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Article ; Online: Review on sterilization techniques, and the application potential of phage lyase and lyase immobilization in fighting drug-resistant bacteria.

Lu, Han / Ni, Shou-Qing

2024 Volume 12, Issue 14, Page(s) 3317–3335

Abstract: Many human health problems and property losses caused by pathogenic contamination cannot be underestimated. Bactericidal techniques have been extensively studied to address this issue of public health and economy. Bacterial resistance develops as a ... ...

Abstract	Many human health problems and property losses caused by pathogenic contamination cannot be underestimated. Bactericidal techniques have been extensively studied to address this issue of public health and economy. Bacterial resistance develops as a result of the extensive use of single or multiple but persistent usage of sterilizing drugs, and the emergence of super-resistant bacteria brings new challenges. Therefore, it is crucial to control pathogen contamination by applying innovative and effective sterilization techniques. As organisms that exist in nature and can specifically kill bacteria, phages have become the focus as an alternative to antibacterial agents. Furthermore, phage-encoded lyases are proteins that play important roles in phage sterilization. The
MeSH term(s)	Humans ; Bacteriophages ; Lyases/pharmacology ; Bacteria ; Bacterial Infections/microbiology ; Sterilization ; Anti-Bacterial Agents/pharmacology
Chemical Substances	Lyases (EC 4.-) ; Anti-Bacterial Agents
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb02366d
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Associations of brominated flame retardants exposure with chronic obstructive pulmonary disease

Lu Han / Qi Wang

Frontiers in Public Health, Vol

A US population-based cross-sectional analysis

2023 Volume 11

Abstract: BackgroundsWhether there existed an association between brominated flame retardants (BFRs) and chronic obstructive pulmonary disease (COPD) prevalence in humans is still a mystery.ObjectiveTo investigate the association between serum single or mixture ... ...

Abstract	BackgroundsWhether there existed an association between brominated flame retardants (BFRs) and chronic obstructive pulmonary disease (COPD) prevalence in humans is still a mystery.ObjectiveTo investigate the association between serum single or mixture BFRs and COPD prevalence.MethodsData of 7,591 participants from NHANES 2007–2016 was utilized. Serum BFRs, including PBDE-28, PBDE-47, PBDE-85, PBDE-99, PBDE-100, PBDE-154, PBDE-183, PBDE-209, and PBB-153 were enrolled. The survey-weighted generalized logistic regression model, restricted cubic splines (RCS), weighted quantile sum (WQS) regression, and quantile-based g-computation (QGC) analysis were performed.ResultsAfter adjustment for all confounding factors, log-transformed continuous serum PBDE-28 (OR: 1.43; 95% CI: 1.10–1.85; P = 0.01), PBDE-47 (OR: 1.39; 95% CI: 1.11–1.75; P = 0.005), PBDE-85 (OR: 1.31; 95% CI: 1.09–1.57; P = 0.005), PBDE-99 (OR: 1.27; 95% CI: 1.05–1.54; P = 0.02), PBDE-100 (OR: 1.33; 95% CI: 1.08–1.66; P = 0.01), PBDE-154 (OR: 1.29; 95% CI: 1.07–1.55; P = 0.01), PBDE-183 (OR: 1.31; 95% CI: 1.04–1.66; P = 0.02), and PBB-153 (OR: 1.25; 95% CI: 1.03–1.53; P = 0.03) were positively correlated with the prevalence of COPD. Restricted cubic splines curves displayed that PBDE-209 was significantly associated with CPOD in an inverted U-shape (P = 0.03). A significant interaction between being male and a high prevalence of COPD was observed for PBDE-28 (P for interaction <0.05), PBDE-47 (P for interaction <0.05), PBDE-85 (P for interaction <0.05), PBDE-99 (P for interaction <0.05), PBDE-100 (P for interaction <0.05), and PBB-153 (P for interaction < 0.05). Mixture BFRs exposure was positively associated with COPD prevalence in WQS regression (OR: 1.40; 95% CI: 1.14–1.72, P = 0.002) and in QGC analysis (OR: 1.49; 95% CI: 1.27–1.74, P < 0.001).ConclusionsOur study confirms that individual and mixture BFRs had positive associations with COPD, and further studies are required in larger-scale populations.
Keywords	brominated flame retardants ; chronic obstructive pulmonary disease ; weighted quantile sum model ; quantile-based g-calculation model ; NHANES ; Public aspects of medicine ; RA1-1270
Subject code	310
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Association between organophosphorus insecticides exposure and the prevalence of sleep problems in the US adults

Lu Han / Qi Wang

Ecotoxicology and Environmental Safety, Vol 255, Iss , Pp 114803- (2023)

An analysis based on the NHANES 2007–2018

2023

Abstract: Objective: The aim of this study was to evaluate the association between organophosphorus pesticides (OPPs) exposure and sleep problems. Methods: In this study, data from 6295 participants aged 18 years or older were collected from the National Health ... ...

Abstract	Objective: The aim of this study was to evaluate the association between organophosphorus pesticides (OPPs) exposure and sleep problems. Methods: In this study, data from 6295 participants aged 18 years or older were collected from the National Health and Nutrition Examination Survey (NHANES). The dialkyl phosphate compounds (DAPs) metabolites, OPPs exposure biomarker, were examined using solid phase extraction-high coupled with isotope dilution-ultrahigh performance liquid chromatography-tandem mass spectrometry. Data on short sleep duration (SSD), self-reported trouble sleeping and self-reported sleep disorder were collected from the database. Weighted generalized logistic model, weighted quantile sum (WQS) model, and quantile-based g calculation (QGC) methods were used for analyzing the collected data. Results: The prevalence of SSD, self-reported trouble sleeping and self-reported sleep disorder in this study were 28.91 % (1814/6274), 25.31 % (1593/6294), and 9.05 % (289/3195), respectively. After confounding factors adjustments, the prevalence of SDD in participants with high log-transformed DETP, DMTP, DEDTP, and DMDTP were 1.19 times (OR: 1.11–1.28, P < 0.001), 1.09 times (OR: 1.03–1.15, P = 0.003), 1.26 times (OR: 1.17–1.37, P < 0.0001), and 1.10 times (OR: 1.04–1.17, P = 0.003) than in participants with low showed, respectively. A non-linear relationship was noted between SSD with the urinary concentration of DEP (P for nonlinearity < 0.001), DMP (P for nonlinearity < 0.001), DMTP (P for nonlinearity = 0.006), and DMDTP (P for nonlinearity = 0.001). The WQS results showed that the prevalence of SDD was 1.28 times (95 % CI: 1.17–1.40, P < 0.001) higher in participants with high co-exposure to OPPs than in those with low co-exposure, with DEDTP having the enormous weights (0.50). The QGC results also revealed a significant positive association between the co-exposure of DAPs and SSD (OR: 1.08, 95 % CI:1.02–1.16, P = 0.01) with DETP having the most positive weight (0.44). As for the ...
Keywords	Organophosphorus insecticides ; Short sleep duration ; Dose-response relationship ; Cross-sectional study ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	150
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Association between brominated flame retardants exposure and markers of oxidative stress in US adults

Lu Han / Qi Wang

Ecotoxicology and Environmental Safety, Vol 263, Iss , Pp 115253- (2023)

An analysis based on the National Health and Nutrition Examination Survey 2007–2016

2023

Abstract: We aimed to investigate the relationship between oxidative stress indicators and brominated flame retardant (BFR) levels in US adults. Using data from the NHANES (National Health and Nutrition Examination Survey) from 2007 to 2016, 8028 participants aged ...

Abstract	We aimed to investigate the relationship between oxidative stress indicators and brominated flame retardant (BFR) levels in US adults. Using data from the NHANES (National Health and Nutrition Examination Survey) from 2007 to 2016, 8028 participants aged 18 and over were enrolled in this study. PBDE28, PBDE47, PBDE85, PBDE99, PBDE100, PBDE153, PBDE154, PBDE209, and PBB153, with over 75 % detection rates, were extracted in this study. Survey-weighted linear regression model, weighted quantile sum (WQS) model, and quantile-based g calculation (QGC) model were used to assess the correlation between serum BFRs levels and oxidative stress indicators (serum bilirubin and gamma-glutamyl transferase [GGT]). Besides, the nonlinear association was explored using restricted cubic splines (RCS). Each of the BFRs was confirmed by the survey-weighted linear regression model to be positively associated with GGT after controlling for variables, and BFRs except for PBDE153 were positively associated with serum bilirubin. Except for PBDE153, serum bilirubin in the highest quartile of BFRs was significantly higher than in the lowest high quartile. Additionally, except for PBDE85, serum GGT in the highest quartile of BFRs was higher than in the lowest high quartile. A significant nonlinear association between all BFRs with bilirubin and the PBDE153, PBDE209, and PBB153 with GGT was identified by RCS analysis. By WQS analysis, combined BFR exposure was associated with serum GGT (β: 0.093; 95 % CI = 0.066–0.121; P < 0.0001) and bilirubin (β: 0.090; 95 % CI = 0.068–0.113; P < 0.0001). QGC analysis found a similar correlation between BFR mixtures with serum GGT (β: 0.098; 95 % CI = 0.075–0.120; P < 0.0001) and bilirubin (β: 0.073; 95 % CI = 0.048–0.097; P < 0.0001). Exposure to BFRs is positively associated with markers of oxidative stress (serum bilirubin and GGT) in US adults, which needs further exploration by a large-scale cohort study.
Keywords	Brominated flame retardants ; Oxidative stress ; Weighted quantile sum ; Quantile-based g calculation ; NHANES ; Population-based study ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	310
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dual functions of a novel effector in the plant and pathogen arms race.

Lu, Han / Gao, Mingjun

Stress biology

2023 Volume 3, Issue 1, Page(s) 33

Abstract: Ralstonia solanacearum is a soil-borne bacterium that causes bacterial wilt disease in over 250 plant species. It has been identified as one of the top ten most serious plant pathogenic bacteria globally, causing significant crop yield loss every year. ... ...

Abstract	Ralstonia solanacearum is a soil-borne bacterium that causes bacterial wilt disease in over 250 plant species. It has been identified as one of the top ten most serious plant pathogenic bacteria globally, causing significant crop yield loss every year. Despite its large impact on agricultural economics, the molecular mechanisms underlying plant defense against Ralstonia infection and by which Ralstonia grows within the plant xylem remain largely unexplored. In a recent article, Ke et al. discovered a distinct pathogen effector, which acted as an immune elicitor in plants but also played dual roles in compromising plant immune activation and increasing nutrient acquisition from the host plants for pathogen propagation.
Language	English
Publishing date	2023-08-18
Publishing country	Switzerland
Document type	Journal Article
ISSN	2731-0450
ISSN (online)	2731-0450
DOI	10.1007/s44154-023-00116-y
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Article: Dynamics and profiles of a degenerated reaction-diffusion host-pathogen model with apparent and inapparent infection period.

Wang, Jinliang / Lu, Han

Communications in nonlinear science & numerical simulation

2023 Volume 125, Page(s) 107318

Abstract: Inapparent infection plays an important role in the disease spread, which is an infection by a pathogen that causes few or no signs or symptoms of infection in the host. Many pathogens, including HIV, typhoid fever, and coronaviruses such as COVID-19 ... ...

Abstract	Inapparent infection plays an important role in the disease spread, which is an infection by a pathogen that causes few or no signs or symptoms of infection in the host. Many pathogens, including HIV, typhoid fever, and coronaviruses such as COVID-19 spread in their host populations through inapparent infection. In this paper, we formulated a degenerated reaction-diffusion host-pathogen model with multiple infection period. We split the infectious individuals into two distinct classes: apparent infectious individuals and inapparent infectious individuals, coming from exposed individuals with a ratio of
Language	English
Publishing date	2023-05-27
Publishing country	China
Document type	Journal Article
ISSN	1007-5704
ISSN	1007-5704
DOI	10.1016/j.cnsns.2023.107318
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Article ; Online: Two novel bacteriophages isolated from the environment that can help control activated sludge foaming.

Xiong, Wenbin / Liu, Bingxin / Lu, Han / Liu, Xinchun

Folia microbiologica

2024

Abstract: Nocardia spp., which belongs to one of the Nocardio-form filamentous bacteria, is usually surface hydrophobic and when overproduced attaches to the surface of bubbles under the action of surfactants, allowing the stable presence of foam on the surface of ...

Abstract	Nocardia spp., which belongs to one of the Nocardio-form filamentous bacteria, is usually surface hydrophobic and when overproduced attaches to the surface of bubbles under the action of surfactants, allowing the stable presence of foam on the surface of aeration tanks, leading to the occurrence of sludge-foaming events. Two novel phages, P69 and KYD2, were isolated from the environment, and their hosts were Nocardia transvalensis and Nocardia carnea, respectively. These two phages are Siphophages-like with long tails. An aeration tank pilot plant was constructed in the laboratory to simulate sludge foaming, and these two strains of phage were applied. Compared with the reactor not dosed with phage, the application of phage could reduce the host level in the reactor, resulting in the highest decrease in turbidity by more than 68% and sludge volume index by more than 25%. The time for surface foam disappearance was 9 h earlier than that of the control group (the group with the same concentration of Nocardia carnea but no bacteriophage applied), significantly improving water quality. The phage can effectively inhibit the propagation of Nocardia in the actual sludge-foaming event, control the sludge foaming, and improve the effluent quality. It provides a novel and relatively economical solution for controlling sludge foaming in sewage treatment plants in the future, shows that the phages have potential application value in the prevention and control of Nocardia, and provides another way to control the sludge-foaming event caused by the excessive reproduction of Nocardia in the future.
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	240503-9
ISSN	1874-9356 ; 0015-5632
ISSN (online)	1874-9356
ISSN	0015-5632
DOI	10.1007/s12223-024-01145-4
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Article ; Online: Spatio-temporal analysis and risk modeling of foot-and-mouth disease outbreaks in China.

Li, Yi / Qiu, Songyin / Lu, Han / Niu, Bing

Preventive veterinary medicine

2024 Volume 224, Page(s) 106120

Abstract: FMD is an acute contagious disease that poses a significant threat to the health and safety of cloven-hoofed animals in Asia, Europe, and Africa. The impact of FMD exhibits geographical disparities within different regions of China. The present ... ...

Abstract	FMD is an acute contagious disease that poses a significant threat to the health and safety of cloven-hoofed animals in Asia, Europe, and Africa. The impact of FMD exhibits geographical disparities within different regions of China. The present investigation undertook an exhaustive analysis of documented occurrences of bovine FMD in China, spanning the temporal range from 2011 to 2020. The overarching objective was to elucidate the temporal and spatial dynamics underpinning these outbreaks. Acknowledging the pivotal role of global factors in FMD outbreaks, advanced machine learning techniques were harnessed to formulate an optimal prediction model by integrating comprehensive meteorological data pertinent to global FMD. Random Forest algorithm was employed with top three contributing factors including Isothermality(bio3), Annual average temperature(bio1) and Minimum temperature in the coldest month(bio6), all relevant to temperature. By encompassing both local and global factors, our study provides a comprehensive framework for understanding and predicting FMD outbreaks. Furthermore, we conducted a phylogenetic analysis to trace the origin of Foot-and-mouth disease virus (FMDV), pinpointing India as the country posing the greatest potential hazard by leveraging the spatio-temporal attributes of the collected data. Based on this finding, a quantitative risk model was developed for the legal importation of live cattle from India to China. The model estimated an average probability of 0.002254% for FMDV-infected cattle imported from India to China. TA sensitivity analysis identified two critical nodes within the model: he possibility of false negative clinical examination in infected cattle at destination (P5) and he possibility of false negative clinical examination in infected cattle at source(P3). This comprehensive approach offers a thorough evaluation of FMD landscape within China, considering both domestic and global perspectives, thereby augmenting the efficacy of early warning mechanisms.
MeSH term(s)	Cattle ; Animals ; Foot-and-Mouth Disease/epidemiology ; Phylogeny ; Cattle Diseases/epidemiology ; Foot-and-Mouth Disease Virus ; Disease Outbreaks/veterinary ; China/epidemiology ; Spatio-Temporal Analysis
Language	English
Publishing date	2024-01-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	43399-8
ISSN	1873-1716 ; 0167-5877
ISSN (online)	1873-1716
ISSN	0167-5877
DOI	10.1016/j.prevetmed.2024.106120
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Article ; Online: A nomogram for predicting short-term prognosis in severely traumatized patients with acute respiratory failure.

Lu, Han / Qiu, Yuyao / Sun, Xuling / Zhao, Yuan

Asian journal of surgery

2024

Language	English
Publishing date	2024-04-10
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.03.198
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Article ; Online: Emergency Response, Influence and Lessons in the 2021 Compound Disaster in Henan Province of China

Zhengru Tao / Lu Han

International Journal of Environmental Research and Public Health, Vol 19, Iss 488, p

2022 Volume 488

Abstract: Henan province, located in central China, suffered a heavy rainstorm and an outbreak of COVID-19 from the middle of July to the middle of August. We review and investigate the emergency response to these two events. The influence of the compound disaster ...

Abstract	Henan province, located in central China, suffered a heavy rainstorm and an outbreak of COVID-19 from the middle of July to the middle of August. We review and investigate the emergency response to these two events. The influence of the compound disaster on provincial economic operations, fixed assets, consumer goods, the logistics industry, high-tech manufacturing, and strategic emerging industries is analyzed in detail. Since the province’s economic situation has been positive for a long time, the influence of the compound disaster was short-term. The countermeasures to the pandemic were efficient since they had previously been in practice at various times in 2020. However, in the face of unusual disasters such as the rainstorm, the gap between early warning and emergency response needs to be bridged, and the sources of relief funds should be diversified.
Keywords	compound disaster ; rainstorm ; pandemic ; COVID-19 ; emergency response ; Medicine ; R
Subject code	950
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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