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  1. Article ; Online: Spectrally efficient optical orthogonal frequency division multiplexing.

    Lowery, Arthur James

    Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

    2020  Volume 378, Issue 2169, Page(s) 20190180

    Abstract: This paper charts the development of spectrally efficient forms of optical orthogonal frequency division multiplexing (OFDM) that are suited for intensity-modulated direct detection systems, such as wireless optical communications. The journey begins ... ...

    Abstract This paper charts the development of spectrally efficient forms of optical orthogonal frequency division multiplexing (OFDM) that are suited for intensity-modulated direct detection systems, such as wireless optical communications. The journey begins with systems using a DC-bias to ensure that no parts of the signal that modulates the optical source are negative in value, as negative optical intensity is unphysical. As the DC-part of the optical signal carries no information, it is wasteful in energy; thus asymmetrically clipped optical OFDM was developed, removing any negative-going peaks below the mean. Unfortunately, the clipping causes second-order distortion and intermodulation, so some subcarriers appear to be unusable, halving spectral efficiency; this is similar for unipolar and flipped optical OFDM. Thus, a considerable effort has been made to regain spectral efficiency, using layered techniques where the clipping distortion is mostly cancelled at the receiver, from a knowledge of one unpolluted layer, enabling one or more extra 'layers/paths/depths' to be received on the previously unusable subcarriers. Importantly, for a given optical power and high-order modulation, layered methods offer the best spectral efficiencies and need the lowest signal-to-noise ratios, especially if diversity combining is used. Thus, they could be important for high-bandwidth optical fibre systems. Efficient methods of generating all layers simultaneously, using fast Fourier transforms with their partial calculations extracted, are discussed, as are experimental demonstrations in both wireless and short-haul communications links. A musical analogy is also provided, which may point to how orchestral and rock music is deciphered in the brain. This article is part of the theme issue 'Optical wireless communication'.
    Language English
    Publishing date 2020-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 208381-4
    ISSN 1471-2962 ; 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    ISSN (online) 1471-2962
    ISSN 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    DOI 10.1098/rsta.2019.0180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Oncological safety of active surveillance for low-risk ductal carcinoma in situ - a systematic review and meta-analysis.

    Davey, Matthew G / Lowery, Aoife J / Kerin, Michael J

    Irish journal of medical science

    2022  Volume 192, Issue 4, Page(s) 1595–1600

    Abstract: Introduction: Current standard of care for patients diagnosed with "low-risk" ductal carcinoma in situ (DCIS) involves surgical resection. Ongoing phase III clinical trials are hoping to establish the oncological safety of active surveillance (AS) in ... ...

    Abstract Introduction: Current standard of care for patients diagnosed with "low-risk" ductal carcinoma in situ (DCIS) involves surgical resection. Ongoing phase III clinical trials are hoping to establish the oncological safety of active surveillance (AS) in managing "low-risk" DCIS.
    Aims: To evaluate the oncological safety of AS versus surgery for "low-risk" DCIS.
    Methods: A systematic review was performed in accordance with PRISMA guidelines. Survival outcomes were expressed as dichotomous variables and reported as odds ratios (OR) with 95% confidence intervals (95% CI) using the Mantel-Haenszel method.
    Results: Four studies including 9626 patients were included, 3.9% of which were managed using AS (374/9626) and 96.1% with surgery (9252/9626). The mean age of included patients was 50.3 years (range: 30-99 years) and mean follow-up was 6.1 years. Invasive cancer detection after surgery and AS were similar (OR: 0.93, 95% CI: 0.41-2.11, P = 0.860, heterogeneity (I
    Conclusion: This study outlines the provisional oncological safety of AS for cases of "low-risk" DCIS. While survival outcomes were comparable for both management strategies, ratification of these results in the ongoing phase III clinical trials is still required prior to changes to current management strategies.
    Prospero registration: CRD42022313241.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Carcinoma, Intraductal, Noninfiltrating/surgery ; Watchful Waiting ; Longitudinal Studies ; Breast Neoplasms/surgery ; Carcinoma, Ductal, Breast/pathology
    Language English
    Publishing date 2022-09-16
    Publishing country Ireland
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-022-03157-w
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  3. Article ; Online: Comparisons of spectrally-enhanced asymmetrically-clipped optical OFDM systems.

    Lowery, Arthur James

    Optics express

    2016  Volume 24, Issue 4, Page(s) 3950–3966

    Abstract: Asymmetrically clipped optical orthogonal frequency-division multiplexing (ACO-OFDM) is a technique that sacrifices spectral efficiency in order to transmit an orthogonally frequency-division multiplexed signal over a unipolar channel, such as a directly ...

    Abstract Asymmetrically clipped optical orthogonal frequency-division multiplexing (ACO-OFDM) is a technique that sacrifices spectral efficiency in order to transmit an orthogonally frequency-division multiplexed signal over a unipolar channel, such as a directly modulated direct-detection fiber or free-space channel. Several methods have been proposed to regain this spectral efficiency, including: asymmetrically clipped DC-biased optical OFDM (ADO-OFDM), enhanced U-OFDM (EU-OFDM), spectral and energy efficient OFDM (SEE-OFDM), Hybrid-ACO-OFDM and Layered-ACO-OFDM. This paper presents simulations up to high-order constellation sizes to show that Layered-ACO-OFDM offers the highest receiver sensitivity for a given optical power at spectral efficiencies above 3 bit/s/Hz. For comparison purposes, white Gaussian noise is added at the receiver, component nonlinearities are not considered, and the fiber is considered to be linear and dispersion-less. The simulations show that LACO-OFDM has a 7-dB sensitivity advantage over DC-biased OFDM (DCO-OFDM) for 1024-QAM at 87.5% of DCO-OFDM's spectral efficiency, at the same bit rate and optical power. This is approximately equivalent to a 4.4-dB advantage at the same spectral efficiency of 87.7% if 896-QAM were to be used for DCO-OFDM.
    Language English
    Publishing date 2016-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.24.003950
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  4. Article ; Online: Intraoperative Parathyroid Hormone in Minimally Invasive Parathyroidectomy-Reply.

    Quinn, Alanna J / Ryan, Éanna J / Lowery, Aoife J

    JAMA otolaryngology-- head & neck surgery

    2021  Volume 147, Issue 10, Page(s) 923–924

    MeSH term(s) Humans ; Parathyroid Hormone ; Parathyroid Neoplasms/surgery ; Parathyroidectomy ; Technetium Tc 99m Sestamibi
    Chemical Substances Parathyroid Hormone ; Technetium Tc 99m Sestamibi (971Z4W1S09)
    Language English
    Publishing date 2021-09-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2021.2252
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  5. Article ; Online: Intraoperative recurrent laryngeal nerve monitoring versus visualisation alone - A systematic review and meta-analysis of randomized controlled trials.

    Davey, Matthew G / Cleere, Eoin F / Lowery, Aoife J / Kerin, Michael J

    American journal of surgery

    2022  Volume 224, Issue 3, Page(s) 836–841

    Abstract: Background: Intraoperative nerve monitoring (IONM) is perceived to reduce recurrent laryngeal nerve injury (RLNI) compared to RLN visualisation alone (VA). We performed a meta-analysis of randomized controlled trials (RCTs) to establish the value of ... ...

    Abstract Background: Intraoperative nerve monitoring (IONM) is perceived to reduce recurrent laryngeal nerve injury (RLNI) compared to RLN visualisation alone (VA). We performed a meta-analysis of randomized controlled trials (RCTs) to establish the value of using IONM instead of RLN VA for patients undergoing thyroidectomy.
    Methods: A meta-analysis of RCTs was performed as per PRISMA guidelines. RLNI rates were expressed as dichotomous variables and pooled as odds ratios (OR) and associated 95% confidence intervals (CI) using the Mantel-Haenszel method.
    Results: Eight RCTs with 2521 patients with 4977 nerves at risk were included. Overall, 49.8% of RLNs underwent IONM (2480/4978) and 50.2% underwent VA (2497/4978). Overall RLNI rates were higher for VA (VA: 3.2% (80/2497) vs. IONM: 2.3% (58/2480), OR: 0.72, 95% CI: 0.51-1.02, P = 0.060, I
    Conclusion: When compared to VA alone, using IONM failed to significantly reduce RLNI rates during thyroid surgery.
    MeSH term(s) Humans ; Monitoring, Intraoperative ; Randomized Controlled Trials as Topic ; Recurrent Laryngeal Nerve ; Recurrent Laryngeal Nerve Injuries ; Thyroidectomy
    Language English
    Publishing date 2022-04-09
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2022.03.036
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  6. Article ; Online: The Impact of Chemotherapy Prescription on Long-Term Survival Outcomes in Early-Stage Invasive Lobular Carcinoma - A Systematic Review and Meta-Analysis.

    Davey, Matthew G / Keelan, Stephen / Lowery, Aoife J / Kerin, Michael J

    Clinical breast cancer

    2022  Volume 22, Issue 8, Page(s) e843–e849

    Abstract: Introduction: Invasive lobular carcinoma (ILCs) are typically endocrine responsive breast cancers which respond poorly to chemotherapy. The long-term survival advantage of prescribing chemotherapy in such cases remains unclear. To perform a systematic ... ...

    Abstract Introduction: Invasive lobular carcinoma (ILCs) are typically endocrine responsive breast cancers which respond poorly to chemotherapy. The long-term survival advantage of prescribing chemotherapy in such cases remains unclear. To perform a systematic review and meta-analysis assessing, the impact of prescribing chemotherapy in such patients on long-term disease-free (DFS) and overall (OS) survival outcomes.
    Methods: A systematic review and meta-analysis was performed in accordance with the PRISMA guidelines. Ten-year DFS and OS were pooled as odds ratios (ORs) with 95% confidence intervals (CI) using the Mantel-Haenszel method. Time-to-effect modelling was performed using the generic inverse variance method.
    Results: Overall, 9 studies including 28,218 patients were included. The mean follow-up was 74 months (range: 0-150 months) and mean age was 60 years (range: 22-90 years). Of these, 34.7% received chemotherapy (9,797/28,218) and 66.3% did not receive chemotherapy (18,421/28,218). Chemotherapy prescription failed to improve 10-year DFS (OR: 0.89, 95% CI: 0.65-1.23) and OS (OR: 0.92, 95% CI: 0.72-1.18). When using time-to-effect modelling, chemotherapy prescription failed to improve DFS (hazard ratio (HR): 1.01, 95% CI: 0.78-1.31) and OS (HR: 1.07, 95% CI: 0.89-1.27, I
    Conclusion: This meta-analysis illustrates no long-term survival advantage associated with chemotherapy prescription in the setting of early-stage ILC. In the absence of well-designed, prospective clinical trials evaluating the impact of chemotherapy on long-term outcomes in ILC, these results should be considered by the multidisciplinary team when deciding on the value of systemic chemotherapy prescription in ILC.
    MeSH term(s) Humans ; Middle Aged ; Female ; Breast Neoplasms/pathology ; Carcinoma, Lobular/pathology ; Prospective Studies ; Breast/pathology ; Disease-Free Survival ; Prescriptions
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2106734-X
    ISSN 1938-0666 ; 1526-8209
    ISSN (online) 1938-0666
    ISSN 1526-8209
    DOI 10.1016/j.clbc.2022.09.005
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  7. Article ; Online: All-optical DAC using counter-propagating optical and electrical pulses in a Mach-Zehnder modulator.

    Lowery, Arthur James

    Optics express

    2014  Volume 22, Issue 21, Page(s) 26429–26437

    Abstract: A novel method of converting binary-level electrical pulses into multi-level optical pulses using only a conventional traveling-wave optical modulator is presented. The method provides low inter-pulse interference due to the counter-propagating pulses, ... ...

    Abstract A novel method of converting binary-level electrical pulses into multi-level optical pulses using only a conventional traveling-wave optical modulator is presented. The method provides low inter-pulse interference due to the counter-propagating pulses, low amplitude noise, and a timing jitter determined chiefly by the quality of the optical pulse source. The method only requires one electrical drive per modulator and provides low-jitter variable-amplitude optical pulses that are suitable for shaping into a wide variety of modulation formats using a programmable optical filter.
    MeSH term(s) Electricity ; Equipment Design ; Optics and Photonics/instrumentation ; Telecommunications/instrumentation
    Language English
    Publishing date 2014-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.22.026429
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  8. Article ; Online: Author response to: Comment on: Meta-analysis of the impact of progesterone receptor status on oncological outcomes in oestrogen receptor-positive breast cancer.

    Boland, M R / Ryan, É J / Lowery, A J

    The British journal of surgery

    2020  Volume 107, Issue 4, Page(s) 466–467

    MeSH term(s) Breast Neoplasms/drug therapy ; Carcinoma, Ductal, Breast ; Estrogens ; Humans ; Receptors, Estrogen ; Receptors, Progesterone
    Chemical Substances Estrogens ; Receptors, Estrogen ; Receptors, Progesterone
    Language English
    Publishing date 2020-03-03
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.11499
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  9. Article ; Online: MicroRNA Expression Profiles and Breast Cancer Chemotherapy.

    Davey, Matthew G / Lowery, Aoife J / Miller, Nicola / Kerin, Michael J

    International journal of molecular sciences

    2021  Volume 22, Issue 19

    Abstract: Breast cancer is the most common malignancy diagnosed in women. Traditionally, radical surgical resection was the cornerstone of breast cancer management, with limited exceptions. In recent times, our enhanced appreciation of the biomolecular ... ...

    Abstract Breast cancer is the most common malignancy diagnosed in women. Traditionally, radical surgical resection was the cornerstone of breast cancer management, with limited exceptions. In recent times, our enhanced appreciation of the biomolecular characteristics of breast cancer has transformed the treatment paradigm to include prescription of chemotherapeutical agents, radiotherapies, targeted therapies, as well as more refined surgical approaches. While treatments with such modalities have enhanced clinico-oncological outcomes for breast cancer patients, the efforts of oncological and translational research have concentrated on the identification of novel biomarkers which may successfully inform prognosis and response to therapies, improve current therapeutic strategies, and enhance prognostication. Mi(cro)RNAs are small, non-coding molecules which are known to play regulatory roles in governing gene expression and cellular activity. Measurement of miRNA expression profiles have been illustrated to inform the response to therapies, such as conventional chemotherapy, and are currently undergoing assessment as means of enhancing treatment strategies with these cytotoxic agents. Herein, this review outlines how chemotherapy prescription has revolutionised breast cancer treatment and illustrates the novel role of miRNAs as biomarkers capable of enhancing current therapeutic strategies using chemotherapy in patients being treated with curative intent for breast cancer.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/genetics ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; MicroRNAs/genetics ; Prognosis
    Chemical Substances Antineoplastic Agents ; Biomarkers, Tumor ; MicroRNAs
    Language English
    Publishing date 2021-10-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms221910812
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  10. Article: Hydrogels: 3D Drug Delivery Systems for Nanoparticles and Extracellular Vesicles.

    Chabria, Yashna / Duffy, Garry P / Lowery, Aoife J / Dwyer, Róisín M

    Biomedicines

    2021  Volume 9, Issue 11

    Abstract: Synthetic and naturally occurring nano-sized particles present versatile vehicles for the delivery of therapy in a range of clinical settings. Their small size and modifiable physicochemical properties support refinement of targeting capabilities, immune ...

    Abstract Synthetic and naturally occurring nano-sized particles present versatile vehicles for the delivery of therapy in a range of clinical settings. Their small size and modifiable physicochemical properties support refinement of targeting capabilities, immune response, and therapeutic cargo, but rapid clearance from the body and limited efficacy remain a major challenge. This highlights the need for a local sustained delivery system for nanoparticles (NPs) and extracellular vesicles (EVs) at the target site that will ensure prolonged exposure, maximum efficacy and dose, and minimal toxicity. Biocompatible hydrogels loaded with therapeutic NPs/EVs hold immense promise as cell-free sustained and targeted delivery systems in a range of disease settings. These bioscaffolds ensure retention of the nano-sized particles at the target site and can also act as controlled release systems for therapeutics over a prolonged period of time. The encapsulation of stimuli sensitive components into hydrogels supports the release of the content on-demand. In this review, we highlight the prospect of the sustained and prolonged delivery of these nano-sized therapeutic entities from hydrogels for broad applications spanning tissue regeneration and cancer treatment. Further understanding of the parameters controlling the release rate of these particles and efficient transfer of cargo to target cells will be fundamental to success.
    Language English
    Publishing date 2021-11-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9111694
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