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Book: Molecular immunotoxicology

Corsini, Emanuela / Loveren, Henk van

2015

Author's details	ed. by Emanuela Corsini and Henk van Loveren
Keywords	Immuntoxikologie
Language	English
Size	XVIII, 333 S., Ill., graph. Darst., 25 cm
Publisher	Wiley-VCH
Publishing place	Weinheim
Document type	Book
Note	Literaturangaben
ISBN	3527335196 ; 9783527335190 ; 9783527676965 ; 9783527676972 ; 9783527676989 ; 9783527676996 ; 3527676961 ; 352767697X ; 3527676988 ; 3527676996
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book: Molecular immunotoxicology

Corsini, Emanuela / Loveren, Henk van

2015

Author's details	ed. by Emanuela Corsini and Henk van Loveren
Keywords	Immuntoxikologie
Language	English
Size	XVIII, 333 S., Ill., graph. Darst., 25 cm
Document type	Book
Note	Literaturangaben
ISBN	3527335196 ; 9783527335190 ; 9783527676965 ; 9783527676972 ; 9783527676989 ; 9783527676996 ; 3527676961 ; 352767697X ; 3527676988 ; 3527676996
Database	Federal Institute for Risk Assessment

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Article ; Online: Scientific and technical guidance for the preparation and presentation of a dossier for evaluation of an infant and/or follow-on formula manufactured from protein hydrolysates (Revision 1).

Turck, Dominique / Bresson, Jean-Louis / Burlingame, Barbara / Dean, Tara / Fairweather-Tait, Susan / Heinonen, Marina / Hirsch-Ernst, Karen Ildico / Mangelsdorf, Inge / McArdle, Harry J / Naska, Androniki / Neuhäuser-Berthold, Monika / Nowicka, Grażyna / Pentieva, Kristina / Sanz, Yolanda / Sjödin, Anders / Stern, Martin / Tomé, Daniel / Loveren, Henk Van / Vinceti, Marco /

Willatts, Peter / Fewtrell, Mary / Przyrembel, Hildegard / Titz, Ariane / Martínez, Silvia Valtueña

EFSA journal. European Food Safety Authority

2021 Volume 19, Issue 3, Page(s) e06556

Abstract: Table: see text] Following a request from the European Commission, EFSA was asked to provide scientific and technical guidance for the preparation and presentation of a dossierfor evaluation of an infant and/or follow-on formula manufactured from ... ...

Abstract	[Table: see text] Following a request from the European Commission, EFSA was asked to provide scientific and technical guidance for the preparation and presentation of a dossierfor evaluation of an infant and/or follow-on formula manufactured from protein hydrolysates. This guidance document addresses the information and data to be submitted to EFSA on infant and follow-on formulae manufactured from protein hydrolysates with respect to the nutritional safety and suitability of the specific formula and/or the formula's efficacy in reducing the risk of developing allergy to milk proteins. The guidance will be further reviewed and updated with the experience gained from the evaluation of specificdossiers, and in the light of applicable Unionguidelines and legislation. The guidance was adopted by the Panel on Dietetic Products, Nutrition and Allergies on 5 April 2017.Upon request from the European Commission in 2020, it has been revised to inform food business operators of the new provisions in the pre-submission phase and in the procedure set out in the General Food Law, as amended by the Transparency Regulation. This revised guidance applies to all dossiers submitted as of 27 March 2021 and shall be consulted for the preparation of dossiers intended to be submitted from that date onwards. For dossiers submitted prior to 27 March 2021, the previous guidance, published in May 2017 remains applicable.
Language	English
Publishing date	2021-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2540248-1
ISSN	1831-4732 ; 1831-4732
ISSN (online)	1831-4732
ISSN	1831-4732
DOI	10.2903/j.efsa.2021.6556
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Safety evaluation of the food enzyme α-cyclodextrin glucanotransferase from

EFSA journal. European Food Safety Authority

2020 Volume 18, Issue 10, Page(s) e06248

Abstract: The food enzyme α-cyclodextrin glucanotransferase ((1→4)-α-d-glucan 4-α-d-[(1→4)-α-d-glucano]-transferase; EC 2.4.1.19) is produced with a genetically ... ...

Abstract	The food enzyme α-cyclodextrin glucanotransferase ((1→4)-α-d-glucan 4-α-d-[(1→4)-α-d-glucano]-transferase; EC 2.4.1.19) is produced with a genetically modified
Language	English
Publishing date	2020-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2540248-1
ISSN	1831-4732 ; 1831-4732
ISSN (online)	1831-4732
ISSN	1831-4732
DOI	10.2903/j.efsa.2020.6248
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Re-evaluation of polydextrose (E 1200) as a food additive.

Younes, Maged / Aquilina, Gabriele / Castle, Laurence / Engel, Karl-Heinz / Fowler, Paul / Fürst, Peter / Gürtler, Rainer / Gundert-Remy, Ursula / Husøy, Trine / Manco, Melania / Mennes, Wim / Moldeus, Peter / Passamonti, Sabina / Shah, Romina / Waalkens-Berendsen, Dina Hendrika / Wölfle, Detlef / Wright, Matthew / Boon, Polly / Crebelli, Riccardo /

Domenico, Alessandro Di / Filipič, Metka / Mortensen, Alicja / Woutersen, Ruud / Loveren, Henk Van / Giarola, Alessandra / Lodi, Federica / Rincon, Ana Maria / Tard, Alexandra / Fernandez, Maria Jose Frutos

EFSA journal. European Food Safety Authority

2021 Volume 19, Issue 1, Page(s) e06363

Abstract: This opinion deals with the re-evaluation of polydextrose (E 1200) when used as a food additive. The Panel followed the conceptual framework for the risk assessment of certain additives and considered that: adequate exposure estimates were available; the ...

Abstract	This opinion deals with the re-evaluation of polydextrose (E 1200) when used as a food additive. The Panel followed the conceptual framework for the risk assessment of certain additives and considered that: adequate exposure estimates were available; the margin of safety (MOS)/margin of exposure (MOE) for arsenic was between 0.5-14 and 8.5 for lead; the exhaustions of the tolerable weekly intake (TWI) for cadmium would be 165%, 10% for mercury, whereas the exhaustion of the tolerable daily intake (TDI) for nickel would be 9%; the absorption is limited and part of polydextrose is fermented in the large intestine into short-chain fatty acids (SCFA); adequate toxicity data were available; there is no concern with respect to genotoxicity; no adverse effects were reported in subchronic studies in rats, dogs or monkeys nor in chronic or carcinogenicity studies in mice and rats at the highest doses tested of up 12,500 mg/kg body weight (bw) per day and 15,000 mg/kg bw per day, respectively; the nephrocalcinosis in dogs given high doses of polydextrose was considered to be a treatment-related but a secondary effect related to diarrhoea, and hence not relevant for the risk assessment; no adverse effects were reported in reproductive or developmental toxicity studies in rats administered up to 10,000 mg polydextrose/kg bw per day, or in a developmental toxicity study in rabbits up to 1,818 mg/kg bw per day (the highest dose tested). Therefore, the Panel concluded that there is no need for numerical acceptable daily intake (ADI) for polydextrose (E 1200), and that there is no safety concern for the reported uses and use levels of polydextrose as a food additive. The Panel recommended that European Commission considers to lower the maximum limit for lead and to introduce limits for arsenic, cadmium and mercury in the EU specifications for polydextrose (E 1200), and to verify that polydextrose-N as a food additive (E 1200) is no longer marketed in the EU.
Language	English
Publishing date	2021-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2540248-1
ISSN	1831-4732 ; 1831-4732
ISSN (online)	1831-4732
ISSN	1831-4732
DOI	10.2903/j.efsa.2021.6363
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Support of drug therapy using functional foods and dietary supplements: focus on statin therapy

Eussen, Simone / Klungel, Olaf / Garssen, Johan / Verhagen, Hans / Kranen, Henk van / Loveren, Henk van / Rompelberg, Cathy

British journal of nutrition. 2010 May, v. 103, issue 9

2010

Abstract: Functional foods and dietary supplements might have a role in supporting drug therapy. These products may (1) have an additive effect to the effect that a drug has in reducing risk factors associated with certain conditions, (2) contribute to improve ... ...

Abstract	Functional foods and dietary supplements might have a role in supporting drug therapy. These products may (1) have an additive effect to the effect that a drug has in reducing risk factors associated with certain conditions, (2) contribute to improve risk factors associated with the condition, other than the risk factor that the drug is dealing with, or (3) reduce drug-associated side effects, for example, by restoring depleted compounds or by reducing the necessary dose of the drug. Possible advantages compared with a multidrug therapy are lower drug costs, fewer side effects and increased adherence. In the present review we have focused on the support of statin therapy using functional foods or dietary supplements containing plant sterols and/or stanols, soluble dietary fibre, n-3 PUFA or coenzyme Q10. We conclude that there is substantial evidence that adding plant sterols and/or stanols to statin therapy further reduces total and LDL-cholesterol by roughly 6 and 10 %, respectively. Adding n-3 PUFA to statin therapy leads to a significant reduction in plasma TAG of at least 15 %. Data are insufficient and not conclusive to recommend the use of soluble fibre or coenzyme Q10 in patients on statin therapy and more randomised controlled trials towards these combinations are warranted. Aside from the possible beneficial effects from functional foods or dietary supplements on drug therapy, it is important to examine possible (negative) effects from the combination in the long term, for example, in post-marketing surveillance studies. Moreover, it is important to monitor whether the functional foods and dietary supplements are taken in the recommended amounts to induce significant effects.
Keywords	drug therapy ; functional foods ; dietary supplements ; phytosterols ; soluble fiber ; dietary fiber ; omega-3 fatty acids ; ubiquinones ; humans ; low density lipoprotein ; blood lipids ; randomized clinical trials
Language	English
Dates of publication	2010-05
Size	p. 1260-1277.
Document type	Article
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114509993230
Database	NAL-Catalogue (AGRICOLA)

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Article: Novel foods: an explorative study into their grey area

Verhagen, Hans / Boekhorst, Janneke te / Kamps, Lisette / Lieshout, Marten J. van / Ploeger, Hilko / Verreth, Daphne / Salminen, Seppo / Loveren, Henk van

British journal of nutrition. 2009 May, v. 101, issue 9

2009

Abstract: European Union Regulation 258/97 defines novel foods as food products and food ingredients that have not been consumed to a significant degree in the European Union before May 1997. However, there are new foods that for some reason are not considered as ... ...

Abstract	European Union Regulation 258/97 defines novel foods as food products and food ingredients that have not been consumed to a significant degree in the European Union before May 1997. However, there are new foods that for some reason are not considered as novel foods, though we think that safety of these products is not always a priori established. We defined a 'grey area' which consists of such foods, and the present paper intends to raise awareness of this 'grey area' of unidentified novel foods. The grey area of novel foods is divided into two categories: (1) food products or ingredients for which the current Regulation leaves too much space for different interpretations and (2) food products or ingredients that are not novel according to the current Regulation, because the current Regulation contains gaps. These categories are illustrated by means of products already on the market in The Netherlands. We found about two dozen examples of products that had not been identified as novel foods according the current Regulation, yet could be considered to be classified as novel foods and hence for which a safety evaluation (toxicological and/or nutritional) would be indicated.
Keywords	novel foods ; European Union ; food law ; food technology ; ingredients ; food safety ; terminology ; food processing ; product development ; meat substitutes ; meat analogs ; feeds ; feed composition ; Europe
Language	English
Dates of publication	2009-05
Size	p. 1270-1277.
Document type	Article
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114508184690
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

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Article: Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants

Stølevik, Solvor Berntsen / Nygaard, Unni Cecilie / Namork, Ellen / Haugen, Margaretha / Kvalem, Helen Engelstad / Meltzer, Helle Margrete / Alexander, Jan / van Delft, Joost H.M / Loveren, Henk van / Løvik, Martinus / Granum, Berit

Food and chemical toxicology. 2011 Aug., v. 49, no. 8

2011

Abstract: The birth cohort BraMat (n=205; a sub-cohort of the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health) was established to study whether prenatal exposure to toxicants from the maternal diet affects ... ...

Abstract	The birth cohort BraMat (n=205; a sub-cohort of the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health) was established to study whether prenatal exposure to toxicants from the maternal diet affects immunological health outcomes in children. We here report on the environmental pollutants polychlorinated biphenyls (PCBs) and dioxins, as well as acrylamide generated in food during heat treatment. The frequency of common infections, eczema or itchiness, and periods of more than 10days of dry cough, chest tightness or wheeze (called wheeze) in the children during the first year of life was assessed by questionnaire data (n=195). Prenatal dietary exposure to the toxicants was estimated using a validated food frequency questionnaire from MoBa. Prenatal exposure to PCBs and dioxins was found to be associated with increased risk of wheeze and exanthema subitum, and also with increased frequency of upper respiratory tract infections. We found no associations between prenatal exposure to acrylamide and the health outcomes investigated. Our results suggest that prenatal dietary exposure to dioxins and PCBs may increase the risk of wheeze and infectious diseases during the first year of life.
Keywords	acrylamides ; chest ; children ; cohort studies ; cough ; dietary exposure ; dioxins ; eczema ; exanthema ; food frequency questionnaires ; heat treatment ; infants ; infectious diseases ; maternal nutrition ; pollutants ; polychlorinated biphenyls ; respiratory tract diseases ; risk ; toxic substances ; toxicology
Language	English
Dates of publication	2011-08
Size	p. 1843-1848.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2011.05.002
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Update of the tolerable upper intake level for vitamin D for infants.

Turck, Dominique / Bresson, Jean-Louis / Burlingame, Barbara / Dean, Tara / Fairweather-Tait, Susan / Heinonen, Marina / Hirsch-Ernst, Karen Ildico / Mangelsdorf, Inge / McArdle, Harry J / Naska, Androniki / Nowicka, Grażyna / Pentieva, Kristina / Sanz, Yolanda / Siani, Alfonso / Sjödin, Anders / Stern, Martin / Tomé, Daniel / Loveren, Henk Van / Vinceti, Marco /

Willatts, Peter / Fewtrell, Mary / Lamberg-Allardt, Christel / Przyrembel, Hildegard / Arcella, Davide / Dumas, Céline / Fabiani, Lucia / Martino, Laura / Tomcikova, Daniela / Neuhäuser-Berthold, Monika

EFSA journal. European Food Safety Authority

2018 Volume 16, Issue 8, Page(s) e05365

Abstract: Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to revise the tolerable upper intake level (UL) for vitamin D for infants (≤ 1 year) set in 2012. From its literature review, the ... ...

Abstract	Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to revise the tolerable upper intake level (UL) for vitamin D for infants (≤ 1 year) set in 2012. From its literature review, the Panel concluded that the available evidence on daily vitamin D intake and the risk of adverse health outcomes (hypercalciuria, hypercalcaemia, nephrocalcinosis and abnormal growth patterns) cannot be used alone for deriving the UL for infants. The Panel conducted a meta-regression analysis of collected data, to derive a dose-response relationship between daily supplemental intake of vitamin D and mean achieved serum 25(OH)D concentrations. Considering that a serum 25(OH)D concentration of 200 nmol/L or below is unlikely to pose a risk of adverse health outcomes in infants, the Panel estimated the percentage of infants reaching a concentration above this value at different intakes of vitamin D. Based on the overall evidence, the Panel kept the UL of 25 μg/day for infants aged up to 6 months and set a UL of 35 μg/day for infants 6-12 months. The Panel was also asked to advise on the safety of the consumption of infant formulae with an increased maximum vitamin D content of 3 μg/100 kcal (Commission Delegated Regulation (EU) 2016/127 repealing Directive 2006/141/EC in 2020). For infants aged up to 4 months, the intake assessment showed that the use of infant formulae containing vitamin D at 3 μg/100 kcal may lead some infants to receive an intake above the UL of 25 μg/day from formulae alone without considering vitamin D supplemental intake. For infants aged 4-12 months, the 95th percentile of vitamin D intake (high consumers) estimated from formulae and foods fortified or not with vitamin D does not exceed the ULs, without considering vitamin D supplemental intake.
Language	English
Publishing date	2018-08-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2540248-1
ISSN	1831-4732 ; 1831-4732
ISSN (online)	1831-4732
ISSN	1831-4732
DOI	10.2903/j.efsa.2018.5365
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants.

Stølevik, Solvor Berntsen / Nygaard, Unni Cecilie / Namork, Ellen / Haugen, Margaretha / Kvalem, Helen Engelstad / Meltzer, Helle Margrete / Alexander, Jan / van Delft, Joost H M / Loveren, Henk van / Løvik, Martinus / Granum, Berit

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2011 Volume 49, Issue 8, Page(s) 1843–1848

Abstract: The birth cohort BraMat (n = 205; a sub-cohort of the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health) was established to study whether prenatal exposure to toxicants from the maternal diet affects ... ...

Abstract	The birth cohort BraMat (n = 205; a sub-cohort of the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health) was established to study whether prenatal exposure to toxicants from the maternal diet affects immunological health outcomes in children. We here report on the environmental pollutants polychlorinated biphenyls (PCBs) and dioxins, as well as acrylamide generated in food during heat treatment. The frequency of common infections, eczema or itchiness, and periods of more than 10 days of dry cough, chest tightness or wheeze (called wheeze) in the children during the first year of life was assessed by questionnaire data (n = 195). Prenatal dietary exposure to the toxicants was estimated using a validated food frequency questionnaire from MoBa. Prenatal exposure to PCBs and dioxins was found to be associated with increased risk of wheeze and exanthema subitum, and also with increased frequency of upper respiratory tract infections. We found no associations between prenatal exposure to acrylamide and the health outcomes investigated. Our results suggest that prenatal dietary exposure to dioxins and PCBs may increase the risk of wheeze and infectious diseases during the first year of life.
MeSH term(s)	Acrylamide/toxicity ; Adult ; Cohort Studies ; Dioxins/toxicity ; Eating ; Environmental Pollutants/toxicity ; Female ; Humans ; Infant ; Maternal Exposure/adverse effects ; Norway ; Polychlorinated Biphenyls/toxicity ; Pregnancy ; Prenatal Exposure Delayed Effects ; Respiratory Sounds/physiopathology ; Respiratory Tract Infections/chemically induced ; Risk Factors ; Surveys and Questionnaires
Chemical Substances	Dioxins ; Environmental Pollutants ; Acrylamide (20R035KLCI) ; Polychlorinated Biphenyls (DFC2HB4I0K)
Language	English
Publishing date	2011-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2011.05.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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