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  1. Article: Key Factors for Improving Rigor and Reproducibility: Guidelines, Peer Reviews, and Journal Technical Reviews.

    Lu, Hong S / Daugherty, Alan

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 856102

    Abstract: To respond to the NIH's policy for rigor and reproducibility in preclinical research, many journals have implemented guidelines and checklists to guide authors in improving the rigor and reproducibility of their research. Transparency in developing ... ...

    Abstract To respond to the NIH's policy for rigor and reproducibility in preclinical research, many journals have implemented guidelines and checklists to guide authors in improving the rigor and reproducibility of their research. Transparency in developing detailed prospective experimental designs and providing raw data are essential premises of rigor and reproducibility. Standard peer reviews and journal-specific technical and statistical reviews are critical factors for enhancing rigor and reproducibility. This brief review also shares some experience from
    Language English
    Publishing date 2022-03-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.856102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Angiotensinogen as a Therapeutic Target for Cardiovascular and Metabolic Diseases.

    Daugherty, Alan / Sawada, Hisashi / Sheppard, Mary B / Lu, Hong S

    Arteriosclerosis, thrombosis, and vascular biology

    2024  Volume 44, Issue 5, Page(s) 1021–1030

    Abstract: AGT (angiotensinogen) is the unique precursor for the generation of all the peptides of the renin-angiotensin system, but it has received relatively scant attention compared to many other renin-angiotensin system components. Focus on AGT has increased ... ...

    Abstract AGT (angiotensinogen) is the unique precursor for the generation of all the peptides of the renin-angiotensin system, but it has received relatively scant attention compared to many other renin-angiotensin system components. Focus on AGT has increased recently, particularly with the evolution of drugs to target the synthesis of the protein. AGT is a noninhibitory serpin that has several conserved domains in addition to the angiotensin II sequences at the N terminus. Increased study is needed on the structure-function relationship to resolve many unknowns regarding AGT metabolism. Constitutive whole-body genetic deletion of
    MeSH term(s) Animals ; Humans ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/genetics ; Angiotensinogen/metabolism ; Angiotensinogen/genetics ; Metabolic Diseases/drug therapy ; Metabolic Diseases/metabolism ; Metabolic Diseases/genetics ; Renin-Angiotensin System/drug effects ; Molecular Targeted Therapy
    Chemical Substances Angiotensinogen (11002-13-4)
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.124.318374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
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  3. Article ; Online: Abdominal aortic aneurysms: insights into mechanical and extracellular matrix effects from mouse models.

    Lu, Hong S / Sawada, Hisashi / Daugherty, Alan

    JVS-vascular science

    2023  Volume 4, Page(s) 100099

    Language English
    Publishing date 2023-02-18
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3503
    ISSN (online) 2666-3503
    DOI 10.1016/j.jvssci.2023.100099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Metformin ameliorates established abdominal aortic aneurysms induced by elastase in mice.

    Lu, Hong S / Sawada, Hisashi / Daugherty, Alan

    JVS-vascular science

    2023  Volume 4, Page(s) 100103

    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3503
    ISSN (online) 2666-3503
    DOI 10.1016/j.jvssci.2023.100103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Divergent Roles of Matrix Metalloproteinase 12 in Abdominal Aortic Aneurysms.

    Sawada, Hisashi / Daugherty, Alan / Lu, Hong S

    Circulation research

    2023  Volume 132, Issue 4, Page(s) 449–451

    MeSH term(s) Humans ; Matrix Metalloproteinase 12 ; Aortic Aneurysm, Abdominal ; Matrix Metalloproteinase 9 ; Angiotensin II ; Aorta, Abdominal
    Chemical Substances Matrix Metalloproteinase 12 (EC 3.4.24.65) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.123.322511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.70: Show issues Location:
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  6. Article ; Online: Abdominal aortic aneurysms and platelets: infiltration, inflammation, and elastin disintegration.

    Li, Bowen / Lu, Hong S / Daugherty, Alan

    Cardiovascular research

    2023  Volume 120, Issue 4, Page(s) 331–332

    MeSH term(s) Humans ; Aortic Aneurysm, Abdominal ; Elastin ; Inflammation ; Aorta, Abdominal
    Chemical Substances Elastin (9007-58-3)
    Language English
    Publishing date 2023-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvae010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
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  7. Article ; Online: Angiotensinogen in Sex and Hypertension: New Insights From the Multi-Ethnic Study of Atherosclerosis (MESA).

    Daugherty, Alan / Lu, Hong S / Bakris, George L

    Journal of the American College of Cardiology

    2023  Volume 81, Issue 13, Page(s) 1260–1262

    MeSH term(s) Humans ; Angiotensinogen ; Atherosclerosis ; Hypertension
    Chemical Substances Angiotensinogen (11002-13-4)
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.01.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 196: Show issues

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  8. Article: Editorial: Cardiovascular Fibrosis and Related Diseases: Basic and Clinical Research Advances.

    Bei, Yihua / Lu, Hong S / Zhong, Jiuchang

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 879780

    Language English
    Publishing date 2022-03-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.879780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Expression of a PCSK9 Gain-of-Function Mutation in C57BL/6J Mice to Facilitate Angiotensin II-Induced AAAs.

    Sawada, Hisashi / Daugherty, Alan / Lu, Hong S

    Biomolecules

    2022  Volume 12, Issue 7

    Abstract: Angiotensin II (AngII) infusion in mice has been used widely to investigate mechanisms of abdominal aortic aneurysms (AAAs). To achieve a high incidence of AngII-induced AAAs, mice should be hypercholesterolemic. Therefore, either low-density lipoprotein ...

    Abstract Angiotensin II (AngII) infusion in mice has been used widely to investigate mechanisms of abdominal aortic aneurysms (AAAs). To achieve a high incidence of AngII-induced AAAs, mice should be hypercholesterolemic. Therefore, either low-density lipoprotein receptor (LDLR) or apolipoprotein E deficiency have been used as a hypercholesterolemic background. However, it is a time-consuming and expensive process to generate compound deficient strains that have either an LDLR or apolipoprotein E deficient background. Proprotein convertase subtilisin/kexin type 9 (PCSK9) facilitates the degradation of LDL receptors. Previous studies demonstrated profound increases of plasma cholesterol concentrations after a single intraperitoneal injection of adeno-associated viruses (AAV) expressing a gain-of-function mutation of mouse PCSK9 (AAV.mPCSK9
    MeSH term(s) Angiotensin II/metabolism ; Animals ; Dependovirus/genetics ; Gain of Function Mutation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Proprotein Convertase 9/genetics
    Chemical Substances Angiotensin II (11128-99-7) ; PCSK9 protein, human (EC 3.4.21.-) ; Pcsk9 protein, mouse (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-)
    Language English
    Publishing date 2022-06-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12070915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Aortic Aneurysm and Dissection: Heterogeneity and Molecular Mechanisms.

    Lu, Hong S / Sawada, Hisashi / Wu, Congqing

    Biomolecules

    2022  Volume 12, Issue 10

    Abstract: Aortic aneurysms and dissections (AAD) are devastating aortic diseases with high risks for aortic rupture, leading to uncontrolled bleeding and death [ ... ]. ...

    Abstract Aortic aneurysms and dissections (AAD) are devastating aortic diseases with high risks for aortic rupture, leading to uncontrolled bleeding and death [...].
    MeSH term(s) Humans ; Aortic Aneurysm, Thoracic/genetics ; Aneurysm, Dissecting ; Aortic Aneurysm
    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12101536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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