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Book: Delbavancin, a novel second generation lipoglycopeptide agent for the treatment of serious gram-positive infections

Lovering, Andrew M.

(The journal of antimicrobial chemotherapy ; 55, Suppl. 2)

2005

Title variant	Delbavancin, a novel second-generation lipoglycopeptide agent for the treatment of serious gram-positive infections
Author's details	ed. by Andrew M. Lovering
Series title	The journal of antimicrobial chemotherapy ; 55, Suppl. 2
Collection
Language	English
Size	ii35 S. : graph. Darst.
Publisher	Oxford Univ. Press
Publishing place	Oxford
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT014332218
Database	Catalogue ZB MED Medicine, Health

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Book: Roxithromycin

Lovering, Andrew M.

additional therapeutic potential

(The journal of antimicrobial chemotherapy ; 41, Suppl. B)

1998

Author's details	ed. by A. M. Lovering
Series title	The journal of antimicrobial chemotherapy ; 41, Suppl. B
Collection
Keywords	Roxithromycin ; Antibiotics, Macrolide
Language	English
Size	V, 97 S. : Ill., graph. Darst.
Publisher	Oxford Univ. Press
Publishing place	Oxford
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT008358015
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Susceptibility of monomicrobial or polymicrobial biofilms derived from infected diabetic foot ulcers to topical or systemic antibiotics in vitro.

Price, Bianca L / Morley, Robert / Bowling, Frank L / Lovering, Andrew M / Dobson, Curtis B

PloS one

2020 Volume 15, Issue 2, Page(s) e0228704

Abstract: Diabetic foot ulcers can become chronic and non-healing despite systemic antibiotic treatment. The penetration of systematically-administered antibiotics to the site of infection is uncertain, as is the effectiveness of such levels against polymicrobial ... ...

Abstract	Diabetic foot ulcers can become chronic and non-healing despite systemic antibiotic treatment. The penetration of systematically-administered antibiotics to the site of infection is uncertain, as is the effectiveness of such levels against polymicrobial biofilms. We have developed an in vitro model to study the effectiveness of different treatments for infected diabetic foot ulcers in a wound-like environment and compared the activity of systemic levels of antibiotics with that for topically applied antibiotics released from calcium sulfate beads. This is the first study that has harvested bacteria from diabetic foot infections and recreated similar polymicrobial biofilms to those present in vivo for individual subjects. After treatment with levels of gentamicin attained in serum after systemic administration (higher than corresponding tissues concentrations) we measured a 0-2 log reduction in bacterial viability of P. aeruginosa, S. aureus or a polymicrobial biofilm. Conversely, addition of gentamicin loaded calcium sulfate beads resulted in 5-9 log reductions in P. aeruginosa, S aureus and polymicrobial biofilms derived from three subjects. We conclude that systemically administered antibiotics are likely to be inadequate for successfully treating these infections, especially given the vastly increased concentrations required to inhibit cells in a biofilm, and that topical antibiotics provide a more effective alternative.
MeSH term(s)	Administration, Topical ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Biofilms/drug effects ; Calcium Sulfate/pharmacology ; Diabetic Foot/drug therapy ; Diabetic Foot/microbiology ; Humans ; Microbial Sensitivity Tests ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/physiology ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/physiology
Chemical Substances	Anti-Bacterial Agents ; Calcium Sulfate (WAT0DDB505)
Language	English
Publishing date	2020-02-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0228704
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of soaking gentamicin-containing collagen implants on potential antimicrobial efficacy.

Lovering, Andrew M / Sunderland, Julie

International journal of surgery (London, England)

2012 Volume 10 Suppl 1, Page(s) S2–4

Abstract: Background: The purpose of this study is to evaluate how wetting of Collatamp (a gentamicin-containing collagen implant [GCCI]) impacts on the gentamicin content of the implant and whether this affects its potential antibacterial efficacy.: Methods: ... ...

Abstract	Background: The purpose of this study is to evaluate how wetting of Collatamp (a gentamicin-containing collagen implant [GCCI]) impacts on the gentamicin content of the implant and whether this affects its potential antibacterial efficacy. Methods: GCCI (Collatamp(®), EUSA Pharma [Europe], Oxford, United Kingdom) containing 130 mg gentamicin and 280 mg collagen (10 cm × 10 cm) were immersed in 300 mL normal saline for up to 6h. At set times after immersion the GCCI were removed, the saline diluted in normal human serum and the gentamicin content assayed by a validated immunoassay (Cedia, Microgenics Ltd, UK) to provide an estimate of the loss from each implant. The mean concentration data were then fitted to an exponential decay model (WinNonLin, Pharsight, US). Results: After a very short immersion period there was significant loss of gentamicin from the implants with a mean loss of 6.7% at 2 s, increasing to 40.5% at 1 min and essentially total loss by 6 h of immersion. Loss of gentamicin followed a complex elution profile, with elution half-lives ranging from 50 s on initial immersion to 99 min late in the elution period. Conclusion: This study provides clear evidence that even a short period of dipping of Collatamp implants, and probably other GCCI, before insertion into the patient results in a significant loss of gentamicin which may be of clinical significance unless the period of soaking is very short. We therefore recommend that wetting of these implants before insertion is not undertaken.
MeSH term(s)	Anti-Bacterial Agents/analysis ; Anti-Bacterial Agents/chemistry ; Collagen/chemistry ; Drug Implants/chemistry ; Gentamicins/analysis ; Gentamicins/chemistry ; Humans ; Prosthesis Implantation
Chemical Substances	Anti-Bacterial Agents ; Drug Implants ; Gentamicins ; Collagen (9007-34-5)
Language	English
Publishing date	2012
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1016/j.ijsu.2012.05.013
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Article ; Online: Linezolid and lactation: measurement of drug levels in breast milk and the nursing infant.

Lim, Felicia H / Lovering, Andrew M / Currie, Andrew / Jenkins, David R

The Journal of antimicrobial chemotherapy

2017 Volume 72, Issue 9, Page(s) 2677–2678

MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/analysis ; Bacteremia/drug therapy ; Female ; Humans ; Infant ; Infant, Newborn ; Linezolid/administration & dosage ; Linezolid/analysis ; Milk, Human/chemistry ; Mothers ; Serum/chemistry ; Staphylococcal Infections/drug therapy
Chemical Substances	Anti-Bacterial Agents ; Linezolid (ISQ9I6J12J)
Language	English
Publishing date	2017-05-20
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkx159
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Development of a Novel Collagen Wound Model To Simulate the Activity and Distribution of Antimicrobials in Soft Tissue during Diabetic Foot Infection.

Price, Bianca L / Lovering, Andrew M / Bowling, Frank L / Dobson, Curtis B

Antimicrobial agents and chemotherapy

2016 Volume 60, Issue 11, Page(s) 6880–6889

Abstract: Diabetes has major implications for public health, with diabetic foot ulcers (DFUs) being responsible for significant morbidity and mortality. A key factor in the development of nonhealing ulcers is infection, which often leads to the development of ... ...

Abstract	Diabetes has major implications for public health, with diabetic foot ulcers (DFUs) being responsible for significant morbidity and mortality. A key factor in the development of nonhealing ulcers is infection, which often leads to the development of biofilm, gangrene, and amputation. A novel approach to treating DFUs is the local release of antibiotics from calcium sulfate beads. We have developed a novel model system to study and compare the release and efficacy of antibiotics released locally, using collagen as a substrate for biofilm growth and incorporating serum to mimic the biochemical complexity of the wound environment. We found that our soft-tissue model supports the growth of a robust Pseudomonas aeruginosa biofilm, and that this was completely eradicated by the introduction of calcium sulfate beads loaded with tobramycin or gentamicin. The model also enabled us to measure the concentration of these antibiotics at different distances from the beads and in simulated wound fluid bathing the collagen matrix. We additionally found that a multidrug-resistant Staphylococcus aureus biofilm, nonsusceptible to antibiotics, nonetheless showed an almost 1-log drop in viable counts when exposed to calcium sulfate beads combined with antibiotics. Together, these data suggest that locally applied antibiotics combined with calcium sulfate provide surprising efficacy in diabetic foot infections and offer an effective alternative approach to infection management. Our study additionally establishes our new system as a biochemically and histologically relevant model that may be used to study the effectiveness of a range of therapies locally or systemically for infected DFUs.
MeSH term(s)	Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Biofilms/drug effects ; Calcium Sulfate/chemistry ; Collagen/metabolism ; Diabetic Foot/complications ; Diabetic Foot/metabolism ; Drug Resistance, Multiple, Bacterial/drug effects ; Gentamicins/pharmacokinetics ; Gentamicins/pharmacology ; Humans ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/pathogenicity ; Microbial Sensitivity Tests ; Pseudomonas Infections/drug therapy ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/pathogenicity ; Soft Tissue Infections/drug therapy ; Soft Tissue Infections/etiology ; Staphylococcal Infections/drug therapy ; Tobramycin/pharmacokinetics ; Tobramycin/pharmacology ; Vancomycin/pharmacology ; Wound Infection/drug therapy ; Wound Infection/etiology
Chemical Substances	Anti-Bacterial Agents ; Gentamicins ; Vancomycin (6Q205EH1VU) ; Collagen (9007-34-5) ; Tobramycin (VZ8RRZ51VK) ; Calcium Sulfate (WAT0DDB505)
Language	English
Publishing date	2016-10-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.01064-16
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

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Article ; Online: The role of microbial biofilms in prosthetic joint infections.

Gbejuade, Herbert O / Lovering, Andrew M / Webb, Jason C

Acta orthopaedica

2014 Volume 86, Issue 2, Page(s) 147–158

Abstract: Prosthetic joint infection (PJI) still remains a significant problem. In line with the forecasted rise in joint replacement procedures, the number of cases of PJI is also anticipated to rise. The formation of biofilm by causative pathogens is central to ... ...

Abstract	Prosthetic joint infection (PJI) still remains a significant problem. In line with the forecasted rise in joint replacement procedures, the number of cases of PJI is also anticipated to rise. The formation of biofilm by causative pathogens is central to the occurrence and the recalcitrance of PJI. The subject of microbial biofilms is receiving increasing attention, probably as a result of the wide acknowledgement of the ubiquity of biofilms in the natural, industrial, and clinical contexts, as well as the notorious difficulty in eradicating them. In this review, we discuss the pertinent issues surrounding PJI and the challenges posed by biofilms regarding diagnosis and treatment. In addition, we discuss novel strategies of prevention and treatment of biofilm-related PJI.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Bacteriophages/growth & development ; Biofilms ; Deoxyribonuclease I/therapeutic use ; Humans ; Joint Prosthesis/adverse effects ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/microbiology ; Prosthesis-Related Infections/therapy
Chemical Substances	Anti-Bacterial Agents ; Deoxyribonuclease I (EC 3.1.21.1)
Language	English
Publishing date	2014-09-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2180677-9
ISSN	1745-3682 ; 1745-3674
ISSN (online)	1745-3682
ISSN	1745-3674
DOI	10.3109/17453674.2014.966290
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Article ; Online: Choosing the right anticoagulant: a critical choice when assessing pharmacokinetic parameters for tetracyclines obtained from human blood samples.

Bayliss, Mark A J / Kyriakides, Mathew / Rigdova, Katarina / Grier, Sally / Lovering, Andrew M / Noel, Alan / MacGowan, Alasdair

The Journal of antimicrobial chemotherapy

2019 Volume 74, Issue 12, Page(s) 3643–3645

MeSH term(s)	Acetic Acid ; Anticoagulants ; Ciprofloxacin ; Edetic Acid ; Ethylenediamines ; Humans ; Tetracyclines ; Tigecycline
Chemical Substances	Anticoagulants ; Ethylenediamines ; Tetracyclines ; Ciprofloxacin (5E8K9I0O4U) ; Tigecycline (70JE2N95KR) ; Edetic Acid (9G34HU7RV0) ; Acetic Acid (Q40Q9N063P)
Language	English
Publishing date	2019-11-15
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkz382
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Article: Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study.

Rawson, Timothy M / Wilson, Richard C / Moore, Luke S P / Macgowan, Alasdair P / Lovering, Andrew M / Bayliss, Mark / Kyriakides, Mathew / Gilchrist, Mark / Roberts, Jason A / Hope, William W / Holmes, Alison H

Open forum infectious diseases

2021 Volume 8, Issue 12, Page(s) ofab573

Abstract: This healthy volunteer study aimed to explore phenoxymethylpenicillin (penicillin-V) pharmacokinetics (PK) to support the planning of large dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicillin-V ... ...

Abstract	This healthy volunteer study aimed to explore phenoxymethylpenicillin (penicillin-V) pharmacokinetics (PK) to support the planning of large dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicillin-V serum concentrations were determined, and a base population PK model was fitted to the data.
Language	English
Publishing date	2021-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofab573
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Article ; Online: Antibiotic elution from bone cement: A study of common cement-antibiotic combinations.

Armstrong, M / Spencer, Robert F / Lovering, Andrew M / Gheduzzi, S / Miles, A W / Learmonth, Ian D

Hip international : the journal of clinical and experimental research on hip pathology and therapy

2017 Volume 12, Issue 1, Page(s) 23–27

Abstract: The in vitro antibiotic elution characteristics (including the effects of cement fracture) of the following cements were studied: 1) CMW 1 with gentamicin, 2) Palacos R with gentamicin, 3) Palacos LV with gentamicin, 4) CMW 1 with gentamicin and ... ...

Abstract	The in vitro antibiotic elution characteristics (including the effects of cement fracture) of the following cements were studied: 1) CMW 1 with gentamicin, 2) Palacos R with gentamicin, 3) Palacos LV with gentamicin, 4) CMW 1 with gentamicin and vancomycin, 5) Palacos R with gentamicin and vancomycin, 6) CMW 1 with gentamicin and flucloxacillin, and 7) Palacos R with gentamicin and flucloxacillin. Elution of both gentamicin and vancomycin was satisfactory in all cases. There tended to be a peak of antibiotic release on cement fracture, suggesting sequestration of active antibiotic within deeper layers of the cement. Palacos LV exhibited the best antibiotic elution characteristics but with the highest post-fracture peak. Palacos R was superior to CMW 1. Flucloxacillin was present only until day 4. Adulteration of proprietary Palacos R/gentamicin with flucloxacillin produced prolonged high elution of gentamicin, possibly due to porosity. Flucloxacilloic acid (microbiologically inactive) was present from day 4 onwards after flucloxacillin was added to cement. These findings suggest that flucloxacillin is not a suitable additive to bone cement in revision surgery. (Hip International 2002; 1: 23-7).
Language	English
Publishing date	2017-01-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1162513-2
ISSN	1724-6067 ; 1120-7000
ISSN (online)	1724-6067
ISSN	1120-7000
DOI	10.5301/HIP.2008.2065
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