mass size was 21.2×13×14.6 cm. Hormonal investigations were normal. Surgical exploration was performed, and the tumor was excised. Pathological analysis revealed an adrenocortical carcinoma and the patient underwent adjuvant chemotherapy. Twelve months later, the carcinoma recurred. The patient underwent a second operation in which the recurrent mass was excised along with the tail of the pancreas and a small part of the left lobe of the liver. The postoperative period was uneventful, and the patient was discharged home on the 7th postoperative day. No further adjuvant therapy was applied. The patient remains disease-free 18 months after the reoperation. CONCLUSIONS Giant adrenocortical carcinomas, although rare, pose a challenge to the surgical team both diagnostically and therapeutically. Surgical excision with the appropriate oncologic support can guarantee excellent outcomes.
MeSH term(s)	Adrenal Cortex Neoplasms/diagnostic imaging ; Adrenal Cortex Neoplasms/surgery ; Adrenocortical Carcinoma/diagnostic imaging ; Adrenocortical Carcinoma/surgery ; Combined Modality Therapy ; Female ; Humans ; Liver ; Middle Aged ; Neoplasm Recurrence, Local
Language	English
Publishing date	2021-04-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.928875
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Article ; Online: The feasibility and effect of intraperitoneal administration of regorafenib on peritoneal carcinomatosis from colorectal cancer in the rat.

Bitsianis, Stefanos / Mantzoros, Ioannis / Gkiouliava, Anna / Chatzakis, Christos / Bekiari, Chryssa / Loutzidou, Lydia / Ntampakis, Georgios / Christidis, Panagiotis / Domvri, Kalliopi / Porpodis, Konstantinos / Ioannidis, Orestis / Aggelopoulos, Stamatios

Annali italiani di chirurgia

2022 Volume 93, Page(s) 592–598

Abstract: Aim: Our goal was to investigate the potential use and efficacy of regorafenib for IPEC in an animal model of colorectal derived peritoneal metastases. Twenty four male rats were included. Carcinogenesis was induced in all rats through intraperitoneal ... ...

Abstract	Aim: Our goal was to investigate the potential use and efficacy of regorafenib for IPEC in an animal model of colorectal derived peritoneal metastases. Twenty four male rats were included. Carcinogenesis was induced in all rats through intraperitoneal injection of cancer. Material and methods: Cells at T0. At T1(Day 28) they were randomly allocated 1:1:1:1 into 4 groups and underwent median laparotomy and the corresponding intervention. Specifically, Group A: no other intervention; Group B: cytoreductive surgery; Group C: intraperitoneal chemotherapy with regorafenib; and Group D: cytoreductive surgery and intraperitoneal chemotherapy with regorafenib. At T2 (Day 56) rats were euthanized and laparotomy was performed for further investigation. The primary outcome was the experimental Peritoneal Cancer Index (ePCI) at T2. Secondary outcomes include relative change of body weight between T1 and T2, weight of the ascites, anastomotic leak/peritonitis and death. Results: The ePCI was significantly lower in Group D as opposed to all other groups. Comparing Group C versus Group A we found a trend towards lesser tumor progression, but no significant difference. Growth of rats in Group D was significantly least affected compared to all other groups. Animals undergoing CRS in Group B developed less ascites than Group A and C. Less ascites was found in Group D compared to Group A and C. Conclusions: Intraperitoneal chemotherapy with regorafenib combined with cytoreductive surgery may impair metastases' progression. Key words: Regorafenib, Chemotherapy, Cytoreductive surgery, Colorectal cancer, Intraperitoneal injection.
MeSH term(s)	Animals ; Antineoplastic Combined Chemotherapy Protocols ; Ascites ; Colorectal Neoplasms/pathology ; Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Feasibility Studies ; Hyperthermia, Induced ; Injections, Intraperitoneal ; Male ; Peritoneal Neoplasms/pathology ; Phenylurea Compounds ; Pyridines ; Rats ; Survival Rate
Chemical Substances	Phenylurea Compounds ; Pyridines ; regorafenib (24T2A1DOYB)
Language	English
Publishing date	2022-10-18
Publishing country	Italy
Document type	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
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Article: Changes of Gastric Secretion after Bolus and Slow Intravenous Administration of Bombesin and Neurotensin.

Tsalis, Konstantinos / Ioannidis, Orestis / Mariorakis, Chrysovalantis / Christidis, Panagiotis / Loutzidou, Lydia / Mantzoros, Ioannis / Kotidis, Efstathios / Pramateftakis, Manousos George / Ouzounidis, Nikolaos / Aggelopoulos, Stamatios

Maedica

2021 Volume 16, Issue 4, Page(s) 642–655

Abstract: Objectives: ...

Abstract	Objectives:
Language	English
Publishing date	2021-12-09
Publishing country	Romania
Document type	Editorial
ZDB-ID	2399972-X
ISSN	2069-6116 ; 1841-9038
ISSN (online)	2069-6116
ISSN	1841-9038
DOI	10.26574/maedica.2021.16.4.642
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Article ; Online: Transdiaphragmatic Intercostal Hernia-An Unusual Hepatic Injury After a Car Accident: A Case Report and Review of the Literature.

Ioannidis, Orestis / Mariorakis, Chrysovalantis / Malliora, Anastasia / Christidis, Panagiotis / Loutzidou, Lydia / Mantzoros, Ioannis / Pramateftakis, Manousos George / Kotidis, Efstathios / Ouzounidis, Nikolaos / Foutsitzis, Vasilis / Aggelopoulos, Stamatios

Discoveries (Craiova, Romania)

2021 Volume 9, Issue 1, Page(s) e123

Abstract: Transdiaphragmatic intercostal hernia, in which the abdominal contents of the hernia protrude through the diaphragm and the thoracic wall defect. is a very rare type of hernia with only a few cases having been reported in the literature. That type of ... ...

Abstract	Transdiaphragmatic intercostal hernia, in which the abdominal contents of the hernia protrude through the diaphragm and the thoracic wall defect. is a very rare type of hernia with only a few cases having been reported in the literature. That type of hernia is usually manifested in male patients after trauma, penetrating or blunt. It is frequently presented with a palpable thoracic mass and pain. The indicated treatment is surgery. We present the case of a 60-year-old female admitted to the hospital after a car accident and suffered multiple rib fractures (6th, 7th, 8th right ribs / 7th, 8th, 9th left ribs), as well as flail thorax, hemothorax bilaterally, left subcutaneous emphysema and swelling of soft tissues of the right lateral thoracoabdominal wall. CT scan revealed herniation of hepatic parenchyma and intestinal loops into the thorax. The patient was treated surgically, and his postoperative course was uneventful. We also review the relevant literature concerning this transdiaphragmatic, intercostal hernia and identify 42 cases. Transdiaphragmatic intercostal hernia is a rare condition, usually manifested in male patients after trauma, penetrating or blunt. It is frequently presented with a palpable thoracic mass and pain. The indicated treatment is surgery.
Language	English
Publishing date	2021-03-04
Publishing country	Romania
Document type	Journal Article
ISSN	2359-7232
ISSN (online)	2359-7232
DOI	10.15190/d.2021.2
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Article ; Online: Laparoscopic Resection of Desmoid Type Fibromatosis of the Splenic Hilum Mimicking a Greater Curvature Gastric GIST.

Kotidis, Efstathios / Strati, Titika Marina / Triantafyllou, Evangelia / Ioannidis, Orestis / Pramateftakis, Manousos George / Mantzoros, Ioannis / Loutzidou, Lydia / Kanellos, Ioannis / Tsalis, Konstantinos

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2018 Volume 28, Issue 9, Page(s) 714–716

Abstract: Desmoid tumor, recently renamed as desmoid type fibromatosis, is an uncommon neoplasm. The mesentery is the usual origin of intra-abdominal desmoid-type fibromatosis and despite the fact there is no metastatic potential, it can infiltrate adjacent organs. ...

Abstract	Desmoid tumor, recently renamed as desmoid type fibromatosis, is an uncommon neoplasm. The mesentery is the usual origin of intra-abdominal desmoid-type fibromatosis and despite the fact there is no metastatic potential, it can infiltrate adjacent organs. There etiology remains unknown, preoperative diagnosis is difficult and differential diagnosis includes among other gastrointestinal stromal tumor (GIST). In resectable tumors, the mainstay of treatment is surgical resection with at least clean microscopic margins. We present a case of a 51-year lady who presented with a 6.2 x 4.5 x 3.3 cm neoplasm in the anatomic area of the greater gastric curvature, the splenic hilum and the tail of the pancreas that was diagnosed as GIST on the CT scan. The patient was submitted to laparoscopic excision of the tumor and histopathological examination revealed desmoid type fibromatosis of the splenic hilum infiltrating the spleen, pancreatic tale and greater gastric curvature. According to the authors' knowledge, this is the first reported case of a sporadic splenic desmoid tumor, which has been treated successfully by laparoscopic en block resection.
MeSH term(s)	Diagnosis, Differential ; Female ; Fibromatosis, Aggressive/diagnosis ; Fibromatosis, Aggressive/surgery ; Gastrointestinal Neoplasms/diagnosis ; Gastrointestinal Stromal Tumors ; Humans ; Laparoscopy/methods ; Spleen/diagnostic imaging ; Splenic Neoplasms/surgery ; Stomach Neoplasms/pathology ; Tomography, X-Ray Computed
Language	English
Publishing date	2018-08-29
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2018.09.714
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