Article ; Online: Hydroxysafflor Yellow A Exerts Neuroprotective Effect by Reducing Aβ Toxicity Through Inhibiting Endoplasmic Reticulum Stress in Oxygen-Glucose Deprivation/Reperfusion Cell Model.
2023 Volume 26, Issue 2, Page(s) 57–67
Abstract: Ischemia stroke is thought to be one of the vascular risks associated with neurodegenerative diseases, such as Alzheimer's disease (AD). Hydroxysafflor yellow A (HSYA) has been reported to protect against stroke and AD, while the underlying mechanism ... ...
| Abstract | Ischemia stroke is thought to be one of the vascular risks associated with neurodegenerative diseases, such as Alzheimer's disease (AD). Hydroxysafflor yellow A (HSYA) has been reported to protect against stroke and AD, while the underlying mechanism remains unclear. In this study, SH-SY5Y cell model treated with oxygen-glucose deprivation/reperfusion (OGD/R) was used to explore the potential mechanism of HSYA. Results from cell counting kit-8 (CCK-8) showed that 10 μM HSYA restored the cell viability after OGD 2 hours/R 24 hours. HSYA reduced the levels of malondialdehyde and reactive oxygen species, while improved the levels of superoxide dismutase and glutathione peroxidase. Furthermore, apoptosis was inhibited, and the expression of brain-derived neurotrophic factor was improved after HSYA treatment. In addition, the expression levels of amyloid-β peptides (Aβ) and BACE1 were decreased by HSYA, as well as the expression levels of binding immunoglobulin heavy chain protein, PKR-like endoplasmic reticulum (ER) kinase pathway, and activating transcription factor 6 pathway, whereas the expression level of protein disulfide isomerase was increased. Based on these results, HSYA might reduce Aβ toxicity after OGD/R by interfering with apoptosis, oxidation, and neurotrophic factors, as well as relieving ER stress. |
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| MeSH term(s) | Humans ; Oxygen/metabolism ; Neuroprotective Agents/pharmacology ; Amyloid Precursor Protein Secretases/pharmacology ; Glucose/metabolism ; Aspartic Acid Endopeptidases/pharmacology ; Neuroblastoma ; Quinones/pharmacology ; Apoptosis ; Chalcone/pharmacology ; Reperfusion Injury/metabolism ; Stroke ; Reperfusion ; Endoplasmic Reticulum Stress |
| Chemical Substances | Oxygen (S88TT14065) ; Neuroprotective Agents ; hydroxysafflor yellow A (146087-19-6) ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Glucose (IY9XDZ35W2) ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; Quinones ; Chalcone (5S5A2Q39HX) |
| Language | English |
| Publishing date | 2023-03-20 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2150779-X |
| ISSN | 1557-8577 ; 1549-1684 |
| ISSN (online) | 1557-8577 |
| ISSN | 1549-1684 |
| DOI | 10.1089/rej.2022.0054 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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