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  1. Article ; Online: Autoimmunity in centenarians. A paradox.

    Anaya, Juan-Manuel / Lozada-Martinez, Ivan David / Torres, Isaura / Shoenfeld, Yehuda

    Journal of translational autoimmunity

    2024  Volume 8, Page(s) 100237

    Abstract: Autoimmune diseases (ADs) are one of the groups of chronic illnesses that impose a significant burden of disease and health costs worldwide. Age is a crucial risk factor for the onset of ADs. Theoretically, it is inferred that with organic and immune ... ...

    Abstract Autoimmune diseases (ADs) are one of the groups of chronic illnesses that impose a significant burden of disease and health costs worldwide. Age is a crucial risk factor for the onset of ADs. Theoretically, it is inferred that with organic and immune system aging, the loss of immune tolerance and specificity of immune activity becomes more intense, the probability of autoimmunity is increasing. However, there is a group of individuals whose prevalence of ADs is very low or non-existent, despite the biological aging. This paradox in autoimmunity raises questions. Centenarians, individuals who are over 100 years old, are possibly the most successful model of biological aging in humans. Most of these individuals exhibit a favorable health phenotype. To date, primary data evidence and potential hypotheses explaining this phenomenon are lacking globally, even though this paradox could provide valuable, original, and relevant information regarding the understanding of risk or protective factors, biological drivers, and biomarkers related to autoimmunity. Herein we discuss some hypothesis that may explain the absence of ADs in centenarians, including inflammaging, immunosenescence and immune resilience, immune system hyperstimulation, proteodynamics, and genetics.
    Language English
    Publishing date 2024-03-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2589-9090
    ISSN (online) 2589-9090
    DOI 10.1016/j.jtauto.2024.100237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Leiden manifesto and evidence-based research: Are the appropriate standards being used for the correct evaluation of pluralism, gaps and relevance in medical research?

    Lozada-Martinez, Ivan David / Lozada-Martinez, Luz Miryam / Fiorillo-Moreno, Ornella

    The journal of the Royal College of Physicians of Edinburgh

    2024  Volume 54, Issue 1, Page(s) 4–6

    MeSH term(s) Humans ; Biomedical Research ; Cultural Diversity
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Editorial
    ZDB-ID 2866363-9
    ISSN 2042-8189 ; 0953-0932
    ISSN (online) 2042-8189
    ISSN 0953-0932
    DOI 10.1177/14782715241227991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3088 -Suppl.-: Show issues Location:
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  3. Article ; Online: Global research on centenarians: A historical and comprehensive bibliometric analysis from 1887 to 2023.

    Lozada-Martinez, Ivan David / Diazgranados-Garcia, Maria Carolina / Castelblanco-Toro, Sandra / Anaya, Juan-Manuel

    Annals of geriatric medicine and research

    2024  

    Abstract: Background: Centenarians are considered the most successful human biological aging model. However, the characteristics and patterns of research among centenarians have not been described or analyzed. Thus, this study aimed to disclose the historical ... ...

    Abstract Background: Centenarians are considered the most successful human biological aging model. However, the characteristics and patterns of research among centenarians have not been described or analyzed. Thus, this study aimed to disclose the historical landscape of global research on centenarians.
    Methods: This bibliometric study investigated historical evidence on centenarian research published in the Scopus database. The bibliometrix package in R was used to perform visual and quantitative analyses of research metrics, trends, and patterns.
    Results: Of the 2061 documents included between 1887 and 2023, 84.2% (n = 1736) were published as articles with primary data. We identified international collaboration and annual growth rates of 21.4% and 3.15%, respectively. The United States published the highest number of papers on centenarians (n = 786), whereas the publications from Italy had the highest impact (h-index = 90). Based on the frequency of keywords, mortality, genetics, dementia, Alzheimer's disease, and immunosenescence are a few of the most studied topics among centenarians, with emerging research related to mitochondrial DNA and comparison of results between nonagenarians and centenarians. Italy, the United States, and China lead the global research collaboration network, collaborating most frequently with Japan and European countries.
    Conclusions: Global research on centenarians has grown over the last 20 years, primarily led by Italy, the United States, and China. Latin American and African countries have conducted little or no research on centenarians. The most widely studied topics include mortality, cognition, immunosenescence, and genetics.
    Language English
    Publishing date 2024-04-08
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3035056-6
    ISSN 2508-4909 ; 2508-4798
    ISSN (online) 2508-4909
    ISSN 2508-4798
    DOI 10.4235/agmr.24.0043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ethnicity, genetic variants, risk factors and cholelithiasis: The need for eco-epidemiological studies and genomic analysis in Latin American surgery.

    Lozada-Martinez, Ivan David / Suarez-Causado, Amileth / Solana-Tinoco, Jose Belisario

    International journal of surgery (London, England)

    2022  Volume 99, Page(s) 106589

    MeSH term(s) Cholelithiasis/epidemiology ; Cholelithiasis/genetics ; Cholelithiasis/surgery ; Ethnicity ; Genomics ; Humans ; Latin America/epidemiology ; Risk Factors
    Language English
    Publishing date 2022-03-03
    Publishing country England
    Document type Letter
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2022.106589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6502: Show issues Location:
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  5. Article ; Online: A commentary on "Surgical results of Hartmann procedure in emergency cases with the left-sided colorectal cancer".

    Rodríguez-Gutiérrez, Mª Manuela / Santa-Gil, Valentina / Lozada-Martínez, Ivan David / Díaz-Rivera, María Carolina

    Cirugia y cirujanos

    2023  Volume 91, Issue 1, Page(s) 141–142

    Title translation Un comentario sobre “Resultados quirúrgicos del procedimiento de Hartmann en casos de emergencia con cáncer colorrectal del lado izquierdo”.
    MeSH term(s) Humans ; Colorectal Neoplasms/surgery ; Colonic Diseases/surgery ; Anastomosis, Surgical
    Language English
    Publishing date 2023-02-08
    Publishing country Mexico
    Document type Journal Article ; Comment
    ZDB-ID 730699-4
    ISSN 2444-054X ; 0009-7411
    ISSN (online) 2444-054X
    ISSN 0009-7411
    DOI 10.24875/CIRU.21000479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 797: Show issues Location:
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  6. Article: Intraoperative finding of papyraceous twin fetus in pregnant woman without specialized follow-up: A summary of difficulties in accessing prenatal services in low- and middle-income countries.

    Álvarez-Acuña, Ana Milena / López-Álvarez, Lina María / Lozada-Martínez, Ivan David / Narvaez-Rojas, Alexis Rafael

    International journal of surgery case reports

    2022  Volume 95, Page(s) 107234

    Abstract: Introduction and importance: The papyraceous fetus is the product of the intrauterine fetal death of a twin in early pregnancy, with retention of the fetus for a minimum of 10 weeks, resulting in mechanical compression of the small fetus. It is a ... ...

    Abstract Introduction and importance: The papyraceous fetus is the product of the intrauterine fetal death of a twin in early pregnancy, with retention of the fetus for a minimum of 10 weeks, resulting in mechanical compression of the small fetus. It is a finding that can be found early by ultrasound to avoid increased obstetric risk, but in low- to middle-income countries it is not always available.
    Case presentation: We present the case of a 22-year-old multipara patient was remitted to the emergency department due to a one-hour history of premature rupture of the membranes. Only one control ultrasound was performed at 25 weeks of pregnancy. Cesarean section was performed and two products were found, one of them a papyraceous fetus.
    Clinical discussion: Almost 50% of women in low- and middle-income countries don't receive adequate antenatal care. It has been estimated that up to half of twins and almost all triplets are born premature and have a higher risk of dying compared to those born at term; specifically, this risk is much higher if the pregnancy is accompanied by rare pathological conditions.
    Conclusion: The papyraceous fetus is a rare condition that represents a risk to the health of the mother and other babies, in case of multiple pregnancy; but it can be diagnosed early through imaging studies. Socio-cultural, socio-economic and direct difficulties of the health system may be the cause of the delay in the diagnosis of this pathological entity, making it an unexpected finding during delivery or intraoperatively.
    Language English
    Publishing date 2022-05-21
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2022.107234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Breast cancer care in Latin America: The ghost burden of a pandemic outbreak.

    Reyes-Monasterio, Antonio / Lozada-Martinez, Ivan David / Cabrera-Vargas, Luis Felipe / Narvaez-Rojas, Alexis Rafael

    International journal of surgery (London, England)

    2022  Volume 104, Page(s) 106784

    MeSH term(s) Breast ; Breast Neoplasms ; Disease Outbreaks ; Female ; Humans ; Latin America ; Pandemics
    Language English
    Publishing date 2022-07-19
    Publishing country England
    Document type Letter
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2022.106784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6502: Show issues Location:
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  8. Article ; Online: Bariatric emergencies recommendations for the general surgeon on duty in low-to middle-income countries: An algorithm proposal - Correspondence.

    Pinzón, Fabio / Rami, Mikler / Gaitan, Laura / Cabrera-Vargas, Luis Felipe / Lozada-Martinez, Ivan David

    International journal of surgery (London, England)

    2022  Volume 102, Page(s) 106674

    MeSH term(s) Algorithms ; Bariatric Surgery ; Bariatrics ; Developing Countries ; Emergencies ; Humans ; Surgeons
    Language English
    Publishing date 2022-05-14
    Publishing country England
    Document type Letter
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2022.106674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6502: Show issues Location:
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  9. Article ; Online: A commentary on "Cephalic duodenopancreatectomy and external tutoring of the Wirsung duct. Results of a series of 80 consecutive cases".

    Díaz-Vallejo, Jhony Alejandro / Rodríguez-Gutiérrez, María Manuela / Rodríguez-Betancourt, Duvier Andrés / Lozada-Martínez, Ivan David

    Cirugia espanola

    2022  Volume 100, Issue 3, Page(s) 186–187

    MeSH term(s) Humans ; Pancreatic Ducts/diagnostic imaging ; Pancreatic Ducts/surgery ; Pancreaticoduodenectomy ; Pancreatitis/surgery
    Language English
    Publishing date 2022-03-18
    Publishing country Spain
    Document type Letter ; Comment
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2022.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  10. Article: CEA-delta could be a biomarker of tumor phenotype, clinical stage, and chemotherapeutic response in rectal cancer with OCT4-positive cancer stem cells.

    Lozada-Martinez, Ivan David / Bolaño-Romero, Maria Paz / Lambis-Anaya, Lina / Liscano, Yamil / Suarez-Causado, Amileth

    Frontiers in oncology

    2023  Volume 13, Page(s) 1258863

    Abstract: Background: There is very limited evidence on biomarkers for evaluating the clinical behavior and therapeutic response in rectal cancer (RC) with positive expression of cancer stem cells (CSCs).: Methods: An exploratory prospective study was ... ...

    Abstract Background: There is very limited evidence on biomarkers for evaluating the clinical behavior and therapeutic response in rectal cancer (RC) with positive expression of cancer stem cells (CSCs).
    Methods: An exploratory prospective study was conducted, which included fresh samples of tumor tissue from 109 patients diagnosed with primary RC. Sociodemographic, pathological and clinical characteristics were collected from medical records and survey. The OCT4 protein was isolated using the Western Blot technique. It was calculated the ΔCEA, ΔOCT4, and ΔOCT4/GUSB values by assessing the changes before and after chemotherapy, aiming to evaluate the therapeutic response.
    Results: Patients had an average age of 69.9 years, with 55% (n=60) being male. Approximately 63.3% of the tumors were undifferentiated, and the most frequent staging classification was pathological stage III (n=64; 58.7%). Initial positive expression was observed in 77.1% of the patients (n=84), and the median ΔCEA was -1.03 (-3.82 - 0.84) ng/ml, with elevated levels (< -0.94 ng/ml) found in 51.4% of the subjects (n=56). Being OCT4 positive and having an elevated ΔCEA value were significantly associated with undifferentiated tumor phenotype (p=0.002), advanced tumor progression stage (p <0.001), and negative values of ΔOCT4 (p <0.001) (suggestive of poor therapeutic response) compared to those without this status.
    Conclusion: This study identified a significant and directly proportional association among the values of ΔCEA, ΔOCT4, and ΔOCT4/GUSB. These findings suggest that ΔCEA holds potential as a clinical biomarker for determining the undifferentiated tumor phenotype, advanced clinical stage, and poor therapeutic response in RC with CSCs positive expression.
    Language English
    Publishing date 2023-09-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1258863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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