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Article ; Online: Phosphinidenes: Fundamental Properties and Reactivity.

Lu, Bo / Zeng, Xiaoqing

Chemistry (Weinheim an der Bergstrasse, Germany)

2024 Volume 30, Issue 15, Page(s) e202303283

Abstract: Phosphinidenes are heavy congeners of nitrenes that have been broadly used as in situ reagents in synthetic phosphorus chemistry and also serve as versatile ligands in coordination with transition metals. However, the detection of free phosphinidenes is ... ...

Abstract	Phosphinidenes are heavy congeners of nitrenes that have been broadly used as in situ reagents in synthetic phosphorus chemistry and also serve as versatile ligands in coordination with transition metals. However, the detection of free phosphinidenes is largely challenged by their high reactivity and also the lack of suitable synthetic methods, rendering the knowledge about the fundamental properties of this class of low-valent phosphorus compounds limited. Recently, an increasing number of free phosphinidenes bearing prototype structural and bonding properties have been prepared for the first time, thus enabling the exploration of their distinct reactivity from the nitrene analogues. This Concept article will discuss the experimental approaches for the generation of the highly unstable phosphinidenes and highlight their distinct reactivity from the nitrogen analogues so as to stimuate future studies about their potential applications in phosphorus chemistry.
Language	English
Publishing date	2024-01-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202303283
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Article ; Online: The Pupa Stage Is the Most Sensitive to Hypoxia in

Stobdan, Tsering / Wen, Nicholas J / Lu-Bo, Ying / Zhou, Dan / Haddad, Gabriel G

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Hypoxia not only plays a critical role in multiple disease conditions; it also influences the growth and development of cells, tissues and organs. To identify novel hypoxia-related mechanisms involved in cell and tissue growth, studying a precise hypoxia- ...

Abstract	Hypoxia not only plays a critical role in multiple disease conditions; it also influences the growth and development of cells, tissues and organs. To identify novel hypoxia-related mechanisms involved in cell and tissue growth, studying a precise hypoxia-sensitive time window can be an effective approach.
MeSH term(s)	Animals ; Drosophila melanogaster ; Pupa ; Drosophila ; Epigenomics ; Hypoxia
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25020710
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Article ; Online: Severe bradycardia induced by postoperative nausea and vomiting: A case report.

Li, Xiaoyu / Lu, Bo

Medicine

2023 Volume 102, Issue 34, Page(s) e34736

Abstract: Introduction: Postoperative nausea and vomiting is a common complication for patients after anesthesia and surgery, which may result in increased parasympathetic activity, such as diaphoresis, pallor, or bradycardia. However, few cases of fatal ... ...

Abstract	Introduction: Postoperative nausea and vomiting is a common complication for patients after anesthesia and surgery, which may result in increased parasympathetic activity, such as diaphoresis, pallor, or bradycardia. However, few cases of fatal bradycardia induced by postoperative nausea and vomiting have been reported before. Clinicians generally attribute bradycardia to certain anesthetics, instead of postoperative nausea or vomiting. Patient concerns: A fifty-year-old female with a history of well-controlled hypertension underwent elective radical mastectomy. When recovering from anesthesia in the post-anesthesia care unit, the patient experienced severe bradycardia accompanied by hypotension and unconsciousness, shortly after nausea and vomiting. Interventions: The patient received cardiopulmonary resuscitation immediately. Outcomes: Five minutes later, She recovered sinus rhythm and her vital sings tended to be stable. Three hours later, blood tests showed the N-terminal pro-B-type natriuretic peptide 127 pg/mL and cardiac troponin I 0.44 ng/mL, which peaked to 2.65 ng/mL 10 hours after the emergency. Electrocardiography revealed sinus rhythm, ST-segment depression in the inferior and anterior lateral leads, QTc prolongation, and left ventricular high voltage. Her serum cTnI continued to decline to 0.27 ng/mL on the 3rd day after surgery. She was discharged from the hospital on the fifth day and had no sequelae. Conclusion: Although postoperative nausea and vomiting occurs frequently, it should be kept in mind as a potential cause to blame for severe bradycardia or even life-threatening situations.
MeSH term(s)	Humans ; Female ; Middle Aged ; Postoperative Nausea and Vomiting/etiology ; Bradycardia/etiology ; Bradycardia/therapy ; Breast Neoplasms ; Mastectomy ; Anesthesia
Language	English
Publishing date	2023-08-31
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000034736
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Article ; Online: TRACE-seq: Rapid, Low-Input, One-Tube RNA-seq Library Construction Based on Tagmentation of RNA/DNA Hybrids.

Lu, Bo / Yi, Chengqi

Current protocols

2023 Volume 3, Issue 4, Page(s) e735

Abstract: Tn5 transposase has been widely used to simultaneously fragment and tag double-stranded DNA (dsDNA) with sequencing adaptors in library construction for next-generation sequencing. Recently, we demonstrated that Tn5 transposase also possesses ... ...

Abstract	Tn5 transposase has been widely used to simultaneously fragment and tag double-stranded DNA (dsDNA) with sequencing adaptors in library construction for next-generation sequencing. Recently, we demonstrated that Tn5 transposase also possesses tagmentation activity toward RNA/DNA hybrids, in addition to its canonical dsDNA substrates. Based on this new activity, we are able to skip multiple laborious and time-consuming steps in traditional RNA-seq methods, and rapid, low-input, cost-effective, one-tube RNA-seq library construction is thus enabled. The libraries constructed by Transposase-assisted RNA/DNA hybrids Co-tagmEntation (termed "TRACE-seq") demonstrate excellent performance in terms of gene expression measurement and differential gene expression analysis. Here, we present detailed protocols for TRACE-seq that will be broadly useful for the study of RNA biology and biomedical research. © 2023 Wiley Periodicals LLC. Basic Protocol 1: Total RNA preparation Basic Protocol 2: TRACE-seq library construction Support Protocol: Tn5 transposome assembly.
MeSH term(s)	RNA/genetics ; RNA-Seq ; Gene Library ; DNA/genetics ; Cloning, Molecular
Chemical Substances	RNA (63231-63-0) ; DNA (9007-49-2)
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Journal Article
ISSN	2691-1299
ISSN (online)	2691-1299
DOI	10.1002/cpz1.735
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Article ; Online: MSC therapy for diabetic kidney disease and nephrotic syndrome.

Lu, Bo / Lerman, Lilach O

Nature reviews. Nephrology

2023 Volume 19, Issue 12, Page(s) 754–755

MeSH term(s)	Humans ; Nephrotic Syndrome/complications ; Nephrotic Syndrome/therapy ; Diabetic Nephropathies/therapy ; Kidney ; Diabetes Mellitus
Language	English
Publishing date	2023-10-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2490366-8
ISSN	1759-507X ; 1759-5061
ISSN (online)	1759-507X
ISSN	1759-5061
DOI	10.1038/s41581-023-00776-z
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Zs.A 6334: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Flexible template matching for observational study design.

Zhao, Ruochen / Lu, Bo

Statistics in medicine

2023 Volume 42, Issue 11, Page(s) 1760–1778

Abstract: Matching is a popular design for inferring causal effect with observational data. Unlike model-based approaches, it is a nonparametric method to group treated and control subjects with similar characteristics together, hence to re-create a randomization- ... ...

Abstract	Matching is a popular design for inferring causal effect with observational data. Unlike model-based approaches, it is a nonparametric method to group treated and control subjects with similar characteristics together, hence to re-create a randomization-like scenario. The application of matched design for real world data may be limited by: (1) the causal estimand of interest; (2) the sample size of different treatment arms. We propose a flexible design of matching, based on the idea of template matching, to overcome these challenges. It first identifies the template group which is representative of the target population, then match subjects from the original data to this template group and make inference. We provide theoretical justification on how it unbiasedly estimates the average treatment effect using matched pairs and the average treatment effect on the treated when the treatment group has a bigger sample size. We also propose using the triplet matching algorithm to improve matching quality and devise a practical strategy to select the template size. One major advantage of matched design is that it allows both randomization-based or model-based inference, with the former being more robust. For the commonly used binary outcome in medical research, we adopt a randomization inference framework of attributable effects in matched data, which allows heterogeneous effects and can incorporate sensitivity analysis for unmeasured confounding. We apply our design and analytical strategy to a trauma care evaluation study.
MeSH term(s)	Humans ; Algorithms ; Biomedical Research ; Causality ; Research Design ; Sample Size ; Observational Studies as Topic
Language	English
Publishing date	2023-03-02
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	843037-8
ISSN	1097-0258 ; 0277-6715
ISSN (online)	1097-0258
ISSN	0277-6715
DOI	10.1002/sim.9698
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Zs.A 1756: Show issues

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Article ; Online: CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells.

Liu, Shufeng / Chen, Xiaoguang / Zhang, Liqi / Lu, Bo

Cancer biology & therapy

2024 Volume 25, Issue 1, Page(s) 2329372

Abstract: Succinylation modification involves in the progression of human cancers. The present study aimed to investigate the role of CPT1A, which is a succinyltransferase in the progression of prostate cancer (PCa). CCK-8 was used to detect the cell viability. ... ...

Abstract	Succinylation modification involves in the progression of human cancers. The present study aimed to investigate the role of CPT1A, which is a succinyltransferase in the progression of prostate cancer (PCa). CCK-8 was used to detect the cell viability. Seahorse was performed to evaluate the cell glycolysis. Luciferase assay was used to detect the transcriptional regulation. ChIP was performed to assess the binding between transcriptional factors with the promoters. Co-IP was used to assess the binding between proteins. We found that CPT1A was highly expressed in PCa tissues and cell lines. Silencing of CPT1A inhibited the viability and glycolysis of PCa cells. Mechanistically, CPT1A promoted the succinylation of SP5, which strengthened the binding between SP5 and the promoter of PDPK1. SP5 activated PDPK1 transcription and PDPK1 activated the AKT/mTOR signal pathway. These findings might provide novel targets for the diagnosis or therapy of prostate cancer.
MeSH term(s)	Male ; Humans ; Transcription Factors/metabolism ; Cell Line ; Signal Transduction ; Prostatic Neoplasms/genetics ; Glycolysis ; 3-Phosphoinositide-Dependent Protein Kinases/metabolism
Chemical Substances	Transcription Factors ; PDPK1 protein, human (EC 2.7.11.1) ; 3-Phosphoinositide-Dependent Protein Kinases (EC 2.7.11.1)
Language	English
Publishing date	2024-03-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2146305-0
ISSN	1555-8576 ; 1538-4047
ISSN (online)	1555-8576
ISSN	1538-4047
DOI	10.1080/15384047.2024.2329372
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Zs.A 5887: Show issues

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Article ; Online: Driving factors of urban community epidemic prevention and control capability: QCA analysis based on typical cases of 20 anti-epidemic communities in China.

Shi, Ruyi / Lu, Bo / Zhong, Yiwen

Frontiers in public health

2024 Volume 11, Page(s) 1296269

Abstract: Introduction: In the wake of the COVID-19 outbreak, urban communities have emerged as the frontline defenders in epidemic prevention and control, providing the most effective means of curbing the spread of virus both inward and outward. This study ... ...

Abstract	Introduction: In the wake of the COVID-19 outbreak, urban communities have emerged as the frontline defenders in epidemic prevention and control, providing the most effective means of curbing the spread of virus both inward and outward. This study attempts to explain the underlying factors and mechanisms that shape the community epidemic prevention and control capacity (CEPCC). Methods: We adopted a resilience-based perspective and drew on a sample of 20 exemplary anti-epidemic communities in China. By constructing an analytical framework and employing the fuzzy set qualitative comparative analysis method (fsQCA), we explored how four conditional variables-infrastructure completeness, community self-organizing ability, redundancy of community resources, and stability of regional economic development-and their various configurations impact the CEPCC. Results: Our findings reveal that the four conditional variables, when considered in isolation, cannot effectively enhance the CEPCC. Instead, four configuration pathways with mixed conditional variables exist. Notably, community self-organizing ability emerges as a vital condition for effectively strengthening the CEPCC. Discussion: This study identifies four pathways to improve the CEPCC and confirms the validity of the data results through case studies. Conclusions of this research contribute to a more nuanced understanding of the factors influencing the CEPCC, which can help communities to better plan and prepare for future epidemics and ensure better response and adaptation to the impacts of future emergencies.
MeSH term(s)	Humans ; Epidemics/prevention & control ; China/epidemiology ; Disease Outbreaks ; COVID-19/epidemiology ; COVID-19/prevention & control ; Economic Development
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1296269
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Article ; Online: Tunable Majorana corner modes by orbital-dependent exchange interaction in a two-dimensional topological superconductor.

Lu, Bo / Zhang, Yiying

Journal of physics. Condensed matter : an Institute of Physics journal

2022 Volume 34, Issue 30

Abstract: We theoretically study the effect of orbital-dependent exchange field in the formation of second order topological superconductors. We demonstrate that changing the orbital difference can induce topological transition and the Majorana corner modes ... ...

Abstract	We theoretically study the effect of orbital-dependent exchange field in the formation of second order topological superconductors. We demonstrate that changing the orbital difference can induce topological transition and the Majorana corner modes therein can be manipulated. We further propose to detect the corner modes via a normal probe terminal. The conductance quantization is found to be robust to changes of the relevant system parameters.
Language	English
Publishing date	2022-05-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/1361-648X/ac709e
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Article ; Online: Optimal insertion site for ultrasound-guided radial artery catheterization utilizing the dynamic needle tip positioning technique: A prospective randomized controlled study.

Sun, Jiahui / Lu, Bo / Shan, Jianbo / Pan, Zhihao / Sun, Jianliang

The journal of vascular access

2024 , Page(s) 11297298241233713

Abstract: Background: The dynamic needle tip positioning technique represents an advanced version of the short-axis out-of-plane ultrasound-guided approach employed for radial artery catheterization. The study aimed to explore the most effective insertion site ... ...

Abstract	Background: The dynamic needle tip positioning technique represents an advanced version of the short-axis out-of-plane ultrasound-guided approach employed for radial artery catheterization. The study aimed to explore the most effective insertion site capable of expeditiously and accurately executing the procedure in a clinical setting. Methods: A prospective randomized controlled study encompassed 246 elective surgery patients necessitating invasive arterial monitoring. Participants were randomly assigned to three distinct groups: Site 1 (targeting the radial styloid process), Site 2 (midway between Sites 1 and 3), and Site 3 (distal one-third of the forearm). The dynamic needle tip positioning technique was implemented across all groups. Crucial parameters, such as first-attempt success rate, time to success, overall success rate, total catheterization time, number of attempts, and complications, were meticulously documented and compared. Results: The Site 2 cohort presented a significantly heightened first-attempt success rate compared to Site 1 (97.5% vs 80%, Conclusions: The optimal insertion site for ultrasound-guided radial artery catheterization utilizing the dynamic needle tip positioning technique in adult patients is situated midway between the radial styloid process and the distal one-third of the forearm.
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2252820-9
ISSN	1724-6032 ; 1129-7298
ISSN (online)	1724-6032
ISSN	1129-7298
DOI	10.1177/11297298241233713
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Zs.A 6414: Show issues

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