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  1. Article ; Online: Synaptogenic effect of

    Zhou, Bo / Lu, Jacqueline G / Siddu, Alberto / Wernig, Marius / Südhof, Thomas C

    Science translational medicine

    2022  Volume 14, Issue 667, Page(s) eabn9380

    Abstract: Mutations in β-amyloid (Aβ) precursor protein ( ...

    Abstract Mutations in β-amyloid (Aβ) precursor protein (
    MeSH term(s) Humans ; Alzheimer Disease/pathology ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/metabolism ; Aspartic Acid Endopeptidases/genetics ; Aspartic Acid Endopeptidases/metabolism ; Mutation/genetics ; Sweden
    Chemical Substances Amyloid beta-Protein Precursor ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; APP protein, human
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abn9380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6941: Show issues Location:
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  2. Article: First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody.

    Omidvari, Negar / Jones, Terry / Price, Pat M / Ferre, April L / Lu, Jacqueline / Abdelhafez, Yasser G / Sen, Fatma / Cohen, Stuart H / Schmiedehausen, Kristin / Badawi, Ramsey D / Shacklett, Barbara L / Wilson, Ian / Cherry, Simon R

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: With the majority of ... ...

    Abstract With the majority of CD8
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.14.23287121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody.

    Omidvari, Negar / Jones, Terry / Price, Pat M / Ferre, April L / Lu, Jacqueline / Abdelhafez, Yasser G / Sen, Fatma / Cohen, Stuart H / Schmiedehausen, Kristin / Badawi, Ramsey D / Shacklett, Barbara L / Wilson, Ian / Cherry, Simon R

    Science advances

    2023  Volume 9, Issue 41, Page(s) eadh7968

    Abstract: With most of the T cells residing in the tissue, not the blood, developing noninvasive methods for in vivo quantification of their biodistribution and kinetics is important for studying their role in immune response and memory. This study presents the ... ...

    Abstract With most of the T cells residing in the tissue, not the blood, developing noninvasive methods for in vivo quantification of their biodistribution and kinetics is important for studying their role in immune response and memory. This study presents the first use of dynamic positron emission tomography (PET) and kinetic modeling for in vivo measurement of CD8
    MeSH term(s) Humans ; Tissue Distribution ; COVID-19/diagnostic imaging ; Positron-Emission Tomography/methods ; CD8-Positive T-Lymphocytes ; Zirconium ; Cell Line, Tumor
    Chemical Substances Zirconium (C6V6S92N3C)
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adh7968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody

    Omidvari, Negar / Jones, Terry / Price, Pat M / Ferre, April L / Lu, Jacqueline / Abdelhafez, Yasser G / Sen, Fatma / Cohen, Stuart H / Schmiedehausen, Kristin / Badawi, Ramsey D / Shacklett, Barbara L / Wilson, Ian / Cherry, Simon R

    medRxiv

    Abstract: With the majority of CD8+ T cells residing and functioning in tissue, not blood, developing noninvasive methods for ... in vivo ... quantification of their biodistribution and kinetics in humans offers the means for studying their key role in adaptive ... ...

    Abstract With the majority of CD8+ T cells residing and functioning in tissue, not blood, developing noninvasive methods for in vivo quantification of their biodistribution and kinetics in humans offers the means for studying their key role in adaptive immune response and memory. This study is the first report on using positron emission tomography (PET) dynamic imaging and compartmental kinetic modeling for in vivo measurement of whole-body biodistribution of CD8+ T cells in human subjects. For this, a 89Zr-labeled minibody with high affinity for human CD8 (89Zr-Df-Crefmirlimab) was used with total-body PET in healthy subjects (N=3) and in COVID-19 convalescent patients (N=5). The high detection sensitivity, total-body coverage, and the use of dynamic scans enabled the study of kinetics simultaneously in spleen, bone marrow, liver, lungs, thymus, lymph nodes, and tonsils, at reduced radiation doses compared to prior studies. Analysis and modeling of the kinetics was consistent with T cell trafficking effects expected from immunobiology of lymphoid organs, suggesting early uptake in spleen and bone marrow followed by redistribution and delayed increasing uptake in lymph nodes, tonsils, and thymus. Tissue-to-blood ratios from the first 7 h of CD8-targeted imaging showed significantly higher values in the bone marrow of COVID-19 patients compared to controls, with an increasing trend between 2 and 6 months post-infection, consistent with net influx rates obtained by kinetic modeling and flow cytometry analysis of peripheral blood samples. These results provide the platform for using dynamic PET scans and kinetic modelling to study total-body immunological response and memory.
    Keywords covid19
    Language English
    Publishing date 2023-03-20
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.03.14.23287121
    Database COVID19

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  5. Article ; Online: A novel

    Lu, Jacqueline G / Bishop, Juliet / Cheyette, Sarah / Zhulin, Igor B / Guo, Su / Sobreira, Nara / Brenner, Steven E

    Cold Spring Harbor molecular case studies

    2018  Volume 4, Issue 1

    Abstract: Paroxysmal kinesigenic dyskinesia (PKD) is a rare neurological disorder characterized by recurrent attacks of dyskinetic movements without alteration of consciousness that are often triggered by the initiation of voluntary movements. Whole-exome ... ...

    Abstract Paroxysmal kinesigenic dyskinesia (PKD) is a rare neurological disorder characterized by recurrent attacks of dyskinetic movements without alteration of consciousness that are often triggered by the initiation of voluntary movements. Whole-exome sequencing has revealed a cluster of pathogenic variants in
    MeSH term(s) Amino Acid Sequence ; Base Sequence ; Child ; Chromosome Segregation/genetics ; Conserved Sequence ; Dystonia/genetics ; Epilepsy, Benign Neonatal/genetics ; Evolution, Molecular ; Family ; Female ; Humans ; Infant ; Inheritance Patterns/genetics ; Male ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Mutation/genetics ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/genetics ; Pedigree
    Chemical Substances Membrane Proteins ; Nerve Tissue Proteins ; PRRT2 protein, human
    Language English
    Publishing date 2018-02-01
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835759-0
    ISSN 2373-2873 ; 2373-2873
    ISSN (online) 2373-2873
    ISSN 2373-2873
    DOI 10.1101/mcs.a002287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Urban tree canopy and asthma, wheeze, rhinitis, and allergic sensitization to tree pollen in a New York City birth cohort.

    Lovasi, Gina S / O'Neil-Dunne, Jarlath P M / Lu, Jacqueline W T / Sheehan, Daniel / Perzanowski, Matthew S / Macfaden, Sean W / King, Kristen L / Matte, Thomas / Miller, Rachel L / Hoepner, Lori A / Perera, Frederica P / Rundle, Andrew

    Environmental health perspectives

    2013  Volume 121, Issue 4, Page(s) 494–500

    Abstract: Background: Urban landscape elements, particularly trees, have the potential to affect airflow, air quality, and production of aeroallergens. Several large-scale urban tree planting projects have sought to promote respiratory health, yet evidence ... ...

    Abstract Background: Urban landscape elements, particularly trees, have the potential to affect airflow, air quality, and production of aeroallergens. Several large-scale urban tree planting projects have sought to promote respiratory health, yet evidence linking tree cover to human health is limited.
    Objectives: We sought to investigate the association of tree canopy cover with subsequent development of childhood asthma, wheeze, rhinitis, and allergic sensitization.
    Methods: Birth cohort study data were linked to detailed geographic information systems data characterizing 2001 tree canopy coverage based on LiDAR (light detection and ranging) and multispectral imagery within 0.25 km of the prenatal address. A total of 549 Dominican or African-American children born in 1998-2006 had outcome data assessed by validated questionnaire or based on IgE antibody response to specific allergens, including a tree pollen mix.
    Results: Tree canopy coverage did not significantly predict outcomes at 5 years of age, but was positively associated with asthma and allergic sensitization at 7 years. Adjusted risk ratios (RRs) per standard deviation of tree canopy coverage were 1.17 for asthma (95% CI: 1.02, 1.33), 1.20 for any specific allergic sensitization (95% CI: 1.05, 1.37), and 1.43 for tree pollen allergic sensitization (95% CI: 1.19, 1.72).
    Conclusions: Results did not support the hypothesized protective association of urban tree canopy coverage with asthma or allergy-related outcomes. Tree canopy cover near the prenatal address was associated with higher prevalence of allergic sensitization to tree pollen. Information was not available on sensitization to specific tree species or individual pollen exposures, and results may not be generalizable to other populations or geographic areas.
    MeSH term(s) African Americans ; Allergens/immunology ; Asthma/epidemiology ; Asthma/etiology ; Asthma/immunology ; Child ; Child, Preschool ; Dominican Republic/ethnology ; Female ; Geographic Information Systems ; Humans ; Hypersensitivity/epidemiology ; Hypersensitivity/etiology ; Hypersensitivity/immunology ; Immunoglobulin E/blood ; Male ; New York City ; Pollen/immunology ; Respiratory Sounds/etiology ; Respiratory Sounds/immunology ; Rhinitis/epidemiology ; Rhinitis/etiology ; Rhinitis/immunology ; Spacecraft ; Surveys and Questionnaires ; Trees
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2013-01-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/ehp.1205513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1360: Show issues Location:
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    Zs.MO 379: Show issues

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  7. Article: Long‐term outcomes of forest restoration in an urban park

    Simmons, Brady L. / Hallett, Richard A. / Sonti, Nancy Falxa / Auyeung, D. S. N. / Lu, Jacqueline W. T.

    Restoration ecology

    Volume v. 24,, Issue no. 1

    Abstract: Creating, restoring, and sustaining forests in urban areas are complicated by habitat fragmentation, invasive species, and degraded soils. Although there is some research on the outcomes of urban reforestation plantings during the first 5 years, there is ...

    Abstract Creating, restoring, and sustaining forests in urban areas are complicated by habitat fragmentation, invasive species, and degraded soils. Although there is some research on the outcomes of urban reforestation plantings during the first 5 years, there is little research on longer term outcomes. Here, we compare the successional trajectories of restored and unrestored forest sites 20 years after initiating restoration. The sites are located within the Rodman's Neck area of Pelham Bay Park, in the northeast corner of the Bronx in New York City (NYC), U.S.A. Compared with unrestored sites, we saw improvements in species diversity, greater forest structure complexity, and evidence of the regeneration and retention of native tree species in restored sites. In addition, we found differences in restoration outcomes depending on the level of intervention: clearing exotic shrubs and vines and planting native trees and shrubs improved tree diversity and canopy closure to a greater extent than clearing exotics alone, and the mechanical removal of invasive plants after the native plantings further improved some measures of restoration, such as tree species diversity and native tree regeneration. The results of this study suggest that the goal of a sustainable forest ecosystem dominated by native trees and other plant species may not be achievable without continued human intervention on site. In addition, these results indicate that the restoration approach adopted by NYC's reforestation practitioners is moving the site toward a more desirable vegetative community dominated by native species.
    Keywords forests ; urban areas ; sustainable forestry ; planting ; ecosystems ; humans ; forest restoration ; introduced species ; habitat fragmentation ; shrubs ; indigenous species ; canopy ; soil degradation ; vines ; invasive species ; reforestation ; trees ; species diversity
    Language English
    Document type Article
    ISSN 1061-2971
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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