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Article ; Online: S100 calcium-binding protein A10 contributes to malignant traits in osteosarcoma cells by regulating glycolytic metabolism via the AKT/mTOR pathway.

Ling, Feng / Lu, Qifeng

2022 Volume 13, Issue 5, Page(s) 12298–12308

Abstract: As an aggressive musculoskeletal malignancy, osteosarcoma (OSa) is popular among young adults and teenagers worldwide. S100 calcium-binding protein A10 (S100A10) functioned as a novel tumor-promoting protein in several human cancers. However, its role in ...

Abstract	As an aggressive musculoskeletal malignancy, osteosarcoma (OSa) is popular among young adults and teenagers worldwide. S100 calcium-binding protein A10 (S100A10) functioned as a novel tumor-promoting protein in several human cancers. However, its role in OSa remains obscure. In this study, gene and protein levels were respectively determined by RT-qPCR or Western blotting. OSa cell proliferation, apoptosis, and metastasis were evaluated via CCK-8, colony formation, flow cytometry, and Transwell assays. To assess the glycolysis level, glucose consumption and lactate production were detected. It was found S100A10 was highly expressed in OSa tissues and cell lines. Besides, S100A10 facilitated proliferation and metastasis, and inhibited apoptosis in OSa cells. In addition, S100A10 regulated OSa cell proliferation, metastasis and apoptosis via mediating the glycolysis process. Furthermore, S100A10-mediated AKT/mTOR signaling accelerated glycolysis, thereby promoting malignant behaviors in OSa cells. Taken together, our findings indicated that S100A10 might promote malignant phenotypes of OSa cells by accelerating glycolysis and activating the AKT/mTOR signaling, providing a promising target for OSa treatment.
MeSH term(s)	Adolescent ; Annexin A2/metabolism ; Apoptosis/genetics ; Benzeneacetamides ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation ; Glycolysis ; Humans ; Osteosarcoma/metabolism ; Osteosarcoma/pathology ; Phenotype ; Proto-Oncogene Proteins c-akt/metabolism ; S100 Proteins/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Annexin A2 ; Benzeneacetamides ; S100 Proteins ; S100 calcium binding protein A10 ; MTOR protein, human (EC 2.7.1.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2022-05-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2737830-5
ISSN	2165-5987 ; 2165-5979
ISSN (online)	2165-5987
ISSN	2165-5979
DOI	10.1080/21655979.2022.2071022
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Article ; Online: The complete chloroplast genome of two Firmiana species and comparative analysis with other related species.

Lu, Qifeng / Luo, Wenhua

Genetica

2022 Volume 150, Issue 6, Page(s) 395–405

Abstract: Firmiana is a small genus within the subfamily Sterculioideae of the Malvaceae. There are nine Firmiana species distributed in South and South-west China, most of which are endangered. Due to the shortage of plastid genomes data, the phylogenetic ... ...

Abstract	Firmiana is a small genus within the subfamily Sterculioideae of the Malvaceae. There are nine Firmiana species distributed in South and South-west China, most of which are endangered. Due to the shortage of plastid genomes data, the phylogenetic relationships and the evolutionary history of this genus remain unclear. Therefore, the complete chloroplast genomes of F. calcarean and F. hainanensis were sequenced using high-throughput sequencing and then compared with the chloroplast genomes of other reported Firmiana species. The genome size of F. calcarean and F. hainanensis is 161,263 and 160,031 bp long, respectively, containing a total of 131 genes (including 85 protein coding genes, 37 tRNAs, 8 rRNAs, and one pseudogene). Comparative analysis revealed that the genome structure, GC content, gene content and order, as well as the RNA editing sites within the chloroplast genomes of F. calcarean and F. hainanensis were similar to previously reported Firmiana species. ML phylogenetic analysis revealed that F. danxiaensis, F. hainanensis, F. calcarean, F. simplex, and F. major form a sister group to F. colorata, F. pulcherrima, and F. kwangsiensis. The SSRs, long repeats, and 21 highly divergent regions (Pi > 0.01) identified in this study might provide potential DNA markers for further population genetics and phylogenetic studies of Firmiana. Our findings can help design new species-specific molecular markers and the general framework to further explore the evolutionary history of Firmiana and to address their conservation challenges.
MeSH term(s)	Genome, Chloroplast ; Phylogeny ; Chloroplasts/genetics ; Microsatellite Repeats ; Malvaceae/genetics
Language	English
Publishing date	2022-11-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2165-9
ISSN	1573-6857 ; 0016-6707
ISSN (online)	1573-6857
ISSN	0016-6707
DOI	10.1007/s10709-022-00169-3
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Article ; Online: The complete chloroplast genome of two Firmiana species and comparative analysis with other related species

Lu, Qifeng / Luo, Wenhua

Genetica. 2022 Dec., v. 150, no. 6 p.395-405

2022

Abstract	Firmiana is a small genus within the subfamily Sterculioideae of the Malvaceae. There are nine Firmiana species distributed in South and South-west China, most of which are endangered. Due to the shortage of plastid genomes data, the phylogenetic relationships and the evolutionary history of this genus remain unclear. Therefore, the complete chloroplast genomes of F. calcarean and F. hainanensis were sequenced using high-throughput sequencing and then compared with the chloroplast genomes of other reported Firmiana species. The genome size of F. calcarean and F. hainanensis is 161,263 and 160,031 bp long, respectively, containing a total of 131 genes (including 85 protein coding genes, 37 tRNAs, 8 rRNAs, and one pseudogene). Comparative analysis revealed that the genome structure, GC content, gene content and order, as well as the RNA editing sites within the chloroplast genomes of F. calcarean and F. hainanensis were similar to previously reported Firmiana species. ML phylogenetic analysis revealed that F. danxiaensis, F. hainanensis, F. calcarean, F. simplex, and F. major form a sister group to F. colorata, F. pulcherrima, and F. kwangsiensis. The SSRs, long repeats, and 21 highly divergent regions (Pi > 0.01) identified in this study might provide potential DNA markers for further population genetics and phylogenetic studies of Firmiana. Our findings can help design new species-specific molecular markers and the general framework to further explore the evolutionary history of Firmiana and to address their conservation challenges.
Keywords	DNA ; Malvaceae ; RNA ; chloroplast genome ; phylogeny ; population genetics ; pseudogenes ; China
Language	English
Dates of publication	2022-12
Size	p. 395-405.
Publishing place	Springer International Publishing
Document type	Article ; Online
ZDB-ID	2165-9
ISSN	1573-6857 ; 0016-6707
ISSN (online)	1573-6857
ISSN	0016-6707
DOI	10.1007/s10709-022-00169-3
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Article: Efficacy and safety of endoscopic retrograde cholangiopancreatography in patients over 75 years of age.

Wang, Shuangping / Lu, Qifeng / Zhou, Yabai / Zhang, Hao

Journal of minimal access surgery

2023 Volume 19, Issue 2, Page(s) 193–201

Abstract: Background: To investigate the efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP) in elderly choledocholithiasis patients compared with younger groups.: Methods: This was a case-control study conducted from January 2018 to ... ...

Abstract	Background: To investigate the efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP) in elderly choledocholithiasis patients compared with younger groups. Methods: This was a case-control study conducted from January 2018 to December 2020 at Fuyang People's Hospital, with 596 patients included. Patients who underwent ERCP were classified as two groups based on age stratification definitions from the National Institute of Health and the World Health Organisation: Patients <75 ages (n = 204) and patients ≥75 ages (n = 392). Demographic characteristics, details of endoscopic therapy, complications were retrospectively reviewed and compared between two groups. The subgroup was pre-formed to further explore the efficacy and safety of ERCP in the elderly population. Results: Between patients ≥75 ages and patients <75 ages, there were no significant differences in the complete stone removal rate and a second ERCP. Intubation difficulty (odds rate [OR]: 1.723, 95% confidence interval [CI]: 1.118-2.657) and longer ERCP operation time (β = 4.314, 95% CI: 2.366-6.262) were observed in the elderly group at a higher frequency than the younger group. Elder patients were more likely to have intra-operative complications (χ Conclusions: ERCP may be efficaciously performed on elderly patients. However, intra-operative and post-operative complications of ECRP should also be taken into consideration when selecting therapeutic options.
Language	English
Publishing date	2023-04-14
Publishing country	India
Document type	Journal Article
ZDB-ID	2186884-0
ISSN	1998-3921 ; 0972-9941
ISSN (online)	1998-3921
ISSN	0972-9941
DOI	10.4103/jmas.jmas_325_21
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Article ; Online: Insights into the mechanism of color formation of the freshwater prawn (Macrobrachium rosenbergii) revealed by de novo assembly transcriptome analysis.

Liu, Junhui / Lu, Qifeng / Wei, Yong / Zhang, Xingqian / Lin, Li / Li, Qingqing

Comparative biochemistry and physiology. Part D, Genomics & proteomics

2024 Volume 50, Page(s) 101237

Abstract: Body color is an important visual indicator of crustacean quality and plays a major role in consumer acceptability, perceived quality, and the market price of crustaceans. The freshwater prawn (Macrobrachium rosenbergii) has two distinct phenotypic ... ...

Abstract	Body color is an important visual indicator of crustacean quality and plays a major role in consumer acceptability, perceived quality, and the market price of crustaceans. The freshwater prawn (Macrobrachium rosenbergii) has two distinct phenotypic variations, characterized by dark blue and light yellow body colors. However, the underlying mechanisms regulating the body color of M. rosenbergii remain unclear. In this study, the composition of shell color parameters and pigment cells of raw and cooked dark blue and light yellow M. rosenbergii was investigated and the mechanisms associated with body color were elucidated by transcriptome analysis. The results showed significant differences in the raw shells of the dark blue and light yellow M. rosenbergii (L: 26.20 ± 0.53 vs. 29.25 ± 0.45; a: -0.88 ± 0.19 vs. 0.35 ± 0.18; b: 1.73 ± 0.20 vs. 3.46 ± 0.37; dE: 70.33 ± 0.53 vs. 67.34 ± 0.45, respectively, p = 0.000) as well as the cooked shells (L: 58.14 ± 0.81 vs. 55.78 ± 0.55; a: 19.30 ± 0.56 vs. 16.42 ± 0.40; b: 23.60 ± 0.66 vs. 20.30 ± 0.40, respectively, p < 0.05). Transcriptome differential gene analysis obtained 39.02 Gb of raw data and 158,026 unigenes. Comprehensive searches of the SwissProt, Nr, KEGG, Pfam, and KOG databases resulted in successful annotations of 23,902 (33 %), 40,436 (25.59 %), 32,015 (20.26 %), 26,139 (16.54 %), and 22,155 (14.02 %) proteins, respectively. By KEGG pathway analysis, numerous differentially expressed genes were related to pigmentation-related pathways (MAPK signaling pathway, Wnt signaling pathway, melanin production, tyrosine metabolism, and cell-cell communication process). Candidate DEGs that may be involved in body color included apolipoprotein D, crustacyanin, cytochrome P450, and tyrosinase, as verified by quantitative real-time PCR. The results of this study provide useful references to further elucidate the molecular mechanisms of color formation of M. rosenbergii and other crustaceans.
Language	English
Publishing date	2024-04-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2212119-5
ISSN	1878-0407 ; 1744-117X
ISSN (online)	1878-0407
ISSN	1744-117X
DOI	10.1016/j.cbd.2024.101237
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Article ; Online: Electric Double Layer Based Epidermal Electronics for Healthcare and Human-Machine Interface.

Gao, Yuan / Zhang, Hanchu / Song, Bowen / Zhao, Chun / Lu, Qifeng

Biosensors

2023 Volume 13, Issue 8

Abstract: Epidermal electronics, an emerging interdisciplinary field, is advancing the development of flexible devices that can seamlessly integrate with the skin. These devices, especially Electric Double Layer (EDL)-based sensors, overcome the limitations of ... ...

Abstract	Epidermal electronics, an emerging interdisciplinary field, is advancing the development of flexible devices that can seamlessly integrate with the skin. These devices, especially Electric Double Layer (EDL)-based sensors, overcome the limitations of conventional electronic devices, offering high sensitivity, rapid response, and excellent stability. Especially, Electric Double Layer (EDL)-based epidermal sensors show great potential in the application of wearable electronics to detect biological signals due to their high sensitivity, fast response, and excellent stability. The advantages can be attributed to the biocompatibility of the materials, the flexibility of the devices, and the large capacitance due to the EDL effect. Furthermore, we discuss the potential of EDL epidermal electronics as wearable sensors for health monitoring and wound healing. These devices can analyze various biofluids, offering real-time feedback on parameters like pH, temperature, glucose, lactate, and oxygen levels, which aids in accurate diagnosis and effective treatment. Beyond healthcare, we explore the role of EDL epidermal electronics in human-machine interaction, particularly their application in prosthetics and pressure-sensing robots. By mimicking the flexibility and sensitivity of human skin, these devices enhance the functionality and user experience of these systems. This review summarizes the latest advancements in EDL-based epidermal electronic devices, offering a perspective for future research in this rapidly evolving field.
MeSH term(s)	Humans ; Epidermis ; Skin ; Electronics ; Lactic Acid ; Delivery of Health Care
Chemical Substances	Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2023-08-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios13080787
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Article ; Online: Flexible Artificial Sensory Systems Based on Neuromorphic Devices.

Sun, Fuqin / Lu, Qifeng / Feng, Simin / Zhang, Ting

ACS nano

2021 Volume 15, Issue 3, Page(s) 3875–3899

Abstract: Emerging flexible artificial sensory systems using neuromorphic electronics have been considered as a promising solution for processing massive data with low power consumption. The construction of artificial sensory systems with synaptic devices and ... ...

Abstract	Emerging flexible artificial sensory systems using neuromorphic electronics have been considered as a promising solution for processing massive data with low power consumption. The construction of artificial sensory systems with synaptic devices and sensing elements to mimic complicated sensing and processing in biological systems is a prerequisite for the realization. To realize high-efficiency neuromorphic sensory systems, the development of artificial flexible synapses with low power consumption and high-density integration is essential. Furthermore, the realization of efficient coupling between the sensing element and the synaptic device is crucial. This Review presents recent progress in the area of neuromorphic electronics for flexible artificial sensory systems. We focus on both the recent advances of artificial synapses, including device structures, mechanisms, and functions, and the design of intelligent, flexible perception systems based on synaptic devices. Additionally, key challenges and opportunities related to flexible artificial perception systems are examined, and potential solutions and suggestions are provided.
MeSH term(s)	Electronics ; Synapses
Language	English
Publishing date	2021-01-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.0c10049
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Article: Low-Dimensional-Materials-Based Flexible Artificial Synapse: Materials, Devices, and Systems.

Lu, Qifeng / Zhao, Yinchao / Huang, Long / An, Jiabao / Zheng, Yufan / Yap, Eng Hwa

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 3

Abstract: With the rapid development of artificial intelligence and the Internet of Things, there is an explosion of available data for processing and analysis in any domain. However, signal processing efficiency is limited by the Von Neumann structure for the ... ...

Abstract	With the rapid development of artificial intelligence and the Internet of Things, there is an explosion of available data for processing and analysis in any domain. However, signal processing efficiency is limited by the Von Neumann structure for the conventional computing system. Therefore, the design and construction of artificial synapse, which is the basic unit for the hardware-based neural network, by mimicking the structure and working mechanisms of biological synapses, have attracted a great amount of attention to overcome this limitation. In addition, a revolution in healthcare monitoring, neuro-prosthetics, and human-machine interfaces can be further realized with a flexible device integrating sensing, memory, and processing functions by emulating the bionic sensory and perceptual functions of neural systems. Until now, flexible artificial synapses and related neuromorphic systems, which are capable of responding to external environmental stimuli and processing signals efficiently, have been extensively studied from material-selection, structure-design, and system-integration perspectives. Moreover, low-dimensional materials, which show distinct electrical properties and excellent mechanical properties, have been extensively employed in the fabrication of flexible electronics. In this review, recent progress in flexible artificial synapses and neuromorphic systems based on low-dimensional materials is discussed. The potential and the challenges of the devices and systems in the application of neuromorphic computing and sensory systems are also explored.
Language	English
Publishing date	2023-01-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13030373
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Article ; Online: Intensity Simulation of a Fourier Transform Infrared Spectrometer.

Ni, Zhuoya / Lu, Qifeng / Xu, Yishu / Huo, Hongyuan

Sensors (Basel, Switzerland)

2020 Volume 20, Issue 7

Abstract: This paper introduces an intensity simulation for the Fourier transform infrared spectrometer whose core element is the Michelson interferometer to provide support for the on-orbit monitoring of the instrument and to improve the data processing and ... ...

Abstract	This paper introduces an intensity simulation for the Fourier transform infrared spectrometer whose core element is the Michelson interferometer to provide support for the on-orbit monitoring of the instrument and to improve the data processing and application of the Fourier transform spectrometer. The Geostationary Interferometric Infrared Imager (GIIRS) aboard on Fengyun-4B (FY-4B) satellite, which will be launched in 2020, aims to provide hyperspectral infrared observations. An intensity simulation of the Michelson interferometer based on the GIIRS's instrument parameters is systematically analyzed in this paper. Off-axis effects and non-linearity response are two important factors to be considered in this simulation. Off-axis effects mainly cause the wavenumber shift to induce a large brightness temperature error compared with the input spectrum, and the non-linearity response reduces the energy received by the detector. Then, off-axis effects and a non-linearity response are added to the input spectrum successively to obtain the final spectrum. Off-axis correction and non-linearity correction are also developed to give a full simulation process. Comparing the corrected spectrum with the input spectrum, we can see that the brightness temperature errors have a magnitude of 10
Language	English
Publishing date	2020-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s20071833
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Article ; Online: Fast and High-Performance Self-Powered Photodetector Based on the ZnO/Metal-Organic Framework Heterojunction.

Wang, Yingyi / Liu, Lin / Shi, Yixiang / Li, Shengzhao / Sun, Fuqin / Lu, Qifeng / Shen, Yaochun / Feng, Simin / Qin, Sujie

ACS applied materials & interfaces

2023 Volume 15, Issue 14, Page(s) 18236–18243

Abstract: Electrical conductive metal-organic frameworks (EC-MOFs) are emerging as an appealing class of highly tailorable electrically conducting materials with potential applications in optoelectronics. Here, we in situ grew nickel hexahydroxytriphenylene (Ni- ... ...

Abstract	Electrical conductive metal-organic frameworks (EC-MOFs) are emerging as an appealing class of highly tailorable electrically conducting materials with potential applications in optoelectronics. Here, we in situ grew nickel hexahydroxytriphenylene (Ni-CAT) on the surface of ZnO nanorods (NRs). The self-powered photodetectors (PDs) were fabricated with heterojunctions formed at the interface of ZnO NRs and Ni-CAT. With this, the built-in electric field (BEF) can effectively separate the photogenerated electron-hole pairs and enhance the photoresponse. We observe that the PDs based on hybrid ZnO/Ni-CAT with 3 h of growth time (ZnO/Ni-CAT-3) show good photoresponse (137 μA/W) with the fast rise (3 ms) and decay time (50 ms) under 450 nm light illumination without biased voltage. This work provides a facile and controllable method for the growth of the ZnO/Ni-CAT heterojunction with an effective BEF zone, which will benefit their optoelectronic applications.
Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c01740
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