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Abstract: This piece was part of a series of Helping Hands stories authored by School of Pharmacy faculty, staff, students, trainees, and alumni who stepped up to assist their family and friends, colleagues, and communities during the COVID-19 pandemic. ... The ... ...

Abstract	This piece was part of a series of Helping Hands stories authored by School of Pharmacy faculty, staff, students, trainees, and alumni who stepped up to assist their family and friends, colleagues, and communities during the COVID-19 pandemic. The Kindness Pantry project supports teachers and students in schools in Howard County, Maryland, by creating Amazon Wishlists of supplies. The project switched gears during the COVID-19 Pandemic to create kits for distribution at schools for families in need of school supplies and snacks. Ashleigh Lowery, School of Pharmacy Alumnus (PharmD 2011) and co-founder of The Kindness Pantry, describes the shift of the project's focus from sending supplies to Howard County Schools to creating kits filled with essential school supplies and snacks to students in need during the COVID-19 crisis.
Keywords	UMB COVID-19 personal narratives ; Coronavirus Disease 2019 (COVID-19) ; The Kindness Pantry ; volunteering ; University of Maryland ; Baltimore ; Baltimore. School of Pharmacy ; COVID-19 (Disease) ; Howard County (Md.) ; Voluntarism ; COVID-19 ; covid19
Subject code	370
Language	English
Publishing date	2020-05-01
Publisher	University of Maryland, Baltimore. School of Pharmacy
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Vascular access device type for systemic anti-cancer therapies in cancer patients: A scoping review.

Duggan, C / Hernon, O / Dunne, R / McInerney, V / Walsh, S R / Lowery, A / McCarthy, M / Carr, P J

Critical reviews in oncology/hematology

2024 Volume 196, Page(s) 104277

Abstract: Background: Patients with cancer can expect to receive numerous invasive vascular access procedures for intravenous therapy and clinical diagnostics. Due to the increased incidence and prevalence of cancer globally there will be significantly more ... ...

Abstract	Background: Patients with cancer can expect to receive numerous invasive vascular access procedures for intravenous therapy and clinical diagnostics. Due to the increased incidence and prevalence of cancer globally there will be significantly more people who require first-line intravenous chemotherapy over the next ten years. Methods: Our objective was to determine the types of evidence that exist for the vascular access device (VAD) type for the delivery of systemic anti-cancer therapy (SACT) in cancer patients. We used JBI scoping review methodology to identify the types of VADs used for SACT and with a specific search strategy included articles from 2012-2022 published in the English language. We identify (i) type of VADs used for SACT delivery (ii) the type of insertion and post-insertion complications (iii) the geographical location and clinical environment (iv) and whether VAD choice impacts on quality of life (QOL). Findings were presented using the PAGER framework. Main findings: Our search strategy identified 10,390 titles, of these, 5318 duplicates were removed. The remaining 5072 sources were screened for eligibility, 240 articles met the inclusion criteria. The most common design include retrospective study designs (n = 91) followed by prospective study designs (n = 31). We found 28 interventional studies with 21 registered in a clinical trial registry and identified no core outcome sets papers specific to VAD for SACT. The most prevalent publications were those that featured two or more VAD types (n = 70), followed by tunnelled intravenous VADs (n = 67). Of 38 unique complications identified, the most frequent catheter related complication was catheter related thrombosis (n = 178, 74%), followed by infection (n = 170, 71%). The county where the most publications originated from was China (n = 62) with one randomized controlled multicenter study from a comprehensive cancer centre. Of the thirty three studies that included QOL we found 4 which reported on body image. No QOL measurement tools specific to the process of SACT administration via VAD are available INTERPRETATION: Our findings suggest a systematic review and meta-analysis of VAD use for intravenous SACT can be considered. However, the development of a core outcome set for SACT should be prioritised. Funding for high quality programs of research for VAD in cancer are needed. Comprehensive cancer centres should lead this research agenda.
MeSH term(s)	Humans ; Quality of Life ; Prospective Studies ; Retrospective Studies ; Neoplasms/drug therapy ; Vascular Access Devices/adverse effects ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
Language	English
Publishing date	2024-03-14
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	605680-5
ISSN	1879-0461 ; 0737-9587 ; 1040-8428
ISSN (online)	1879-0461
ISSN	0737-9587 ; 1040-8428
DOI	10.1016/j.critrevonc.2024.104277
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Article ; Online: Pharmacological Thromboprophylaxis for VTE Post-Endovenous Ablation of Varicose Veins: Network Meta-Analysis.

Westby, Daniel / Gasior, Sara / Twyford, Mark / Power Foley, Megan / Lowery, Aoife / Walsh, Stewart R

Vascular and endovascular surgery

2024 , Page(s) 15385744241245079

Abstract: Objective: Endovenous ablation has revolutionized treatment of varicose vein surgery but is associated with a risk of venous thromboembolism. There is no consensus regarding anticoagulation protocols for these patients. This network meta-analysis (NMA) ... ...

Abstract	Objective: Endovenous ablation has revolutionized treatment of varicose vein surgery but is associated with a risk of venous thromboembolism. There is no consensus regarding anticoagulation protocols for these patients. This network meta-analysis (NMA) aims to identify which anticoagulant is optimal in this cohort for clot prevention with minimal risk of adverse bleeding events. Methods: Library databases were searched for studies where patients were treated with one or more anticoagulants following endovenous ablation for varicose veins. The methodological quality of included studies was quantified using the Risk of Bias (ROB) assessment tools. Findings were reported using the meta-analysis of observational studies in epidemiology (MOOSE) checklist. Statistical analysis was carried out using metainsight (rpackage). Results: Observational data on just under 1500 patients prescribed post ablation anticoagulation (Rivaroxaban, Enoxaparin, Fondaparinux) were analyzed. Patient characteristics were comparable across the cohorts. 81 thrombotic and 40 minor bleeding events occurred in total. Overall rivaroxaban is found to be superior to the other agents. Conclusions: This NMA indicates that prophylactic rivaroxaban is the highest ranked anticoagulant for thromboprophylaxis in patients post endovenous ablation for varicose veins, with a low risk of adverse bleeding. The choice whether to anticoagulate these patients is likely to remain at the discretion of the treating clinician.
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2076272-0
ISSN	1938-9116 ; 1538-5744
ISSN (online)	1938-9116
ISSN	1538-5744
DOI	10.1177/15385744241245079
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Article ; Online: Revisiting the automaticity of reading: Electrophysiological recordings show that stroop words capture spatial attention.

Lowery, Andrew / McDonald, John J

Journal of experimental psychology. General

2022 Volume 152, Issue 2, Page(s) 309–321

Abstract: Interference in the Stroop task is reduced when the word and color patch are placed at different locations and is diluted further by the presence of another distractor that is response neutral. Such dilution indicates that reading is not independent of ... ...

Abstract	Interference in the Stroop task is reduced when the word and color patch are placed at different locations and is diluted further by the presence of another distractor that is response neutral. Such dilution indicates that reading is not independent of an observer's attentional focus and thus is not a fully automatic process. So where does reading fall on the automaticity continuum? To address this question, we sought to determine whether an irrelevant word that appears abruptly in the field of view invariably draws attention to its location or whether observers can successfully ignore it while identifying a centrally presented target. In two experiments, electrical brain activity was recorded while healthy young adults participated in nonintegrated Stroop tasks. Irrelevant color words appearing randomly to the left or right of a target shape elicited an event-related potential component that reflects the spatial focusing of attention (posterior contralateral N2; N2pc). This N2pc was observed when participants discriminated the color of the target and when they discriminated the shape of the target. These findings demonstrate that color words reflexively capture spatial attention even when their meaning is unrelated to the task at hand. We conclude that although reading is not fully automatic, skilled readers cannot ignore words that appear abruptly in their field of view. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
MeSH term(s)	Young Adult ; Humans ; Reading ; Reaction Time/physiology ; Evoked Potentials ; Color Perception/physiology ; Stroop Test
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	189732-9
ISSN	1939-2222 ; 0096-3445
ISSN (online)	1939-2222
ISSN	0096-3445
DOI	10.1037/xge0001260
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Article ; Online: Optimizing DC restoration in Kramers-Kronig optical single-sideband receivers.

Wang, Tianyu / Corcoran, Bill / Lowery, Arthur

Optics express

2022 Volume 30, Issue 2, Page(s) 2825–2835

Abstract: Kramers-Kronig optical single-sideband receivers remove the signal-signal beat interference (SSBI) that occurs when detecting a signal that has electrical signals mapped onto its optical field at the transmitter; such signals support electronic ... ...

Abstract	Kramers-Kronig optical single-sideband receivers remove the signal-signal beat interference (SSBI) that occurs when detecting a signal that has electrical signals mapped onto its optical field at the transmitter; such signals support electronic dispersion compensation without the need for a coherent receiver. To use the full range of the analog-to-digital converter's (ADC) range, it is best to a.c.-couple the photocurrent, to remove its DC content; however, the DC must be restored digitally before the KK algorithm is applied. Recent publications have concentrated on perfectly determining the restored DC's required level from the signal, with a view this is optimal for lowering error rates. In this paper, we investigate signal-signal beat interference (SSBI) cancellation in a single photodiode receiver using Kramers-Kronig receiver algorithm, with large variations in optical carrier-to-signal power ratio (CSPR) and DC offset level. Through simulations and experiments, we find a strategy to optimize the signal quality without the need of an extensive search for the DC offset value. We also find that a theoretically perfect determination of the original DC level does not provide best signal quality especially for low CSPRs; in order to achieve maximum cancellation of signal-signal beat interference, the level of the restored DC has an optimum value that depends on the optical CSPR. We define a digital CSPR, which is the value of the CSPR in the digital domain after DC restoration. Our measurements show that we simply need to bias the signal upwards and make the minimum signal above zero by 0.1% of the r.m.s. signal amplitude when the optical CSPR is low. For higher values of optical CSPR, the optimal digital CSPR is about 2-dB lower than the optical CSPR, and the optimal DC offset can be calculated from this digital CSPR. We find that the boundary between our low optical CSPR region and high optical CSPR region depends on the noise level in the system.
Language	English
Publishing date	2022-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.447902
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Article ; Online: Role of micro-RNAs in breast cancer surgery.

McAnena, P / Lowery, A / Kerin, M J

The British journal of surgery

2018 Volume 105, Issue 2, Page(s) e19–e30

Abstract: Background: The management of breast cancer has changed dramatically in the molecular era. Micro-RNAs can contribute to multiple facets of cancer surgery.: Methods: This narrative review, based on years of research on the role of micro-RNAs, focused ... ...

Abstract	Background: The management of breast cancer has changed dramatically in the molecular era. Micro-RNAs can contribute to multiple facets of cancer surgery. Methods: This narrative review, based on years of research on the role of micro-RNAs, focused on the potential of these small, robust RNAs to influence all aspects of breast cancer surgery. Results: Micro-RNAs have a potential role as biomarkers in the diagnosis, prognosis and evaluation of response to therapy in breast cancer. They may also contribute to future therapeutic strategies. Conclusion: The molecular era has changed understanding of cancer. Micro-RNAs have the potential for use in personalized cancer strategies.
MeSH term(s)	Biomarkers, Tumor/metabolism ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Breast Neoplasms/surgery ; Female ; Gene Expression Regulation, Neoplastic ; Genetic Predisposition to Disease ; Humans ; MicroRNAs ; Prognosis
Chemical Substances	Biomarkers, Tumor ; MicroRNAs
Language	English
Publishing date	2018-01-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1002/bjs.10790
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Article ; Online: Varicella Zoster Virus Reactivation Involving the Vagus Nerve.

Davis, Seth / Thomas, Evan / Lowery, Anne / Kahue, Charissa / Gelbard, Alexander

The Annals of otology, rhinology, and laryngology

2022 Volume 132, Issue 7, Page(s) 818–824

Abstract: Objectives: To characterize the presentation, clinical course and functional outcomes of patients with varicella zoster virus (VZV) reactivation involving the vagus nerve. To highlight the role of otolaryngology in acute and long-term management of ... ...

Abstract	Objectives: To characterize the presentation, clinical course and functional outcomes of patients with varicella zoster virus (VZV) reactivation involving the vagus nerve. To highlight the role of otolaryngology in acute and long-term management of laryngopharyngeal VZV and its sequelae. Methods: Retrospective review of 3 patients with laryngopharyngeal VZV, managed at a tertiary referral center. Results: All cases presented with vesicular lesions involving mucosa of the laryngopharynx. Each experienced vocal fold hypomobility, among other otolaryngologic sequelae. All were treated with systemic antivirals and corticosteroids. Mucosal lesions resolved within 7 days of treatment initiation; functional deficits persisted for months to years. Dysphonia improved to a plateau at 3 months, while dysphagia took longer to resolve. One patient with disseminated disease experienced bilateral vocal fold paralysis requiring temporary tracheostomy. Conclusions: Vagal neuropathy secondary to VZV reactivation is a rare clinical entity with a variety of laryngeal manifestations. Early initiation of systemic therapy and serial endoscopic evaluations are critical components of acute management when laryngopharyngeal involvement is suspected. Otolaryngologists should plan for long-term phonatory and deglutitive therapy in these cases, as neurologic sequelae can persist for months to years following initial insult. Level of evidence: Level 4 (Case-series).
MeSH term(s)	Humans ; Herpesvirus 3, Human/physiology ; Herpes Zoster/complications ; Herpes Zoster/diagnosis ; Herpes Zoster/drug therapy ; Antiviral Agents ; Vocal Cord Paralysis/therapy ; Vocal Cord Paralysis/complications ; Vagus Nerve
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2022-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/00034894221111259
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Article ; Online: Age and Fear of Missing Out as Moderators of the Association between Peak Drinks and Alcohol-Induced Blackouts among Adolescents and Young Adults.

Lewis, Melissa A / Zhou, Zhengyang / Litt, Dana M / Kannard, Emma / Lowery, Ashley

Substance use & misuse

2023 Volume 58, Issue 6, Page(s) 739–745

Abstract: ... ...

Abstract	Background
MeSH term(s)	Humans ; Female ; Young Adult ; Adolescent ; Adult ; Male ; Risk Factors ; Memory Disorders/chemically induced ; Ethanol/adverse effects ; Surveys and Questionnaires
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2023-03-29
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.1080/10826084.2023.2177958
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Article ; Online: Imprecise risk estimation of chemotherapy-related cardiotoxicity in HER2-positive breast cancer using the recently reported societal risk tools.

Soliman, Osama / Lowery, Aoife / Kerin, Michael

Breast cancer research and treatment

2021 Volume 190, Issue 3, Page(s) 355–356

MeSH term(s)	Breast Neoplasms/drug therapy ; Breast Neoplasms/epidemiology ; Cardiotoxicity/etiology ; Female ; Humans ; Receptor, ErbB-2/genetics ; Trastuzumab/adverse effects
Chemical Substances	Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2021-09-29
Publishing country	Netherlands
Document type	Letter
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-021-06403-4
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Article ; Online: Histology-validated electromagnetic characterization of ex-vivo ovine lung tissue for microwave-based medical applications.

Vidjak, Klementina / Farina, Laura / Challapalli, Ritihaas Surya / Quinn, Anne Marie / O'Halloran, Martin / Lowery, Aoife / Ruvio, Giuseppe / Cavagnaro, Marta

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5940

Abstract: Microwave thermal ablation is an established therapeutic technique for treating malignant tissue in various organs. Its success greatly depends on the knowledge of dielectric properties of the targeted tissue and on how they change during the treatment. ... ...

Abstract	Microwave thermal ablation is an established therapeutic technique for treating malignant tissue in various organs. Its success greatly depends on the knowledge of dielectric properties of the targeted tissue and on how they change during the treatment. Innovation in lung navigation has recently increased the clinical interest in the transbronchial microwave ablation treatment of lung cancer. However, lung tissue is not largely characterized, thus its dielectric properties investigation prior and post ablation is key. In this work, dielectric properties of ex-vivo ovine lung parenchyma untreated and ablated at 2.45 GHz were recorded in the 0.5-8 GHz frequency range. The measured dielectric properties were fitted to 2-pole Cole-Cole relaxation model and the obtained model parameters were compared. Based on observed changes in the model parameters, the physical changes of the tissue post-ablation were discussed and validated through histology analysis. Additionally, to investigate the link of achieved results with the rate of heating, another two sets of samples, originating from both ovine and porcine tissues, were heated with a microwave oven for different times and at different powers. Dielectric properties were measured in the same frequency range. It was found that lung tissue experiences a different behavior according to heating rates: its dielectric properties increase post-ablation while a decrease is found for low rates of heating. It is hypothesized, and validated by histology, that during ablation, although the tissue is losing water, the air cavities deform, lowering air content and increasing the resulting tissue properties.
MeSH term(s)	Sheep ; Animals ; Swine ; Microwaves/therapeutic use ; Hot Temperature ; Sheep, Domestic ; Lung ; Electromagnetic Phenomena ; Liver
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55035-3
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