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Article: [Cost-effectiveness analysis of Biyuan Tongqiao Granules combined with Triamcinolone Acetonide Nasal Spray in treatment of chronic rhinosinusitis].

Huang, Zhi-Yan / Zhang, Xu-Sheng / Gong, Wen-Qiao / Liu, Juan / Lu, Li-Juan

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2023 Volume 48, Issue 15, Page(s) 4237–4242

Abstract: This study aims to evaluate the effectiveness and economic efficiency of Biyuan Tongqiao Granules combined with Triamcinolone Acetonide Nasal Spray in the treatment of chronic rhinosinusitis(CRS). The randomized controlled trial(RCT) of Biyuan Tongqiao ... ...

Abstract	This study aims to evaluate the effectiveness and economic efficiency of Biyuan Tongqiao Granules combined with Triamcinolone Acetonide Nasal Spray in the treatment of chronic rhinosinusitis(CRS). The randomized controlled trial(RCT) of Biyuan Tongqiao Granules combined with Triamcinolone Acetonide Nasal Spray in the treatment of CRS was searched against EMbase, PubMed, Cochrane Library, CNKI, VIP, SinoMed, and Wanfang. The efficacy, nasal mucociliary transport time, and safety of the therapy above in the treatment of CRS were analyzed with single-group rate and Meta-analysis, and the economy and sensitivity were evaluated from the perspective of payer. A total of 9 RCTs were included, including 1 145 patients. Meta-analysis showed that compared with Triamcinolone Acetonide Nasal Spray alone, Biyuan Tongqiao Granules combined with Triamcinolone Acetonide Nasal Spray in the treatment of CRS patients increased the effective rate(RR=1.17, 95%CI[1.11, 1.24], P<0.000 01) and shortened the nasal mucociliary transport time(MD=-3.32, 95%CI[-5.86,-0.78], P=0.01), there was no significant difference in the incidence of adverse reactions between the two groups. The incremental cost-effectiveness analysis showed that the treatment costs of the control group and the observation group were 44.15 yuan and 1 044.96 yuan, respectively. In the Biyuan Tongqiao Granules combined with Triamcinolone Acetonide Nasal Spray treatment group, 75.48 yuan was spent to improve the effective rate of CRS by 1%. The one-way sensitivity analysis indicated the days of treatment, the RR of Biyuan Tongqiao Granules combined with Triamcinolone Acetonide Nasal Spray, the price of unit preparation of Biyuan Tongqiao Granules, and the effective rate of Triamcinolone Acetonide Nasal Spray alone had great influence on the incremental cost-effectiveness ratio. In conclusion, Biyuan Tongqiao Granules combined with Triamcinolone Acetonide Nasal Spray improves the therapeutic effect on CRS. The probabilistic sensitivity analysis showed that when the willingness to pay was greater than 7 920 yuan(less than 0.1 of GDP per capita 8 098 yuan), the combined therapy was economically superior to the control. Due to the limited number of articles published, it is necessary to carry out a real-world clinical trial of Biyuan Tongqiao Gra-nules and Triamcinolone Acetonide Nasal Spray in the treatment of CRS, so as to compare the cost-effectiveness of Biyuan Tongqiao Granules and Triamcinolone Acetonide Nasal Spray.
MeSH term(s)	Humans ; Triamcinolone Acetonide/therapeutic use ; Triamcinolone Acetonide/adverse effects ; Nasal Sprays ; Cost-Effectiveness Analysis ; Sinusitis/drug therapy ; Chronic Disease
Chemical Substances	Triamcinolone Acetonide (F446C597KA) ; Nasal Sprays
Language	Chinese
Publishing date	2023-10-06
Publishing country	China
Document type	Meta-Analysis ; English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20230318.501
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Article ; Online: Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.

Gao, Ying / Lu, Li-Juan / Zhang, Zhao-Zheng / Yang, Xiao / Du, Jun / Wen, Ke / Huang, Hua / Wang, Xiao-Peng / Sun, Xue-Liang

Journal of ethnopharmacology

2023 Volume 315, Page(s) 116678

Abstract: Ethnopharmacological relevance: Xue-Jie-San (XJS), as a traditional Chinese herb prescription, has satisfactory effects on improving clinical symptoms and facilitating the healing of intestinal ulcers in patients with Crohn's disease (CD). This ... ...

Abstract	Ethnopharmacological relevance: Xue-Jie-San (XJS), as a traditional Chinese herb prescription, has satisfactory effects on improving clinical symptoms and facilitating the healing of intestinal ulcers in patients with Crohn's disease (CD). This motivates the application of XJS on CD-associated complications. Aim of the study: Intestinal fibrosis is a debilitating complication of CD. Currently, there is no effective medication available for preventing or reversing CD-related intestinal fibrosis. This study aimed to assess the efficacy and underlying mechanisms of XJS in the treatment of colitis-associated intestinal fibrosis. Materials and methods: A rat model of CD-related intestinal fibrosis was induced by 2,4,6-trinitrobenzene sulfonic acid administration and treated with XJS. The pathological changes of intestinal fibrosis were evaluated using Masson staining. Collagen deposition and epithelial-to-mesenchymal transition (EMT) were verified by immunohistochemical staining and Western blot analysis. Endothelial-to-mesenchymal transition (EndoMT) was assessed with immunofluorescence and immunohistochemical staining as well as Western blot analysis. Transmission electron microscopy was utilized to observe autophagosomes. The levels of autophagy-related proteins were detected via immunofluorescence staining and Western blot. Finally, the mTOR/ULK1 signaling pathway regulated by Notch1 or FGL1 was analyzed by Western blot. Results: The results found that XJS ameliorated intestinal fibrosis through reducing the deposition of collagens such as Collagen 1 and Collagen 3. XJS inhibited the EMT process by increasing E-cadherin levels and decreasing the expressions of N-cadherin, Vimentin and Snail, which played a crucial role in collagen secretion and intestinal fibrosis. In addition, XJS also repressed the EndoMT process as reflected by the upregulation of CD31 and VE-cadherin levels and the downregulation of FSP1 and α-SMA expressions. Autophagy was activated following XJS treatment via suppression of the mTOR/ULK1 signaling pathway. Furthermore, XJS acted as an inhibitor of Notch1 and FGL1 signals, both of which regulated the mTOR signaling. Conclusions: Our findings validated that XJS prevented the early development of CD-related intestinal fibrosis by blocking the Notch1 and FGL1 signaling pathways to activate autophagy and thereby inhibit EMT and EndoMT.
MeSH term(s)	Rats ; Animals ; Intestines/pathology ; Colitis/chemically induced ; Colitis/complications ; Colitis/drug therapy ; Fibrosis ; Signal Transduction ; TOR Serine-Threonine Kinases ; Epithelial-Mesenchymal Transition ; Receptor, Notch1
Chemical Substances	TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Notch1 protein, rat ; Receptor, Notch1
Language	English
Publishing date	2023-05-30
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116678
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Article: Pan-Genomic Analysis Identifies the Chinese Strain as a New Subspecies of

Wei, Feng / Liang, Xia / Shi, Jian-Cheng / Luo, Jing-Nan / Qiu, Li-Juan / Li, Xi-Xuan / Lu, Li-Juan / Wen, Ying-Qiang / Feng, Jia-Yue

Plant disease

2024 Volume 108, Issue 1, Page(s) 45–49

Abstract: Xanthomonas ... ...

Abstract	Xanthomonas fragariae
MeSH term(s)	Genomics ; Multilocus Sequence Typing ; Xanthomonas/genetics
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-05-23-0933-SC
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Article ; Online: An outbreak of

Meng, Hui / Chen, ZhaoYin / Chen, LanChun / Tang, WeiXin / He, Fang / Yan, XianRang / Lin, XiaoHong / Se, XiaoLong / Xie, MingFei / Li, ZhanHan / Lu, LiJuan / Yu, Xuetao

Clinical toxicology (Philadelphia, Pa.)

2023 Volume 61, Issue 4, Page(s) 270–275

Abstract: Background: The mushroom : Methods: We described a series of 10 patients with : Results: Among the 10 patients, 9 survived, while 1 died. Gastrointestinal symptoms were the first to appear (average latency period, 11 ± 4.2 h). Diarrhea was the ... ...

Abstract	Background: The mushroom Methods: We described a series of 10 patients with Results: Among the 10 patients, 9 survived, while 1 died. Gastrointestinal symptoms were the first to appear (average latency period, 11 ± 4.2 h). Diarrhea was the most common clinical symptom (average duration, 4.4 days). Abdominal distention was an important sign, especially in severely-ill patients. Thrombocytopenia occurred on day 2 after mushroom ingestion and persisted for 3-4 days. Alanine aminotransferase and total bilirubin peaked on days 2-3. Conclusion: Amanita exitialis
MeSH term(s)	Humans ; Mushroom Poisoning/therapy ; Liver ; Amanita ; Gastrointestinal Diseases ; Disease Outbreaks ; Thrombocytopenia
Language	English
Publishing date	2023-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	204476-6
ISSN	1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
ISSN (online)	1556-9519
ISSN	0009-9309 ; 0731-3810 ; 1556-3650
DOI	10.1080/15563650.2022.2159830
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Article: Observation and measurement of applied anatomical features for thoracic intervertebral foramen puncture on computed tomography images.

Wang, Ran / Sun, Wei-Wei / Han, Ying / Fan, Xiao-Xue / Pan, Xue-Qin / Wang, Shi-Chong / Lu, Li-Juan

World journal of clinical cases

2021 Volume 9, Issue 18, Page(s) 4607–4616

Abstract: Background: Thoracic intervertebral foramen puncture is the key step for interventional therapy on the thoracic nerve roots or dorsal root ganglia. The anatomical features of the thoracic spine are complex, and puncture injury to the pleura, blood ... ...

Abstract	Background: Thoracic intervertebral foramen puncture is the key step for interventional therapy on the thoracic nerve roots or dorsal root ganglia. The anatomical features of the thoracic spine are complex, and puncture injury to the pleura, blood vessels, spinal cord, and other tissues may cause serious complications. The spatial anatomical characteristics and related parameters for thoracic intervertebral foramen puncture remain poorly understood. Aim: To observe and summarize the spatially applied anatomical characteristics for intervertebral foramen puncture on different vertebral segments. Methods: A total of 88 patients (41 males and 47 females) who underwent thoracic minimally invasive interventional treatment at Nanjing Drum Tower Hospital from January 2019 to June 2020 were included. Computed tomography images of 167 thoracic vertebral segments scanned in the prone position were collected. The width of the intertransverse space (D Results: No rib head/neck occlusion (D Conclusion: It is necessary to identify the spatial impact of the rib head/neck on the puncture path of the intervertebral foramina and design appropriate puncture angles for different segments.
Language	English
Publishing date	2021-07-03
Publishing country	United States
Document type	Journal Article
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v9.i18.4607
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Article: Systemic Colonization of

Wang, Dan-Juan / Shi, Jian-Cheng / Fan, Li / Wang, Ruo-Jing / Wei, Feng / Ma, Yang-Yang / Cai, Xiao-Lin / Fan, Si-Hao / Liang, Xia / Yang, Hong-Liang / Xing, Kun / Qiu, Li-Juan / Lu, Li-Juan / Li, Xi-Xuan / Wen, Ying-Qiang / Feng, Jia-Yue

Plant disease

2023 Volume 107, Issue 11, Page(s) 3542–3552

Abstract: Xanthomonas ... ...

Abstract	Xanthomonas fragariae
MeSH term(s)	Fragaria/microbiology ; Xanthomonas ; China
Language	English
Publishing date	2023-11-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-04-22-0783-RE
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Article: Accuracy study of a binocular-stereo-vision-based navigation robot for minimally invasive interventional procedures.

Wang, Ran / Han, Ying / Luo, Min-Zhou / Wang, Nai-Kun / Sun, Wei-Wei / Wang, Shi-Chong / Zhang, Hua-Dong / Lu, Li-Juan

World journal of clinical cases

2020 Volume 8, Issue 16, Page(s) 3440–3449

Abstract: Background: Medical robot is a promising surgical tool, but no specific one has been designed for interventional treatment of chronic pain. We developed a computed tomography-image based navigation robot using a new registration method with binocular ... ...

Abstract	Background: Medical robot is a promising surgical tool, but no specific one has been designed for interventional treatment of chronic pain. We developed a computed tomography-image based navigation robot using a new registration method with binocular vision. This kind of robot is appropriate for minimal invasive interventional procedures and easy to operate. The feasibility, accuracy and stability of this new robot need to be tested. Aim: To assess quantitatively the feasibility, accuracy and stability of the binocular-stereo-vision-based navigation robot for minimally invasive interventional procedures. Methods: A box model was designed for assessing the accuracy for targets at different distances. Nine (three sets) lead spheres were embedded in the model as puncture goals. The entry-to-target distances were set 50 mm (short-distance), 100 mm (medium-distance) and 150 mm (long-distance). Puncture procedure was repeated three times for each goal. The Euclidian error of each puncture was calculated and statistically analyzed. Three head phantoms were used to explore the clinical feasibility and stability. Three independent operators conducted foramen ovale placement on head phantoms (both sides) by freehand or under the guidance of robot (18 punctures with each method). The operation time, adjustment time and one-time success rate were recorded, and the two guidance methods were compared. Results: On the box model, the mean puncture errors of navigation robot were 1.7 ± 0.9 mm for the short-distance target, 2.4 ± 1.0 mm for the moderate target and 4.4 ± 1.4 mm for the long-distance target. On the head phantom, no obvious differences in operation time and adjustment time were found among the three performers ( Conclusion: In the laboratory environment, accuracy of binocular-stereo-vision-based navigation robot is acceptable for target at 100 mm depth or less. Compared with freehand, foramen ovale placement accuracy can be improved with robot guidance.
Language	English
Publishing date	2020-09-02
Publishing country	United States
Document type	Journal Article
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v8.i16.3440
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Article: Correlation between

Lu, Li-Juan / Hao, Ning-Bo / Liu, Jian-Jun / Li, Xue / Wang, Rui-Ling

Gastroenterology research and practice

2018 Volume 2018, Page(s) 7410801

Abstract: Background: Previous studies have suggested a link between : Methods: All enrolled participants underwent a carbon-13 urea breath test (: Results: The study included 1867 (393 females and 1474 males, aged 54.0 ± 9.6 years) people that took a ... ...

Abstract	Background: Previous studies have suggested a link between Methods: All enrolled participants underwent a carbon-13 urea breath test ( Results: The study included 1867 (393 females and 1474 males, aged 54.0 ± 9.6 years) people that took a physical examination. There was no significant difference in gender and age between the study participants with and without Conclusion: H. pylori
Language	English
Publishing date	2018-03-20
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2435460-0
ISSN	1687-630X ; 1687-6121
ISSN (online)	1687-630X
ISSN	1687-6121
DOI	10.1155/2018/7410801
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Article: Synthesis of dispirocyclopentyl-3,3â²-bisoxindoles via base promoted cyclization reaction of 3-phenacylideneoxindoles with nitromethane

Lu, Li-Juan / Chao-Guo Yan

Tetrahedron. 2014 Dec. 23, v. 70

2014

Abstract: A special kind of dispirocyclopentyl-3,3â²-bisoxindoles, in which the two oxindole units exist at 1,2-positions of the newly formed cyclopentyl ring, were conveniently prepared in 49â86% yields by cyclization reaction of nitromethane with two ... ...

Abstract	A special kind of dispirocyclopentyl-3,3â²-bisoxindoles, in which the two oxindole units exist at 1,2-positions of the newly formed cyclopentyl ring, were conveniently prepared in 49â86% yields by cyclization reaction of nitromethane with two molecules of 3-phenacylideneoxindoles in refluxing ethanol in the presence of DBU as base. The reaction has the advantages of readily available starting materials, operational simplicity, good yields, and high diastereoselectivity.
Keywords	chemical reactions ; chemical structure ; ethanol
Language	English
Dates of publication	2014-1223
Size	p. 9587-9591.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	204285-x
ISSN	1464-5416 ; 0040-4020 ; 0563-2064
ISSN (online)	1464-5416
ISSN	0040-4020 ; 0563-2064
DOI	10.1016/j.tet.2014.11.028
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Systemic Colonization of Xanthomonas fragariae Strain YL19 Causing Dry Cavity Rot of Strawberry Crown Tissue in China

Plant Disease. 2023 Nov. 01, v. 107, no. 11 p.3542-3552

2023

Abstract: Xanthomonas fragariae usually causes angular leaf spot (ALS) of strawberry, a serious bacterial disease in many strawberry-producing regions worldwide. Recently, a new strain of X. fragariae (YL19) was isolated from strawberry in China and has been shown ...

Abstract	Xanthomonas fragariae usually causes angular leaf spot (ALS) of strawberry, a serious bacterial disease in many strawberry-producing regions worldwide. Recently, a new strain of X. fragariae (YL19) was isolated from strawberry in China and has been shown to cause dry cavity rot in strawberry crown. In this study, we constructed a green fluorescent protein (GFP)-labeled Xf YL19 (YL19-GFP) to visualize the infection process and pathogen colonization in strawberries. Foliar inoculation of YL19-GFP resulted in the pathogen migrating from the leaves to the crown, whereas dip inoculation of wounded crowns or roots resulted in the migration of bacteria from the crowns or roots to the leaves. These two invasion types both resulted in the systematic spread of YL19-GFP, but inoculation of a wounded crown was more harmful to the strawberry plant than foliar inoculation. Results increased our understanding of the systemic invasion of X. fragariae, and the resultant crown cavity caused by Xf YL19.
Keywords	Xanthomonas fragariae ; green fluorescent protein ; leaf spot ; pathogens ; strawberries ; China ; colonization ; crown cavity ; green fluorescent protein (GFP) ; movement ; strawberry
Language	English
Dates of publication	2023-1101
Size	p. 3542-3552.
Publishing place	The American Phytopathological Society
Document type	Article ; Online
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-04-22-0783-RE
Database	NAL-Catalogue (AGRICOLA)

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