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  1. AU="Low, Keat"
  2. AU="Zick, G."
  3. AU=Miles Alexander
  4. AU="Orzan, Fulvio"
  5. AU="Shruti A. Anant"
  6. AU="Jin, Hong-Wei"
  7. AU="Gonzalez, Louis"
  8. AU=Torres Victor J.
  9. AU="Manning, Nyla"
  10. AU="Sindkar, Anushka"
  11. AU=Rodieux Frdrique
  12. AU="Tote, Sachin"

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  1. Artikel: An optimized strategy for lutein production via microwave-assisted microalgae wet biomass extraction process

    Low, Keat Long / Idris, Ani / Yusof, Noordin Mohd

    Process biochemistry. 2022 June 15,

    2022  

    Abstract: Lutein is a bioactive substance with functional properties, applicable in food supplementation and food fortification. Wet microalgae biomass processing is a propitious practice, yet receives limited exploration for lutein production. Here, novel ... ...

    Abstract Lutein is a bioactive substance with functional properties, applicable in food supplementation and food fortification. Wet microalgae biomass processing is a propitious practice, yet receives limited exploration for lutein production. Here, novel microwave-assisted extraction methods utilizing wet biomass are designed. By manipulating the chemical composition and mixing process of the extraction mixture, mass transfer was improved thus maximising lutein liberation from biomass. Through our optimum extraction method, the amount of lutein recovered increases by 1.88 fold (from 8.06mgg⁻¹ to 15.14mgg⁻¹), uses -125.32 fold less amount of KOH solution (from 142.86ml to 1.14ml), uses -8.34 fold less amount of acetone (from 1428.57ml to171.3ml), requires -1.80 fold less extraction time (from 36min to 20min) and consumes -30.85 fold less energy (from 106.73 kWh to 3.46 kWh) as compared to the dried biomass extraction. Extracted lutein also retained high antioxidant capacity in 0.43 ± 0.16 µmol α-tocopherol equivalent. This designed process is feasible as wet biomass could be stored in a refrigerator up to 3 weeks without affecting the amount of extractable lutein. The outcome of this proposed lutein production method has achieved high product recovery, quality, remarkable process efficacy and potential sustainability for future industry application.
    Schlagwörter acetone ; alpha-tocopherol ; antioxidant activity ; bioactive compounds ; biomass ; energy ; food fortification ; industrial applications ; lutein ; mass transfer ; microalgae ; microwave treatment ; refrigerators
    Sprache Englisch
    Erscheinungsverlauf 2022-0615
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ISSN 1359-5113
    DOI 10.1016/j.procbio.2022.06.014
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel ; Online: Thrombocytopenia, splenomegaly, and periportal fibrosis in a migrant.

    Phan, Timothy / Low, Michael Sze Yuan / Low, Keat / Braude, Michael

    Annals of hematology

    2022  Band 101, Heft 8, Seite(n) 1883–1884

    Mesh-Begriff(e) Fibrosis ; Humans ; Leukopenia ; Liver Cirrhosis/complications ; Splenomegaly/diagnostic imaging ; Splenomegaly/etiology ; Thrombocytopenia/etiology ; Transients and Migrants
    Sprache Englisch
    Erscheinungsdatum 2022-04-20
    Erscheinungsland Germany
    Dokumenttyp Letter
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-022-04838-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Uh III Zs.181: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Artikel: Novel protocol optimized for microalgae lutein used as food additives

    Low, Keat Long / Idris, Ani / Mohd Yusof, Noordin

    Food chemistry. 2019 Sept. 30,

    2019  

    Abstract: Lutein available in the current market is derived from marigold petals. However, extensive studies showed that microalgae are rich in lutein content and potentially exploitable for its dietary and other industrial applications. In this study, microwave ... ...

    Abstract Lutein available in the current market is derived from marigold petals. However, extensive studies showed that microalgae are rich in lutein content and potentially exploitable for its dietary and other industrial applications. In this study, microwave assisted binary phase solvent extraction method (MABS) was the novel protocol being developed and optimized to achieve maximum lutein recovery from microalgae Scenedesmus sp biomass. Results showed that 60 % potassium hydroxide solution with acetone in the ratio of 0.1 (ml/ml) was the ideal binary phase solvent composition. Empirical model developed using response surface methodology revealed highest lutein content can be recovered through MABS extraction method at 55 oC treatment temperature, 36 min in extraction time, 0.7 (mg/ml) for biomass to solvent ratio, 250 Watt microwave power and 250 rpm stirring speed. This optimized novel protocol had increased the amount of lutein recovered by 130% and shorten the overall extraction time by 3-folds.
    Schlagwörter Scenedesmus ; acetone ; biomass ; corolla ; empirical models ; food additives ; industrial applications ; lutein ; markets ; microalgae ; microwave treatment ; mixing ; potassium hydroxide ; response surface methodology ; solvents ; temperature
    Sprache Englisch
    Erscheinungsverlauf 2019-0930
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2019.125631
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 3634: Hefte anzeigen

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  4. Artikel ; Online: The efficacy of tin-filtration for computed tomography in diagnosing urolithiasis.

    Tan, Sarah Li Hui / Badawy, Mohamed / Schneider, Michal / Lau, Kenneth K / Low, Keat / Kutschera, Peter

    Clinical imaging

    2019  Band 55, Seite(n) 126–131

    Abstract: Introduction: The purpose of this study was to evaluate the radiation dose and image quality of computed tomography urograms (CTU) using tin-filtration compared to conventional CTU (without tin-filtration) examinations in patients with suspected ... ...

    Abstract Introduction: The purpose of this study was to evaluate the radiation dose and image quality of computed tomography urograms (CTU) using tin-filtration compared to conventional CTU (without tin-filtration) examinations in patients with suspected urolithiasis.
    Methods: Group 1 consisted of 100 patients who were examined using the tin-filtered CTU protocols (Sn100kVp or Sn150kVp); Group 2 consisted of 100 patients who were examined using the same protocols but without tin-filtration (GE-NI41 or GE-NI43). The scanning protocol was based on the patients' body weight (<80 kg and ≥80 kg). The effective doses of all scans were compared between the two groups. Subjective image quality was evaluated by two blinded radiologists. The objective image quality was assessed for noise, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and figure-of-merit (FOM) using the CTU scans acquired from both the tin-filtered and non-tin-filtered protocols.
    Results: Tin-filtration resulted in the reduction of effective radiation dose ranging between 72% to 88% for the ≥80 kg and <80 kg patient groups respectively. For both groups, tin-filtration resulted in no significant differences in SNR and a significant increase in FOM. For the <80 kg group, tin-filtration resulted in significantly noisier images but with no significant difference in CNR. For the ≥80 kg group, tin-filtration resulted in significantly higher CNR. There was no significant difference in subjective image quality when assessed by the radiologists in terms of diagnostic confidence for urolithiasis.
    Conclusion: Tin-filtration significantly reduces patient dose while maintaining diagnostic image quality of CTUs for patients with suspected urolithiasis.
    Mesh-Begriff(e) Female ; Humans ; Male ; Middle Aged ; Observer Variation ; Radiation Dosage ; Radiation Protection/methods ; Radiation-Protective Agents/therapeutic use ; Radiographic Image Interpretation, Computer-Assisted/methods ; Radiologists ; Signal-To-Noise Ratio ; Tin/therapeutic use ; Tomography, X-Ray Computed/methods ; Tomography, X-Ray Computed/standards ; Urography/methods ; Urography/standards ; Urolithiasis/diagnostic imaging
    Chemische Substanzen Radiation-Protective Agents ; Tin (7440-31-5)
    Sprache Englisch
    Erscheinungsdatum 2019-02-22
    Erscheinungsland United States
    Dokumenttyp Evaluation Studies ; Journal Article
    ZDB-ID 1028123-x
    ISSN 1873-4499 ; 0899-7071
    ISSN (online) 1873-4499
    ISSN 0899-7071
    DOI 10.1016/j.clinimag.2019.02.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1469: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Artikel ; Online: Fine focal spot size improves image quality in computed tomography abdomen and pelvis.

    Goh, Yin P / Lau, Kenneth K / Low, Keat / Buchan, Kevin / Oh, Lawrence Chia Wei / Kuganesan, Ahilan / Huynh, Minh

    European radiology

    2016  Band 26, Heft 12, Seite(n) 4545–4550

    Abstract: Objectives: To compare the image quality between fine focal spot size (FFSS) and standard focal spot size (SFSS) in computed tomography of the abdomen and pelvis (CTAP) METHODS: This retrospective review included all consecutive adult patients ... ...

    Abstract Objectives: To compare the image quality between fine focal spot size (FFSS) and standard focal spot size (SFSS) in computed tomography of the abdomen and pelvis (CTAP) METHODS: This retrospective review included all consecutive adult patients undergoing contrast-enhanced CTAP between June and September 2014. Two blinded radiologists assessed the margin clarity of the abdominal viscera and the detected lesions using a five-point grading scale. Cohen's kappa test was used to examine the inter-observer reliability between the two reviewers for organ margin clarity. Mann-Whitney U testing was utilised to assess the statistical difference of the organ and lesion margin clarity.
    Results: 100 consecutive CTAPs were recruited. 52 CTAPs were examined with SFSS of 1.1 × 1.2 mm and 48 CTAPs were examined with FFSS of 0.6 × 0.7 mm. Results showed that there was substantial agreement for organ margin clarity (mean κ = 0.759, p < 0.001) among the reviewers. FFSS produces images with clearer organ margins (U = 76194.0, p < 0.001, r = 0.523) and clearer lesion margins (U = 239, p = 0.052, r = 0.269).
    Conclusion: FFSS CTAP improves image quality in terms of better organ and lesion margin clarity. Fine focus CT scanning is a novel technique that may be applied in routine CTAP imaging.
    Key points: • Fine focal spot improves organ margin clarity. • Fine focal spot improves lesion margin clarity. • Fine focal spot can be used in routine CT abdominal imaging.
    Mesh-Begriff(e) Abdominal Cavity/diagnostic imaging ; Adult ; Aged ; Aged, 80 and over ; Artifacts ; Cysts/diagnostic imaging ; Female ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography/methods ; Multidetector Computed Tomography/standards ; Neoplasms/diagnostic imaging ; Observer Variation ; Pelvis/diagnostic imaging ; Radiography, Abdominal/methods ; Reproducibility of Results ; Retrospective Studies ; Vascular Diseases/diagnostic imaging ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2016-03-14
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-016-4313-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3300: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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