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  1. Article ; Online: The Effects of Open Innovation at the Network Level

    Lu Cheng

    Sustainability, Vol 14, Iss 15519, p

    2022  Volume 15519

    Abstract: To open the black box of how open innovation works at the network level, we particularly focused on the effects of TFs’ collective openness of external knowledge search on RIN innovation performance in different innovation environments of disruptiveness. ...

    Abstract To open the black box of how open innovation works at the network level, we particularly focused on the effects of TFs’ collective openness of external knowledge search on RIN innovation performance in different innovation environments of disruptiveness. To conduct the research, we adopted a bottom-up research approach and designed an agent-based simulation model. The simulation results show that either collective breadth or depth exerts significant effects on the RIN innovation performance, and their effectiveness is significantly moderated by disruptiveness. Our results reveal the followings: (1) RIN innovation performance can be considerably enhanced by high collective openness, but it is not necessarily true that more collective openness is better, which reflects that the “inverted U-shaped” relationships broadly argued in firm-level open innovation studies also exists at the network level. (2) The effect of collective openness depends on the disruptiveness of innovation environment. The likelihood of a positive effect of collective openness on RIN innovation performance increases as the disruptiveness is enhanced. The trends of the polarization of individual TFs’ innovation performance in an RIN is alleviated as the disruptiveness is enhanced. Based on these findings, we give some guidance of innovation policymaking. When the industry is in its emerging stage, aggressive collective openness—high collective breadth and depth—aiming at achieving high RIN innovation performance is recommended. When the industry steps into its developing stage, directed collective openness—high collective depth and moderate collective breadth—aiming at fostering future industry leaders in the RIN is recommended. When the industry reaches its maturity, conservative collective openness—low collective depth and moderate collective breadth—aiming at maximum utilization of current RIN’s competitive advantages is recommended.
    Keywords open innovation ; collective openness ; RIN innovation performance ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 690
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Role of mitochondria in neonatal hypoxic-ischemic encephalopathy.

    Kong, Weijing / Lu, Cheng

    Histology and histopathology

    2024  , Page(s) 18710

    Abstract: Neonatal hypoxic-ischemic encephalopathy, an important cause of death as well as long-term disability in survivors, is caused by oxygen and glucose deprivation, and limited blood flow. Following hypoxic-ischemic injury in the neonatal brain, three main ... ...

    Abstract Neonatal hypoxic-ischemic encephalopathy, an important cause of death as well as long-term disability in survivors, is caused by oxygen and glucose deprivation, and limited blood flow. Following hypoxic-ischemic injury in the neonatal brain, three main biochemical damages (excitotoxicity, oxidative stress, and exacerbated inflammation) are triggered. Mitochondria are involved in all three cascades. Mitochondria are the nexus of metabolic pathways to offer most of the energy that our body needs. Hypoxic-ischemic injury affects the characteristics of mitochondria, including dynamics, permeability, and ATP production, which also feed back into the process of neonatal hypoxic-ischemic encephalopathy. Mitochondria can be a cellular hub in inflammation, which is another main response of the injured neonatal brain. Some treatments for neonatal hypoxic-ischemic encephalopathy affect the function of mitochondria or target mitochondria, including therapeutic hypothermia and erythropoietin. This review presents the main roles of mitochondria in neonatal hypoxic-ischemic encephalopathy and discusses some potential treatments directed at mitochondria, which may foster the development of new therapeutic strategies for this encephalopathy.
    Language English
    Publishing date 2024-01-15
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 83911-5
    ISSN 1699-5848 ; 0213-3911
    ISSN (online) 1699-5848
    ISSN 0213-3911
    DOI 10.14670/HH-18-710
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  3. Article ; Online: Postoperative myocardial injury phenotypes and self-reported disability in patients undergoing noncardiac surgery. Comment on Br J Anaesth 2024; 132: 35-44.

    Hee, Hui-Zen / Lu, Cheng-Wei

    British journal of anaesthesia

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2024.04.002
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  4. Article: Editorial: Diabetic neuropathy and its complications.

    Wang, Hung-Chen / Lu, Cheng-Hsien

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1267417

    Language English
    Publishing date 2023-08-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1267417
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  5. Article ; Online: Comparative safety of immune checkpoint inhibitors in recurrent or metastatic head and neck squamous cell carcinoma: a systematic review and network meta-analysis.

    Wang, Shan / Yan, Li / Yu, Jing / Lu, Cheng

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2024  

    Abstract: Background: To indirectly compare the safety of immune checkpoint inhibitors (ICIs) in the treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) by network meta-analysis (NMA).: Methods: Through August 1, 2023, we ... ...

    Abstract Background: To indirectly compare the safety of immune checkpoint inhibitors (ICIs) in the treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) by network meta-analysis (NMA).
    Methods: Through August 1, 2023, we searched PubMed, Cochrane Library, Embase, Web of Science, and ClinicalTrials.gov for randomized clinical trials (RCTs) of ICI-based treatment for R/M HNSCC. Outcomes of interest included overall and organ-specific immune-related adverse events (irAEs). Addis 16.5 software was used to perform NMA. Confidence in Network Meta-Analysis (CINeMA) was used to assess confidence in the evidence.
    Results: Nine RCTs were included in this NMA, involving a total of 4016 patients. The general safety of ICI-based treatments in descending order was as follows: Durvalumab + Tremelimumab, Camrelizumab + Chemotherapy, Durvalumab, Toripalimab + Chemotherapy, Pembrolizumab, Pembrolizumab + Chemotherapy, Nivolumab, Tremelimumab. There were differences in the toxicity profile among Toripalimab + Chemotherapy (dermatologic irAEs), Camrelizumab + Chemotherapy (hypothyroidism), Nivolumab + Ipilimumab (hyperthyroidism, pneumonitis), Pembrolizumab (nephrotoxicity), Pembrolizumab + Chemotherapy (colitis). ICI-based treatment increased the incidence of endocrine irAEs (hyperthyroidism and hypothyroidism) and pneumonitis compared to conventional therapy. Besides, the combination of dual ICIs resulted in a greater occurrence of irAEs compared to the use of a single ICI.
    Conclusions: The safety ranking of treatments based on ICIs is significantly influenced by specific irAEs. These irAEs, which vary in type and severity, play a crucial role in determining the overall safety profile of each ICI regimen.
    Systematic review registration: PROSPERO CRD42023460267.
    Language English
    Publishing date 2024-02-15
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-024-08517-z
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  6. Article ; Online: Clinical characteristics of BRAT1-related disease: a systematic literature review.

    Kong, Weijing / Cao, Xianying / Lu, Cheng

    Acta neurologica Belgica

    2024  

    Abstract: Background: BRAT1 (BRCA1-associated ataxia telangiectasia mutated activator 1) is involved in many important biological processes, including DNA damage response and maintenance of mitochondrial homeostasis. Dysfunctional BRAT1 causes variable clinical ... ...

    Abstract Background: BRAT1 (BRCA1-associated ataxia telangiectasia mutated activator 1) is involved in many important biological processes, including DNA damage response and maintenance of mitochondrial homeostasis. Dysfunctional BRAT1 causes variable clinical phenotypes, which hinders BRAT1-related disease from recognition and diagnosis.
    Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement was the guideline for this systematic review. MEDLINE was searched by terms ("BAAT1" and "BRAT1") from inception until June 21, 2022.
    Results: Twenty-eight studies, screened out of 49 records, were included for data extraction. The data from fifty patients with mutated BRAT1 were collected. There are 3 high relevant phenotypes, 4 medium relevant phenotypes and 3 low relevant phenotypes. Eye-related abnormal features were most frequently reported: 27 abnormal features were observed. Thirty-nine kinds of pathogenic nucleotide change in BRAT1 were reported. Top three common mutations of BRAT1 were c.638_639insA (16 cases), c.1395G > A (5 cases) and c.294dupA (4 cases). Homozygous mutations in BRAT1 presented a more severe phenotype than those who are compound heterozygotes.
    Conclusions: This is the first comprehensive systematic review to present quantitative data about clinical characteristics of BRAT1-related disease, which helps doctors to recognize and diagnose it easier.
    Language English
    Publishing date 2024-04-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-024-02507-y
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  7. Article ; Online: Fe deficiency‐induced ethylene synthesis confers resistance to Botrytis cinerea

    Lu, Cheng Kai / Liang, Gang

    New Phytologist. 2023 Mar., v. 237, no. 5 p.1843-1855

    2023  

    Abstract: Although iron (Fe) deficiency is an adverse condition to growth and development of plants, it increases the resistance to pathogens. How Fe deficiency induces the resistance to pathogens is still unclear. Here, we reveal that the inoculation of Botrytis ... ...

    Abstract Although iron (Fe) deficiency is an adverse condition to growth and development of plants, it increases the resistance to pathogens. How Fe deficiency induces the resistance to pathogens is still unclear. Here, we reveal that the inoculation of Botrytis cinerea activates the Fe deficiency response of plants, which further induces ethylene synthesis and then resistance to B. cinerea. FIT and bHLH Ib are a pair of bHLH transcription factors, which control the Fe deficiency response. Both the Fe deficiency‐induced ethylene synthesis and resistance are blocked in fit‐2 and bhlh4x‐1 (a quadruple mutant for four bHLH Ib members). SAM1 and SAM2, two ethylene synthesis‐associated genes, are induced by Fe deficiency in a FIT‐bHLH Ib‐dependent manner. Moreover, SAM1 and SAM2 are required for the increased ethylene and resistance to B. cinerea under Fe‐deficient conditions. Our findings suggest that the FIT‐bHLH Ib module activates the expression of SAM1 and SAM2, thereby inducing ethylene synthesis and resistance to B. cinerea. This study uncovers that Fe signaling also functions as a part of the plant immune system against pathogens.
    Keywords Botrytis cinerea ; ethylene ; growth and development ; immune system ; mutants ; nutrient deficiencies
    Language English
    Dates of publication 2023-03
    Size p. 1843-1855.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.18638
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  8. Article ; Online: Fe deficiency-induced ethylene synthesis confers resistance to Botrytis cinerea.

    Lu, Cheng Kai / Liang, Gang

    The New phytologist

    2022  Volume 237, Issue 5, Page(s) 1843–1855

    Abstract: Although iron (Fe) deficiency is an adverse condition to growth and development of plants, it increases the resistance to pathogens. How Fe deficiency induces the resistance to pathogens is still unclear. Here, we reveal that the inoculation of Botrytis ... ...

    Abstract Although iron (Fe) deficiency is an adverse condition to growth and development of plants, it increases the resistance to pathogens. How Fe deficiency induces the resistance to pathogens is still unclear. Here, we reveal that the inoculation of Botrytis cinerea activates the Fe deficiency response of plants, which further induces ethylene synthesis and then resistance to B. cinerea. FIT and bHLH Ib are a pair of bHLH transcription factors, which control the Fe deficiency response. Both the Fe deficiency-induced ethylene synthesis and resistance are blocked in fit-2 and bhlh4x-1 (a quadruple mutant for four bHLH Ib members). SAM1 and SAM2, two ethylene synthesis-associated genes, are induced by Fe deficiency in a FIT-bHLH Ib-dependent manner. Moreover, SAM1 and SAM2 are required for the increased ethylene and resistance to B. cinerea under Fe-deficient conditions. Our findings suggest that the FIT-bHLH Ib module activates the expression of SAM1 and SAM2, thereby inducing ethylene synthesis and resistance to B. cinerea. This study uncovers that Fe signaling also functions as a part of the plant immune system against pathogens.
    MeSH term(s) Arabidopsis Proteins/metabolism ; Arabidopsis/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Botrytis/physiology ; Ethylenes/metabolism ; Plant Diseases/genetics ; Gene Expression Regulation, Plant ; Disease Resistance
    Chemical Substances Arabidopsis Proteins ; Basic Helix-Loop-Helix Transcription Factors ; Ethylenes
    Language English
    Publishing date 2022-12-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.18638
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  9. Article ; Online: Synthesis and Processing of Dynamic Covalently Crosslinked Polydextran/Carbon Dot Nanocomposite Hydrogels with Tailorable Microstructures and Properties.

    Lu, Cheng-Hsun / Yeh, Yi-Cheun

    ACS biomaterials science & engineering

    2022  Volume 8, Issue 10, Page(s) 4289–4300

    Abstract: Using functionalized nanoparticles to crosslink hydrophilic polymers is a growing theme of directly constructing nanocomposite (NC) hydrogels. Employing dynamic covalent chemistry at the nanoparticle-polymer interface is particularly attractive due to ... ...

    Abstract Using functionalized nanoparticles to crosslink hydrophilic polymers is a growing theme of directly constructing nanocomposite (NC) hydrogels. Employing dynamic covalent chemistry at the nanoparticle-polymer interface is particularly attractive due to the spontaneous formation and reversible manner of dynamic covalent bonds. However, the structure and property modulation of the dynamic covalently crosslinked NC hydrogels has not been thoroughly discussed. Here, we fabricated NC hydrogels by using amine-functionalized carbon dots (CDs) to crosslink polydextran aldehyde (PDA) polymers through imine bond formation. The role of PDA with different oxidation degrees (i.e., PDA10, PDA30, and PDA50) in affecting the microstructures and properties of PDA@CD hydrogels was systematically investigated, showing that the PDA50@CD hydrogel presented the densest structure and the highest mechanical strength among the three PDA@CD hydrogels. The pH-responsiveness, 3D printing, electrospinning, and biocompatibility of PDA@CD hydrogels were also demonstrated, showing the great promise of using PDA@CD hydrogels for applications in biomedicine and biofabrication.
    MeSH term(s) Aldehydes ; Amines ; Carbon ; Hydrogels/chemistry ; Imines ; Nanogels ; Polymers
    Chemical Substances Aldehydes ; Amines ; Hydrogels ; Imines ; Nanogels ; Polymers ; Carbon (7440-44-0)
    Language English
    Publishing date 2022-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.2c00873
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  10. Article ; Online: Wrist deformity following falling down.

    Lee, Chih-Yao / Lu, Cheng-Chang

    Emergency medicine journal : EMJ

    2022  Volume 39, Issue 11, Page(s) 866–880

    MeSH term(s) Humans ; Wrist
    Language English
    Publishing date 2022-10-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2021-211860
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