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  1. Article ; Online: Overview of anti-viral effects of probiotics via immune cells in pre-, mid- and post-SARS-CoV2 era.

    Kanauchi, Osamu / Low, Zhao Xuan / Jounai, Kenta / Tsuji, Ryohei / AbuBakar, Sazaly

    Frontiers in immunology

    2023  Volume 14, Page(s) 1280680

    Abstract: The COVID-19 outbreak has caused significant global changes and increased public awareness of SARS-CoV-2. Substantial progress in developing vaccines, enhancing sanitation practices, and implementing various measures to combat the virus, including the ... ...

    Abstract The COVID-19 outbreak has caused significant global changes and increased public awareness of SARS-CoV-2. Substantial progress in developing vaccines, enhancing sanitation practices, and implementing various measures to combat the virus, including the utilization of probiotics has been made. This comprehensive review examined the medical impact of clinically proven probiotics on infectious diseases, considering three crucial time periods: before (pre-), during (mid-), and after (post-) COVID-19 pandemic era. This review also showed a perspective on the use of probiotics to stimulate the innate immune system and prevent infectious diseases. In pre-COVID-19 era, several probiotic strains were found to be clinically effective in addressing gastrointestinal infectious diseases, the common cold and flu. However, the mechanism by which probiotics exerted their antiviral effects remained relatively unclear during that period. Nevertheless, probiotics,
    MeSH term(s) Humans ; COVID-19 ; RNA, Viral ; SARS-CoV-2 ; Pandemics/prevention & control ; Probiotics ; Antiviral Agents/therapeutic use ; Communicable Diseases/drug therapy ; Interferons ; Vaccines
    Chemical Substances RNA, Viral ; Antiviral Agents ; Interferons (9008-11-1) ; Vaccines
    Language English
    Publishing date 2023-12-05
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1280680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Seroprevalence of dengue and chikungunya viruses among urban refugees in Klang Valley, Malaysia.

    Sahimin, Norhidayu / Low, Zhao Xuan / Hassandarvish, Pouya / Mohd Hanapi, Izzah Ruzana / Mohd Zain, Siti Nursheena / Yahaya, Hasmawati / Abu Bakar, Sazaly

    Transactions of the Royal Society of Tropical Medicine and Hygiene

    2024  Volume 118, Issue 5, Page(s) 328–335

    Abstract: Background: Mosquito-borne diseases pose a significant global public health threat, with Malaysia's Klang Valley experiencing numerous outbreaks in densely populated urban areas.: Methods: This study aimed to estimate the seroprevalence of anti- ... ...

    Abstract Background: Mosquito-borne diseases pose a significant global public health threat, with Malaysia's Klang Valley experiencing numerous outbreaks in densely populated urban areas.
    Methods: This study aimed to estimate the seroprevalence of anti-dengue and anti-chikungunya antibodies among urban refugees in the Klang Valley, Malaysia, and identify associated risk factors.
    Results: High seroprevalence of anti-dengue immunoglobulin G (IgG) and IgM (60.0% [confidence interval {CI} 55.39 to 64.48] and 9.2% [CI 6.77 to 12.25], respectively) were observed among refugees >18 years of age (χ22=11.720, p=0.003), Kachin ethnicity (χ28=72.253, p<0.001), without formal education (χ21=3.856, p=0.050), homes near waste disposal sites (χ21=10.378, p=0.001) and refugees who have experienced flooding (χ21=5.460, p=0.019). Meanwhile, the overall seroprevalence of anti-chikungunya IgG and IgM was 9.7% (CI 7.15 to 12.73) and 10.8% (CI 8.09 to 13.93), respectively, with ages 12-18 years (χ22=6.075, p=0.048), Rohingya ethnicity (χ28=31.631, p<0.001) and homes close to waste disposal sites (χ21=3.912, p=0.048) being significant risk factors. Results showed a link to poor environmental living conditions, with an increase in the vector population with higher availability of breeding sites and thus exposure to dengue and chikungunya virus.
    Conclusions: Health education among the community is the key to disease prevention, as there are no specific antiviral drugs for treatment and limited vaccine availability.
    MeSH term(s) Humans ; Malaysia/epidemiology ; Seroepidemiologic Studies ; Dengue/epidemiology ; Dengue/immunology ; Dengue/blood ; Male ; Chikungunya Fever/epidemiology ; Chikungunya Fever/blood ; Chikungunya Fever/immunology ; Female ; Adult ; Refugees/statistics & numerical data ; Adolescent ; Child ; Chikungunya virus/immunology ; Young Adult ; Antibodies, Viral/blood ; Immunoglobulin M/blood ; Middle Aged ; Immunoglobulin G/blood ; Dengue Virus/immunology ; Risk Factors ; Child, Preschool ; Urban Population
    Chemical Substances Antibodies, Viral ; Immunoglobulin M ; Immunoglobulin G
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 441375-1
    ISSN 1878-3503 ; 0035-9203
    ISSN (online) 1878-3503
    ISSN 0035-9203
    DOI 10.1093/trstmh/trad097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article ; Online: Antiviral activity of silymarin and baicalein against dengue virus.

    Low, Zhao Xuan / OuYong, Brian Ming / Hassandarvish, Pouya / Poh, Chit Laa / Ramanathan, Babu

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 21221

    Abstract: Dengue is an arthropod-borne viral disease that has become endemic and a global threat in many countries with no effective antiviral drug available currently. This study showed that flavonoids: silymarin and baicalein could inhibit the dengue virus in ... ...

    Abstract Dengue is an arthropod-borne viral disease that has become endemic and a global threat in many countries with no effective antiviral drug available currently. This study showed that flavonoids: silymarin and baicalein could inhibit the dengue virus in vitro and were well tolerated in Vero cells with a half-maximum cytotoxic concentration (CC
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Antiviral Agents/toxicity ; Chlorocebus aethiops ; Dengue Virus/drug effects ; Dengue Virus/physiology ; Flavanones/pharmacology ; Flavanones/toxicity ; Inhibitory Concentration 50 ; Protein Binding ; Silymarin/pharmacology ; Silymarin/toxicity ; Vero Cells ; Viral Envelope Proteins/metabolism ; Virus Internalization/drug effects ; Virus Replication/drug effects
    Chemical Substances Antiviral Agents ; Flavanones ; Silymarin ; Viral Envelope Proteins ; baicalein (49QAH60606)
    Language English
    Publishing date 2021-10-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-98949-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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