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  1. Article ; Online: A novel QA phantom based on scintillating fiber ribbons with implementation of 2D dose tomography for small-field radiotherapy.

    Esteves, Josué / Pivot, Odran / Ribouton, Julien / Jalade, Patrice / Zouaoui, Abdelaali / Desbat, Laurent / Rit, Simon / Blanc, Frédéric / Haefeli, Guido / Hopchev, Plamen / Galvan, Jean-Marc / Lu, Guo-Neng / Pittet, Patrick

    Medical physics

    2022  Volume 50, Issue 1, Page(s) 619–632

    Abstract: Purpose: To develop a novel instrument for real-time quality assurance (QA) procedures in radiotherapy. The system implements a scintillation-based phantom and associated signal acquisition and processing modules and aims to monitor two-dimensional (2D) ...

    Abstract Purpose: To develop a novel instrument for real-time quality assurance (QA) procedures in radiotherapy. The system implements a scintillation-based phantom and associated signal acquisition and processing modules and aims to monitor two-dimensional (2D) dose distributions of small fields.
    Materials and methods: For the proposed phantom, we have designed and realized a prototype implementing six high-resolution tissue-equivalent scintillating fiber ribbons stacked with in-plane 30° rotated orientations from each other. Each ribbon output is coupled to a silicon photodiode linear array (with an element pitch of 400 μm) to detect scintillating signal, which represents the projected irradiation profile perpendicular to the ribbon's orientation. For the system providing six acquired projected dose profiles at different orientations, we have developed a two-step signal processing method to perform 2D dose reconstruction. The first step is to determine irradiation field geometry parameters using a tomographic geometry approach, and the second one is to perform specific penumbra estimation. The QA system prototype has been tested on a Novalis TrueBeam STX with a 6-MV photon beam for small elliptic fields defined by 5- and 10-mm cone collimators and for 10 × 10- and 20 × 10-mm
    Results: The reconstructed 2D dose distributions have gamma index pass rates higher than 95% for all the tested configurations as compared with EBT3 film measurements with both 2%-DD/700-μm-DTA and 1%-DD/1-mm criteria. 2D global gamma analysis shows that the two-step and FBP radiation field reconstruction methods systematically outperform the SIRT approach. Moreover, higher gamma index success rates are obtained with the two-step method than with FBP in the case of the fields defined with the stereotactic cones.
    Conclusions: The proposed small-field QA system makes a use of six water-equivalent scintillating detectors (fiber ribbons) to acquire dose distribution. The developed two-step signal processing method performs tomographic 2D dose reconstruction. A system prototype has been built and tested using hospital facilities with small rectangular and elliptic fields. Testing results show 2D reconstructed dose distributions with high accuracy and resolution. Such a system could potentially be an alternative approach to film dosimetry for small-field QA, which is still widely used as reference in clinical practice.
    MeSH term(s) Radiometry ; Tomography ; Imaging, Three-Dimensional ; Phantoms, Imaging ; Water ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1002/mp.15902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fan-Beam Based Virtual Fluoroscopy for Navigated Catheterization in Interventional Radiology.

    Guiral, Pierrick / Pittet, Patrick / Grondin, Yannick / Jalade, Patrice / Galvan, Jean-Marc / Lu, Guo-Neng / Desbat, Laurent / Cinquin, Philippe

    Studies in health technology and informatics

    2019  Volume 264, Page(s) 74–78

    Abstract: Personalized medicine implies reducing invasiveness of therapeutic procedures. Although interventional radiology proved a very interesting alternative to surgical procedures, it still raises concerns due to the irradiation dose received by the medical ... ...

    Abstract Personalized medicine implies reducing invasiveness of therapeutic procedures. Although interventional radiology proved a very interesting alternative to surgical procedures, it still raises concerns due to the irradiation dose received by the medical team (and by the patient). We propose a novel concept allowing to reduce very significantly the irradiation dose during the phases where tools inserted in the patient have to be tracked with respect to previously acquired images. This implies inserting a miniaturized X-ray detector in the tip of the tools, and reducing the dose by a "rotating collimator". We demonstrate that real-time processing of the signals allows accurate localization of the tip of the tools, with a dose reduction of at least ten times.
    MeSH term(s) Catheterization ; Fluoroscopy ; Humans ; Radiation Dosage ; Radiology, Interventional/instrumentation ; User-Computer Interface
    Language English
    Publishing date 2019-07-09
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI190186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fully Depleted, Trench-Pinned Photo Gate for CMOS Image Sensor Applications.

    Roy, Francois / Suler, Andrej / Dalleau, Thomas / Duru, Romain / Benoit, Daniel / Arnaud, Jihane / Cazaux, Yvon / Chaton, Catherine / Montes, Laurent / Morfouli, Panagiota / Lu, Guo-Neng

    Sensors (Basel, Switzerland)

    2020  Volume 20, Issue 3

    Abstract: Tackling issues of implantation-caused defects and contamination, this paper presents a new complementary metal-oxide-semiconductor (CMOS) image sensor (CIS) pixel design concept based on a native epitaxial layer for photon detection, charge storage, and ...

    Abstract Tackling issues of implantation-caused defects and contamination, this paper presents a new complementary metal-oxide-semiconductor (CMOS) image sensor (CIS) pixel design concept based on a native epitaxial layer for photon detection, charge storage, and charge transfer to the sensing node. To prove this concept, a backside illumination (BSI), p-type, 2-µm-pitch pixel was designed. It integrates a vertical pinned photo gate (PPG), a buried vertical transfer gate (TG), sidewall capacitive deep trench isolation (CDTI), and backside oxide-nitride-oxide (ONO) stack. The designed pixel was fabricated with variations of key parameters for optimization. Testing results showed the following achievements: 13,000 h+ full-well capacity with no lag for charge transfer, 80% quantum efficiency (QE) at 550-nm wavelength, 5 h+/s dark current at 60 °C, 2 h+ temporal noise floor, and 75 dB dynamic range. In comparison with conventional pixel design, the proposed concept could improve CIS performance.
    Language English
    Publishing date 2020-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s20030727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Implementation and validation of a fluence pencil kernels model for GaN-based dosimetry in photon beam radiotherapy.

    Wang, Ruoxi / Pittet, Patrick / Ribouton, Julien / Lu, Guo-Neng / Chaikh, Abdulhamid / Ahnesjö, Anders

    Physics in medicine and biology

    2013  Volume 58, Issue 19, Page(s) 6701–6712

    Abstract: Gallium nitride (GaN), a direct-gap semiconductor that is radioluminescent, can be used as a transducer yielding a high signal from a small detecting volume and thus potentially suitable for use in small fields and for high dose gradients. A common ... ...

    Abstract Gallium nitride (GaN), a direct-gap semiconductor that is radioluminescent, can be used as a transducer yielding a high signal from a small detecting volume and thus potentially suitable for use in small fields and for high dose gradients. A common drawback of semiconductor dosimeters with effective atomic numbers higher than soft tissues is that their responses depend on the presence of low energy photons for which the photoelectric cross section varies strongly with atomic number, which may affect the accuracy of dosimetric measurements. To tackle this 'over-response' issue, we propose a model for GaN-based dosimetry with readout correction. The local photon spectrum is calculated by convolving fluence pencil kernel spectra with the beam aperture fluence distribution. The response of a GaN detector is modelled by combining large cavity theory and small cavity theory for the low and high energy components of the local spectrum. Monte Carlo simulations are employed for determination of specific correction factors for different GaN transducer sizes and irradiation conditions. Some model parameters such as the cut-off energy and partitioning energy are discussed. The accuracy of the GaN dosimetric response model has been evaluated for tissue phantom ratio experiments along the central axis. These experiments have shown that calculated and measured GaN responses stay within ±3% at all depths beyond the build-up depth. The calculated GaN response factor is also in good agreement with measured data (±2.5%). The validated model with response compensation improves significantly the accuracy of dosimetric measurements: below 2.5% deviation as compared to 13% without compensation, for a 10 × 10 cm(2) field, at depth from 1.5 to 22 cm.
    MeSH term(s) Gallium ; Models, Theoretical ; Monte Carlo Method ; Photons/therapeutic use ; Radiometry/instrumentation ; Radiotherapy/instrumentation ; Semiconductors
    Chemical Substances gallium nitride (1R9CC3P9VL) ; Gallium (CH46OC8YV4)
    Language English
    Publishing date 2013-10-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/0031-9155/58/19/6701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: 1T Pixel Using Floating-Body MOSFET for CMOS Image Sensors.

    Lu, Guo-Neng / Tournier, Arnaud / Roy, François / Deschamps, Benoît

    Sensors (Basel, Switzerland)

    2009  Volume 9, Issue 1, Page(s) 131–147

    Abstract: We present a single-transistor pixel for CMOS image sensors (CIS). It is a floating-body MOSFET structure, which is used as photo-sensing device and source-follower transistor, and can be controlled to store and evacuate charges. Our investigation into ... ...

    Abstract We present a single-transistor pixel for CMOS image sensors (CIS). It is a floating-body MOSFET structure, which is used as photo-sensing device and source-follower transistor, and can be controlled to store and evacuate charges. Our investigation into this 1T pixel structure includes modeling to obtain analytical description of conversion gain. Model validation has been done by comparing theoretical predictions and experimental results. On the other hand, the 1T pixel structure has been implemented in different configurations, including rectangular-gate and ring-gate designs, and variations of oxidation parameters for the fabrication process. The pixel characteristics are presented and discussed.
    Language English
    Publishing date 2009-01-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s90100131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Review of the CMOS Buried Double Junction (BDJ) Photodetector and its Applications.

    Feruglio, Sylvain / Lu, Guo-Neng / Garda, Patrick / Vasilescu, Gabriel

    Sensors (Basel, Switzerland)

    2008  Volume 8, Issue 10, Page(s) 6566–6594

    Abstract: A CMOS Buried Double Junction PN (BDJ) photodetector consists of two vertically-stacked photodiodes. It can be operated as a photodiode with improved performance and wavelength-sensitive response. This paper presents a review of this device and its ... ...

    Abstract A CMOS Buried Double Junction PN (BDJ) photodetector consists of two vertically-stacked photodiodes. It can be operated as a photodiode with improved performance and wavelength-sensitive response. This paper presents a review of this device and its applications. The CMOS implementation and operating principle are firstly described. This includes the description of several key aspects directly related to the device performances, such as surface reflection, photon absorption and electron-hole pair generation, photocurrent and dark current generation, etc. SPICE modelling of the detector is then presented. Next, design and process considerations are proposed in order to improve the BDJ performance. Finally, several BDJ-detector-based image sensors provide a survey of their applications.
    Language English
    Publishing date 2008-10-23
    Publishing country Switzerland
    Document type Review ; Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s8106566
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: CMOS buried quad p-n junction photodetector for multi-wavelength analysis.

    Richard, Charles / Courcier, Thierry / Pittet, Patrick / Martel, Stéphane / Ouellet, Luc / Lu, Guo-Neng / Aimez, Vincent / Charette, Paul G

    Optics express

    2012  Volume 20, Issue 3, Page(s) 2053–2061

    Abstract: This paper presents a buried quad p-n junction (BQJ) photodetector fabricated with a HV (high-voltage) CMOS process. Multiple buried junction photodetectors are wavelength-sensitive devices developed for spectral analysis applications where a compact ... ...

    Abstract This paper presents a buried quad p-n junction (BQJ) photodetector fabricated with a HV (high-voltage) CMOS process. Multiple buried junction photodetectors are wavelength-sensitive devices developed for spectral analysis applications where a compact integrated solution is preferred over systems involving bulk optics or a spectrometer due to physical size limitations. The BQJ device presented here is designed for chip-based biochemical analyses using simultaneous fluorescence labeling of multiple analytes such as with advanced labs-on-chip or miniaturized photonics-based biosensors. Modeling and experimental measurements of the spectral response of the device are presented. A matrix-based method for estimating individual spectral components in a compound spectrum is described. The device and analysis method are validated via a test setup using individually modulated LEDs to simulate light from 4-component fluorescence emission.
    MeSH term(s) Equipment Design ; Equipment Failure Analysis ; Miniaturization ; Photometry/instrumentation ; Semiconductors
    Language English
    Publishing date 2012-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.20.002053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Implementation of electrochemiluminescence microanalysis in PCB technology.

    Pittet, Patrick / Lu, Guo-Neng / Galvan, Jean-Marc / Ferrigno, Rosaria / Stephan, Khaled / Blum, Loïc J / Leca-Bouvier, Béatrice D

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2007  Volume 2007, Page(s) 2944–2947

    Abstract: We present an instrumental development to implement electrochemiluminescence (ECL) microanalysis using printed circuit board (PCB) technology. PCB gold macro-(10 mm2) and micro- (0.09 mm2) electrodes and two ECL microfluidic devices are designed, ... ...

    Abstract We present an instrumental development to implement electrochemiluminescence (ECL) microanalysis using printed circuit board (PCB) technology. PCB gold macro-(10 mm2) and micro- (0.09 mm2) electrodes and two ECL microfluidic devices are designed, fabricated and tested via luminol ECL detection. Potential modulation is performed between 0.7 and 0 V vs. Ag/AgCl for luminol oxidation, thus giving rise to on/off ECL responses in the presence of hydrogen peroxide. Synchronous detection is adopted to allow weak ECL signal recovery at a very low signal-to-noise ratio (SNR). The detection limit obtained with the two ECL microfluidic devices is 50 nM and 100 nM H2O2 for macroelectrodes and microelectrodes, respectively.
    MeSH term(s) Electrochemistry ; Electronics ; Hydrogen Peroxide/chemistry ; Luminescent Agents/chemistry ; Luminescent Measurements/instrumentation ; Luminescent Measurements/methods ; Luminol/chemistry ; Microelectrodes ; Microfluidic Analytical Techniques ; Silver/chemistry ; Silver Compounds/chemistry
    Chemical Substances Luminescent Agents ; Silver Compounds ; Silver (3M4G523W1G) ; Luminol (5EXP385Q4F) ; Hydrogen Peroxide (BBX060AN9V) ; silver chloride (MWB0804EO7)
    Language English
    Publishing date 2007-11-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2375-7477
    ISSN 2375-7477
    DOI 10.1109/IEMBS.2007.4352946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: PCB-based integration of electrochemiluminescence detection for microfluidic systems.

    Pittet, Patrick / Lu, Guo-Neng / Galvan, Jean-Marc / Ferrigno, Rosaria / Blum, Loïc J / Leca-Bouvier, Béatrice

    The Analyst

    2007  Volume 132, Issue 5, Page(s) 409–411

    Abstract: This communication presents an instrumental development based on the printed circuit board (PCB) technology to integrate electrochemiluminescence (ECL) analysis in microfluidic systems. PCB gold macro- (10 mm2) and micro- (0.09 mm2) electrodes and two ... ...

    Abstract This communication presents an instrumental development based on the printed circuit board (PCB) technology to integrate electrochemiluminescence (ECL) analysis in microfluidic systems. PCB gold macro- (10 mm2) and micro- (0.09 mm2) electrodes and two ECL microfluidic devices are designed, fabricated and tested via luminol ECL detection. Potential modulation is performed between 0.7 and 0 V vs. Ag/AgCl for luminol oxidation, thus giving rise to on/off ECL responses in the presence of hydrogen peroxide. Synchronous detection is adopted to allow weak ECL signal recovery at a very low signal-to-noise ratio (SNR). The detection limit obtained with the two ECL microfluidic devices is 50 nM and 100 nM H2O2 for macroelectrodes and microelectrodes, respectively.
    MeSH term(s) Computers ; Electrochemistry/instrumentation ; Electrochemistry/methods ; Electrodes ; Gold ; Hydrogen Peroxide/analysis ; Luminescent Measurements/instrumentation ; Luminescent Measurements/methods ; Microelectrodes ; Microfluidic Analytical Techniques/instrumentation ; Microfluidic Analytical Techniques/methods ; Sensitivity and Specificity ; Silver
    Chemical Substances Silver (3M4G523W1G) ; Gold (7440-57-5) ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2007-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 0003-2654
    ISSN 0003-2654
    DOI 10.1039/b701296a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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