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  1. Book: Hereditary gynecologic cancer

    Lu, Karen H.

    risk, prevention and management

    2008  

    Author's details ed. by Karen H. Lu
    Keywords Genital Neoplasms, Female / genetics ; Genital Neoplasms, Female / prevention & control ; Genital Neoplasms, Female / therapy ; Neoplastic Syndromes, Hereditary ; Genes, BRCA1 ; Genes, BRCA2
    Language English
    Size XV, 285 S. : Ill., graph. Darst.
    Publisher Informa Healthcare
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015727807
    ISBN 978-1-4200-5287-9 ; 1-4200-5287-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 6470 order for loan Magazin

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  2. Article ; Online: Screening for Ovarian Cancer in Asymptomatic Women.

    Lu, Karen H

    JAMA

    2018  Volume 319, Issue 6, Page(s) 557–558

    MeSH term(s) CA-125 Antigen ; Female ; Humans ; Mass Screening ; Ovarian Neoplasms ; Ultrasonography
    Chemical Substances CA-125 Antigen
    Language English
    Publishing date 2018--13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2017.21894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Endometrial Cancer. Reply.

    Lu, Karen H / Broaddus, Russell R

    The New England journal of medicine

    2021  Volume 384, Issue 6, Page(s) 586

    MeSH term(s) Endometrial Neoplasms ; Female ; Humans
    Language English
    Publishing date 2021-02-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2035378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Juvenile granulosa cell tumor in a transgender male with Ollier disease: A case report.

    Ing, Brandon I / Huepenbecker, Sarah P / Hameed, Nadia / Lu, Karen H

    Gynecologic oncology reports

    2023  Volume 49, Page(s) 101287

    Abstract: Multiple case reports are published on patients with Ollier's disease presenting simultaneously with granulosa cell tumors.•More medical conditions are being treated with androgens and estrogens, including gender dysphoria.•Caution should be given to ... ...

    Abstract •Multiple case reports are published on patients with Ollier's disease presenting simultaneously with granulosa cell tumors.•More medical conditions are being treated with androgens and estrogens, including gender dysphoria.•Caution should be given to transgender patients on active hormonal therapy.•Providers should consider prescreening for hormonally responsive medical conditions.
    Language English
    Publishing date 2023-10-02
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2818505-5
    ISSN 2352-5789
    ISSN 2352-5789
    DOI 10.1016/j.gore.2023.101287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Endometrial Cancer.

    Lu, Karen H / Broaddus, Russell R

    The New England journal of medicine

    2020  Volume 383, Issue 21, Page(s) 2053–2064

    MeSH term(s) Age of Onset ; Body Mass Index ; Colorectal Neoplasms, Hereditary Nonpolyposis/complications ; Combined Modality Therapy ; Endometrial Neoplasms/epidemiology ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/pathology ; Endometrial Neoplasms/therapy ; Female ; Humans ; Hysterectomy/methods ; Neoplasm Staging ; Obesity/complications ; Uterine Neoplasms/ethnology
    Language English
    Publishing date 2020-11-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra1514010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Unanswered Questions in High-Risk Women Undergoing Risk-Reducing Salpingo-oophorectomy.

    Cun, Han T / Lu, Karen H

    Obstetrics and gynecology

    2020  Volume 135, Issue 3, Page(s) 495–497

    MeSH term(s) Female ; Humans ; Ovariectomy ; Salpingectomy ; Salpingo-oophorectomy
    Language English
    Publishing date 2020-02-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000003733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Determination of quality of life-related health utilities for surgical complications in ovarian cancer.

    Suidan, Rudy S / Sun, Charlotte C / Schneider, Amy K / Lu, Karen H / Giordano, Sharon H / Meyer, Larissa A

    Gynecologic oncology

    2024  Volume 185, Page(s) 101–107

    Abstract: Objective: To assess the health state utilities of ovarian cancer patients, clinicians, and non-cancer controls regarding surgical complications in ovarian cancer.: Methods: Utilities for 14 surgical complications were assessed from patients with ... ...

    Abstract Objective: To assess the health state utilities of ovarian cancer patients, clinicians, and non-cancer controls regarding surgical complications in ovarian cancer.
    Methods: Utilities for 14 surgical complications were assessed from patients with recently diagnosed or recurrent ovarian cancer, clinicians, and non-cancer controls using the visual analog scale (VAS) and time trade-off (TTO) methods. Health state utilities were converted to a 0-to-1 scale, where 0 represents the least favorable outcome and 1 represents the most favorable outcome.
    Results: Fifty patients, 50 clinicians, and 50 controls participated. Median VAS scores were lower than TTO scores across all groups (p < 0.01). Patients viewed 'bleeding requiring transfusion' most favorably (VAS utility 0.75), followed in order by less favorable utility scores for hernia, thromboembolism, pleural effusion, abscess, ileus/bowel obstruction, wound infection, bowel obstruction requiring surgery, anastomotic leak requiring drain, temporary ostomy, anastomotic leak requiring surgery, genito-urinary fistula, permanent ostomy, and genito-intestinal fistula (VAS utility 0.2). Overall, clinicians perceived complications more favorably than patients by VAS (overall utility score 0.49 vs 0.43, p < 0.01), but not by the TTO. There were no differences in overall utility scores between patients and controls. Patients who had not experienced certain surgical complications had less favorable scores than patients who did (utility score for ostomy = 0.2 for patients without ostomy vs. 0.7 for patients with ostomy, p = 0.02).
    Conclusions: This study establishes health state utilities for surgical complications associated with ovarian cancer. These utilities can be used in future cost-effectiveness evaluations to determine quality-adjusted outcomes and may help in counseling patients during the shared decision-making process.
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 801461-9
    ISSN 1095-6859 ; 0090-8258
    ISSN (online) 1095-6859
    ISSN 0090-8258
    DOI 10.1016/j.ygyno.2024.01.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Next steps in the early detection of ovarian cancer.

    Bast, Robert C / Han, Chae Young / Lu, Zhen / Lu, Karen H

    Communications medicine

    2021  Volume 1

    Abstract: A recent ovarian cancer screening trial found no reduction in mortality, despite increased detection of early stage disease. Here, we discuss these findings and examine next steps to develop more effective approaches for the early detection of ovarian ... ...

    Abstract A recent ovarian cancer screening trial found no reduction in mortality, despite increased detection of early stage disease. Here, we discuss these findings and examine next steps to develop more effective approaches for the early detection of ovarian cancer.
    Language English
    Publishing date 2021-10-05
    Publishing country England
    Document type Journal Article
    ISSN 2730-664X
    ISSN (online) 2730-664X
    DOI 10.1038/s43856-021-00037-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Salpingectomy for the Primary Prevention of Ovarian Cancer: A Systematic Review.

    Kahn, Ryan M / Gordhandas, Sushmita / Godwin, Kendra / Stone, Rebecca L / Worley, Michael J / Lu, Karen H / Long Roche, Kara C

    JAMA surgery

    2023  Volume 158, Issue 11, Page(s) 1204–1211

    Abstract: Importance: Most ovarian cancers originate in the fimbriated end of the fallopian tube. This has led to the hypothesis that surgical resection of the fallopian tubes at the time of gynecologic and nongynecologic surgical procedures-referred to as an ... ...

    Abstract Importance: Most ovarian cancers originate in the fimbriated end of the fallopian tube. This has led to the hypothesis that surgical resection of the fallopian tubes at the time of gynecologic and nongynecologic surgical procedures-referred to as an opportunistic salpingectomy-may prevent the development of epithelial ovarian cancer for women at an average risk of developing the disease.
    Objective: To compile a comprehensive, state-of-the-science review examining the current landscape of performing bilateral salpingectomy for ovarian cancer prevention.
    Evidence review: A systematic review of the literature was performed on March 4, 2022, to identify studies examining salpingectomy for ovarian cancer prevention. This review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020 statement. Four databases were selected: PubMed via the National Library of Medicine's PubMed.gov, Embase via Elsevier's Embase.com, Cochrane Central Register of Controlled Trials (CENTRAL) via Wiley's Cochrane Library, and Northern Light Life Sciences Conference Abstracts via Ovid. A total of 20 gray literature sources, including 1 database, 2 registers, 1 repository, 1 index, 1 archive, 1 preprint server, 1 agency, and 12 organizations, were also searched.
    Findings: The initial search produced 1089 results; a total of 158 publications were included in the final review. Salpingectomy has been associated with ovarian cancer risk reduction of approximately 80%. Studies have demonstrated that salpingectomy was safe, cost-effective, and was not associated with an earlier age of menopause onset. With widespread implementation, salpingectomy has the potential to reduce ovarian cancer mortality in the US by an estimated 15%. Both physician and patient awareness regarding the adnexa as the origin for most ovarian cancers, as well as the existence of salpingectomy and its potential benefits in reducing ovarian cancer risk, has increased during the past decade. Raising awareness and developing effective implementation strategies are essential.
    Conclusions and relevance: The results of this systematic review suggest that bilateral salpingectomy for ovarian cancer prevention was safe and feasible and has the potential to be a cost-effective and cost-saving strategy across the population. Prospective studies to demonstrate long-term survival outcomes and feasibility in nongynecologic surgical procedures are warranted.
    MeSH term(s) Female ; Humans ; Prospective Studies ; Ovarian Neoplasms/prevention & control ; Ovarian Neoplasms/surgery ; Salpingectomy/methods ; Hysterectomy/methods ; Primary Prevention
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.4164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Salpingectomy for ovarian cancer prevention: Video education for the surgeon.

    MacArthur, Emily / Long Roche, Kara / Sakran, Joseph / Patel, Sunil H / Najjar, Peter / Lu, Karen H / Gornet, Megan / Frost, Anja S / Walrath, Meghan / Bauer, Tom / Oh, Gyyong / Stone, Rebecca

    Gynecologic oncology reports

    2024  Volume 53, Page(s) 101368

    Abstract: Given the unremitting obstacles to effectively screen for and treat ovarian cancer (OC), prevention is a necessary countermeasure. The recent discovery of the fallopian tube as the origin of the most common and deadly type of OC, high grade serous cancer ...

    Abstract Given the unremitting obstacles to effectively screen for and treat ovarian cancer (OC), prevention is a necessary countermeasure. The recent discovery of the fallopian tube as the origin of the most common and deadly type of OC, high grade serous cancer (HGSC), makes prevention through salpingectomy possible (Madsen et al., 2015). Opportunistic salpingectomy (OS) is the practice of removing the post-reproductive fallopian tubes at the time of other intraperitoneal surgery, or for sterilization in lieu of tubal ligation, to decrease OC risk (Falconer et al., 2015). The safety, effectiveness, and reach of OS as a primary prevention strategy depends on the knowledge mobilization of a standard surgical approach for surgeons (Hanley et al., 2017, Morelli et al., 2013). Resources for accomplishing this knowledge mobilization activity are needed. We therefore aim to create a peer-reviewed, publicly available surgical instructional video that facilitates standardization of the practice of salpingectomy for the purpose of OC prevention. Content creation was generated by a team of surgeon stakeholders, medical illustrators, instructional designers, and health education specialists. Expert gynecologic surgeons were filmed performing salpingectomy in order to build a video library. Accurate illustration and editing of live video footage was executed to support surgeons in visualizing key anatomic landmarks to ensure safe and complete fallopian tube excision. Review of eligibility criteria, fundamentals of preoperative counseling, and strategic and technical points were prioritized. This endeavor is strictly educational, with no commercial benefit. Publicly available, peer-reviewed surgical education tools will help us collaborate to safely and equitably expand OS within and beyond the current scope of surgical practice.
    Language English
    Publishing date 2024-03-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2818505-5
    ISSN 2352-5789
    ISSN 2352-5789
    DOI 10.1016/j.gore.2024.101368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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