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  1. Book: STIs and HIV in Pakistan

    Low, Nicola

    from analysis to action

    (Sexually transmitted infections ; 85, Suppl. 2)

    2009  

    Author's details guest ed.: Nicola Low
    Series title Sexually transmitted infections ; 85, Suppl. 2
    Collection
    Language English
    Size ii42 S. : graph. Darst.
    Publisher BMJ Publ. Group
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015886928
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Chlamydia trachomatis

    Low, Nicola

    Sexually transmitted infections

    2020  Volume 96, Issue 5, Page(s) 315–317

    MeSH term(s) Chlamydia Infections ; Chlamydia trachomatis ; Humans ; Infertility ; Reproductive Health
    Language English
    Publishing date 2020-01-27
    Publishing country England
    Document type Editorial
    ZDB-ID 1420303-0
    ISSN 1472-3263 ; 1368-4973
    ISSN (online) 1472-3263
    ISSN 1368-4973
    DOI 10.1136/sextrans-2019-054279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Understanding the factors affecting global political priority for controlling sexually transmitted infections: a qualitative policy analysis.

    Wu, Dadong / Low, Nicola / Hawkes, Sarah J

    BMJ global health

    2024  Volume 9, Issue 1

    Abstract: Introduction: Sexually transmitted infections (STIs) are a significant public health challenge, but there is a perceived lack of political priority in addressing STIs as a global health issue. Our study aimed to understand the determinants of global ... ...

    Abstract Introduction: Sexually transmitted infections (STIs) are a significant public health challenge, but there is a perceived lack of political priority in addressing STIs as a global health issue. Our study aimed to understand the determinants of global political priority for STIs since the 1980s and to discern implications for future prioritisation.
    Methods: Through semistructured interviews from July 2021 to February 2022, we engaged 20 key stakeholders (8 women, 12 men) from academia, United Nations agencies, international non-governmental organisations, philanthropic organisations and national public health agencies. A published policy framework was employed for thematic analysis, and findings triangulated with relevant literature and policy documents. We examined issue characteristics, prevailing ideas, actor power dynamics and political contexts.
    Results: A contrast in perspectives before and after the year 2000 emerged. STI control was high on the global health agenda during the late 1980s and 1990s, as a means to control HIV. A strong policy community agreed on evidence about the high burden of STIs and that STI management could reduce the incidence of HIV. The level of importance decreased when further research evidence did not find an impact of STI control interventions on HIV incidence. Since 2000, cohesion in the STI community has decreased. New framing for broad STI control has not emerged. Interventions that have been funded, such as human papillomavirus vaccination and congenital syphilis elimination have been framed as cancer control or improving newborn survival, rather than as STI control.
    Conclusion: Globally, the perceived decline in STI control priority might stem from discrepancies between investment choices and experts' views on STI priorities. Addressing STIs requires understanding the intertwined nature of politics and empirical evidence in resource allocation. The ascent of universal health coverage presents an opportunity for integrated STI strategies but high-quality care, sustainable funding and strategic coordination are essential.
    MeSH term(s) Male ; Infant, Newborn ; Humans ; Female ; Papillomavirus Infections ; Papillomavirus Vaccines ; Sexually Transmitted Diseases ; Policy ; HIV Infections
    Chemical Substances Papillomavirus Vaccines
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2059-7908
    ISSN 2059-7908
    DOI 10.1136/bmjgh-2023-014237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Working together to improve the evidence base: abridged Cochrane reviews in

    Low, Nicola

    Sexually transmitted infections

    2018  Volume 95, Issue 1, Page(s) 2–3

    MeSH term(s) Editorial Policies ; Evidence-Based Medicine ; Humans ; Periodicals as Topic ; Review Literature as Topic ; Sexually Transmitted Diseases
    Language English
    Publishing date 2018-10-19
    Publishing country England
    Document type Editorial
    ZDB-ID 1420303-0
    ISSN 1472-3263 ; 1368-4973
    ISSN (online) 1472-3263
    ISSN 1368-4973
    DOI 10.1136/sextrans-2018-053762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Condom use and HIV testing among adults in Switzerland: repeated national cross-sectional surveys 2007, 2012, and 2017.

    Buitrago-Garcia, Diana / Salanti, Georgia / Low, Nicola

    BMC public health

    2023  Volume 23, Issue 1, Page(s) 2158

    Abstract: Background: Monitoring of HIV and sexually transmitted infection (STI) prevention is important for guiding national sexual health programmes for both the general population and key populations. The objectives of this study were to examine trends and ... ...

    Abstract Background: Monitoring of HIV and sexually transmitted infection (STI) prevention is important for guiding national sexual health programmes for both the general population and key populations. The objectives of this study were to examine trends and patterns of condom use at last intercourse and lifetime HIV testing in 2007, 2012 and 2017 in Switzerland, and to explore factors associated with these behaviours in men and women with opposite-sex partners and with same sex partners.
    Methods: We analysed data from the 2007, 2012 and 2017 Swiss Health Survey. For each time point, outcome and population group, we conducted a descriptive analysis of weighted data and conducted multivariable logistic regression to obtain adjusted odds ratios (aOR) with 95% confidence intervals (CI) and compared outcomes between the timepoints.
    Results: In total, 46,320 people were interviewed: 21,847 men and 23,141 women, who reported having sex only with partners of the opposite sex, 633 men who reported sex with a male partner and 699 women who reported sex with a female partner. Among the three surveys the prevalence of condom did not change but varied from 22 to 26% of men and 15 to 21% in women with only opposite-sex partners (aOR men, 0.93, 95% CI 0.82, 1.06; women 0.98, 95% CI 0.86 to 1.11). In men with any same sex partner the prevalence of condom use was 40% in 2007, 33% in 2012 and 54% in 2017 (aOR 1.80, 95% CI 0.97, 3.34). In multivariable analysis, the factor most strongly associated with condom use was sex with an occasional partner at last intercourse. HIV testing ever increased across all three survey years in people with opposite sex partners: 2017 vs. 2007, aOR men with only opposite-sex partners 1.64 (95% CI 1.49, 1.82), women with only opposite-sex partners 1.67 (1.51, 1.85), men with any same sex partner 0.98 (0.49, 1.96), women with any same sex partner 1.31 (0.74, 2.30).
    Conclusions: Monitoring of condom use, and HIV testing should continue and contribute to the development of the national sexual health programme. Stronger promotion of condoms for people with opposite-sex partners might be needed, since overall condom use at last intercourse has not changed since 2007.
    MeSH term(s) Humans ; Male ; Female ; Adult ; Condoms ; Cross-Sectional Studies ; Switzerland/epidemiology ; Sexual Behavior ; Sexual Partners ; Sexually Transmitted Diseases/prevention & control ; Surveys and Questionnaires ; HIV Testing ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/prevention & control
    Language English
    Publishing date 2023-11-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-17056-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: From testing to screening for STIs.

    Low, Nicola

    Sexually transmitted infections

    2017  Volume 93, Issue 1, Page(s) 75

    Language English
    Publishing date 2017-02
    Publishing country England
    Document type Letter
    ZDB-ID 1420303-0
    ISSN 1472-3263 ; 1368-4973
    ISSN (online) 1472-3263
    ISSN 1368-4973
    DOI 10.1136/sextrans-2016-053001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Studies of prevalence: how a basic epidemiology concept has gained recognition in the COVID-19 pandemic.

    Buitrago-Garcia, Diana / Salanti, Georgia / Low, Nicola

    BMJ open

    2022  Volume 12, Issue 10, Page(s) e061497

    Abstract: Background: Prevalence measures the occurrence of any health condition, exposure or other factors related to health. The experience of COVID-19, a new disease caused by SARS-CoV-2, has highlighted the importance of prevalence studies, for which issues ... ...

    Abstract Background: Prevalence measures the occurrence of any health condition, exposure or other factors related to health. The experience of COVID-19, a new disease caused by SARS-CoV-2, has highlighted the importance of prevalence studies, for which issues of reporting and methodology have traditionally been neglected.
    Objective: This communication highlights key issues about risks of bias in the design and conduct of prevalence studies and in reporting them, using examples about SARS-CoV-2 and COVID-19.
    Summary: The two main domains of bias in prevalence studies are those related to the study population (selection bias) and the condition or risk factor being assessed (information bias). Sources of selection bias should be considered both at the time of the invitation to take part in a study and when assessing who participates and provides valid data (respondents and non-respondents). Information bias appears when there are systematic errors affecting the accuracy and reproducibility of the measurement of the condition or risk factor. Types of information bias include misclassification, observer and recall bias. When reporting prevalence studies, clear descriptions of the target population, study population, study setting and context, and clear definitions of the condition or risk factor and its measurement are essential. Without clear reporting, the risks of bias cannot be assessed properly. Bias in the findings of prevalence studies can, however, impact decision-making and the spread of disease. The concepts discussed here can be applied to the assessment of prevalence for many other conditions.
    Conclusions: Efforts to strengthen methodological research and improve assessment of the risk of bias and the quality of reporting of studies of prevalence in all fields of research should continue beyond this pandemic.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; SARS-CoV-2 ; Reproducibility of Results ; Bias
    Language English
    Publishing date 2022-10-27
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-061497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Survival among people hospitalized with COVID-19 in Switzerland: a nationwide population-based analysis.

    Anderegg, Nanina / Panczak, Radoslaw / Egger, Matthias / Low, Nicola / Riou, Julien

    BMC medicine

    2022  Volume 20, Issue 1, Page(s) 164

    Abstract: Background: Increasing age, male sex, and pre-existing comorbidities are associated with lower survival from SARS-CoV-2 infection. The interplay between different comorbidities, age, and sex is not fully understood, and it remains unclear if survival ... ...

    Abstract Background: Increasing age, male sex, and pre-existing comorbidities are associated with lower survival from SARS-CoV-2 infection. The interplay between different comorbidities, age, and sex is not fully understood, and it remains unclear if survival decreases linearly with higher ICU occupancy or if there is a threshold beyond which survival falls.
    Method: This national population-based study included 22,648 people who tested positive for SARS-CoV-2 infection and were hospitalized in Switzerland between February 24, 2020, and March 01, 2021. Bayesian survival models were used to estimate survival after positive SARS-CoV-2 test among people hospitalized with COVID-19 by epidemic wave, age, sex, comorbidities, and ICU occupancy. Two-way interactions between age, sex, and comorbidities were included to assess the differential risk of death across strata. ICU occupancy was modeled using restricted cubic splines to allow for a non-linear association with survival.
    Results: Of 22,648 people hospitalized with COVID-19, 4785 (21.1%) died. The survival was lower during the first epidemic wave than in the second (predicted survival at 40 days after positive test 76.1 versus 80.5%). During the second epidemic wave, occupancy among all available ICU beds in Switzerland varied between 51.7 and 78.8%. The estimated survival was stable at approximately 81.5% when ICU occupancy was below 70%, but worse when ICU occupancy exceeded this threshold (survival at 80% ICU occupancy: 78.2%; 95% credible interval [CrI] 76.1 to 80.1%). Periods with higher ICU occupancy (>70 vs 70%) were associated with an estimated number of 137 (95% CrI 27 to 242) excess deaths. Comorbid conditions reduced survival more in younger people than in older people. Among comorbid conditions, hypertension and obesity were not associated with poorer survival. Hypertension appeared to decrease survival in combination with cardiovascular disease.
    Conclusions: Survival after hospitalization with COVID-19 has improved over time, consistent with improved management of severe COVID-19. The decreased survival above 70% national ICU occupancy supports the need to introduce measures for prevention and control of SARS-CoV-2 transmission in the population well before ICUs are full.
    MeSH term(s) Aged ; Bayes Theorem ; COVID-19/epidemiology ; Hospitalization ; Humans ; Hypertension ; Male ; SARS-CoV-2 ; Switzerland/epidemiology
    Language English
    Publishing date 2022-04-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2131669-7
    ISSN 1741-7015 ; 1741-7015
    ISSN (online) 1741-7015
    ISSN 1741-7015
    DOI 10.1186/s12916-022-02364-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Estimating the global burden of sexually transmitted infections.

    Peters, Remco P H / Chico, R Matthew / Rowley, Jane / Low, Nicola

    The Lancet. Infectious diseases

    2022  Volume 22, Issue 8, Page(s) 1112–1113

    MeSH term(s) Humans ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/prevention & control
    Language English
    Publishing date 2022-07-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(22)00415-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The changing landscape of chlamydia control strategies.

    Low, Nicola / Hocking, Jane S / van Bergen, Jan

    Lancet (London, England)

    2021  Volume 398, Issue 10309, Page(s) 1386–1388

    MeSH term(s) Chlamydia ; Chlamydia Infections/diagnosis ; Chlamydia Infections/epidemiology ; Chlamydia Infections/prevention & control ; Diagnostic Tests, Routine ; Humans
    Language English
    Publishing date 2021-09-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)02002-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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