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  1. Article: Ultrasound-guided microwave ablation for giant breast leiomyoma: A case report.

    Zhang, Siqi / Wang, Lu / Yang, Jianquan / Lu, Man

    Frontiers in oncology

    2023  Volume 13, Page(s) 1095891

    Abstract: Rationale: Breast leiomyoma is the rarest non-epithelial tumor of the breast. As a benign tumor, its main treatment is regular follow-up. Surgical treatment is often used in clinical practice when patients have symptoms or strongly require treatment. ... ...

    Abstract Rationale: Breast leiomyoma is the rarest non-epithelial tumor of the breast. As a benign tumor, its main treatment is regular follow-up. Surgical treatment is often used in clinical practice when patients have symptoms or strongly require treatment. However, if the tumor is large or located around the nipple or areola, the cosmetic effect of surgery is not good, so it is urgent to find new treatment methods. We pioneered the use of microwave ablation in the treatment of giant breast leiomyoma and achieved good results.
    Patient concerns: A 37-year-old female was admitted to hospital because she found a breast mass of approximately 8 cm. She had no obvious clinical symptoms, but had great psychological pressure.
    Diagnosis: Pathological biopsy showed leiomyoma followingly the surgical operation of giant breast leiomyoma was planned. However, the breast mass was large, and the postoperative scar would affect the breast appearance.
    Interventions: The consent was obtained from the patient and her family. The Ultrasound-guided microwave ablation was successfully performed.
    Outcomes: The patient was followed up for 10 months, and the tumor volume ablation rate was 69.8%. The cosmetic effect of breast was excellent.
    Lessons: To our knowledge, this is the first case to using microwave ablation (MWA) for the treatment of breast leiomyoma. Ultrasound-guided MWA can be used for the treatment of breast leiomyoma, especially when the mass is large and requires traditional surgical resection. It can effectively improve the breast aesthetics and further improve the quality of life of patients. However, it is only a case report, and needs more research to verify MWA in breast leiomyoma.
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1095891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Value of transrectal ultrasound-guided biopsy in endoscopy negative biopsy patients with rectal lesions.

    Li, Tingting / Lu, Man / Li, Yuan / Yang, Wei

    BMC gastroenterology

    2023  Volume 23, Issue 1, Page(s) 173

    Abstract: Objective: To evaluate the value of transrectal ultrasound (TRUS) guided biopsy in endoscopy negative biopsy patients with rectal lesions.: Methods: 150 endoscopy negative biopsy result rectal lesions adopted the transrectal ultrasound-guided biopsy. ...

    Abstract Objective: To evaluate the value of transrectal ultrasound (TRUS) guided biopsy in endoscopy negative biopsy patients with rectal lesions.
    Methods: 150 endoscopy negative biopsy result rectal lesions adopted the transrectal ultrasound-guided biopsy. Based on whether the patients received contrast-enhanced ultrasound examination or not before the biopsies, all enrolled cases were divided into TRUS guided group and contrast-enhanced TRUS (CE-TRUS) guided group, and the safety and diagnostic performances were analyzed retrospectively.
    Results: We obtained adequate specimens in the majority of cases (98.7%,148/150); There were no complications identified in our study. 126 patients received contrast-enhanced TRUS examination before biopsy to evaluate vascular perfusion and necrosis. The sensitivity, specificity, PPV, NPV, and overall accuracy of all biopsies were 89.1%, 100%,100%, 70.4%, and 91.3% respectively; The sensitivity, specificity, PPV, NPV, and accuracy for TRUS-guided biopsy and CE-TRUS guided biopsy were 73.7%, 100%,100%, 50%,79.2% and 92.1%,100%,100%,75%,93.6% separately; The increase in correct diagnoses was significant (p < 0.05) between TRUS guided biopsy and CE-TRUS guided biopsy.
    Conclusion: TRUS-guided biopsy is a reliable procedure that can be augmented by endoscopic biopsy techniques if the biopsy yields negative results. CE-TRUS might assist in the location of the biopsy and decrease sampling errors.
    MeSH term(s) Humans ; Retrospective Studies ; Rectum ; Biopsy ; Ultrasonography ; Ultrasonography, Interventional ; Image-Guided Biopsy/methods
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-023-02806-3
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  3. Article ; Online: The Distinct Pattern of Granulomatous Lobular Mastitis with Erythema Nodosum: More Severe Conditions and Extensive Lesions.

    Zheng, Bilian / Lu, Man / Chen, Chuang / Sun, Shengrong

    Journal of investigative surgery : the official journal of the Academy of Surgical Research

    2023  Volume 36, Issue 1, Page(s) 2257770

    Abstract: Purpose: Granulomatous lobular mastitis (GLM) is a benign inflammatory disease of the mammary gland with unknown etiology. Erythema nodosum (EN) is a rare, extramammary symptom of GLM. The purpose of this article was to investigate the clinical features ...

    Abstract Purpose: Granulomatous lobular mastitis (GLM) is a benign inflammatory disease of the mammary gland with unknown etiology. Erythema nodosum (EN) is a rare, extramammary symptom of GLM. The purpose of this article was to investigate the clinical features of EN associated with GLM.
    Methods: We recruited 102 GLM patients diagnosed between December 2018 and December 2021 at Renmin Hospital of Wuhan University. The clinical characteristics and laboratory indices of the EN group (
    Results: The proportion of GLM patients with lesions involving ≥2 quadrants and high peripheral white blood cell count, absolute neutrophil count and neutrophil-to-lymphocyte ratio (NLR) was larger in the EN group than in the non-EN group (
    Conclusion: Our findings suggest that GLM concomitant with EN suggests the presence of a more severe condition and extensive lesions.
    MeSH term(s) Female ; Humans ; Erythema Nodosum/diagnosis ; Erythema Nodosum/epidemiology ; Erythema Nodosum/etiology ; Granulomatous Mastitis/complications ; Granulomatous Mastitis/diagnosis ; Lymphocytes ; Inflammation ; Neutrophils
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639444-9
    ISSN 1521-0553 ; 0894-1939
    ISSN (online) 1521-0553
    ISSN 0894-1939
    DOI 10.1080/08941939.2023.2257770
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comparison of Micro-flow Imaging and Contrast-Enhanced Ultrasound in Ultrasound-Guided Microwave Ablation of Benign Thyroid Nodules.

    Zhuang, Min / Lu, Man / Jiang, Zirui / Liang, Yin / Wang, Shishi / Wang, Lu / Li, Jiami

    Ultrasound in medicine & biology

    2024  Volume 50, Issue 5, Page(s) 729–734

    Abstract: Objective: The study described here was aimed at ascertaining the utility of micro-flow imaging (MFI) during ultrasound (US)-guided microwave ablation (MWA) of thyroid nodules by contrasting its effectiveness with that of contrast-enhanced ultrasound ( ... ...

    Abstract Objective: The study described here was aimed at ascertaining the utility of micro-flow imaging (MFI) during ultrasound (US)-guided microwave ablation (MWA) of thyroid nodules by contrasting its effectiveness with that of contrast-enhanced ultrasound (CEUS).
    Methods: Seventy-three patients with eighty-eight thyroid nodules who underwent US-guided MWA were included in our study from January 2020 to June 2023. Thirty-five patients underwent CEUS during the MWA process, and thirty-eight patients underwent MFI during the MWA process. We compared the two groups' baseline characteristics, tumor volume (V), volume reduction rate (VRR), complications and clinical characteristics.
    Results: Both groups exhibited similar outcomes with respect to V and VRR at 1, 3, 6, 12 and 18 mo after MWA (p > 0.05). Consistency was observed with respect to post-operative complications, supplementary ablation times and surgical duration (p > 0.05). It is worth noting that the MFI group had lower treatment costs compared with the CEUS group (11,337.64 ± 80.93 yuan for the MFI group versus 12,971.23 ± 254.89 yuan for the CEUS group, p < 0.05).
    Conclusion: In the MWA procedure for thyroid nodules, MFI is similar to CEUS with respect to safety and efficacy. Simultaneously, it offers the advantage of reducing surgical expenses, which lessens the economic burden for patients.
    MeSH term(s) Humans ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/surgery ; Thyroid Nodule/pathology ; Microwaves/therapeutic use ; Ultrasonography/methods ; Catheter Ablation/methods ; Ultrasonography, Interventional ; Treatment Outcome ; Retrospective Studies
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2024.01.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ultrasound-guided microwave ablation for treatment of lip cancer.

    Wei, Ting / Lu, Man / Wang, Lu / Xu, Jinshun / Zhuang, Min

    Journal of cancer research and therapeutics

    2023  Volume 19, Issue 6, Page(s) 1685–1688

    Abstract: Lip and oral cavity cancer is a severe and growing problem, ranked 16th for both incidence and mortality worldwide. These malignancies are mainly treated with surgery, which can cause a wide range of sequelae. Despite ultrasound-guided microwave ablation ...

    Abstract Lip and oral cavity cancer is a severe and growing problem, ranked 16th for both incidence and mortality worldwide. These malignancies are mainly treated with surgery, which can cause a wide range of sequelae. Despite ultrasound-guided microwave ablation (MWA) being widely used, there is no report concerning its application in lip cancer. This study presents a case of ultrasound-guided MWA in a 97-year-old man with squamous cell carcinoma (SCC) and lymph node metastases under the lower lip. The patient was unsuitable for surgery due to his older age. At the most recent 1-year follow-up after treatment, the patient remained in good condition with no symptoms of dysphagia or slurred speech, and the cosmetic results were excellent. Based on clinical evaluation and radiographic imaging, there was no evidence of metastasis or recurrence. Ultrasound-guided MWA could be a promising option for the management of lip cancer.
    MeSH term(s) Male ; Humans ; Aged, 80 and over ; Lip Neoplasms/diagnostic imaging ; Lip Neoplasms/surgery ; Microwaves/therapeutic use ; Lymphatic Metastasis ; Catheter Ablation/methods ; Ultrasonography, Interventional ; Treatment Outcome ; Retrospective Studies
    Language English
    Publishing date 2023-12-28
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/jcrt.jcrt_190_23
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  6. Article: Multi-Omics Analysis of the Prognostic and Immunological Role of Runt-Related Transcription Factor 3 in Pan-Cancer.

    Zhou, Quan / Ding, Dou-Dou / Lu, Man / Zuo, Man-Zhen

    Critical reviews in eukaryotic gene expression

    2023  Volume 33, Issue 4, Page(s) 63–83

    Abstract: Runt-related transcription factor 3 (RUNX3) plays a pivotal role in tumor microenvironment and immune infiltration. However, the prognostic and immunological roles of RUNX3 in pancancer remain unclear. In the current study, we explored the expression ... ...

    Abstract Runt-related transcription factor 3 (RUNX3) plays a pivotal role in tumor microenvironment and immune infiltration. However, the prognostic and immunological roles of RUNX3 in pancancer remain unclear. In the current study, we explored the expression profiles, prognostic landscape, and immune infiltration of RUNX3 in pancancer through a variety of online platforms, including HPA, ONCOMINE, UALCAN, GEPIA, PrognoScan, TCGA, TIMER, R2, and Reactome databases. In general, RUNX3 was widely expressed in tonsil, gallbladder, skin, spleen, lymph node, and bone marrow, and RUNX3 was frequently higher expression in tumor tissues compared to normal tissues. In prognostic analysis, the RUNX3 expression level was significantly correlated with the clinical outcomes of bladder cancer, blood cancer, brain cancer, breast cancer, colorectal cancer, lung cancer, and ovarian cancer. In mutation analysis, a total 72 mutation sites were located within amino acids 1 to 415 of RUNX3, including 65 missense sites and seven truncating sites, whereas the mutation frequency of skin cutaneous melanoma and uterine corpus endometrial carcinoma (UCEC) is relatively high (> 3%). In immune infiltration analysis, the RUNX3 expression level was significantly related to recognized markers and the immune infiltration levels of various types of immune cells in colon adenocarcinoma (COAD) and brain lower grade glioma (LGG). After that, 453 RUNX3 co-expressed genes were recognized in COAD, lymphoid neoplasm diffuse large B-cell lymphoma, LGG, and ovarian serous cystadenocarcinoma (OV). Pathway enrichment analysis revealed that RUNX3 co-expressed genes were remarkably enriched in immune system and tumor progression pathways. RUNX3 expression is associated with clinical prognosis, immune infiltration, and identified RUNX3 related pathways in a variety of tumors, which may serve as targets of promising prognostic markers and novel therapeutic targets for various human cancers.
    MeSH term(s) Humans ; Melanoma ; Transcription Factor 3 ; Prognosis ; Adenocarcinoma ; Multiomics ; Skin Neoplasms ; Colonic Neoplasms ; Glioma ; Tumor Microenvironment/genetics ; Melanoma, Cutaneous Malignant
    Chemical Substances Transcription Factor 3
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071345-1
    ISSN 1045-4403
    ISSN 1045-4403
    DOI 10.1615/CritRevEukaryotGeneExpr.2023044081
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  7. Article: Recent Perspectives on the Mechanism of Recurrence After Ablation of Hepatocellular Carcinoma: A Mini-Review.

    Yang, Jianquan / Guo, Wen / Lu, Man

    Frontiers in oncology

    2022  Volume 12, Page(s) 895678

    Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Hepatectomy, liver transplantation, and ablation are the three radical treatments for early-stage hepatocellular carcinoma (ESHCC), but not all patients are fit for or can ... ...

    Abstract Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Hepatectomy, liver transplantation, and ablation are the three radical treatments for early-stage hepatocellular carcinoma (ESHCC), but not all patients are fit for or can tolerate surgery; moreover, liver donors are limited. Therefore, ablation plays an important role in the treatment of ESHCC. However, some studies have shown that ablation has a higher local recurrence (LR) rate than hepatectomy and liver transplantation. The specific mechanism is unknown. The latest perspectives on the mechanism of recurrence after ablation of HCC were described and summarized. In this review, we discussed the possible mechanisms of recurrence after ablation of HCC, including epithelial-mesenchymal transition (EMT), activating autophagy, changes in non-coding RNA, and changes in the tumor microenvironment. A systematic and comprehensive understanding of the mechanism will contribute to the research and development of related treatment, combined with ablation to improve the therapeutic effect in patients with ESHCC.
    Language English
    Publishing date 2022-08-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.895678
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  8. Article ; Online: Confusion about the article: Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ.

    Yang, Jianquan / Guo, Wen / Lu, Man

    Cancer letters

    2022  Volume 534, Page(s) 115568

    MeSH term(s) Biological Products/pharmacology ; Diterpenes ; Epoxy Compounds ; Head and Neck Neoplasms/drug therapy ; Hexokinase ; Humans ; Phenanthrenes ; Pyroptosis
    Chemical Substances Biological Products ; Diterpenes ; Epoxy Compounds ; Phenanthrenes ; triptolide (19ALD1S53J) ; Hexokinase (EC 2.7.1.1)
    Language English
    Publishing date 2022-02-04
    Publishing country Ireland
    Document type Journal Article ; Review ; Comment
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2022.01.021
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  9. Article ; Online: The Value of IOTA Simple Rules Combined With CEUS Scoring System in the Diagnosis of Benign and Malignant Ovarian Masses and Its Correlation With MVD and VEGF: A Preliminary Study.

    Liu, Chun / Li, Yuan / Zhu, Yi / Lu, Man

    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

    2022  Volume 41, Issue 12, Page(s) 2983–2992

    Abstract: Objectives: To investigate the diagnostic value of International Ovarian Tumor Analysis (IOTA) simple rules combined with contrast-enhanced ultrasound (CEUS) scoring system in the differential diagnosis of ovarian tumors, and the correlations of the ... ...

    Abstract Objectives: To investigate the diagnostic value of International Ovarian Tumor Analysis (IOTA) simple rules combined with contrast-enhanced ultrasound (CEUS) scoring system in the differential diagnosis of ovarian tumors, and the correlations of the scoring system with microvessel density (MVD) and vascular endothelial growth factor (VEGF).
    Methods: One hundred eighty-nine patients with ovarian tumors were examined by routine ultrasound and CEUS. The enhanced characteristics of CEUS were observed, and the masses were classified by IOTA simple rules. To compare the diagnostic value of IOTA simple rules combined with CEUS scoring system and IOTA simple rules in the diagnosis of ovarian tumors. Immunohistochemistry was used to detect the expression of MVD and VEGF in postoperative tissue samples. The correlations between the new scoring system with MVD and VEGF were analyzed.
    Results: The sensitivity (93.98%), specificity (94.34%), positive predictive value (92.86%), negative predictive value (95.24%), and accuracy (94.18%) of IOTA simple rules combined with CEUS scoring system in the diagnosis of ovarian tumors were higher than those of IOTA simple rules alone (all P < .05). The score system was significantly positively correlated with MVD and VEGF, and the r values were 0.77 and 0.63, respectively (P < .001).
    Conclusions: IOTA simple rules combined with CEUS scoring system was helpful to improve the accuracy of ultrasound diagnosis of ovarian tumors, which was significantly correlated with MVD and VEGF. It could provide important reference information for treatment scheme formulation and prognosis evaluation.
    MeSH term(s) Female ; Humans ; Vascular Endothelial Growth Factor A ; Microvascular Density ; Sensitivity and Specificity ; Ultrasonography ; Ovarian Neoplasms/diagnostic imaging ; Ovarian Neoplasms/pathology ; Diagnosis, Differential
    Chemical Substances Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2022-04-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 604829-8
    ISSN 1550-9613 ; 0278-4297
    ISSN (online) 1550-9613
    ISSN 0278-4297
    DOI 10.1002/jum.15999
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  10. Article ; Online: Letter to the editor regarding"Radiosensitivity of colorectal cancer and radiation-induced gut damages are regulated by gasdermin E″.

    Yang, Jianquan / Guo, Wen / Lu, Man

    Cancer letters

    2022  Volume 534, Page(s) 115569

    MeSH term(s) Colorectal Neoplasms/radiotherapy ; Humans ; Radiation Tolerance
    Language English
    Publishing date 2022-02-11
    Publishing country Ireland
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2022.01.022
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