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  1. Article ; Online: Immune checkpoints in rheumatoid arthritis: progress and promise.

    Small, Annabelle / Lowe, Katie / Wechalekar, Mihir D

    Frontiers in immunology

    2023  Volume 14, Page(s) 1285554

    Abstract: Rheumatoid arthritis (RA) is one of the most prevalent autoimmune inflammatory conditions, and while the mechanisms driving pathogenesis are yet to be completely elucidated, self-reactive T cells and immune checkpoint pathways have a clear role. In this ... ...

    Abstract Rheumatoid arthritis (RA) is one of the most prevalent autoimmune inflammatory conditions, and while the mechanisms driving pathogenesis are yet to be completely elucidated, self-reactive T cells and immune checkpoint pathways have a clear role. In this review, we provide an overview of the importance of checkpoint pathways in the T cell response and describe the involvement of these in RA development and progression. We discuss the relationship between immune checkpoint therapy in cancer and autoimmune adverse events, draw parallels with the involvement of immune checkpoints in RA pathobiology, summarise emerging research into some of the lesser-known pathways, and the potential of targeting checkpoint-related pathways in future treatment approaches to RA management.
    MeSH term(s) Humans ; Arthritis, Rheumatoid ; Autoimmune Diseases ; Neoplasms/therapy ; T-Lymphocytes
    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1285554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Impact of Bariatric Surgery on Renal Function.

    Dewantoro, Dickson / Fultang, Joshua / Lowe, Katie / Chinaka, Ugochukwu / Bakhshi, Andisheh / Ali, Abdulmajid

    Cureus

    2021  Volume 13, Issue 10, Page(s) e18534

    Abstract: Introduction Bariatric surgery offers superior benefits for weight loss, quality of life and a spectrum of metabolic diseases. Despite these benefits, studies so far have shown varying results on its effect on renal function. Aim In this study, we aim to ...

    Abstract Introduction Bariatric surgery offers superior benefits for weight loss, quality of life and a spectrum of metabolic diseases. Despite these benefits, studies so far have shown varying results on its effect on renal function. Aim In this study, we aim to look at bariatric surgery's effect on renal function at one, two and three year post operation (post-op). Methods This is a retrospective cross-sectional single-center study of patients who underwent bariatric surgery between 11/2008 and 06/2018. Renal function was calculated by using Cockroft-Gault equation, expressed as Creatinine Clearance (CrCl). Statistical analysis used was one-way ANOVA (Welch's) with Games-Howell Post-Hoc Test. Results From 307 patients who underwent bariatric surgery within the time period, 145 were studied. 30.3% (n=44) were male. The average age and body mass index (BMI) at referral were 48.1±8.6 years and 47.96±7.9 kgm
    Language English
    Publishing date 2021-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.18534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment.

    Lowe, Katie / Small, Annabelle / Song, Qingxuan / Hao, Ling-Yang / Murray-Brown, William / Proudman, Susanna / Smith, Malcolm D / Nagpal, Sunil / Wechalekar, Mihir D

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 2847

    Abstract: Programmed cell death protein 1 (PD-1)-expressing T cells are expanded in individuals with established rheumatoid arthritis (RA). However, little is known about their functional role in the pathogenesis of early RA. To address this, we investigated the ... ...

    Abstract Programmed cell death protein 1 (PD-1)-expressing T cells are expanded in individuals with established rheumatoid arthritis (RA). However, little is known about their functional role in the pathogenesis of early RA. To address this, we investigated the transcriptomic profiles of circulating CD4
    MeSH term(s) Humans ; CD4-Positive T-Lymphocytes ; Transcriptome ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/metabolism ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Antirheumatic Agents/pharmacology ; Antirheumatic Agents/therapeutic use ; Antirheumatic Agents/metabolism ; Apoptosis
    Chemical Substances Programmed Cell Death 1 Receptor ; Antirheumatic Agents
    Language English
    Publishing date 2023-02-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-29971-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Parental monitoring, parental warmth, and minority youths' academic outcomes: exploring the integrative model of parenting.

    Lowe, Katie / Dotterer, Aryn M

    Journal of youth and adolescence

    2013  Volume 42, Issue 9, Page(s) 1413–1425

    Abstract: Guided by the integrative model of parenting, the present study investigated the relationship between parental monitoring and racial/ethnic minority adolescents' school engagement and academic motivation as a function of parental warmth, and explored ... ...

    Abstract Guided by the integrative model of parenting, the present study investigated the relationship between parental monitoring and racial/ethnic minority adolescents' school engagement and academic motivation as a function of parental warmth, and explored whether these associations varied for boys and girls. Participants (60 % female) were 208 sixth through eighth grade students (63 % African American, 19 % Latino, 18 % Multiracial) from an urban middle school in the Midwestern United States. Youth completed an in-school survey with items on parenting (parental monitoring, mothers'/fathers' warmth), cognitive engagement (school self-esteem), behavioral engagement (school trouble), and academic motivation (intrinsic motivation). As hypothesized, mothers' warmth enhanced the association between parental monitoring and youths' engagement and motivation. No gender differences in these associations emerged. Fathers' warmth strengthened the negative association between parental monitoring and school trouble, and this association was stronger for boys. Implications regarding the importance of sustaining a high level of monitoring within the context of warm parent-adolescent relationships to best support academic outcomes among minority youth are discussed.
    MeSH term(s) Achievement ; Adolescent ; Adolescent Behavior/ethnology ; Adolescent Behavior/psychology ; African Americans/psychology ; Child ; Female ; Health Surveys ; Hispanic Americans/psychology ; Humans ; Linear Models ; Longitudinal Studies ; Love ; Male ; Midwestern United States ; Minority Groups/psychology ; Models, Educational ; Models, Psychological ; Motivation ; Parent-Child Relations/ethnology ; Parenting/ethnology ; Parenting/psychology ; Psychology, Adolescent ; Schools ; Self Concept ; Sex Factors
    Language English
    Publishing date 2013-03-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186743-x
    ISSN 1573-6601 ; 0047-2891
    ISSN (online) 1573-6601
    ISSN 0047-2891
    DOI 10.1007/s10964-013-9934-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Differential expansion of T peripheral helper cells in early rheumatoid arthritis and osteoarthritis synovium.

    Murray-Brown, William / Guo, Yanxia / Small, Annabelle / Lowe, Katie / Weedon, Helen / Smith, Malcolm D / Lester, Susan E / Proudman, Susanna M / Rao, Navin L / Hao, Ling-Yang / Nagpal, Sunil / Wechalekar, Mihir D

    RMD open

    2022  Volume 8, Issue 2

    Abstract: Objectives: Programmed cell death protein 1 (PD-1)-expressing T cells are implicated in the pathogenesis of autoimmune inflammatory diseases such as rheumatoid arthritis. A subset of CXCR5 ... - ... T cells, termed T peripheral helper (Tph) cells, ... ...

    Abstract Objectives: Programmed cell death protein 1 (PD-1)-expressing T cells are implicated in the pathogenesis of autoimmune inflammatory diseases such as rheumatoid arthritis. A subset of CXCR5<sup>-</sup> T cells, termed T peripheral helper (Tph) cells, which drive B cell differentiation, have been identified in ectopic lymphoid structures in established rheumatoid arthritis synovial tissue. Here, we aimed to characterise these in treatment-naïve, early rheumatoid arthritis to determine whether these cells accumulate prior to fully established disease.
    Methods: Fresh dissociated tissue and peripheral blood mononuclear cell (PBMC) suspensions were stained with Zombie UV, followed by anti-CD45RO, PD-1, CD3, ICOS, CD8, CD4, CD20, CXCR5, TIGIT and CD38 antibodies prior to analysis. For histology, rheumatoid arthritis synovial sections were prepared for Opal multispectral immunofluorescence with anti-CD45RO, CD20, PD-1 and CXCR5 antibodies. Images were acquired on the Perkin Elmer Vectra V.3.0 imaging system and analysed using InForm Advanced Image Analysis software.
    Results: Flow cytometry revealed T cell infiltration in the rheumatoid arthritis synovium with differential expression of PD-1, CD45RO, ICOS, TIGIT and CD38. We observed a higher frequency of PD1<sup>hi</sup>CXCR5<sup>-</sup> Tph in rheumatoid arthritis synovial tissue and PBMCs versus controls, and no significant difference in T follicular helper cell frequency. Microscopy identified a 10-fold increase of Tph cells in early rheumatoid arthritis synovial follicular and diffuse regions, and identified Tph adjacent to germinal centre B cells.
    Conclusions: These data demonstrate that PD-1<sup>hi</sup> Tph cells are present in early rheumatoid arthritis, but not osteoarthritis synovium, and therefore may provide a target for treatment of patients with early rheumatoid arthritis.
    MeSH term(s) Humans ; Programmed Cell Death 1 Receptor/metabolism ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/pathology ; T-Lymphocytes, Helper-Inducer/metabolism ; T-Lymphocytes, Helper-Inducer/pathology ; Synovial Membrane/metabolism ; Receptors, CXCR5/metabolism ; Arthritis, Rheumatoid ; Osteoarthritis/pathology
    Chemical Substances Programmed Cell Death 1 Receptor ; Receptors, CXCR5
    Language English
    Publishing date 2022-10-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2022-002563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Classroom context, school engagement, and academic achievement in early adolescence.

    Dotterer, Aryn M / Lowe, Katie

    Journal of youth and adolescence

    2011  Volume 40, Issue 12, Page(s) 1649–1660

    Abstract: Classroom context and school engagement are significant predictors of academic achievement. These factors are especially important for academically at-risk students. Grounded in an ecological systems perspective, this study examined links between ... ...

    Abstract Classroom context and school engagement are significant predictors of academic achievement. These factors are especially important for academically at-risk students. Grounded in an ecological systems perspective, this study examined links between classroom context, school engagement, and academic achievement among early adolescents. We took a multidimensional approach to the measurement of classroom context and school engagement, incorporating both observational and self-reported assessments of various dimensions of classroom context (instruction quality, social/emotional climate, and student-teacher relationship) and school engagement (psychological and behavioral engagement). Using data from the NICHD Study of Early Child Care and Youth Development, we tested whether school engagement mediated the link between classroom context and academic achievement among 5th grade students, and whether these pathways were the same for students with previous achievement difficulties identified in 3rd grade. Participants included 1,014 children (50% female) in 5th grade (mean age = 11). The majority of the participants were white (77%) and 23% were children of color. Results indicated that psychological and behavioral engagement mediated the link between classroom context and academic achievement for students without previous achievement difficulties. However, for students with previous achievement difficulties psychological and behavioral engagement did not mediate the link between classroom context and academic achievement. These results suggest that improving classroom quality may not be sufficient to improve student engagement and achievement for students with previous achievement difficulties. Additional strategies may be needed for these students.
    MeSH term(s) Achievement ; Adolescent ; Age Factors ; Child ; Educational Status ; Female ; Follow-Up Studies ; Humans ; Male ; Schools ; Social Environment ; Students/psychology
    Language English
    Publishing date 2011-03-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 186743-x
    ISSN 1573-6601 ; 0047-2891
    ISSN (online) 1573-6601
    ISSN 0047-2891
    DOI 10.1007/s10964-011-9647-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Academic Growth Trajectories and Family Relationships among African American Youth.

    Dotterer, Aryn M / Lowe, Katie / McHale, Susan M

    Journal of research on adolescence : the official journal of the Society for Research on Adolescence

    2014  Volume 24, Issue 4, Page(s) 734–747

    Abstract: This study explored trajectories of African American youths' academic functioning and assessed whether changes in parent-adolescent relationships were associated with changes in youths' academic functioning. The data were drawn from a three-year ... ...

    Abstract This study explored trajectories of African American youths' academic functioning and assessed whether changes in parent-adolescent relationships were associated with changes in youths' academic functioning. The data were drawn from a three-year longitudinal study of gender socialization and development in two-parent African American families and included 197 families. Findings revealed gender differences in achievement trajectories and indicated that boys not only had lower levels of academic achievement compared to girls, but also experienced steeper declines in school self-esteem during adolescence. Changes in parent-adolescent relationship quality were linked to changes in academic functioning: Increases in conflict were related to decreases in GPA, school bonding, and school self-esteem and increases in warmth were related to increases in school bonding and school self-esteem.
    Language English
    Publishing date 2014-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2017369-6
    ISSN 1532-7795 ; 1050-8392
    ISSN (online) 1532-7795
    ISSN 1050-8392
    DOI 10.1111/jora.12080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Publication Rates of Abstracts Presented at the Society of General Internal Medicine Annual Meeting.

    Egloff, Heidi M / West, Colin P / Wang, Amy T / Lowe, Katie M / Edakkanambeth Varayil, Jithinraj / Beckman, Thomas J / Sawatsky, Adam P

    Journal of general internal medicine

    2017  , Page(s) 673–678

    Abstract: Background: Abstracts accepted at scientific meetings are often not subsequently published. Data on publication rates are largely from subspecialty and surgical studies.: Objective: The aims of this study were to 1) determine publication rates of ... ...

    Abstract Background: Abstracts accepted at scientific meetings are often not subsequently published. Data on publication rates are largely from subspecialty and surgical studies.
    Objective: The aims of this study were to 1) determine publication rates of abstracts presented at a general internal medicine meeting; 2) describe research activity among academic general internists; 3) identify factors associated with publication and with the impact factor of the journal of publication; and 4) evaluate for publication bias.
    Design: Retrospective cohort study.
    Participants: All scientific abstracts presented at the Society of General Internal Medicine 2009 Annual Meeting.
    Main measures: Publication rates were determined by searching for full-text publications in MEDLINE. Data were abstracted regarding authors' institution, research topic category, number of study sites, sample size, study design, statistical significance (p value and confidence interval) in abstract and publication, journal of publication, publication date, and journal impact factor.
    Key results: Of the 578 abstracts analyzed, 274 (47.4%) were subsequently published as a full article in a peer-reviewed journal indexed in MEDLINE. In a multivariable model adjusting for institution site, research topic, number of study sites, study design, sample size, and abstract results, publication rates for academic general internists were highest in the areas of medical education (52.5%, OR 5.05, 95% CI 1.57-17.25, reference group Veterans Affairs (VA)-based research, publication rate 36.7%), mental health/substance use (67.7%, OR 4.16, 95% CI 1.39-13.06), and aging/geriatrics/end of life (65.7%, OR 3.31, 95% CI 1.15-9.94, p = 0.01 across topics). Publication rates were higher for multicenter studies than single-institution studies (52.4% vs. 40.4%, OR 1.66, 95% CI 1.10-2.52, p = 0.04 across categories). Randomized controlled trials had higher publication rates than other study designs (66.7% vs. 45.9%, OR 2.72, 95% CI 1.30-5.94, p = 0.03 across study designs). Studies with positive results did not predict higher publication rates than negative studies (OR 0.89, 95% CI 0.6-1.31, p = 0.21).
    Conclusions: This study demonstrated that 47.4% of abstracts presented at a general internal medicine national conference were subsequently published in a peer-reviewed journal indexed in MEDLINE.
    Language English
    Publishing date 2017-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-017-3990-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: High-resolution esophageal manometry in pediatrics: Effect of esophageal length on diagnostic measures.

    Singendonk, Maartje M J / Ferris, Lara F / McCall, Lisa / Seiboth, Grace / Lowe, Katie / Moore, David / Hammond, Paul / Couper, Richard / Abu-Assi, Rammy / Cock, Charles / Benninga, Marc A / van Wijk, Michiel P / Omari, Taher I

    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

    2019  Volume 32, Issue 1, Page(s) e13721

    Abstract: Background: High-resolution esophageal manometry (HREM), derived esophageal pressure topography metrics (EPT), integrated relaxation pressure (IRP), and distal latency (DL) are influenced by age and size. Combined pressure and intraluminal impedance ... ...

    Abstract Background: High-resolution esophageal manometry (HREM), derived esophageal pressure topography metrics (EPT), integrated relaxation pressure (IRP), and distal latency (DL) are influenced by age and size. Combined pressure and intraluminal impedance also allow derivation of metrics that define distension pressure and bolus flow timing. We prospectively investigated the effects of esophageal length on these metrics to determine whether adjustment strategies are required for children.
    Methods: Fifty-five children (12.3 ± 4.5 years) referred for HREM, and 30 healthy adult volunteers (46.9 ± 3.8 years) were included. Studies were performed using the MMS system and a standardized protocol including 10 × 5 mL thin liquid bolus swallows (SBM kit, Trisco Foods) and analyzed via Swallow Gateway (www.swallowgateway.com). Esophageal distension pressures and swallow latencies were determined in addition to EGJ resting pressure and standard EPT metrics. Effects of esophageal length were examined using partial correlation, correcting for age. Adult-derived upper limits were adjusted for length using the slopes of the identified linear equations.
    Key results: Mean esophageal length in children was 16.8 ± 2.8 cm and correlated significantly with age (r = 0.787, P = .000). Shorter length correlated with higher EGJ resting pressure and 4-s integrated relaxation pressures (IRP), distension pressures, and shorter contraction latencies. Ten patients had an IRP above the adult upper limit. Adjustment for esophageal length reduced the number of patients with elevated IRP to three.
    Conclusions & inferences: We prospectively confirmed that certain EPT metrics, as well as potential useful adjunct pressure-impedance measures such as distension pressure, are substantially influenced by esophageal length and require adjusted diagnostic thresholds specifically for children.
    MeSH term(s) Child ; Esophageal Motility Disorders/diagnosis ; Esophagus/anatomy & histology ; Esophagus/physiology ; Female ; Humans ; Male ; Manometry/methods ; Middle Aged ; Organ Size ; Pediatrics/methods
    Language English
    Publishing date 2019-09-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1186328-6
    ISSN 1365-2982 ; 1350-1925
    ISSN (online) 1365-2982
    ISSN 1350-1925
    DOI 10.1111/nmo.13721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Do Common Mynas significantly compete with native birds in urban environments?

    Lowe, Katie A / Taylor, Charlotte E / Major, Richard E

    Journal of ornithology. 2011 Oct., v. 152, no. 4

    2011  

    Abstract: In Australia, the introduced Common Myna (Acridotheres tristis) is commonly believed to aggressively displace native birds and outcompete them for food and nest resources. However, the current paucity of scientific evidence makes it difficult to devise ... ...

    Abstract In Australia, the introduced Common Myna (Acridotheres tristis) is commonly believed to aggressively displace native birds and outcompete them for food and nest resources. However, the current paucity of scientific evidence makes it difficult to devise appropriate management strategies for protection of urban bird populations. This study investigates the way in which the Common Myna uses the urban environment and interacts with other species while foraging and nesting in Sydney, Australia. The bird community varied between habitat types along an urbanisation gradient, and the abundance of the Common Myna increased significantly with the degree of habitat modification. Surveys of the frequency of interspecific interactions revealed that the Common Myna did not initiate a significantly greater number of aggressive encounters than did other species. Focal observations of two potential native competitors showed that despite foraging in close proximity, the Common Myna rarely interfered with feeding activity. Assessment of natural tree hollow occupancy found that Common Mynas used significantly fewer tree hollows than did native species. Analysis of nest site selection indicated that Common Mynas chose to nest in more highly modified habitats, and in artificial structures rather than in vegetation. These findings suggest that, in this study area, Common Mynas have little competitive impact on resource use by native bird species in the urban matrix. The logical conclusion of these results is that the substantial efforts currently directed towards culling of Common Mynas in heavily urbanised environments is misdirected, and resources would be better directed to improvement of natural habitat quality in these areas if the purpose of control is to enhance urban bird diversity.
    Keywords Acridotheres ; birds ; foraging ; habitats ; indigenous species ; nesting ; nesting sites ; nests ; surveys ; trees ; urbanization ; vegetation ; Australia
    Language English
    Dates of publication 2011-10
    Size p. 909-921.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 2134595-8
    ISSN 1439-0361 ; 2193-7206 ; 2193-7192
    ISSN (online) 1439-0361 ; 2193-7206
    ISSN 2193-7192
    DOI 10.1007/s10336-011-0674-5
    Database NAL-Catalogue (AGRICOLA)

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