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Article: Revisiting decade-old questions in proanthocyanidin biosynthesis: current understanding and new challenges.

Lu, Nan

2024 Volume 15, Page(s) 1373975

Abstract: Proanthocyanidins (PAs), one of the most abundant natural polymers found in plants, are gaining increasing attention because of their beneficial effects for agriculture and human health. The study of PA biosynthesis has been active for decades, and ... ...

Abstract	Proanthocyanidins (PAs), one of the most abundant natural polymers found in plants, are gaining increasing attention because of their beneficial effects for agriculture and human health. The study of PA biosynthesis has been active for decades, and progress has been drastically accelerated since the discovery of key enzymes such as Anthocyanidin Reductase (ANR), Leucoanthocyanidin Reductase (LAR), and key transcription factors such as Transparent Testa 2 (TT2) and Transparent Testa 8 (TT8) in the early 2000s. Scientists raised some compelling questions regarding PA biosynthesis about two decades ago in the hope that addressing these questions would lead to an enhanced understanding of PA biosynthesis in plants. These questions focus on the nature of starter and extension units for PA biosynthesis, the stereochemistry of PA monomers and intermediates, and how and where the polymerization or condensation steps work subcellularly. Here, I revisit these long-standing questions and provide an update on progress made toward answering them. Because of advanced technologies in genomics, bioinformatics and metabolomics, we now have a much-improved understanding of functionalities of key enzymes and identities of key intermediates in the PA biosynthesis and polymerization pathway. Still, several questions, particularly the ones related to intracellular PA transportation and deposition, as well as enzyme subcellular localization, largely remain to be explored. Our increasing understanding of PA biosynthesis in various plant species has led to a new set of compelling open questions, suggesting future research directions to gain a more comprehensive understanding of PA biosynthesis.
Language	English
Publishing date	2024-03-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2024.1373975
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Biophysical and economic constraints on China's natural climate solutions. RB p789

Lu, Nan

Nature climate change

2022 Volume 12, Issue 9, Page(s) 847

Language	English
Document type	Article
ZDB-ID	2614383-5
ISSN	1758-678x
Database	Current Contents Nutrition, Environment, Agriculture

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Article: The dynamics of nocturnal sap flow components of a typical revegetation shrub species on the semiarid Loess Plateau, China.

Fang, Weiwei / Liu, Jianbo / Lu, Nan / Li, Ruiping

Frontiers in plant science

2024 Volume 15, Page(s) 1370362

Abstract: Introduction: The components of nighttime sap flux (En), which include transpiration (Qn) and stem water recharge (Rn), play important roles in water balance and drought adaptation in plant communities in water-limited regions. However, the quantitative ...

Abstract	Introduction: The components of nighttime sap flux (En), which include transpiration (Qn) and stem water recharge (Rn), play important roles in water balance and drought adaptation in plant communities in water-limited regions. However, the quantitative and controlling factors of En components are unclear. Methods: This study used the heat balance method to measure sap flow density in Results: The results showed that the mean values were 1.04 and 2.34 g h Discussion: These results provided a new understanding of ecophysiological responses and adaptation of
Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2024.1370362
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Article ; Online: Relationship Between Coronary Artery Revascularization and Postoperative Delirium: Progress and Perspectives.

Lu, Nan / Chi, Yunpeng / Liu, Meiyan

Angiology

2024 , Page(s) 33197241252467

Abstract: Brain dysfunction resulting from damage to the heart-brain link leads to a decline in cognitive function. This, in turn, gives rise to the clinical symptom of perioperative delirium in patients undergoing coronary artery revascularization. Those affected ...

Abstract	Brain dysfunction resulting from damage to the heart-brain link leads to a decline in cognitive function. This, in turn, gives rise to the clinical symptom of perioperative delirium in patients undergoing coronary artery revascularization. Those affected are provided symptomatic treatment, but many do not recover fully. Thus, medium- and long-term mortality and adverse event rates remain relatively high in patients with perioperative delirium. Despite the relatively high incidence of perioperative delirium in patients undergoing coronary artery revascularization, it has not been systematically investigated. Inflammation, vascular damage, neuronal damage, and embolism are all involved in the injury process. Here, we discuss the incidence rate, pathological mechanisms, and prognosis of delirium after coronary artery revascularization. We also discuss in detail the risk factors for delirium after coronary artery revascularization, such as anxiety, depression, mode of operation, and drug use. We hope that prevention, early diagnosis, assessment, and potential treatment can be achieved by cardiologists to improve patient prognosis.
Language	English
Publishing date	2024-05-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80040-5
ISSN	1940-1574 ; 0003-3197
ISSN (online)	1940-1574
ISSN	0003-3197
DOI	10.1177/00033197241252467
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Article ; Online: Surface-surface contacted direct Z-scheme TiO

Wang, Yaqi / Lu, Nan / Quan, Xie

Chemosphere

2024 Volume 351, Page(s) 141210

Abstract: Bisphenols (BPs) are a series of widely used endocrine disruptors, which potentially harm the environment and human health. In this work, a novel Z-scheme ... ...

Abstract	Bisphenols (BPs) are a series of widely used endocrine disruptors, which potentially harm the environment and human health. In this work, a novel Z-scheme TiO
MeSH term(s)	Humans ; Phenols/chemistry ; Benzhydryl Compounds/chemistry ; Phenol ; Endocrine Disruptors ; Sunlight
Chemical Substances	bisphenol A (MLT3645I99) ; Phenols ; Benzhydryl Compounds ; Phenol (339NCG44TV) ; Endocrine Disruptors
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141210
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Article ; Online: Perceived neighborhood environment, social capital and life satisfaction among older adults in Shanghai, China.

Lu, Nan / Wu, Bei

Scientific reports

2022 Volume 12, Issue 1, Page(s) 6686

Abstract: This study examined the mediator role of social capital on the association between perceived neighborhood environment and life satisfaction among older adults in urban China, and further tested the moderating effect of gender in the above paths (i.e., ... ...

Abstract	This study examined the mediator role of social capital on the association between perceived neighborhood environment and life satisfaction among older adults in urban China, and further tested the moderating effect of gender in the above paths (i.e., from neighborhood environment to life satisfaction; from neighborhood environment to social capital; from social capital to life satisfaction). We used quota sampling approach to recruit 472 respondents aged 60 years old or older in Shanghai in 2020. From the perspective of structural equation modeling, multiple group analysis was conducted to examine the proposed hypotheses. The measurement model of social capital was well established in urban Chinese community contexts. Based on the whole sample, the results of the mediation model showed that social capital played a mediation role in the association between neighborhood environment and life satisfaction. Furthermore, the results of multiple group analysis showed that the association between neighborhood environment and cognitive social capital was only significant among older women. The findings highlight the role of neighborhood environment and social capital in building age-friendly communities.
MeSH term(s)	Aged ; Asians ; China ; Female ; Humans ; Middle Aged ; Personal Satisfaction ; Residence Characteristics ; Social Capital ; Social Environment
Language	English
Publishing date	2022-04-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-10742-7
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Article ; Online: How does neighbourhood environment influence loneliness in later life in Urban China? The role of financial status.

Zhang, Jingyue / Lu, Nan

Health & social care in the community

2022 Volume 30, Issue 6, Page(s) e5314–e5325

Abstract: This study aimed to examine whether older adults' financial status moderated the association between neighbourhood environment (i.e. physical and social environment) and loneliness among older adults in urban China. A cross-sectional survey was collected ...

Abstract	This study aimed to examine whether older adults' financial status moderated the association between neighbourhood environment (i.e. physical and social environment) and loneliness among older adults in urban China. A cross-sectional survey was collected from urban communities of Shanghai in mid-2020. The final analytic sample was 459 older adults (age range = 60-91 years; proportion of women: 55.8%). Multiple group analysis was applied to test the hypothesised model. A measurement model of community social capital (i.e. cognitive and structural dimensions of social capital), a crucial indicator of neighbourhood social environment, was first established in both high-income and low-income groups. Factor loading invariance was established in these two groups. The results show that structural social capital (i.e. organisation memberships, volunteering, social participation and citizenship activities) was negatively associated with loneliness among older respondents from the high-income group only, whereas better community security was significantly associated with lower levels of loneliness among low-income older respondents only. The findings imply that both structural social capital and household income should be considered as important indicators in needs assessment among lonely older adults. Future social policies and interventions should pay attention to enhancing the role of both social and physical neighbourhood environment among older adults.
MeSH term(s)	Female ; Humans ; Aged ; Middle Aged ; Aged, 80 and over ; Loneliness/psychology ; China ; Cross-Sectional Studies ; Social Support ; Social Capital ; Neighborhood Characteristics
Language	English
Publishing date	2022-08-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1155902-0
ISSN	1365-2524 ; 0966-0410
ISSN (online)	1365-2524
ISSN	0966-0410
DOI	10.1111/hsc.13950
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Article ; Online: A multiple-group analysis of social Capital and loneliness among community-dwelling older adults in urban China during the outbreak of the COVID-19 pandemic.

Lu, Nan / Zhang, Jingyue

Aging & mental health

2022 Volume 27, Issue 7, Page(s) 1368–1376

Abstract: Objectives: The present study examined the moderating effects of family social capital on the relationship between community social capital and loneliness among older adults in urban Chinese communities during the COVID-19 outbreak period between ... ...

Abstract	Objectives: The present study examined the moderating effects of family social capital on the relationship between community social capital and loneliness among older adults in urban Chinese communities during the COVID-19 outbreak period between January and March 2020.
Language	English
Publishing date	2022-08-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1474804-6
ISSN	1364-6915 ; 1360-7863
ISSN (online)	1364-6915
ISSN	1360-7863
DOI	10.1080/13607863.2022.2116394
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Article ; Online: Analysis of soil fertility and toxic metal characteristics in open-pit mining areas in northern Shaanxi.

Wang, Na / Liu, Zhe / Sun, Yingying / Lu, Nan / Luo, Yuhu

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2273

Abstract: The study specifically focused on the Hongliulin mining area, where a total of 40 soil samples were meticulously collected and analyzed from within a 1000 m radius extending from the tailings dam. The findings revealed that soil pH within the 0-1000 m ... ...

Abstract	The study specifically focused on the Hongliulin mining area, where a total of 40 soil samples were meticulously collected and analyzed from within a 1000 m radius extending from the tailings dam. The findings revealed that soil pH within the 0-1000 m range generally leaned towards the alkaline side. In terms of soil nutrient content, encompassing factors such as soil organic matter (SOM), total nitrogen (TN), total phosphorus (TP), total potassium (TK), alkali nitrogen (AK), available phosphorus (AP), and quick-acting potassium (AK), the variations fell within the following ranges: 2.23-13.58 g/kg, 0.12-0.73 g/kg, 0.18-1.15 g/kg, 9.54-35.82 g/kg, 2.89-6.76 mg/kg, 3.45-11.25 mg/kg, and 5.86-130.9 mg/kg. Collectively, these values indicate relatively low levels of soil nutrients. Within the 0-500 m range of soil samples, the average concentrations of Cd, Hg, Pb, and As were 0.778, 0.198, 24.87, and 17.92 mg/kg, respectively. These concentrations exceeded the established soil background values of Shaanxi Province and emerged as the primary pollutants in the study area. Within this same range, the mean values of eight toxic metals (Pi) were ranked in the following descending order: 1.726 (Hg), 1.400 (As), 1.129 (Cr), 1.109 (Pb), 0.623 (Zn), 0.536 (Cd), 0.309 (Cu), and 0.289 (Ni). With the exception of Hg, As, Cr, and Pb, which exhibited slight pollution, the other toxic metals were found to be within acceptable pollution limits for this sampling range, in line with the results obtained using the geo-accumulation index method. The average potential ecological risk index for the eight toxic metals in the study area stood at 185.0, indicating a moderate overall pollution level. When assessing individual elements, the proportions of ecological risk attributed to Hg, As, Pb, and Cd were 34.57%, 27.44%, 25.11%, and 23.11%, respectively. This suggests that the primary potential ecological risk elements in the study area are Hg and As, followed by Cd and Pb. Notably, toxic metals Hg and Pb, as well as As and Pb, exhibited significant positive correlations within the sampling area, suggesting a common source. An analysis of the relationship between soil physicochemical properties and toxic metals indicated that soil pH, SOM, TN, and TP were closely linked to toxic metal concentrations. The toxic metal elements in the research area's soil exhibit moderate variability (0.16 < CV < 0.36) to high variability (CV > 0.36). Within the range of 0-200 m, the CV values for Cd and Hg exceed 1, indicating a high level of variability. The coefficient of variation for SOM, TP, AP, AK and TK is relatively high with the of 2.93, 2.36, 2.36, 21.01, 7.54. The soil in the sampling area has undergone significant disturbances due to human activities, resulting in toxic metal pollution and nutrient deficiencies.
MeSH term(s)	Humans ; Soil/chemistry ; Metals, Heavy/toxicity ; Metals, Heavy/analysis ; Cadmium/analysis ; Lead/analysis ; Soil Pollutants/toxicity ; Soil Pollutants/analysis ; Environmental Monitoring/methods ; Risk Assessment ; Mining ; Mercury/analysis ; Nitrogen/analysis ; Phosphorus/analysis ; Potassium/analysis ; China
Chemical Substances	Soil ; Metals, Heavy ; Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Soil Pollutants ; Mercury (FXS1BY2PGL) ; Nitrogen (N762921K75) ; Phosphorus (27YLU75U4W) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2024-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52886-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Could nerve transplantation be the future of this field: a bibliometric analysis about lumbosacral plexus injury.

Wang, Sheng / Xia, Demeng / Song, Danyan / Lu, Nan / Chen, Aimin

International journal of surgery (London, England)

2024

Abstract: Background: Lumbosacral plexus injury is a highly distressing clinical issue with profound implications for patients' quality of life. Since the publication of the first relevant study in 1953, there has been very limited progress in basic research and ... ...

Abstract	Background: Lumbosacral plexus injury is a highly distressing clinical issue with profound implications for patients' quality of life. Since the publication of the first relevant study in 1953, there has been very limited progress in basic research and clinical treatment in this field, and the developmental trajectory and research priorities in this field have not been systematically summarized using scientific methods, leaving the future direction of this research to be explored. Methods: Utilizing publications from the Web of Science (WoS) database, our research employed bibliometric methodology to analyze the fundamental components of publications, synthesize research trends, and forecast future directions. Results: A total of 150 publications were included in our study, and the impressive advancement of research heat in this field can be attributed to the continuous increase in the number of papers, ranging from 14 papers in 2000 to 34 papers in 2023 over five years. Regarding the country, a central position in both quantity (H-index=125) and quality of publications (65 publications) is occupied by the United States, and close collaborations with other countries are observed. In terms of publication institutions, the highest number of publications (9 publications) is held by the Second Military Medical University. The journal with the most publications (5 publications) is the Journal of Trauma-Injury Infection and Critical Care. A pivotal role has been played by basic medical research in the development of this field. Concerning hotspots, the focus of the research core can be divided into three clusters (etiology, diagnosis and treatment; molecular, cells and mechanisms; physiology and pathology). Conclusion: This marks the inaugural bibliometric analysis of lumbosacral plexus injuries, offering a comprehensive overview of current publications. Our findings illuminate future research directions, international collaborations, and interdisciplinary relationships. Future research will emphasize clinical treatment and mechanism research, with a focus on sacral nerve stimulation and nerve transplantation.
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000001332
Database	MEDical Literature Analysis and Retrieval System OnLINE

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