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Article ; Online: Synergistic Palladium/Chiral Phosphoric Acid-Catalyzed Kinetic Resolution via Stereoselective Intramolecular Substitution of Unactivated Allylic Alcohols.

Chou, Chun-Ting / Lu, Chun-Wei / Wu, Bing-Syuan / Tsai, Cheng-Che

2023 Volume 88, Issue 9, Page(s) 5813–5826

Abstract: This paper reports the kinetic resolution of racemic secondary alcohols ( ...

Abstract	This paper reports the kinetic resolution of racemic secondary alcohols (
Language	English
Publishing date	2023-04-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.3c00236
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Zs.A 4473: Show issues

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Article: The Challenges in Managing Pulmonary Arterial Hypertension Associated with Congenital Heart Disease.

Lu, Chun-Wei

Acta Cardiologica Sinica

2016 Volume 31, Issue 6, Page(s) 516–517

Abstract: Congenital heart disease; Eisenmenger syndrome; Pulmonary arterial hypertension. ...

Abstract	Congenital heart disease; Eisenmenger syndrome; Pulmonary arterial hypertension.
Language	English
Publishing date	2016-04-28
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	1051394-2
ISSN	1011-6842
ISSN	1011-6842
DOI	10.6515/acs20151014a
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Zs.A 3059: Show issues

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Article ; Online: Dupilumab for STAT3-Hyper-IgE Syndrome With Refractory Intestinal Complication.

Lu, Chun-Wei / Lee, Wen-I / Chung, Wen-Hung

Pediatrics

2021 Volume 148, Issue 3

Abstract: STAT3 hyper-immunoglobulin E syndrome (STAT3-HIES) is a rare primary immunodeficiency syndrome characterized by elevated serum immunoglobulin E levels, eczema, recurrent skin and respiratory tract infections, and several gastrointestinal (GI) problems. ... ...

Abstract	STAT3 hyper-immunoglobulin E syndrome (STAT3-HIES) is a rare primary immunodeficiency syndrome characterized by elevated serum immunoglobulin E levels, eczema, recurrent skin and respiratory tract infections, and several gastrointestinal (GI) problems. GI manifestations, such as gastroesophageal reflux disease, dysphagia, abdominal pain, gut dysmotility, bowel perforation, eosinophilic esophagitis, and diarrhea, have been reported in 60% of patients. Until now, there was no efficient treatment that could effectively manage all aspects of the syndrome. In this report, we present the case of a 21-year-old man who suffered from undetectable pathogenic refractory diarrhea that persisted >21 days despite aggressive antibiotic and steroid treatment since he was 2 years old. STAT3 Int10(-2)A > G splicing mutation-caused STAT3-HIES was diagnosed by next-generation sequencing. The patient had suffered recurrent intestinal and colon perforations since he was 10 years old. He had received multiple surgeries and continuous systemic intravenous immunoglobulin therapy to manage his GI symptoms. However, refractory diarrhea occurring >5 to 6 times per day with severe eczematous dermatitis and frequent abscess formation remained threats to his life. Dupilumab 300 mg every 3 weeks was prescribed to control his skin problems, but the patient's diarrhea also completely subsided. As such, it appears that dupilumab may not only effectively treat the skin inflammation but also the GI manifestation-related inflammation of STAT3-HIES refractory to traditional immunomodulators.
MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; Diarrhea/drug therapy ; Diarrhea/etiology ; Eczema/drug therapy ; Eczema/etiology ; Humans ; Interleukin-4 Receptor alpha Subunit/antagonists & inhibitors ; Job Syndrome/complications ; Male ; Young Adult
Chemical Substances	Antibodies, Monoclonal, Humanized ; Interleukin-4 Receptor alpha Subunit ; dupilumab (420K487FSG)
Language	English
Publishing date	2021-08-20
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2021-050351
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Article ; Online: Images of the month 2: Disseminated gonococcal infection presenting as the arthritis-dermatitis syndrome.

Wang, Chi-Hui / Lu, Chun-Wei

Clinical medicine (London, England)

2019 Volume 19, Issue 4, Page(s) 340–341

MeSH term(s)	Arthritis, Infectious/microbiology ; Arthritis, Infectious/pathology ; Dermatitis/microbiology ; Dermatitis/pathology ; Gonorrhea/microbiology ; Gonorrhea/pathology ; Hand/pathology ; Humans ; Leg/pathology ; Male ; Middle Aged ; Skin/pathology
Language	English
Publishing date	2019-06-28
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2048646-7
ISSN	1473-4893 ; 1470-2118
ISSN (online)	1473-4893
ISSN	1470-2118
DOI	10.7861/clinmedicine.19-4-340
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Zs.A 5439: Show issues

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Article ; Online: The Lived Experience of First-time Mothers with Congenital Heart Disease.

Liu, Yu-Ting / Lu, Chun-Wei / Mu, Pei-Fan / Shu, Ying-Mei / Chen, Chi-Wen

Asian nursing research

2022 Volume 16, Issue 3, Page(s) 140–148

Abstract: Purpose: Nowadays most children with congenital heart disease (CHD) are expected to survive to adulthood. The healthcare focus needs to pay close attention to the important developmental tasks during their growth process. The women with CHD face some ... ...

Abstract	Purpose: Nowadays most children with congenital heart disease (CHD) are expected to survive to adulthood. The healthcare focus needs to pay close attention to the important developmental tasks during their growth process. The women with CHD face some challenges in their critically developmental stages during pregnancy, delivery, and even motherhood. The lived experience of being a mother needs to be further concerned. This study aimed to explore the lived experience of first-time mothers with CHD. Methods: Descriptive phenomenological design was adopted. Semi-structured interviews were conducted from April to August 2018 with 11 primiparous women with CHD, who were recruited from the pediatric and adult cardiology outpatient departments at a medical center and who had a child aged between 6 months and 3 years. Giorgi's phenomenological analysis method was employed. Results: Six main themes arose from the analysis: (1) recognizing pregnancy risks, (2) performing self-care for health, (3) building self-worth from my baby, (4) adapting to postpartum life and adjusting priorities, (5) enjoying being a first-time mother, and (6) the factors contributing to success in high-risk childbirth. Conclusions: The experiences that occurred prior to and after labor that were identified in this study can assist women with CHD to more capably prepare for and understand the process of becoming a mother, including recognition of the importance of a prepregnancy evaluation. The findings of this study can help women with CHD to better understand the path to becoming a mother and prepare themselves for the challenges that lie ahead.
MeSH term(s)	Adult ; Child ; Female ; Heart Defects, Congenital ; Humans ; Infant ; Mothers ; Postpartum Period ; Pregnancy ; Qualitative Research
Language	English
Publishing date	2022-05-24
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2481635-8
ISSN	2093-7482 ; 2093-7482
ISSN (online)	2093-7482
ISSN	2093-7482
DOI	10.1016/j.anr.2022.05.003
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Article ; Online: Health-promoting lifestyle and life satisfaction in full-time employed adults with congenital heart disease: grit as a mediator.

Liu, Yu-Shiu / Lu, Chun-Wei / Chung, Hung-Tao / Wang, Jou-Kou / Su, Wen-Jen / Chen, Chi-Wen

European journal of cardiovascular nursing

2023

Abstract: Aims: Enhancing life satisfaction is vital for adults with congenital heart disease (ACHD). Life satisfaction potentially correlates with a health-promoting lifestyle and grit. However, the mediating role of grit-a trait marked by perseverance and long- ... ...

Abstract	Aims: Enhancing life satisfaction is vital for adults with congenital heart disease (ACHD). Life satisfaction potentially correlates with a health-promoting lifestyle and grit. However, the mediating role of grit-a trait marked by perseverance and long-term goal-oriented passion-between a health-promoting lifestyle and life satisfaction in ACHD remains unverified. This study aimed to examine the relationships between health-promoting lifestyle, grit, and life satisfaction in full-time employed ACHD and to confirm the mediating role of grit. Methods and results: A total of 181 full-time employed ACHD aged 20-59 years with patient-reported New York Heart Association class I-IV were recruited from two medical centers in northern Taiwan. Participants completed questionnaires, including the short version of the Chinese Health-Promoting Lifestyle Profile scale, Grit-10 scale, and Satisfaction with Life Scale between February and December 2022. Data analysis employed the Hayes PROCESS macro. Health-promoting lifestyle, grit, and life satisfaction were discovered to be positively correlated. Overall grit score was a partial mediator between a health-promoting lifestyle and life satisfaction, accounting for 20% of the total variation. Of the grit domains, perseverance served as a partial mediator between a health-promoting lifestyle and life satisfaction, accounting for 32% of the total variation, whereas passion had a nonsignificant mediation effect. Conclusion: A health-promoting lifestyle boosts ACHD individuals' life satisfaction through grit, particularly perseverance. Integrating grit into such a lifestyle could benefit from comprehending support systems and influential factors aiding grit development for enhanced life satisfaction.
Language	English
Publishing date	2023-10-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2151245-0
ISSN	1873-1953 ; 1474-5151
ISSN (online)	1873-1953
ISSN	1474-5151
DOI	10.1093/eurjcn/zvad104
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Zs.A 5938: Show issues

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Article ; Online: A Potential Association of Zinc Deficiency and Tyrosine Kinase Inhibitor-Induced Hand-Foot Skin Reaction.

Yeh, Chun-Nan / Huang, Wen-Kuan / Lu, Chun-Wei / Chen, Chiao-Ping / Lin, Sheng-Hsuan / Pan, Yi-Ru / Wu, Chiao-En

Biological trace element research

2023 Volume 201, Issue 12, Page(s) 5540–5545

Abstract: Hand-foot skin reaction (HFSR) is a common skin-related adverse event induced by multikinase inhibitors targeting both platelet-derived growth factor receptor and vascular endothelial growth factor receptor, possibly due to inadequate repair following ... ...

Abstract	Hand-foot skin reaction (HFSR) is a common skin-related adverse event induced by multikinase inhibitors targeting both platelet-derived growth factor receptor and vascular endothelial growth factor receptor, possibly due to inadequate repair following frictional trauma. Zinc is a trace element and essential nutrient in humans that plays critical roles in the development and differentiation of skin cells. Zinc transporters (Zrt- and Irt-like proteins and Zn transporters) and metallothioneins are involved in zinc efflux, uptake, and homeostasis and have been reported to be involved in skin differentiation. The underlying mechanism of HFSR remains unclear, and the association between HFSR and zinc has not been previously studied. However, some case reports and case series provide potential evidence to suggest that zinc deficiency may be involved in HFSR development and zinc supplementation may relieve HFSR symptoms. However, no large-scale clinical studies have been conducted to examine this role. Therefore, this review summarizes the evidence supporting a possible link between HFSR development and zinc and proposes potential mechanisms underlying this association based on current evidence.
MeSH term(s)	Humans ; Malnutrition ; Protein Kinase Inhibitors/adverse effects ; Skin/pathology ; Tyrosine Kinase Inhibitors/adverse effects ; Vascular Endothelial Growth Factor A ; Zinc/deficiency ; Skin Diseases/chemically induced
Chemical Substances	Protein Kinase Inhibitors ; Tyrosine Kinase Inhibitors ; Vascular Endothelial Growth Factor A ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-023-03618-y
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Zs.B 2323: Show issues

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Article ; Online: Combination of slow pathway late activation maps and voltage gradient maps in guidance of atrioventricular nodal reentrant tachycardia cryoablation.

Tseng, Wei-Chieh / Wu, Mei-Hwan / Lu, Chun-Wei / Wu, Kun-Lang / Wang, Jou-Kou / Lin, Ming-Tai / Chen, Chun-An / Chiu, Shuenn-Nan

Heart rhythm

2023 Volume 20, Issue 7, Page(s) 1026–1032

Abstract: Background: The optimal strategy for electroanatomic mapping-guided cryoablation of atrioventricular nodal reentry tachycardia (AVNRT) remains unclear.: Objective: The purpose of this study was to investigate the effectiveness of slow pathway late ... ...

Abstract	Background: The optimal strategy for electroanatomic mapping-guided cryoablation of atrioventricular nodal reentry tachycardia (AVNRT) remains unclear. Objective: The purpose of this study was to investigate the effectiveness of slow pathway late activation mapping (SPLAM) and voltage gradient mapping for AVNRT cryoablation. Methods: From June 2020 to February 2022, all consecutive patients with AVNRT underwent SPLAM to define the wave collision point and voltage gradient mapping to define the low-voltage bridge (LVB). Conventional procedures performed from August 2018 to May 2020 served as control. Results: The study and control groups comprised 36 patients (age 16.5 ± 8.2 years) and 37 patients (age 15.5 ± 7.3 years), respectively. Total procedural times were comparable, and acute success rates were 100% in both groups. Compared to controls, the number of cryomapping attempts (median 3 vs 5; P = .012) and cryoablation applications (median 1 vs 2; P <.001) were significantly lower in the study group. At median follow-up of 14.6 and 18.3 months, recurrence rates were 5.6% (2 patients) and 10.8% (4 patients) in the study and control groups (P = .402), respectively. Mapping of the Koch triangle took 11.8 ± 3.6 minutes, during which 1562 ± 581 points were collected. In SPLAM, wave collision points were defined and compatible with the final successful lesion sites in all patients, including those with multiple slow pathways. LVB could not be defined in 6 patients (16.7%), and LVB was not compatible with the final successful lesion in another 6 (16.7%). Conclusion: For AVNRT cryoablation, SPLAM could effectively guide the localization of slow pathway ablation sites and was particularly beneficial in patients with multiple slow pathways.
MeSH term(s)	Humans ; Child ; Adolescent ; Young Adult ; Adult ; Tachycardia, Atrioventricular Nodal Reentry/diagnosis ; Tachycardia, Atrioventricular Nodal Reentry/surgery ; Cryosurgery/methods ; Treatment Outcome ; Arrhythmias, Cardiac/surgery ; Catheter Ablation/methods ; Recurrence
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2023.04.006
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Zs.A 6278: Show issues

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Article ; Online: Atrial fibrillation in adult congenital heart disease and the general population.

Wu, Mei-Hwan / Chiu, Sheunn-Nan / Tseng, Wei-Chieh / Lu, Chun-Wei / Kao, Feng-Yu / Huang, San-Kuei

Heart rhythm

2023 Volume 20, Issue 9, Page(s) 1248–1254

Abstract: Background: Atrial fibrillation (AF) in adult patients with congenital heart disease (ACHD) may appear early, depending on individual characteristics.: Objectives: The goals of this study were to investigate the epidemiological spectrum of AF in the ... ...

Abstract	Background: Atrial fibrillation (AF) in adult patients with congenital heart disease (ACHD) may appear early, depending on individual characteristics. Objectives: The goals of this study were to investigate the epidemiological spectrum of AF in the entire cohort of ACHD and compare it with that in the general population. Methods: A retrospective study was performed in the nationwide cohort 2000-2014 with AF onset during 2003-2014. Results: In the cohort of ACHD, 2350 patients had AF; the incidence increased with age, plateauing around age 70. In patients aged 25-29, 45-49, 65-69, 75-79, and ≥80 years, the annual incidence was 1.3, 7.9, 20.6, 23.7, and 21.4/1000 per year, respectively. In the general population without CHD, 347,979 patients had AF; the annual incidence was <1/1000 per year in those aged <55 years but increased steadily with age (3.6, 8.6, and 14.2/1000 per year in aged 65-69, 75-79, and ≥80 years, respectively). Compared with individuals without ACHD, ACHD patients aged <50 years and those aged both 50-54 and 55-59 years exhibited a 20-fold and 10-fold higher incidence of AF, respectively. Patients with complex congenital heart disease and Ebstein's anomaly had the highest risk of AF (cumulative risk >10% by age 50 and >20% by age 60), followed by those with tetralogy of Fallot, tricuspid atresia, endocardial cushion defect, and secundum atrial septal defect (cumulative risk >5% by age 50 and >10% by age 60). Conclusion: Compared with individuals without ACHD, AF in patients with ACHD likely appeared 30 years earlier, with a 10- to 20-fold higher incidence plateauing around age 70. Yet, incidence in individuals without ACHD continued to increase. AF burden in patients with ACHD is not expected to increase in a never-ending way.
MeSH term(s)	Humans ; Adult ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/epidemiology ; Heart Defects, Congenital/surgery ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/etiology ; Retrospective Studies ; Ebstein Anomaly ; Heart Septal Defects, Atrial/complications
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2023.05.009
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Article ; Online: Zinc supplementation is associated with improvement in hand-foot skin reaction in patients on vascular endothelial growth factor receptor-tyrosine kinase inhibitors: A cohort study.

Lu, Chun-Wei / Yeh, Chun-Nan / Hsu, Hung-Chih / Chen, Chun-Bing / Yang, Tsai-Sheng / Pan, Yi-Ru / Chung, Wen-Hung / Hung, Shuen-Iu

Journal of the American Academy of Dermatology

2023 Volume 90, Issue 4, Page(s) 814–815

MeSH term(s)	Humans ; Vascular Endothelial Growth Factor A ; Tyrosine Kinase Inhibitors ; Cohort Studies ; Zinc/adverse effects ; Protein Kinase Inhibitors/adverse effects ; Receptors, Vascular Endothelial Growth Factor ; Dietary Supplements
Chemical Substances	Vascular Endothelial Growth Factor A ; Tyrosine Kinase Inhibitors ; Zinc (J41CSQ7QDS) ; Protein Kinase Inhibitors ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2023.11.054
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