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Book ; Online ; E-Book: New theories and predictions on the ozone hole and climate change

Lu, Qing-Bin

2015

Author's details	Qing-Bin Lu
Language	English
Size	1 Online-Ressource (285 Seiten)
Publisher	World Scientific
Publishing place	New Jersey ; London ; Singapore ; Beijing ; Shanghai ; Hongkong ; Taipei ; Chennai
Publishing country	Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019425913
ISBN	978-981-4619-45-5 ; 9789814619448 ; 981-4619-45-0 ; 9814619442
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Formulation of the cosmic ray-driven electron-induced reaction mechanism for quantitative understanding of global ozone depletion.

Lu, Qing-Bin

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 27, Page(s) e2303048120

Abstract: This paper formulates the cosmic ray-driven electron-induced reaction as a universal mechanism to provide a quantitative understanding of global ozone depletion. Based on a proposed electrostatic bonding mechanism for charge-induced adsorption of ... ...

Abstract	This paper formulates the cosmic ray-driven electron-induced reaction as a universal mechanism to provide a quantitative understanding of global ozone depletion. Based on a proposed electrostatic bonding mechanism for charge-induced adsorption of molecules on surfaces and on the measured dissociative electron transfer (DET) cross sections of ozone-depleting substances (ODSs) adsorbed on ice, an analytical equation is derived to give atmospheric chlorine atom concentration: [Formula: see text] where Φ
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2303048120
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Reaction Cycles of Halogen Species in the Immune Defense: Implications for Human Health and Diseases and the Pathology and Treatment of COVID-19.

Lu, Qing-Bin

Cells

2020 Volume 9, Issue 6

Abstract: There is no vaccine or specific antiviral treatment for COVID-19, which is causing a global pandemic. One current focus is drug repurposing research, but those drugs have limited therapeutic efficacies and known adverse effects. The pathology of COVID-19 ...

Abstract	There is no vaccine or specific antiviral treatment for COVID-19, which is causing a global pandemic. One current focus is drug repurposing research, but those drugs have limited therapeutic efficacies and known adverse effects. The pathology of COVID-19 is essentially unknown. Without this understanding, it is challenging to discover a successful treatment to be approved for clinical use. This paper addresses several key biological processes of reactive oxygen, halogen and nitrogen species (ROS, RHS and RNS) that play crucial physiological roles in organisms from plants to humans. These include why superoxide dismutases, the enzymes to catalyze the formation of H
MeSH term(s)	Animals ; Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Heterocyclic Compounds/therapeutic use ; Humans ; Hydrocarbons, Halogenated/therapeutic use ; Hydrogen Peroxide/metabolism ; Lysosomes/drug effects ; Pandemics ; Phagocytosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; Pneumonia, Viral/metabolism ; Respiratory Burst/drug effects ; Signal Transduction
Chemical Substances	Antiviral Agents ; Heterocyclic Compounds ; Hydrocarbons, Halogenated ; Hydrogen Peroxide (BBX060AN9V)
Keywords	covid19
Language	English
Publishing date	2020-06-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells9061461
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Preventing mother-to-child transmission of HBV.

Lu, Qing-Bin / Cui, Fuqiang

The Lancet. Infectious diseases

2022 Volume 22, Issue 8, Page(s) 1096–1097

MeSH term(s)	DNA, Viral ; Female ; Hepatitis B Surface Antigens ; Hepatitis B Vaccines ; Hepatitis B e Antigens ; Hepatitis B virus ; Humans ; Infectious Disease Transmission, Vertical/prevention & control ; Pregnancy ; Pregnancy Complications, Infectious/prevention & control
Chemical Substances	DNA, Viral ; Hepatitis B Surface Antigens ; Hepatitis B Vaccines ; Hepatitis B e Antigens
Language	English
Publishing date	2022-05-25
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(22)00216-X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5743: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: New combination chemotherapy of cisplatin with an electron-donating compound for treatment of multiple cancers.

Zhang, Qinrong / Lu, Qing-Bin

Scientific reports

2021 Volume 11, Issue 1, Page(s) 788

Abstract: Cisplatin is the first and most widely used platinum-based chemotherapy drug and is the cornerstone agent in treating a broad spectrum of cancers. However, its clinical application is often limited by severe toxic side effects and drug resistance. Based ... ...

Abstract	Cisplatin is the first and most widely used platinum-based chemotherapy drug and is the cornerstone agent in treating a broad spectrum of cancers. However, its clinical application is often limited by severe toxic side effects and drug resistance. Based on the discovered dissociative electron transfer mechanism of cisplatin, a novel combination of cisplatin with [9-(2-carboxyphenyl)-6-diethylamino-3-xanthenylidene]-diethylammonium chloride (basic violet 10, BV10) is proposed to potentiate the chemotherapeutic effect of cisplatin. Here, we show that this combination enhances the anti-cancer effect of cisplatin in both in vitro cell lines and in vivo xenograft mouse models of cisplatin-sensitive and -resistant lung, ovarian and cervical cancers while introducing minimal additional toxic side effects. Furthermore, femtosecond time-resolved laser spectroscopic measurements demonstrate that cisplatin reacts with BV10 via an electron transfer mechanism. These results indicate that the combination of cisplatin with BV10 is promising for improving the chemotherapy of cancers with various extents of cisplatin resistance.
MeSH term(s)	Ammonium Compounds/administration & dosage ; Ammonium Compounds/pharmacology ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Cisplatin/administration & dosage ; Cisplatin/pharmacology ; Drug Resistance, Neoplasm ; Female ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology ; Xenograft Model Antitumor Assays
Chemical Substances	Ammonium Compounds ; Antineoplastic Agents ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2021-01-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-80876-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Reaction Cycles of Halogen Species in the Immune Defense: Implications for Human Health and Diseases and the Pathology and Treatment of COVID-19

Lu, Qing-Bin

Abstract	There is no vaccine or specific antiviral treatment for COVID-19, which is causing a global pandemic. One current focus is drug repurposing research, but those drugs have limited therapeutic efficacies and known adverse effects. The pathology of COVID-19 is essentially unknown. Without this understanding, it is challenging to discover a successful treatment to be approved for clinical use. This paper addresses several key biological processes of reactive oxygen, halogen and nitrogen species (ROS, RHS and RNS) that play crucial physiological roles in organisms from plants to humans. These include why superoxide dismutases, the enzymes to catalyze the formation of H2O2, are required for protecting ROS-induced injury in cell metabolism, why the amount of ROS/RNS produced by ionizing radiation at clinically relevant doses is ~1000 fold lower than the endogenous ROS/RNS level routinely produced in the cell and why a low level of endogenous RHS plays a crucial role in phagocytosis for immune defense. Herein we propose a plausible amplification mechanism in immune defense: ozone-depleting-like halogen cyclic reactions enhancing RHS effects are responsible for all the mentioned physiological functions, which are activated by H2O2 and deactivated by NO signaling molecule. Our results show that the reaction cycles can be repeated thousands of times and amplify the RHS pathogen-killing (defense) effects by 100,000 fold in phagocytosis, resembling the cyclic ozone-depleting reactions in the stratosphere. It is unraveled that H2O2 is a required protective signaling molecule (angel) in the defense system for human health and its dysfunction can cause many diseases or conditions such as autoimmune disorders, aging and cancer. We also identify a class of potent drugs for effective treatment of invading pathogens such as HIV and SARS-CoV-2 (COVID-19), cancer and other diseases, and provide a molecular mechanism of action of the drugs or candidates.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #603067
Database	COVID19

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Book ; Online: Reaction Cycles of Halogen Species in the Immune Defense

Lu, Qing-Bin

Implications for Human Health and Diseases and the Pathology and Treatment of Covid19

2020

Abstract: There is no vaccine or specific antiviral treatment for COVID19 that is causing a global pandemic. One current focus is drug repurposing research, but those drugs have limited therapeutic efficacies and known adverse effects. The pathology of COVID19 is ... ...

Abstract	There is no vaccine or specific antiviral treatment for COVID19 that is causing a global pandemic. One current focus is drug repurposing research, but those drugs have limited therapeutic efficacies and known adverse effects. The pathology of COVID19 is essentially unknow. Without this understanding, it is challenging to discover a successful treatment to be approved for clinical use. This paper addresses several key biological processes of reactive oxygen, halogen and nitrogen species (ROS, RHS and RNS) that play crucial physiological roles in organisms from plants to humans. It includes why superoxide dismutases, the enzymes to catalyze the formation of H2O2, are required for protecting ROS-induced injury in cell metabolism, why the amount of ROS/RNS produced by ionizing radiation at clinically relevant doses is ~1000 fold lower than the endogenous ROS/RNS level routinely produced in the cell, and why a low level of endogenous RHS plays a crucial role in the innate immune defense. Here we propose a striking yet plausible amplification mechanism in the immune defense: ozone-depleting-like halogen cyclic reactions enhancing RHS effects are responsible for all the mentioned physiological functions, which are activated by H2O2 and deactivated by NO signaling molecule. Our calculated results show that the reaction cycles can be repeated thousands of times and amplify the RHS pathogen-killing (defense) effects by 100000 folds, resembling the cyclic O3-depleting reactions in the stratosphere. It is unraveled that H2O2 is a required protective signaling molecule (angel) in the defense system for human health and its dysfunction can cause many diseases such as autoimmune disorders, aging and cancer. We also identify a class of potent drugs for effective treatment of invading pathogens (COVID19), cancer and other diseases, and provide a molecular mechanism of action of the drugs or candidates. Comment: 18 pages, 4 figures, 1 table
Keywords	Quantitative Biology - Cell Behavior ; Quantitative Biology - Biomolecules ; Quantitative Biology - Subcellular Processes ; covid19
Subject code	572
Publishing date	2020-04-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effect of individualized weight management intervention on excessive gestational weight gain and perinatal outcomes: a randomized controlled trial.

Xu, Mei-Yan / Guo, Yan-Jun / Zhang, Li-Juan / Lu, Qing-Bin

PeerJ

2022 Volume 10, Page(s) e13067

Abstract: It is unclear whether weight management is still effective for pregnant women with excessive weight gain in the second or third trimester in China. This study adopted individualized weight management intervention for pregnant women with abnormal weight ... ...

Abstract	It is unclear whether weight management is still effective for pregnant women with excessive weight gain in the second or third trimester in China. This study adopted individualized weight management intervention for pregnant women with abnormal weight gain in the second or third trimester, to analyze the effect of intervention by observing the gestational weight gain and perinatal outcomes. This randomized controlled trial was performed at Aerospace Center Hospital. The obstetrician determined whether the pregnant women gained too much weight in the second or third trimester according to the Institute of Medicine guidelines, and randomly divided the pregnant women who gained too much weight in the second or third trimester into the intervention group or the control group according to the inclusion and exclusion criteria. The pregnant women in the intervention group and in the control group all received routine prenatal examination and diet nutrition education by the doctors in the Department of Obstetrics and Gynecology. The intervention group underwent individualized weight management, including individualized diet, exercise, psychological assessment, cognitive intervention and continuous communication, the whole process is tracked and managed by professional nutritionists. The obstetrician collected the prenatal examination data and pregnancy outcome data of all enrolled pregnant women. The primary outcome measure was weight gain during pregnancy. A generalized linear model and a logistic regression model were used to compare the outcomes between the two groups. In total, 348 pregnant women participated in this study with 203 in the intervention group and 145 in the control group. The whole gestational weight gain in the intervention group (15.8 ± 5.4 Kg) was lower than that in the control group (17.5 ± 3.6 Kg; adjusted
Language	English
Publishing date	2022-03-08
Publishing country	United States
Document type	Clinical Trial
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.13067
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Vaccination with the Inactivated Vaccine (Sinopharm BBIBP-CorV) Ensures Protection against SARS-CoV-2 Related Disease.

Wang, Chao / Chen, Lin-Yi / Lu, Qing-Bin / Cui, Fuqiang

Vaccines

2022 Volume 10, Issue 6

Abstract: Vaccination against coronavirus disease 2019 (COVID-19) has become an important public health solution. Developing a safe and effective vaccine against COVID-19 is a viable long-term solution to control the pandemic. As one of the two inactivated severe ... ...

Abstract	Vaccination against coronavirus disease 2019 (COVID-19) has become an important public health solution. Developing a safe and effective vaccine against COVID-19 is a viable long-term solution to control the pandemic. As one of the two inactivated severe acute respiratory syndrome virus 2 (SARS-CoV-2) vaccines developed in China that entered the WHO emergency use list, Sinopharm BBIBP-CorV, an aluminum-hydroxide-adjuvanted, inactivated whole-virus vaccine, has been widely distributed, with more than 400 million doses administered in more than 40 countries. The evidence of the safety, efficacy, and effectiveness of BBIBP-CorV is gathered and reviewed. We further comment on one of the latest papers that disclosed the effectiveness results between BBIBP-CorV, rAd26-rAd5, and ChAdOx1.
Language	English
Publishing date	2022-06-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10060920
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metabolic alterations in urine among the patients with severe fever with thrombocytopenia syndrome.

Zhang, Shan-Shan / Yang, Xin / Zhang, Wan-Xue / Zhou, Yiguo / Wei, Ting-Ting / Cui, Ning / Du, Juan / Liu, Wei / Lu, Qing-Bin

Virology journal

2024 Volume 21, Issue 1, Page(s) 11

Abstract: Background: The pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) remained unclear. We aimed to profile the metabolic alterations in urine of SFTS patients and provide new evidence for its pathogenesis.: Methods: A case-control study ...

Abstract	Background: The pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) remained unclear. We aimed to profile the metabolic alterations in urine of SFTS patients and provide new evidence for its pathogenesis. Methods: A case-control study was conducted in the 154th hospital in China. Totally 88 cases and 22 controls aged ≥ 18 years were enrolled. The cases were selected from laboratory-confirmed SFTS patients. The controls were selected among SFTSV-negative population. Those with diabetes, cancer, hepatitis and other sexually transmitted diseases were excluded in both groups. Fatal cases and survival cases were 1:1 matched. Inter-group differential metabolites and pathways were obtained, and the inter-group discrimination ability was evaluated. Results: Tryptophan metabolism and phenylalanine metabolism were the top one important metabolism pathway in differentiating the control and case groups, and the survival and fatal groups, respectively. The significant increase of differential metabolites in tryptophan metabolism, including 5-hydroxyindoleacetate (5-HIAA), L-kynurenine (KYN), 5-hydroxy-L-tryptophan (5-HTP), 3-hydroxyanthranilic acid (3-HAA), and the increase of phenylpyruvic acid and decrease of hippuric acid in phenylalanine metabolism indicated the potential metabolic alterations in SFTSV infection. The increase of 5-HIAA, KYN, 5-HTP, phenylpyruvic acid and hippuric acid were involved in the fatal progress of SFTS patients. Conclusions: Tryptophan metabolism and phenylalanine metabolism might be involved in the pathogenesis of SFTSV infection. These findings provided new evidence for the pathogenesis and treatment of SFTS.
MeSH term(s)	Humans ; Severe Fever with Thrombocytopenia Syndrome ; 5-Hydroxytryptophan ; Case-Control Studies ; Hydroxyindoleacetic Acid ; Tryptophan ; Phenylalanine
Chemical Substances	hippuric acid (TE0865N2ET) ; phenylpyruvic acid (X7CO62M413) ; 5-Hydroxytryptophan (C1LJO185Q9) ; Hydroxyindoleacetic Acid (54-16-0) ; Tryptophan (8DUH1N11BX) ; Phenylalanine (47E5O17Y3R)
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2160640-7
ISSN	1743-422X ; 1743-422X
ISSN (online)	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-024-02285-2
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