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  1. Book ; Online ; E-Book: Diagnostic imaging of drug resistant pulmonary tuberculosis

    Lu, Pu-Xuan / Lu, Hong-zhou / Yi, Yong-xiang

    2023  

    Author's details Pu-Xuan Lu, Hong-zhou Lu, Yong-xiang Yi editors
    Keywords Radiology
    Language English
    Size 1 Online-Ressource (xx, 267 Seiten), Illustrationen, Diagramme
    Publisher People's Medical Publishing House
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030697346
    ISBN 978-981-99-8339-1 ; 9789819983384 ; 981-99-8339-8 ; 981998338X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Inflammatory liver diseases and susceptibility to sepsis.

    Lu, Hong

    Clinical science (London, England : 1979)

    2024  Volume 138, Issue 7, Page(s) 435–487

    Abstract: Patients with inflammatory liver diseases, particularly alcohol-associated liver disease and metabolic dysfunction-associated fatty liver disease (MAFLD), have higher incidence of infections and mortality rate due to sepsis. The current focus in the ... ...

    Abstract Patients with inflammatory liver diseases, particularly alcohol-associated liver disease and metabolic dysfunction-associated fatty liver disease (MAFLD), have higher incidence of infections and mortality rate due to sepsis. The current focus in the development of drugs for MAFLD is the resolution of non-alcoholic steatohepatitis and prevention of progression to cirrhosis. In patients with cirrhosis or alcoholic hepatitis, sepsis is a major cause of death. As the metabolic center and a key immune tissue, liver is the guardian, modifier, and target of sepsis. Septic patients with liver dysfunction have the highest mortality rate compared with other organ dysfunctions. In addition to maintaining metabolic homeostasis, the liver produces and secretes hepatokines and acute phase proteins (APPs) essential in tissue protection, immunomodulation, and coagulation. Inflammatory liver diseases cause profound metabolic disorder and impairment of energy metabolism, liver regeneration, and production/secretion of APPs and hepatokines. Herein, the author reviews the roles of (1) disorders in the metabolism of glucose, fatty acids, ketone bodies, and amino acids as well as the clearance of ammonia and lactate in the pathogenesis of inflammatory liver diseases and sepsis; (2) cytokines/chemokines in inflammatory liver diseases and sepsis; (3) APPs and hepatokines in the protection against tissue injury and infections; and (4) major nuclear receptors/signaling pathways underlying the metabolic disorders and tissue injuries as well as the major drug targets for inflammatory liver diseases and sepsis. Approaches that focus on the liver dysfunction and regeneration will not only treat inflammatory liver diseases but also prevent the development of severe infections and sepsis.
    MeSH term(s) Humans ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease/metabolism ; Liver Cirrhosis/metabolism ; Liver Diseases, Alcoholic/metabolism ; Sepsis/complications
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20230522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Development of the Global Film Industry

    Li, Qiao / Guan, Yanqiu / Lu, Hong

    2020  

    Abstract: The global film industry has witnessed significant transformation in the past few years. Regions outside the US have begun to prosper while non-traditional production companies, such as Netflix have assumed a larger market share, and online movies ... ...

    Abstract The global film industry has witnessed significant transformation in the past few years. Regions outside the US have begun to prosper while non-traditional production companies, such as Netflix have assumed a larger market share, and online movies adapted from literature have continued to gain in popularity. How have these trends shaped the global film industry? This book answers this question by analysing an increasingly globalised business through a global lens. Development of the Global Film Industry examines the recent history and current state of the business in all parts of the world. While many existing studies focus on the internal workings of the industry such as production, distribution, and screening, this study takes a 'big picture' view encompassing the transnational integration of the cultural and entertainment industry as a whole, and paying more attention to the coordinated development of the film industry in the light of influence from literature, television, animation, games and other sectors. This volume is a critical reference for students, scholars and the public to help them understand the major trends facing the global film industry in today's world
    Keywords Dramatic representation. The theater ; Communication. Mass media
    Size 1 electronic resource (270 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020676569
    ISBN 9780367508234 ; 0367508230
    DOI 10.4324/b22628
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Narrative Review: Glucocorticoids in Alcoholic Hepatitis-Benefits, Side Effects, and Mechanisms.

    Lu, Hong

    Journal of xenobiotics

    2022  Volume 12, Issue 4, Page(s) 266–288

    Abstract: Alcoholic hepatitis is a major health and economic burden worldwide. Glucocorticoids (GCs) are the only first-line drugs recommended to treat severe alcoholic hepatitis (sAH), with limited short-term efficacy and significant side effects. In this review, ...

    Abstract Alcoholic hepatitis is a major health and economic burden worldwide. Glucocorticoids (GCs) are the only first-line drugs recommended to treat severe alcoholic hepatitis (sAH), with limited short-term efficacy and significant side effects. In this review, I summarize the major benefits and side effects of GC therapy in sAH and the potential underlying mechanisms. The review of the literature and data mining clearly indicate that the hepatic signaling of glucocorticoid receptor (GR) is markedly impaired in sAH patients. The impaired GR signaling causes hepatic down-regulation of genes essential for gluconeogenesis, lipid catabolism, cytoprotection, and anti-inflammation in sAH patients. The efficacy of GCs in sAH may be compromised by GC resistance and/or GC's extrahepatic side effects, particularly the side effects of intestinal epithelial GR on gut permeability and inflammation in AH. Prednisolone, a major GC used for sAH, activates both the GR and mineralocorticoid receptor (MR). When GC non-responsiveness occurs in sAH patients, the activation of MR by prednisolone might increase the risk of alcohol abuse, liver fibrosis, and acute kidney injury. To improve the GC therapy of sAH, the effort should be focused on developing the biomarker(s) for GC responsiveness, liver-targeting GR agonists, and strategies to overcome GC non-responsiveness and prevent alcohol relapse in sAH patients.
    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649720-7
    ISSN 2039-4713 ; 2039-4713
    ISSN (online) 2039-4713
    ISSN 2039-4713
    DOI 10.3390/jox12040019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A novel dual targeted antibacterial agent for Helicobacter pylori.

    Chen, Jinnan / Lu, Hong

    The Lancet. Infectious diseases

    2024  

    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(24)00063-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
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  6. Article ; Online: Reply to: Minocycline versus tetracycline in bismuth-containing quadruple therapy for Helicobacter pylori rescue treatment: a multicentre, randomized controlled trial.

    Huang, Yu / Lu, Hong

    Journal of gastroenterology

    2024  Volume 59, Issue 4, Page(s) 358

    MeSH term(s) Humans ; Bismuth/therapeutic use ; Minocycline/therapeutic use ; Helicobacter pylori ; Anti-Bacterial Agents/therapeutic use ; Tetracycline/therapeutic use ; Helicobacter Infections/drug therapy ; Drug Therapy, Combination ; Amoxicillin/therapeutic use ; Treatment Outcome ; Proton Pump Inhibitors/therapeutic use
    Chemical Substances Bismuth (U015TT5I8H) ; Minocycline (FYY3R43WGO) ; Anti-Bacterial Agents ; Tetracycline (F8VB5M810T) ; Amoxicillin (804826J2HU) ; Proton Pump Inhibitors
    Language English
    Publishing date 2024-02-14
    Publishing country Japan
    Document type Randomized Controlled Trial ; Multicenter Study ; Letter
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-024-02085-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 620: Show issues Location:
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  7. Article ; Online: Does every Staphylococcus aureus infection require anti-MRSA drugs? Three case reports of a Staphylococcus aureus infection.

    Chen, Guangbin / Lu, Hong-Zhou

    Drug discoveries & therapeutics

    2023  Volume 17, Issue 2, Page(s) 144–147

    Abstract: Staphylococcus aureus is a common clinical pathogen. Does every S. aureus infection require anti-MRSA drugs? Reported here are three cases of a community-acquired infection with S. aureus. The first case involveds a 45-year-old male who was admitted due ... ...

    Abstract Staphylococcus aureus is a common clinical pathogen. Does every S. aureus infection require anti-MRSA drugs? Reported here are three cases of a community-acquired infection with S. aureus. The first case involveds a 45-year-old male who was admitted due to right ankle pain for 1 month; he was diagnosed with chronic suppurative osteomyelitis and an acute soft tissue infection of the ankle. S.aureus was cultured from the pus and was resistant to penicillin and sensitive to oxacillin and vancomycin. After receiving oxacillin, he was cured and discharged 45 days after admission. The second case involved a 44-year-old male who was admitted due to lumbar pain with right lower limb numbness for more than 1 month and fever for 1 day. S. aureus was cultured from blood specimens and was resistant to penicillin and sensitive to oxacillin and vancomycin. After receiving oxacillin, he as cured. The third case involved a 7-day-old newborn who was admitted due to skin jaundice for 6 days. S. aureus was cultured from skin secretions specimens and was resistant to penicillin and sensitive to oxacillin, erythromycin, and vancomycin. The newborn was treated with oxacillin for 4 days, and she was cured and discharged. Not all cases a suspected S. aureus infection require anti-MRSA drugs; instead, previous S. aureus susceptibility results in the area and hospital, as well as the patient's clinical profile, need to be taken into account.
    MeSH term(s) Male ; Female ; Infant, Newborn ; Humans ; Middle Aged ; Adult ; Staphylococcus aureus ; Vancomycin/pharmacology ; Vancomycin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Microbial Sensitivity Tests ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/diagnosis ; Oxacillin/pharmacology ; Oxacillin/therapeutic use ; Methicillin-Resistant Staphylococcus aureus
    Chemical Substances Vancomycin (6Q205EH1VU) ; Anti-Bacterial Agents ; Oxacillin (UH95VD7V76)
    Language English
    Publishing date 2023-04-09
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2568828-5
    ISSN 1881-784X ; 1881-784X
    ISSN (online) 1881-784X
    ISSN 1881-784X
    DOI 10.5582/ddt.2022.01102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: DNA methyltransferase 3a-induced hypermethylation of the fructose-1,6-bisphosphatase-2 promoter contributes to gastric carcinogenesis.

    Huang, Yu / Lu, Hong / Li, He

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 78

    Abstract: Background: Aberrant DNA methylation has been implicated in the development of gastric cancer (GC). In our previous study, we demonstrated that fructose-1,6-bisphosphatase-2 (FBP2), an enzyme that suppresses cell glycolysis and growth, is downregulated ... ...

    Abstract Background: Aberrant DNA methylation has been implicated in the development of gastric cancer (GC). In our previous study, we demonstrated that fructose-1,6-bisphosphatase-2 (FBP2), an enzyme that suppresses cell glycolysis and growth, is downregulated in GC due to promoter methylation. However, the precise mechanism underlying this process remains unknown. Thus, this study aimed to elucidate the mechanisms involved in FBP2 promoter hypermethylation.
    Methods and results: The methylation levels in GC and normal adjacent tissues were quantified using methylation-specific polymerase chain reaction. FBP2 promoter was frequently hypermethylated in primary GC tissues compared to adjacent normal tissues. To explore the functional consequences of this hypermethylation, we employed small interfering RNA-mediated knockdown of DNA methyltransferase 3a (DNMT3a) in GC cells. FBP2 expression increased following DNMT3a knockdown, suggesting that reduced methylation of the FBP2 promoter contributed to this upregulation. To further investigate this interaction, chromatin immunoprecipitation assays were conducted. The results confirmed an interaction between DNMT3a and the FBP2 promoter region, providing evidence that DNMT3a-mediated hypermethylation of the FBP2 promoter promotes GC progression.
    Conclusions: This study provides evidence that DNMT3a is involved in the hypermethylation of the FBP2 promoter and regulation of GC cell metabolism. Hypermethylation of the FBP2 promoter may be a promising prognostic biomarker in GC.
    MeSH term(s) Humans ; Carcinogenesis ; DNA Methylation/genetics ; DNA Methyltransferase 3A ; DNA Modification Methylases ; Fructose ; Fructose-Bisphosphatase/genetics ; Promoter Regions, Genetic/genetics ; Stomach Neoplasms/genetics
    Chemical Substances DNA Methyltransferase 3A (EC 2.1.1.37) ; DNA Modification Methylases (EC 2.1.1.-) ; Fructose (30237-26-4) ; Fructose-Bisphosphatase (EC 3.1.3.11) ; FBP2 protein, human (EC 3.1.3.11) ; DNMT3A protein, human
    Language English
    Publishing date 2024-01-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-023-08966-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
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  9. Article ; Online: Exploring the symptom patterns of depression and anxiety among teachers during COVID-19: A latent profile analysis.

    Lu, Zekai / Yuan, Rongqin / Liu, Zelin / Lu, Hong

    Psychological trauma : theory, research, practice and policy

    2024  

    Abstract: Objective: The present study used the latent profile analysis (LPA) approach to explore the symptom patterns of depression and anxiety among Chinese teachers during COVID-19 and its relationship with fear of COVID-19 and suicidal ideation.: Method: A ...

    Abstract Objective: The present study used the latent profile analysis (LPA) approach to explore the symptom patterns of depression and anxiety among Chinese teachers during COVID-19 and its relationship with fear of COVID-19 and suicidal ideation.
    Method: A sample of 6,121 teachers from primary and secondary schools in a district-level administrative unit in southern China was used. The LPA was employed to identify different symptom patterns of depression and anxiety. We subsequently used logistic regression to analyze the effects of demographic variables on the different profiles. The Bolck-Croon-Hagenaars method assessed the relationships between each profile and fear of COVID-19 and suicidal ideation.
    Results: The study identified five significant latent profiles and two subtypes in the moderate psychological disorder group. We also found that gender, professional title, and age significantly influenced the distribution of the profiles. The risk for both fear of COVID-19 and suicidal ideation was highest in the severe psychological disorder group. The high anxiety subtype had a significantly greater fear of the new coronavirus epidemic than the high depression subtype, which had a significantly higher level of suicidal ideation than the high anxiety subtype.
    Conclusion: The profiles we identified have distinct features that confirm their unique patterns of symptom endorsement. Our study may have important implications for early warning and intervention in teacher mental health. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2497028-1
    ISSN 1942-969X ; 1942-9681
    ISSN (online) 1942-969X
    ISSN 1942-9681
    DOI 10.1037/tra0001686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A commentary on "Distribution of coronal plane alignment of the knee classification in Chinese osteoarthritic and healthy population: A retrospective cross-sectional observational study".

    Xiong, Ao / Luo, Fei / Lu, Hong

    International journal of surgery (London, England)

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000001433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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