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Article ; Online: Association between hyperglycemia during pregnancy and offspring's refractive error: A focused review.

Guo, Yufan / Lu, Jingru / Zhu, Linlin / Hao, Xuemei / Huang, Kun

2024 , Page(s) 11206721241238389

Abstract: This review article explores the relationship between hyperglycemia during pregnancy and the visual development of offspring, specifically focusing on refractive error. The authors conducted a comprehensive search for relevant articles in various ... ...

Abstract	This review article explores the relationship between hyperglycemia during pregnancy and the visual development of offspring, specifically focusing on refractive error. The authors conducted a comprehensive search for relevant articles in various databases and assessed the methodological quality of the included studies. The findings consistently indicate that hyperglycemia during pregnancy can have a detrimental impact on the structural and functional aspects of visual development in offspring. The intrauterine hyperglycemic environment appears to negatively affect the retina and lens, leading to refractive errors. In conclusion, there is likely an association between hyperglycemia during pregnancy and the development of refractive errors in offspring.
Language	English
Publishing date	2024-03-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721241238389
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Article ; Online: Sex-specific association between maternal mild anemia and children's behavioral development: a birth cohort study.

Hao, Xuemei / Guo, Yufan / Lu, Jingru / Zhu, Linlin / Yan, Shuangqin / Tao, Fangbiao / Huang, Kun

European child & adolescent psychiatry

2024

Abstract: There has been limited research on maternal anemia affecting children's behavioral development, with a lack of studies focusing on sex differences in this association. Based on the Ma'anshan Birth Cohort, 2132 mother-child pairs were included. Maternal ... ...

Abstract	There has been limited research on maternal anemia affecting children's behavioral development, with a lack of studies focusing on sex differences in this association. Based on the Ma'anshan Birth Cohort, 2132 mother-child pairs were included. Maternal anemia was evaluated based on the hemoglobin concentration and children's behavioral development was assessed by Achenbach Child Behavior Checklist 1.5-5. Binary logistic regression models indicated that compared with children born of mothers without anemia throughout pregnancy, maternal mild anemia during pregnancy or only anemia in the 3rd trimester was associated with increased risks of aggressive behaviors in boys. Maternal mild anemia only in the 2nd trimester was associated with increased risks of attention problems in boys. In girls, maternal mild anemia during pregnancy was associated with increased risks of withdrawn, internalizing problems and total problems. Girls born of mothers with mild anemia only in the 2nd trimester had higher risks of total problems. Maternal mild anemia in both 2nd and 3rd trimesters was associated with increased risks of internalizing problems in girls. Our study identified sex-specific effects of maternal mild anemia during pregnancy on children's behavioral development problems.
Language	English
Publishing date	2024-03-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1118299-4
ISSN	1435-165X ; 1018-8827 ; 1433-5719
ISSN (online)	1435-165X
ISSN	1018-8827 ; 1433-5719
DOI	10.1007/s00787-024-02411-z
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Zs.A 3524: Show issues

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Article ; Online: Are there bidirectional associations between maternal thyroid function and glucose metabolism in singleton live births? A birth cohort study.

Lu, Jingru / Zhu, Linlin / Guo, Yufan / Hao, Xuemei / Yan, Shuangqin / Tao, Fangbiao / Huang, Kun

Diabetes research and clinical practice

2024 Volume 209, Page(s) 111569

Abstract: 1) Aims: To examine the associations between maternal thyroid function and glucose metabolism during pregnancy. (2) Methods: This study was based on Ma' anshan Birth Cohort in China. Totally 2375 pregnant women were included in data analysis. Maternal ... ...

Abstract	(1) Aims: To examine the associations between maternal thyroid function and glucose metabolism during pregnancy. (2) Methods: This study was based on Ma' anshan Birth Cohort in China. Totally 2375 pregnant women were included in data analysis. Maternal thyroid-stimulating hormone (TSH), free thyroxine (FT
MeSH term(s)	Pregnancy ; Female ; Humans ; Thyroid Gland ; Cohort Studies ; Thyroxine ; Retrospective Studies ; Live Birth ; Thyrotropin ; Glucose
Chemical Substances	Thyroxine (Q51BO43MG4) ; Thyrotropin (9002-71-5) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2024-02-08
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2024.111569
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Zs.A 2047: Show issues

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Article ; Online: Association of gestational weight gain rate in pregnant women with children's cognitive and behavioral development: A birth cohort study.

Hao, Xuemei / Zhu, Linlin / Guo, Yufan / Lu, Jingru / Yan, Shuangqin / Tao, Fangbiao / Huang, Kun

Journal of affective disorders

2024 Volume 350, Page(s) 792–800

Abstract: Background: The evidences on the relationship between gestational weight gain rate (GWGR) and children's cognitive and behavioral development have been limited.: Methods: A total of 3273 singleton live birth mother-child pairs from the Ma'anshan ... ...

Abstract	Background: The evidences on the relationship between gestational weight gain rate (GWGR) and children's cognitive and behavioral development have been limited. Methods: A total of 3273 singleton live birth mother-child pairs from the Ma'anshan Birth Cohort in China were included in the study. Maternal GWGR was calculated based on the weights measured at multiple antenatal checkups. Children's cognitive and behavioral development were assessed by Chinese version of Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition and Achenbach Child Behavior Checklist 1.5-5. Then generalized linear models were performed for analyses. Results: In the field of children's cognitive development, excessive GWGR in the second trimester was associated with increased visual space index (VSI), fluid reasoning index (FRI) and full scale intelligence quotient (FSIQ) scores, while excessive GWGR in the third trimester was associated with decreased VSI, working memory index (WMI) and FSIQ scores. In the field of children's behavioral development, excessive GWGR in the second trimester was associated with decreased aggressive behaviors and externalizing problems scores. Limitations: Children's behavioral development was assessed by main caregivers and might cause a certain degree of bias. There might be other potential confounders that we did not take into account. Conclusions: A high GWGR in the second trimester might be beneficial for children's cognitive and behavioral development, while a high GWGR in the third trimester might be harmful.
MeSH term(s)	Child, Preschool ; Female ; Humans ; Pregnancy ; Cohort Studies ; Pregnant Women ; Gestational Weight Gain ; Pregnancy Trimester, Third ; Cognition
Language	English
Publishing date	2024-01-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2024.01.154
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Zs.A 1485: Show issues

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Article: A broadly applicable quantitative relative reactivity model for nucleophilic aromatic substitution (S

Lu, Jingru / Paci, Irina / Leitch, David C

Chemical science

2022 Volume 13, Issue 43, Page(s) 12681–12695

Abstract: We report a multivariate linear regression model able to make accurate predictions for the relative rate and regioselectivity of nucleophilic aromatic substitution ( ... ...

Abstract	We report a multivariate linear regression model able to make accurate predictions for the relative rate and regioselectivity of nucleophilic aromatic substitution (S
Language	English
Publishing date	2022-10-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d2sc04041g
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Article: Identification of Four Novel

Wang, Sai / Shao, Yingfei / Wang, Yixiu / Lu, Jingru / Shao, Leping

Frontiers in genetics

2022 Volume 13, Page(s) 847777

Abstract: Chronic renal disease associated with X-linked Alport syndrome (XLAS) is relatively rare. However, due to the lack of specificity in the pathologic and clinical manifestations of the disease, it is easy to be misdiagnosed. In this study, we included ... ...

Abstract	Chronic renal disease associated with X-linked Alport syndrome (XLAS) is relatively rare. However, due to the lack of specificity in the pathologic and clinical manifestations of the disease, it is easy to be misdiagnosed. In this study, we included three Chinese families with XLAS and used targeted NGS to find gene variants. In family X1, the 36-year-old male proband had hematuria, massive proteinuria, sensorineural deafness and ESRD at 33.
Language	English
Publishing date	2022-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.847777
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Article: A reactivity model for oxidative addition to palladium enables quantitative predictions for catalytic cross-coupling reactions.

Lu, Jingru / Donnecke, Sofia / Paci, Irina / Leitch, David C

Chemical science

2022 Volume 13, Issue 12, Page(s) 3477–3488

Abstract: Making accurate, quantitative predictions of chemical reactivity based on molecular structure is an unsolved problem in chemical synthesis, particularly for complex molecules. We report an approach to reactivity prediction for catalytic reactions based ... ...

Abstract	Making accurate, quantitative predictions of chemical reactivity based on molecular structure is an unsolved problem in chemical synthesis, particularly for complex molecules. We report an approach to reactivity prediction for catalytic reactions based on quantitative structure-reactivity models for a key step common to many catalytic mechanisms. We demonstrate this approach with a mechanistically based model for the oxidative addition of (hetero)aryl electrophiles to palladium(0), which is a key step in myriad catalytic processes. This model links simple molecular descriptors to relative rates of oxidative addition for 79 substrates, including chloride, bromide and triflate leaving groups. Because oxidative addition often controls the rate and/or selectivity of palladium-catalyzed reactions, this model can be used to make quantitative predictions about catalytic reaction outcomes. Demonstrated applications include a multivariate linear model for the initial rate of Sonogashira coupling reactions, and successful site-selectivity predictions for Suzuki, Buchwald-Hartwig, and Stille reactions of multihalogenated substrates relevant to the synthesis of pharmaceuticals and natural products.
Language	English
Publishing date	2022-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d2sc00174h
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Article ; Online: Maternal Pre-Pregnancy Body Mass Index, Gestational Weight Gain and Children's Cognitive Development: A Birth Cohort Study.

Hao, Xuemei / Lu, Jingru / Yan, Shuangqin / Tao, Fangbiao / Huang, Kun

Nutrients

2022 Volume 14, Issue 21

Abstract: To investigate the joint effect of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) on children's cognitive development. We recruited 1685 mother-child pairs from the Ma'anshan Birth Cohort in China. Pre-pregnancy BMI and ... ...

Abstract	To investigate the joint effect of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) on children's cognitive development. We recruited 1685 mother-child pairs from the Ma'anshan Birth Cohort in China. Pre-pregnancy BMI and GWG were calculated based on the height and weights measured at multiple antenatal checkups. Children's cognition was assessed by Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition. Poisson regression model was used to analyze the association between maternal pre-pregnancy BMI and children's cognitive dimensions under different GWG categories. Women with overweight or obese before pregnancy were more likely to obtain excessive GWG. When women had excessive GWG, pre-pregnancy overweight was associated with low children's PSI (
MeSH term(s)	Child, Preschool ; Female ; Pregnancy ; Humans ; Body Mass Index ; Gestational Weight Gain ; Overweight ; Thinness ; Cohort Studies ; Weight Gain ; Birth Cohort ; Obesity/complications ; Mothers ; Cognition ; Birth Weight
Language	English
Publishing date	2022-11-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14214613
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Article ; Online: Maternal pregnancy-related anxiety and children's physical growth: the Ma'anshan birth cohort study.

Zhou, Jixing / Zhang, Shanshan / Teng, Yuzhu / Lu, Jingru / Guo, Yufan / Yan, Shuangqin / Tao, Fangbiao / Huang, Kun

BMC pregnancy and childbirth

2023 Volume 23, Issue 1, Page(s) 384

Abstract: Background: Epidemiological studies have identified maternal antenatal anxiety and several adverse birth outcomes, but limited studies have focused on the relationship with the long-term physical growth of children. The study aimed to assess the ... ...

Abstract	Background: Epidemiological studies have identified maternal antenatal anxiety and several adverse birth outcomes, but limited studies have focused on the relationship with the long-term physical growth of children. The study aimed to assess the influence of maternal pregnancy-related anxiety on physical growth in children at different exposure periods during pregnancy. Methods: 3,154 mother-child pairs were included based on the Ma'anshan birth cohort study. Maternal prenatal anxiety was obtained by administering a questionnaire using the pregnancy-related anxiety questionnaire (PRAQ) scale during the 1st, 2nd and 3rd trimesters of pregnancy. Body fat (BF) (48 to 72 months) and Body Mass Index (BMI) (birth to 72 months) were collected repeatedly for children. Group-based trajectory models were applied to fit the different trajectories of BMI and BF. Results: Maternal anxiety in the 2nd (OR = 0.81; 95% CI: 0.68 to 0.98; P < 0.025) and 3rd (OR = 0.80; 95% CI: 0.67 to 0.97; P = 0.020) trimesters was associated with a decreased risk of rapid weight gain (RWG) in the first year of life. Children aged 48 to 72 months of mothers with anxiety in the 3rd trimester had lower BMI (β = -0.161; 95% CI, -0.293 to -0.029; P = 0.017) and BF (β = -0.190; 95% CI, -0.334 to -0.046; P = 0.010), and these children were less likely to develop a very high BMI trajectory (OR = 0.54; 95% CI: 0.34 to 0.84; P = 0.006), and a high BF trajectory (OR = 0.72; 95% CI: 0.53 to 0.99; P = 0.043). Similar associations were found between maternal anxiety in both 2nd and 3rd trimesters and children's physical growth. Conclusions: Offspring of mothers with prenatal anxiety in the 2nd and 3rd trimesters predicts poorer growth in infancy and preschool age. Early improvement and treatment of prenatal anxiety could benefit physical health and development in early childhood.
MeSH term(s)	Female ; Pregnancy ; Humans ; Child, Preschool ; Cohort Studies ; Mothers ; Pregnancy Trimester, Third ; Body Mass Index ; Anxiety/epidemiology ; Parturition ; Prenatal Exposure Delayed Effects
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-023-05711-5
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Article ; Online: Chiral, air stable, and reliable Pd(0) precatalysts applicable to asymmetric allylic alkylation chemistry.

Huang, Jingjun / Keenan, Thomas / Richard, François / Lu, Jingru / Jenny, Sarah E / Jean, Alexandre / Arseniyadis, Stellios / Leitch, David C

Nature communications

2023 Volume 14, Issue 1, Page(s) 8058

Abstract: Stereoselective carbon-carbon bond formation via palladium-catalyzed asymmetric allylic alkylation is a crucial strategy to access chiral natural products and active pharmaceutical ingredients. However, catalysts based on the privileged Trost and Pfaltz- ... ...

Abstract	Stereoselective carbon-carbon bond formation via palladium-catalyzed asymmetric allylic alkylation is a crucial strategy to access chiral natural products and active pharmaceutical ingredients. However, catalysts based on the privileged Trost and Pfaltz-Helmchen-Williams PHOX ligands often require high loadings, specific preactivation protocols, and excess chiral ligand. This makes these reactions uneconomical, often unreproducible, and thus unsustainable. Here we report several chiral single-component Pd(0) precatalysts that are active and practically-applicable in a variety of asymmetric allylic alkylation reactions. Despite the decades-long history and widespread use of Trost-type ligands, the precatalysts in this work are the only reported examples of stable, isolable Pd(0) complexes with these ligands. Evaluating these precatalysts across nine asymmetric allylic alkylation reactions reveals high reactivity and selectivity at low Pd loading. Importantly, we also report an unprecedented Pd-catalyzed enantioselective allylation of a hydantoin, achieved on gram scale in high yield and enantioselectivity with only 0.2 mol% catalyst.
Language	English
Publishing date	2023-12-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-43512-8
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