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  1. Article ; Online: Taiwan's assistance in providing oral care for special needs patients in New South Bound countries.

    Huang, Tsui-Hsien / Yu, Chuan-Hang / Lu, Ming-Yi / Kao, Chia-Tze

    Journal of dental sciences

    2023  Volume 19, Issue 1, Page(s) 661–662

    Language English
    Publishing date 2023-11-11
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2023.10.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Maxillomandibular advancement surgery can alleviate mental health issues associated with obstructive sleep apnea syndrome.

    Kao, Chuan-Yi / Kao, Chia-Tze / Lu, Ming Yi / Huang, Tsui-Hsien

    Journal of dental sciences

    2023  Volume 19, Issue 2, Page(s) 1263–1265

    Language English
    Publishing date 2023-11-22
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2023.10.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Interns' perception of haptic virtual reality oral surgery simulator learning for impacted lower third molar extraction.

    Lu, Ming-Yi / Peng, Chih-Yu / Chang, Yu-Chao

    Journal of dental sciences

    2022  Volume 17, Issue 4, Page(s) 1825–1826

    Language English
    Publishing date 2022-07-30
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2022.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effective dose and radiation risk under 640-slice abdominal computed tomography examination without contrast medium injection.

    Lu, Ming-Yi / Ting, Chien-Yi / Jao, Jo-Chi

    Journal of X-ray science and technology

    2022  Volume 30, Issue 4, Page(s) 657–666

    Abstract: Background: Medical imaging plays a crucial role in modern medicine. In order to provide fast and accurate medical diagnosis, computed tomography (CT) is a commonly used tool in radiological examinations, and 640-slice CT is the most advanced CT imaging ...

    Abstract Background: Medical imaging plays a crucial role in modern medicine. In order to provide fast and accurate medical diagnosis, computed tomography (CT) is a commonly used tool in radiological examinations, and 640-slice CT is the most advanced CT imaging modality.
    Objective: To evaluate the radiation dose and the risk under 640-slice abdominal CT examination.
    Methods: Examinations were performed using a 640-slice CT scanner on an Alderson-Rando anthropomorphic phantom. The used scanning acquisition parameters were the same as those used on abdominal examination without contrast medium injection in clinical practice. To measure the absorbed doses, optically stimulated luminescence dosimeters (OSLDs) were put into liver, stomach, bladder, gonads, colon, small intestine, bone marrow, and skin.
    Results: According to the 1990 Recommendations of the International Commission on Radiological Protection (ICRP Publication 60), the calculated effective doses received from this examination were 0.90 mSv in males and 0.89 mSv in females. According to the 2007 Recommendations of the International Commission on Radiological Protection (ICRP Publication 103), the calculated effective dose received from this examination was 0.83 mSv in both sexes.
    Conclusions: Radiation doses obtained from the abdominal 640-slice CT examination are lower than the yearly cumulative doses received from natural radiation, revealing there is no deterministic effect and radiation risk is relatively low; therefore, this CT examination is considered safe.
    MeSH term(s) Female ; Humans ; Male ; Phantoms, Imaging ; Radiation Dosage ; Radiation Protection ; Tomography Scanners, X-Ray Computed ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-04-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012019-9
    ISSN 1095-9114 ; 0895-3996
    ISSN (online) 1095-9114
    ISSN 0895-3996
    DOI 10.3233/XST-211101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: CO2 and diode lasers-combined excision of a recurrent pyogenic granuloma.

    Su, Ni-Yu / Lu, Ming-Yi / Chang, Yu-Chao

    Journal of dental sciences

    2021  Volume 16, Issue 4, Page(s) 1323–1324

    Language English
    Publishing date 2021-03-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2021.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Use of reconstruction plates prebent on three-dimensional models to reduce the complications of mandibular reconstruction.

    Chiu, Yu-Wei / Chen, Pei-Yin / Chen, Yen-Lin / Peng, Chih-Yu / Lu, Ming-Yi / Chen, Yi-Tzu / Yang, Cheng-Chieh

    Journal of dental sciences

    2023  Volume 19, Issue 1, Page(s) 473–478

    Abstract: Background/purpose: Though the gold standard method for mandible reconstruction of the defect from segmental mandibulectomy is by osseous flap or graft, using reconstruction plates is still indicated in some cases. Traditionally, the plate is bended ... ...

    Abstract Background/purpose: Though the gold standard method for mandible reconstruction of the defect from segmental mandibulectomy is by osseous flap or graft, using reconstruction plates is still indicated in some cases. Traditionally, the plate is bended immediately after the segmental mandibulectomy by freehand. However, it's difficult to fit well to the original position of mandible, which may result in more complications. This study therefore aimed to investigate whether using prebent plates on computer-aided 3D printing models could reduce the complication rate.
    Materials and methods: Patients who received mandible reconstruction by reconstruction plate from 2018 to 2022 were enrolled and evaluated in this study. The data, including demographics, indications for surgery, pre-existed preoperative and postoperative therapies, classification of defects, and postoperative outcomes were collected and analyzed.
    Results: A total of 52 patients were enrolled in our study. The prebent group exhibited a significantly lower complication rate than that of the immediately bent group (
    Conclusion: Prebent plates on computer-aided printing models proved to be an effective approach to reduce the complications for mandibular reconstruction in segmental mandibulectomy.
    Language English
    Publishing date 2023-09-14
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2023.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The functional roles of microRNAs in the pathogenesis of oral submucous fibrosis.

    Hsieh, Pei-Ling / Chen, Szu-Han / Huang, Yu-Feng / Lu, Ming-Yi / Yu, Cheng-Chia

    Journal of dental sciences

    2021  Volume 17, Issue 2, Page(s) 683–687

    Abstract: Oral potentially malignant disorders (OPMD) are lesions that may precede the onset of cancers in the oral cavity, and oral submucosal fibrosis (OSF) is one of the OPMD that is usually found in the buccal mucosa. Considerable effort has been made to ... ...

    Abstract Oral potentially malignant disorders (OPMD) are lesions that may precede the onset of cancers in the oral cavity, and oral submucosal fibrosis (OSF) is one of the OPMD that is usually found in the buccal mucosa. Considerable effort has been made to elucidate the pathogenesis of OSF, and emerging evidence has suggested that microRNAs may play significant roles in the development of OSF. Several studies demonstrated that aberrant expression of miRNAs is also observed in the fibrotic BMFs (fBMFs) derived from OSF tissues. For instance, it has been shown that miR-10b, miR-21, and miR-1246 are significantly elevated, and miR-29b, miR-200b, and miR-200c are reduced in fBMFs. This review systematically summarizes the current knowledge regarding the aberrant expression of microRNAs, molecular mechanisms underlying oral fibrogenesis by the dysregulated microRNAs, and how the interaction between microRNAs and long non-coding RNAs contributes to the progression of OSF. An overview of the modes of action by these microRNAs will provide a fundamental basis for clinical application.
    Language English
    Publishing date 2021-08-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2021.07.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: LINC00084/miR-204/ZEB1 Axis Mediates Myofibroblastic Differentiation Activity in Fibrotic Buccal Mucosa Fibroblasts: Therapeutic Target for Oral Submucous Fibrosis.

    Lee, Yu-Hsien / Liao, Yi-Wen / Lu, Ming-Yi / Hsieh, Pei-Ling / Yu, Cheng-Chia

    Journal of personalized medicine

    2021  Volume 11, Issue 8

    Abstract: Oral submucosal fibrosis (OSF) is a precancerous condition in the oral cavity and areca nut consumption has been regarded as one of the etiologic factors implicated in the development of OSF via persistent activation of buccal mucosal fibroblasts (BMFs). ...

    Abstract Oral submucosal fibrosis (OSF) is a precancerous condition in the oral cavity and areca nut consumption has been regarded as one of the etiologic factors implicated in the development of OSF via persistent activation of buccal mucosal fibroblasts (BMFs). It has been previously reported that an epithelial to mesenchymal transition (EMT) factor, ZEB1, mediated the areca nut-associated myofibroblast transdifferentiation. In the current study, we aimed to elucidate how areca nut affected non-coding RNAs and the subsequent myofibroblast activation via ZEB1. We found that long non-coding RNA LINC00084 was elicited in the BMFs treated with arecoline, a major alkaloid of areca nut, and silencing LINC00084 prevented the arecoline-induced activities (such as collagen gel contraction, migration, and wound healing capacities). The upregulation of LINC00084 was also observed in the OSF tissues and fibrotic BMFs (fBMFs), and positively correlated with several fibrosis factors. Moreover, we showed knockdown of LINC00084 markedly suppressed the myofibroblast features in fBMFs, including myofibroblast phenotypes and marker expression. The results from the luciferase reporter assay confirmed that LINC00084 acted as a sponge of miR-204 and miR-204 inhibited ZEB1 by directly interacting with it. Altogether, these findings suggested that the constant irritation of arecoline may result in upregulation of LINC00084 in BMFs, which increased the ZEB1 expression by sequestering miR-204 to induce myofibroblast transdifferentiation.
    Language English
    Publishing date 2021-07-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11080707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: miR-146a participates in the regulation of cancer stemness of oral carcinoma cells.

    Liu, Yen-Tze / Yu, Cheng-Chia / Lu, Ming-Yi / Chao, Shih-Chi / Liao, Yi-Wen / Yu, Chuan-Hang / Lee, Yu-Hsien

    Journal of dental sciences

    2022  Volume 18, Issue 2, Page(s) 503–509

    Abstract: Background/purpose: Increasing evidence regarded the existence of cancer stem cells (CSCs) as a leading cause of therapy failure and tumor relapse due to their self-renewal and differentiation abilities. Although ectopic overexpression of micro-RNAs ( ... ...

    Abstract Background/purpose: Increasing evidence regarded the existence of cancer stem cells (CSCs) as a leading cause of therapy failure and tumor relapse due to their self-renewal and differentiation abilities. Although ectopic overexpression of micro-RNAs (miRNAs) can modulate the cancer stemness and tumor development in oral cancer, their molecular mechanism is still unclear. Therefore, in the present study, we attempt to uncover the role of miR-146a in the maintenance of oral CSCs.
    Materials and methods: The expression of miR-146a was determined using qRT-PCR analysis. Aldehyde dehydrogenase (ALDH) enzymic activity and sphere formation assays were used to evaluate the cancer stemness and self-renewal, respectively. Functional assays, including migration/invasion Transwell and colony formation assay, were used to evaluate the aggressive abilities. Luciferase reporter assay was performed to validate the relationship between miR-146a and Numb.
    Results: In the present study, we reported an increased expression of miR-146a in the oral squamous cell carcinoma (OSCC) specimen, primary OSCC cells sphere, and high ALDH1 activity population within OSCC cells. Inhibition of miR-146a significantly suppressed the ALDH1 activity, self-renewal capacity, and aggressive abilities, including migration, invasion, and colony formation. Moreover, we demonstrated that Numb is a functional target of miR-146a in OSCC-CSCs. Notably, silencing of Numb could retrieve the self-renewal and migration impaired by knockdown of miR-146a.
    Conclusion: Our results indicate that miR-146a can regulate the cancer stemness in OSCC by modulating Numb, and hence miR-146a/Numb axis can serve as a potential target for oral cancer therapy.
    Language English
    Publishing date 2022-09-28
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2022.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: miR-509 inhibits cancer stemness properties in oral carcinomas via directly targeting PlK1.

    Lu, Ming-Yi / Fang, Chih-Yuan / Hsieh, Pei-Ling / Liao, Yi-Wen / Tsai, Lo-Lin / Yu, Cheng-Chia

    Journal of dental sciences

    2021  Volume 17, Issue 2, Page(s) 653–658

    Abstract: Background/purpose: Oral cancer is one of the common cancers worldwide. Emerging evidence has indicated that microRNAs (non-coding RNA molecules of approximately 22 nucleotides in length) are implicated in the regulation of cancer stemness. However, the ...

    Abstract Background/purpose: Oral cancer is one of the common cancers worldwide. Emerging evidence has indicated that microRNAs (non-coding RNA molecules of approximately 22 nucleotides in length) are implicated in the regulation of cancer stemness. However, the functional role of microRNA-509 (miR-509) in the characteristics of oral cancer stem cells (CSCs) has not been unraveled.
    Materials and methods: The expression level of miR-509 in ALDH1
    Results: We showed the expression of miR-509 was downregulated in the CSCs derived from oral cancer cells (SAS), and upregulation of miR-509 diminished the several CSCs features, including ALDH1 activity, self-renewal capacity, CD44 expression, migration, and colony-forming abilities. Moreover, the result from the luciferase reporter assay validated the direct binding of miR-509 to plk1.
    Conclusion: Our results suggest that the miR-509/plk1 axis may mediate the cancer stemness in oral cancer, and targeting this axis may attenuate the progression of oral cancer.
    Language English
    Publishing date 2021-10-08
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2021.09.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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