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Article ; Online: LncRNA HOTAIR in exercise-induced neuro-protective function in Alzheimer's disease.

Lu, Jianxia / Liu, Lihua / Chen, Jin / Zhi, Juan / Li, Jiabin / Li, Le / Jiang, Zhongli

2023 Volume 60, Issue 4, Page(s) 414–420

Abstract: Introduction: Exercise is effective in Alzheimer's disease (AD), which is characterized by neuro-degenerative progress with increasing morbidity. The present study aimed to explore whether HOTAIR participated in the regulation of exercise in AD.: ... ...

Abstract	Introduction: Exercise is effective in Alzheimer's disease (AD), which is characterized by neuro-degenerative progress with increasing morbidity. The present study aimed to explore whether HOTAIR participated in the regulation of exercise in AD. Material and methods: A relative expression of serum HOTAIR was detected using quantitative real-time polymerase chain reaction (PCR). The diagnostic significance of HOTAIR on distinguishing AD patients was evaluated by receiver operating characteristic (ROC) curve. Correlations between HOTAIR expression and Mini-Mental State Examination (MMSE) score or Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) score were analyzed with Pearson's test. Logistic regression analysis was applied to investigate factors as independent indicators for HOTAIR expression. Results: In AD patients, the expression of HOTAIR was increased, and it could function as a diagnostic marker in AD patients. The expression of HOTAIR was associated with MMSE score and ADAS-Cog score in AD patients before exercise. Exercise ameliorated the cognitive impairment and reduced the relative serum expression of HOTAIR. Exercise was proved to be an independent indicator of HOTAIR expression. Conclusions: HOTAIR was a possible biomarker for indicating AD patients, and it was correlated with MMSE scores and ADAS-Cog results. Exercise might moderate AD progress via controlling HOTAIR.
MeSH term(s)	Humans ; Alzheimer Disease/diagnosis ; Alzheimer Disease/genetics ; Biomarkers ; Cognitive Dysfunction ; Neuropsychological Tests ; RNA, Long Noncoding/genetics
Chemical Substances	Biomarkers ; RNA, Long Noncoding ; HOTAIR long untranslated RNA, human
Language	English
Publishing date	2023-02-03
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1310363-5
ISSN	1509-572X ; 0028-3894 ; 1641-4640
ISSN (online)	1509-572X
ISSN	0028-3894 ; 1641-4640
DOI	10.5114/fn.2022.118961
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Article ; Online: The Involvement of lncRNA HOTAIR/miR-130a-3p Axis in the Regulation of Voluntary Exercise on Cognition and Inflammation of Alzheimer's Disease.

Lu, Jianxia / Liu, Lihua / Chen, Jin / Zhi, Juan / Li, Jiabin / Li, Le / Jiang, Zhongli

American journal of Alzheimer's disease and other dementias

2022 Volume 37, Page(s) 15333175221091424

Abstract: Background: Alzheimer's disease (AD) is an age-related neurodegenerative disease and exercises might mitigate the progression of AD. This investigation aimed to manifest the potential mechanism of exercises in AD.: Methods: Morris water maze (MWM) ... ...

Abstract	Background: Alzheimer's disease (AD) is an age-related neurodegenerative disease and exercises might mitigate the progression of AD. This investigation aimed to manifest the potential mechanism of exercises in AD. Methods: Morris water maze (MWM) test was conducted to evaluate the cognitive function in APP/PS1 mice. Quantitative real-time PCR was performed to detect the expression of HOTAIR and miR-130a-3p. The enzyme-linked immunosorbent assay was applied to appraise the concentration of IL-1β, IL-6, and TNF-α. A luciferase report experiment was implemented to substantiate the relationship between miR-130a-3p and HOTAIR. Results: Exercises contributed to the elevated expression of HOTAIR. The findings of MWM implied HOTAIR inhibited the impacts of voluntary exercises on escape latency, distance moved, percentage of time spent in the target quadrant, platform crossing times, and inflammation. MiR-130a-3p mediated the function of HOTAIR on cognitive ability and inflammation. Conclusion: HOTAIR participated in the regulation of exercises on AD by sponging miR-130a-3p.
MeSH term(s)	Alzheimer Disease/genetics ; Animals ; Cognition ; Humans ; Inflammation/genetics ; Mice ; MicroRNAs/genetics ; Neurodegenerative Diseases ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
Chemical Substances	HOTAIR long non-coding RNA, mouse ; MicroRNAs ; RNA, Long Noncoding
Language	English
Publishing date	2022-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1283069-0
ISSN	1938-2731 ; 0895-5336 ; 1082-5207 ; 1533-3175
ISSN (online)	1938-2731
ISSN	0895-5336 ; 1082-5207 ; 1533-3175
DOI	10.1177/15333175221091424
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Article ; Online: More utilitarian judgment in Internet addiction? An exploration using process dissociation and the CNI model.

Lu, Jianxia / Xie, Junjie / Chen, Jin / Zeng, Yan / Jiang, Zhongli / Wang, Yunqiang / Zheng, Hui

Brain and behavior

2022 Volume 12, Issue 3, Page(s) e2510

Abstract: Background: Internet addiction (IA), which is disadvantageous for decision making, such as moral judgment, is a pernicious threat to contemporary societies. However, few studies consider social cognition abilities as an important variable in IA.: ... ...

Abstract	Background: Internet addiction (IA), which is disadvantageous for decision making, such as moral judgment, is a pernicious threat to contemporary societies. However, few studies consider social cognition abilities as an important variable in IA. Objectives: This study explores the psychological mechanism of IA facing the moral dilemma. Methods: Forty participants with IA and 89 healthy participants were recruited. They finished the Internet Addiction Test and completed the moral judgment task. The process dissociation (PD) method and the consequences, norms, and generalized inaction (CNI) model were used to analyze moral judgment data. Results: Compared with the healthy control (HC) group, the traditional analysis showed that the IA group made more utilitarian judgment regarding moral dilemmas. PD analysis showed that the IA group had decreased deontological inclination, without utilitarian inclination. The CNI model further showed that the sensitivity of the IA group to moral rules was significantly lower than that of the HC group, while there was no significant difference between groups in the sensitivity to the consequences and the general preference for action. Conclusions: Individuals with IA make more utilitarian judgment when faced with a moral dilemma, which is related to their weak sensitivity to moral norms.
MeSH term(s)	Cognition ; Ethical Theory ; Humans ; Internet Addiction Disorder ; Judgment ; Morals
Language	English
Publishing date	2022-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.2510
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Article ; Online: Bu-Shen-Zhu-Yun decoction induces PRLR deubiquitination and JAK2/STAT5 activation via CSN5

Feng, Hua / Zhou, Huifang / Lu, Jianxia / Zhang, Qing / Tang, Xingran / Shang, Yujie

Aging

2021 Volume 13, Issue 16, Page(s) 20418–20437

Abstract: Purpose: To determine the effect of Bu-Shen-Zhu-Yun Decoction (BSZY-D) on the kisspeptin through JAK2/STAT5 signaling pathway in hyperprolactinemia (HPRL) infertility.: Method: SD rats were treated with BSZY-D for cerebrospinal fluid (CSF) extraction. ...

Abstract	Purpose: To determine the effect of Bu-Shen-Zhu-Yun Decoction (BSZY-D) on the kisspeptin through JAK2/STAT5 signaling pathway in hyperprolactinemia (HPRL) infertility. Method: SD rats were treated with BSZY-D for cerebrospinal fluid (CSF) extraction. GT1-7 cells were subjected to different treatments. The phosphorylation levels of JAK2 and STAT5, and the expressions of PRLR and kisspeptin of GT1-7 cells in different groups were detected by western blot, RT-qPCR and immunofluorescence. The expressions of CSN5 and GATA1 and other molecular features were checked by western blot, RT-PCR, co-immunoprecipitation and renilla luciferase activity. Results: The phosphorylation levels of JAK2 and STAT5, and the expressions of PRLR and kisspeptin in the HPRL group were significantly decreased, and these changes could be reversed after BSZY-D treatment. In addition, the presence of PRLR deubiquitination was detected in the HPRL group, which could be reversed by shRNA-CSN5, suggesting that BSZY-D played a role through targeting CSN5. The binding level of GATA1 and CSN5 promoter in the HPRL group was significantly decreased, but elevated in the HPRL (BSZY-D/CSF) group (P < 0.05). Conclusion: BSZY-D improved the transcription activity of GATA1 and increased the binding of GATA1 and CSN5. BSZY-D was involved in the deubiquitination of PRLR, which contributes to alleviating the symptoms of HPRL infertility.
MeSH term(s)	Animals ; COP9 Signalosome Complex/genetics ; COP9 Signalosome Complex/metabolism ; Drugs, Chinese Herbal/administration & dosage ; Female ; GATA1 Transcription Factor/genetics ; GATA1 Transcription Factor/metabolism ; Humans ; Hyperprolactinemia/drug therapy ; Hyperprolactinemia/genetics ; Hyperprolactinemia/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Janus Kinase 2/genetics ; Janus Kinase 2/metabolism ; Prolactin/genetics ; Prolactin/metabolism ; Rats ; Rats, Sprague-Dawley ; STAT5 Transcription Factor/genetics ; STAT5 Transcription Factor/metabolism ; Signal Transduction/drug effects
Chemical Substances	Drugs, Chinese Herbal ; GATA1 Transcription Factor ; Gata1 protein, rat ; Gps1 protein, rat ; Intracellular Signaling Peptides and Proteins ; STAT5 Transcription Factor ; Prolactin (9002-62-4) ; Jak2 protein, rat (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2) ; COP9 Signalosome Complex (EC 3.4.19.12)
Language	English
Publishing date	2021-08-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.203426
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Article ; Online: Addiction Symptom Network of Young Internet Users: Network Analysis.

Lu, Jianxia / Zhang, Qinhan / Zhong, Na / Chen, Jin / Zhai, Yujia / Guo, Lei / Lu, Chunlei / Chen, Tianzhen / Jiang, Zhongli / Zheng, Hui

Journal of medical Internet research

2022 Volume 24, Issue 11, Page(s) e38984

Abstract: Background: An increasing number of people are becoming addicted to the internet as a result of overuse. The Internet Addiction Test (IAT) is a popular tool for evaluating internet use behaviors. The interaction between different symptoms and the ... ...

Abstract	Background: An increasing number of people are becoming addicted to the internet as a result of overuse. The Internet Addiction Test (IAT) is a popular tool for evaluating internet use behaviors. The interaction between different symptoms and the relationship between IAT and clinical diagnostic criteria are not well understood. Objective: This study aimed to explore the core symptoms of internet addiction (IA) and the correlation between different symptoms of the IA symptom network. Network analysis was also conducted to explore the association between the IAT scale and the Diagnostic and Statistical Manual of Mental Disorders-5th edition (DSM-5) criteria for IA. Methods: We recruited 4480 internet users (aged 14-24 years), and they completed the IAT. The final analysis included 63.50% (2845/4480) of the participants after screening the submitted questionnaires. Participants were classified into IA group and non-IA (NIA) group. By using partial correlation with Lasso regularization networks, we identified the core symptoms of IA in each group and compared the group differences in network properties (strength, closeness, and betweenness). Then, we analyzed the symptom networks of the DSM-5 diagnostic criteria and IAT scale for IA. Results: A total of 12.47% (355/2845) of the patients were in the IA group and 87.52% (2490/2845) of the patients were in the NIA group, and both groups were evaluated for the following nodes: IAT_06 (school work suffers; strength=0.511), IAT_08 (job performance suffers; strength=0.531), IAT_15 (fantasize about being on the web; strength=0.474), IAT_17 (fail to stop being on the web; strength=0.526), and IAT_12 (fear about boredom if offline; strength=0.502). The IA groups had a stronger edge between IAT_09 (defensive or secretive about being on the web) and IAT_18 (hidden web time) than the NIA groups. The items in DSM-5 had a strong association with IAT_12 (weight=-0.066), IAT_15 (weight=-0.081), IAT_17 (weight=-0.106), IAT_09 (weight=-0.198), and IAT_18 (weight=-0.052). Conclusions: The internet use symptom network of the IA group is significantly different from that of the NIA group. Nodes IAT_06 (school work affected) and IAT_08 (work performance affected) are the resulting symptoms affected by other symptoms, whereas nodes IAT_12 (fear about boredom if offline), IAT_17 (inability to stop being on the web), and IAT_15 (fantasize about being on the web) are key symptoms that activate other symptoms of IA and are strongly linked to the inability to control the intention to play games in the DSM-5.
MeSH term(s)	Humans ; Behavior, Addictive/diagnosis ; Surveys and Questionnaires ; Internet Addiction Disorder/diagnosis ; Internet ; Schools
Language	English
Publishing date	2022-11-10
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1438-8871
ISSN (online)	1438-8871
ISSN	1438-8871
DOI	10.2196/38984
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Article ; Online: Network analysis of internet addiction and sleep disturbance symptoms.

Lu, Jian-Xia / Zhai, Yu-Jia / Chen, Jin / Zhang, Qin-Han / Chen, Tian-Zhen / Lu, Chun-Lei / Jiang, Zhong-Li / Guo, Lei / Zheng, Hui

Progress in neuro-psychopharmacology & biological psychiatry

2023 Volume 125, Page(s) 110737

Abstract: Background: Internet addiction (IA) is a behavioral addiction to problematic internet use. IA is associated with poorer sleep quality. Few studies to date, however, have explored the interactions between symptoms of IA and symptoms of sleep disturbance. ...

Abstract	Background: Internet addiction (IA) is a behavioral addiction to problematic internet use. IA is associated with poorer sleep quality. Few studies to date, however, have explored the interactions between symptoms of IA and symptoms of sleep disturbance. This study uses network analysis to identify bridge symptoms by analyzing these interactions in a large sample of students. Method: We recruited 1977 university students to participate in our study. Each student completed the Internet Addiction Test (IAT) and the Pittsburgh Sleep Quality Index (PSQI). We used these collected data for network analysis to identify the bridge symptoms in the IAT-PSQI network by calculating the bridge centrality. Furthermore, the closest symptom connected with the bridge symptom was found to identify the comorbidity mechanisms. Results: The core symptom of IA and the sleep disturbance network was "I08" (Study efficiency suffers due to internet use). The bridge symptoms between IA and sleep disturbance were "I14" (Surfing the internet late instead of sleeping), "P_DD" (Daytime dysfunction), and "I02" (Spending much time online instead of socializing in real life). Among the symptoms, "I14" had the highest bridge centrality. The edge connecting nodes "I14" and "P_SDu" (Sleep duration) had the strongest weight (0.102) around all the symptoms of sleep disturbance. Nodes "I14" and "I15" (Thinking about online shopping, games, social networking, and other network activities when unable to access the internet) had the strongest weight (0.181), connecting all the symptoms of IA. Conclusions: IA leads to poorer sleep quality, most likely by shortening sleep duration. Preoccupation with and craving the internet while being offline may lead to this situation. Healthy sleep habits should be learned, and craving may be a good point at which to treat the symptoms of IA and sleep disturbance.
MeSH term(s)	Humans ; Internet Addiction Disorder/epidemiology ; Students ; Comorbidity ; Sleep ; Sleep Initiation and Maintenance Disorders ; Behavior, Addictive/complications ; Behavior, Addictive/diagnosis ; Sleep Wake Disorders/complications ; Sleep Wake Disorders/epidemiology ; Internet
Language	English
Publishing date	2023-03-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2023.110737
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Article: Glucocorticoids offer protection against myocardial injury in a murine model of sepsis.

Lu, Zhong-Qian / Lu, Jian-Xia / Deng, Yi-Jun

International journal of clinical and experimental medicine

2015 Volume 8, Issue 8, Page(s) 12211–12218

Abstract: Sepsis is a serious infection-related complication that, in causing significant inflammation, often leads to myocardial injury. Severe inflammation, including in sepsis, is sometimes treated with exogenous glucocorticoids (GCs). Here, to explore the ... ...

Abstract	Sepsis is a serious infection-related complication that, in causing significant inflammation, often leads to myocardial injury. Severe inflammation, including in sepsis, is sometimes treated with exogenous glucocorticoids (GCs). Here, to explore the potential effect of GCs to protect against myocardial injury, we created a model of sepsis in rats by performing cecal ligation and puncture (CLP) in 96 rats randomly divided into sham-operated control (N=32), untreated sepsis (CLP, N=32), and GC-treated sepsis (N=32) groups. At 3, 6, 12, and 24 h after surgery, the changes in cardiac hemodynamic indexes, serum inflammatory response factor levels, and myocardial enzymes were measured, along with mitochondrial membrane potential in myocardial cells, apoptosis of myocardial cells, and the expression of nuclear factor kappa B (NF-κB p65) in myocardial tissues. Pathological changes in myocardial cells were also observed. Compared to the sham-operated group, CLP rats experienced deterioration of left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), maximum rate of left ventricular pressure rise (+dP/dtmax), and the maximum rate of left ventricular pressure drop (-dP/dtmax). CLP rats also had a rise in serum tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), cardiac troponin I (cTnI), creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and NF-κB p65 in myocardial tissues. The GCs-treated group had lower levels of these inflammatory response molecules than the CLP group, with the exception of anti-inflammatory cytokine interleukin-10 (IL-10), which was higher in the GC-treated rats than the CLP group at each time point post-surgery. Compared to the sham group, CLP rats had a rise in myocardial cell apoptosis and a drop in mitochondrial membrane potential in myocardial cells. In addition, GCs-treated rats had a marked drop in the myocardial cell apoptosis rate and a rise in the mitochondrial membrane potential compared to CLP rats. After intervention with GCs, the pathological changes in heart tissues were also reduced compared to those in the sepsis group. Based on these results, we conclude that exogenous GCs can inhibit a drop in myocardial mitochondrial membrane potential and inhibit myocardial cell apoptosis by blocking the activation of NF-κB, decreasing the generation of proinflammatory cytokines, and relieving inflammatory injury in heart tissues.
Language	English
Publishing date	2015-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2418305-2
ISSN	1940-5901
ISSN	1940-5901
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Article ; Online: Effect of aloe polysaccharide on caspase-3 expression following cerebral ischemia and reperfusion injury in rats.

Lu, Zhong-Qian / Deng, Yi-Jun / Lu, Jian-Xia

Molecular medicine reports

2012 Volume 6, Issue 2, Page(s) 371–374

Abstract: Stroke is a leading cause of cardiovascular morbidity, economic and social burden and mortality. Novel approaches are needed to address stroke prevention and treatment. The purpose of this study was to explore the effects of aloe polysaccharide on ... ...

Abstract	Stroke is a leading cause of cardiovascular morbidity, economic and social burden and mortality. Novel approaches are needed to address stroke prevention and treatment. The purpose of this study was to explore the effects of aloe polysaccharide on caspase-3 expression following cerebral ischemia reperfusion injury in rats. Male Wistar rats were randomly divided into 5 groups (16 rats in each group): aloe polysaccharide, ginkgo leaf tablet, nimodipine, model and sham surgery groups. The rats were administered the appropriate drug or normal saline for 7 days by gavage. A rat model of cerebral ischemia and reperfusion injury was established using the middle cerebral artery occlusion (MCAO) model. Caspase-3 protein and mRNA expression levels in the cerebral cortex were detected by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR), respectively. Results showed that caspase-3 protein and mRNA expression levels in the cerebral cortex in the aloe polysaccharide, ginkgo leaf tablet and nimodipine groups were significantly lower compared with the model group and were higher than the sham surgery group (P<0.05). No significant difference was observed in caspase-3 protein and mRNA expression among the aloe polysaccharide, the ginkgo leaf tablet and the nimodipine groups (P>0.05). In conclusion, aloe polysaccharide has a protective effect on cerebral ischemia that may be due to the inhibition of neuronal cell apoptosis.
MeSH term(s)	Aloe/chemistry ; Animals ; Brain Ischemia/drug therapy ; Brain Ischemia/enzymology ; Brain Ischemia/pathology ; Caspase 3/genetics ; Caspase 3/metabolism ; Cerebral Cortex/drug effects ; Cerebral Cortex/enzymology ; Cerebral Cortex/pathology ; Gene Expression Regulation, Enzymologic ; Ginkgo biloba/chemistry ; Immunohistochemistry ; Infarction, Middle Cerebral Artery/pathology ; Infarction, Middle Cerebral Artery/surgery ; Male ; Models, Animal ; Neurons/enzymology ; Neurons/pathology ; Neuroprotective Agents/administration & dosage ; Neuroprotective Agents/pharmacology ; Nimodipine/administration & dosage ; Nimodipine/pharmacology ; Phytotherapy ; Plant Leaves/chemistry ; Polysaccharides/administration & dosage ; Polysaccharides/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar ; Reperfusion Injury/drug therapy ; Reperfusion Injury/enzymology ; Reperfusion Injury/pathology ; Reverse Transcriptase Polymerase Chain Reaction ; Tablets/administration & dosage
Chemical Substances	Neuroprotective Agents ; Polysaccharides ; RNA, Messenger ; Tablets ; Nimodipine (57WA9QZ5WH) ; Casp3 protein, rat (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2012-05-24
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2012.927
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Article: [The expression and significance of ANXA2 in human glioma].

Lu, Zhong-qian / Gao, Yi-lu / Lu, Jian-xia

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

2010 Volume 26, Issue 8, Page(s) 787–789

Abstract: Aim: to investigate the relation between the expression of ANXA2 in human glioma and its pathological grades, and research the possibility that if ANXA2 could be as a useful diagnostic marker for glioma.: Method: Semi-quantity RT-PCR and ... ...

Abstract	Aim: to investigate the relation between the expression of ANXA2 in human glioma and its pathological grades, and research the possibility that if ANXA2 could be as a useful diagnostic marker for glioma. Method: Semi-quantity RT-PCR and immunohistochemistry were proceeded fro corresponding specimens to detect the level of ANXA2 and ANXA2mRNA. Results: In RT-PCR, the expression level of ANXA2mRNA in glioma was higher than that in surrounding brain tissue. (P < 0.05), as the same, in immunohistochemistry, the expression level of ANXA2 in glioma is higher than that is surrounding brain tissues (P< 0.05). Conclusion: ANXA2 expression was much higher in glioma samples than in the surrounding brain tissues, and positive correlation between its expression and pathological grades was found. It could be used as an assistant diagnostic index for glioma.
MeSH term(s)	Adolescent ; Adult ; Aged ; Annexin A2/genetics ; Annexin A2/metabolism ; Brain/metabolism ; Brain/pathology ; Female ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Glioma/metabolism ; Glioma/pathology ; Humans ; Male ; Middle Aged ; Young Adult
Chemical Substances	ANXA2 protein, human ; Annexin A2
Language	Chinese
Publishing date	2010-08
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1007-8738
ISSN	1007-8738
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Article: [Simultaneous determination of 103 pesticide residues in cabbages and apples using programmable temperature vaporizer-based large volume injection by gas chromatography-negative chemical ionization mass spectrometry].

Dong, Jing / Pan, Yuxiang / Qin, Yaping / Lü, Jianxia / Yu, Qiongwei

Se pu = Chinese journal of chromatography

2010 Volume 28, Issue 7, Page(s) 654–663

Abstract: A gas chromatography-mass spectrometric (GC-MS) method has been established for the simultaneous determination of 103 pesticide residues in cabbages and apples using programmable temperature vaporizer-based large volume injection (PTV-LVI) and negative ... ...

Abstract	A gas chromatography-mass spectrometric (GC-MS) method has been established for the simultaneous determination of 103 pesticide residues in cabbages and apples using programmable temperature vaporizer-based large volume injection (PTV-LVI) and negative chemical ionization (NCI). It was found that much lower detection limits for the investigated pesticides can be obtained. Prior to GC-NCI/MS analysis, the optimized parameters of PTV-LVI were as follows: inlet temperature was set at 45 degrees C, split vent flow rate was 20 mL/min, evaporation time was 1 min and evaporation temperature was set at 60 degrees C. The volume of injection was 10 microL. Co-extractives were removed from the acetonitrile extracts using solid phase extraction with octadecyl (200 mg) and primary secondary amine (100 mg) sorbents. Matrix matched calibration solutions were used for all the analyses. To evaluate performance of the method, validation experiments were carried out in cabbages and apples at two spiking levels (5 and 10 microg/kg). The average recoveries ranged from 58.5% to 113.2%, and the relative standard deviations (RSDs, n = 6) were in the range of 3.3% - 14.5%. The limits of detection (S/N = 3) were less than 5 microg/kg for all the pesticides. The results show that this method is simple, rapid, sensitive and specific. It is appropriate for the simultaneous identification and quantification of the multi-residues in cabbages and apples.
Language	Chinese
Publishing date	2010-10-13
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1000-8713
ISSN	1000-8713
DOI	10.3724/sp.j.1123.2010.00654
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