Article: ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma.
bioRxiv : the preprint server for biology
2024
Abstract: Cellular plasticity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) starting from the conversion of normal cells into precancerous lesions to the progression of carcinoma subtypes associated with aggressiveness and therapeutic response. We ... ...
| Abstract | Cellular plasticity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) starting from the conversion of normal cells into precancerous lesions to the progression of carcinoma subtypes associated with aggressiveness and therapeutic response. We discovered that normal acinar cell differentiation, maintained by the transcription factor Pdx1, suppresses a broad gastric cell identity that is maintained in metaplasia, neoplasia, and the classical subtype of PDAC in mouse and human. We have identified the receptor tyrosine kinase Ror2 as marker of a gastric metaplasia (SPEM)-like identity in the pancreas. Ablation of |
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| Language | English |
| Publishing date | 2024-01-16 |
| Publishing country | United States |
| Document type | Preprint |
| DOI | 10.1101/2023.12.13.571566 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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