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  1. Article ; Online: Metastatic melanoma and rare melanoma variants: a review.

    Lowe, Lori

    Pathology

    2022  Volume 55, Issue 2, Page(s) 236–244

    Abstract: The histopathological diagnosis of melanoma is fraught with potential pitfalls. In the setting of cutaneous metastatic melanoma, it is important to recognise the various histological patterns that can be encountered from the more common to the rare, ... ...

    Abstract The histopathological diagnosis of melanoma is fraught with potential pitfalls. In the setting of cutaneous metastatic melanoma, it is important to recognise the various histological patterns that can be encountered from the more common to the rare, including epidermotropic, folliculotropic, naevoid, and blue naevus-like. In addition, melanoma is notorious for phenotypic plasticity. Thus, there are many different subtypes and cytomorphological variations that can be difficult to recognise as melanoma, particularly in the recurrent or metastatic setting. Select melanoma variants including primary dermal, clear cell, plasmacytoid, signet ring cell, small cell, myxoid, rhabdoid, and dedifferentiated melanoma will be discussed, in addition to composite melanocytic neoplasms. This review is intended to remind the practitioner of key concepts of metastatic disease and select rare melanoma variants, while providing practical guidelines for accurate diagnosis.
    MeSH term(s) Humans ; Diagnosis, Differential ; Melanoma/diagnosis ; Melanoma/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology ; Nevus, Blue ; Neoplasms, Second Primary/diagnosis
    Language English
    Publishing date 2022-12-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2022.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 723: Show issues Location:
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  2. Article ; Online: Commentary on Systematic Review of Technical Variations for "Mohs Micrographic Surgery for Melanoma".

    Johnson, Timothy M / Lowe, Lori

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2021  Volume 47, Issue 12, Page(s) 1545–1546

    MeSH term(s) Humans ; Melanoma/surgery ; Mohs Surgery ; Skin Neoplasms/surgery
    Language English
    Publishing date 2021-11-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000003262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1212: Show issues Location:
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  3. Article: Peristomal intestinal metaplasia with response to serial electrosurgery.

    Poppens, McKayla / Hester, Thomas / Renati, Sruthi / Billi, Allison C / Lowe, Lori / Mervak, Julie E

    JAAD case reports

    2024  Volume 45, Page(s) 38–40

    Language English
    Publishing date 2024-01-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2024.01.002
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  4. Article ; Online: Myelodysplasia Cutis.

    Whittington, Carli P / Ross, Charles W / Ramirez, James A / Lowe, Lori / Brown, Noah / Hristov, Alexandra C

    Archives of pathology & laboratory medicine

    2024  Volume 148, Issue 4, Page(s) 385–389

    Abstract: Context.—: Myelodysplasia cutis is an emerging concept in cutaneous neoplasia. Many of these cases were previously included under the umbrella of histiocytoid Sweet syndrome. However, with the advent of next-generation sequencing, cutaneous involvement ... ...

    Abstract Context.—: Myelodysplasia cutis is an emerging concept in cutaneous neoplasia. Many of these cases were previously included under the umbrella of histiocytoid Sweet syndrome. However, with the advent of next-generation sequencing, cutaneous involvement by myelodysplastic syndrome is being increasingly recognized.
    Objective.—: To review histiocytoid Sweet syndrome and myelodysplasia cutis and discuss our current understanding of these entities. Additionally, to discuss how next-generation sequencing can be applied in the evaluation of cutaneous infiltrates of immature histiocytoid cells.
    Data sources.—: The English-language literature from 2005 to 2023 on the topic of histiocytoid Sweet syndrome and myelodysplasia cutis was reviewed.
    Conclusions.—: Biopsy specimens showing infiltrates of histiocytoid, immature myeloid cells may represent cutaneous involvement by myelodysplastic syndrome. Close clinical correlation is recommended in these cases. Recent studies suggest that next-generation sequencing is useful in separating myelodysplasia cutis from true histiocytoid Sweet syndrome. This distinction has important implications for patients.
    MeSH term(s) Humans ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/pathology ; Skin/pathology ; Skin Neoplasms/pathology ; Sweet Syndrome/diagnosis ; Sweet Syndrome/pathology
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2023-0132-RA
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Clinical and Histopathologic Spectrum of Toxic Erythema of Chemotherapy: A Series of 56 Cases From a Single Institution.

    Cole, Daniel W / Menge, Tyler D / Lowe, Lori / Chan, May P / Bresler, Scott C

    The American Journal of dermatopathology

    2023  

    Abstract: Introduction: Although many individual cases and small series of toxic erythema of chemotherapy (TEC) have been described, the full spectrum of findings is not well understood.: Objective: To provide a comprehensive review of the clinical and ... ...

    Abstract Introduction: Although many individual cases and small series of toxic erythema of chemotherapy (TEC) have been described, the full spectrum of findings is not well understood.
    Objective: To provide a comprehensive review of the clinical and histopathologic features of TEC with an emphasis on novel histopathologic findings.
    Methods: We searched our electronic medical record for "toxic erythema of chemotherapy" or "neutrophilic eccrine hidradenitis." Fifty-six cases meeting clinical and histopathologic criteria were identified. The electronic medical record and accompanying hematoxylin and eosin-stained slides were retrospectively reviewed.
    Results: The clinical findings were heterogeneous but included classic presentations such as intertriginous eruptions (34%) and acral erythema (25%). The most common histopathologic features were apoptotic keratinocytes (95%), basal vacuolar change (91%), and epithelial dysmaturation (79%). Eccrine squamous syringometaplasia was seen in over half of the cases (33/56; 59%), whereas neutrophilic eccrine hidradenitis was uncommon (16%). Interestingly, many cases showed prominent interstitial histiocytes (55%). Other novel findings included irregular orthohyperkeratosis (23%), irregular epidermal hyperplasia (14%), and acantholysis (9%).
    Limitations: As a retrospective study, it is subject to information bias.
    Conclusion: This is the largest reported series of TEC. In addition to confirming previously reported features, we identify novel histopathologic findings to add to the spectrum of TEC.
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002450
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    Zs.A 1518: Show issues Location:
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  6. Article ; Online: Detection of antibody-coated Mucor in skin biopsy by direct immunofluorescence.

    Brent, Ashley A / Chen, Olivia / Eshaq, Milad / Lowe, Lori / Chan, May P

    Journal of cutaneous pathology

    2023  Volume 50, Issue 7, Page(s) 637–641

    Abstract: Cutaneous mucormycosis may be caused by direct inoculation or hematogenous spread of mucormycetes in immunocompromised patients. Skin biopsy is characterized by a deep fungal infection with frequent angioinvasion. The fungal hyphae can usually be ... ...

    Abstract Cutaneous mucormycosis may be caused by direct inoculation or hematogenous spread of mucormycetes in immunocompromised patients. Skin biopsy is characterized by a deep fungal infection with frequent angioinvasion. The fungal hyphae can usually be identified on H&E stain. We report a case of cutaneous angioinvasive mucormycosis in which the fungi were also visualized on direct immunofluorescence. A 57-year-old patient with relapsed myelodysplastic syndrome status-post allogeneic hematopoietic cell transplant, diabetes mellitus, and graft-versus-host disease presented with painful, palpable, dark-red to violaceous retiform purpuric plaques. Light microscopy of punch biopsy revealed numerous broad, ribbon-like, pauci-septate hyphae in the dermis with angioinvasion, consistent with mucormycosis. Direct immunofluorescence performed on a concurrent biopsy to exclude immune complex vasculitis showed smooth IgG, IgA (weak), IgM (faint), and C3 deposition on the hyphal structures, compatible with antibody-coated fungi. Tissue culture subsequently confirmed Mucor species. Although mucormycosis was readily diagnosable on routine light microscopy in this case, recognition of the unique phenomenon of antibody-coated fungi can be crucial when the invasive fungi are sparse or only present in the direct immunofluorescence specimen.
    MeSH term(s) Humans ; Middle Aged ; Mucor ; Mucormycosis/diagnosis ; Fluorescent Antibody Technique, Direct ; Hematopoietic Stem Cell Transplantation ; Biopsy
    Language English
    Publishing date 2023-04-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/cup.14435
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    Zs.A 1043: Show issues Location:
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  7. Article ; Online: A striking presentation of pustular Sweet syndrome induced by trimethoprim-sulfamethoxazole.

    Ryder, C Yoonhee / Matthews, Natalie H / Lowe, Lori / Wang, Frank

    The Australasian journal of dermatology

    2022  Volume 63, Issue 4, Page(s) e356–e359

    Abstract: We describe a strikingly robust presentation of trimethoprim-sulfamethoxazole (TMP-SMX)-induced pustular Sweet syndrome and discuss how to distinguish it from iododerma and other neutrophil-rich conditions. A review of the literature indicates that TMP- ... ...

    Abstract We describe a strikingly robust presentation of trimethoprim-sulfamethoxazole (TMP-SMX)-induced pustular Sweet syndrome and discuss how to distinguish it from iododerma and other neutrophil-rich conditions. A review of the literature indicates that TMP-SMX-induced Sweet syndrome (SS) may have higher rates of neutrophilia and greater ocular, mucosal, and musculoskeletal involvement compared to SS from other drugs. Recognizing these features and identifying the offending agent are critical for correctly diagnosing TMP-SMX-induced SS in a timely manner.
    MeSH term(s) Humans ; Trimethoprim, Sulfamethoxazole Drug Combination/adverse effects ; Sweet Syndrome/chemically induced ; Sweet Syndrome/diagnosis
    Chemical Substances Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2)
    Language English
    Publishing date 2022-07-22
    Publishing country Australia
    Document type Review ; Journal Article
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.13897
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    Zs.A 236: Show issues Location:
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  8. Article: Metastatic same-site squamous cell carcinoma arising during vismodegib therapy for basal cell carcinoma.

    Zhao, Raymond / Wang, Bo / Lowe, Lori / Dlugosz, Andrzej / Bichakjian, Christopher K

    JAAD case reports

    2022  Volume 28, Page(s) 54–57

    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2022.07.032
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  9. Article ; Online: Unusual drug reaction with features of colchicine toxicity in a patient on colchicine and allopurinol.

    Salari, Behzad / Joseph, Mallory / Eshaq, Milad / Lowe, Lori / Fullen, Douglas R

    Journal of cutaneous pathology

    2022  Volume 49, Issue 11, Page(s) 938–942

    Abstract: A 58-year-old woman was admitted for heart failure and concern for cardiogenic shock. The patient had been recently placed on colchicine and allopurinol, 4 months and 3 weeks, respectively, prior to admission. Upon admission, she had a cutaneous eruption ...

    Abstract A 58-year-old woman was admitted for heart failure and concern for cardiogenic shock. The patient had been recently placed on colchicine and allopurinol, 4 months and 3 weeks, respectively, prior to admission. Upon admission, she had a cutaneous eruption that had started abruptly several days after allopurinol initiation. It included multiple erythematous papules with scant scale on the forearms and numerous erythematous papules on the legs. Because of the varied morphologic presentation, biopsies from both the thigh and forearm were performed for a suspected drug reaction. The specimen from the thigh showed a superficial-dermal, band-like lymphocytic infiltrate with dyskeratosis and numerous intraepidermal mitotic figures predominantly in metaphase. In addition, there were neutrophils with leukocytoclasia. The specimen from the forearm showed superficial perivascular lymphocytic inflammation and intraepidermal dyskeratosis with mitotic figures similar to the thigh biopsy specimen but without a dermal neutrophilic infiltrate. An unusual drug eruption with features of colchicine toxicity was favored. Colchicine toxicity is not a commonly encountered clinical scenario and cutaneous findings have only rarely been described. Herein we report an exceedingly rare case of an unusual drug reaction with "colchicine figures" (i.e., ring-shaped mitotic figures arrested in metaphase) consistent with colchicine toxicity.
    MeSH term(s) Allopurinol/adverse effects ; Colchicine/adverse effects ; Drug Eruptions/etiology ; Erythema ; Exanthema ; Female ; Humans ; Middle Aged
    Chemical Substances Allopurinol (63CZ7GJN5I) ; Colchicine (SML2Y3J35T)
    Language English
    Publishing date 2022-07-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/cup.14280
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  10. Article: The spectrum of clinical and genetic findings in hereditary leiomyomatosis and renal cell cancer (HLRCC) with relevance to patient outcomes: a retrospective study from a large academic tertiary referral center.

    Scharnitz, Thomas / Nakamura, Mio / Koeppe, Erika / Henry, Marie-Louise / Lowe, Lori / Else, Tobias / Cha, Kelly B

    American journal of cancer research

    2023  Volume 13, Issue 1, Page(s) 236–244

    Abstract: Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an autosomal dominant condition attributed to pathogenic variants ... ...

    Abstract Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an autosomal dominant condition attributed to pathogenic variants in
    Language English
    Publishing date 2023-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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